Antitumor effects of β-elemene via targeting the phosphorylation of insulin receptor

Hepatic protein tyrosine phosphatase receptor gamma links obesity-induced inflammation to insulin resistance

(2017) Xavier Brenachot et al.   Nature Communications

Interplay of DNA methyltransferase 1 and EZH2 through inactivation of Stat3 contributes to β-elemene-inhibited growth of nasopharyngeal carcinoma cells

(2017) JingJing Wu et al.   Scientific Reports

IGF-1R and mTOR Blockade: Novel Resistance Mechanisms and Synergistic Drug Combinations for Ewing Sarcoma

(2016) Salah-Eddine Lamhamedi-Cherradi et al.   JNCI-Journal of the National Cancer Institute

Disruption of insulin receptor function inhibits proliferation in endocrine-resistant breast cancer cells

(2016) J Y Chan et al.   ONCOGENE

IGF-1R and mTOR Blockade: Novel Resistance Mechanisms and Synergistic Drug Combinations for Ewing Sarcoma

(2016) Salah-Eddine Lamhamedi-Cherradi et al.   JNCI-Journal of the National Cancer Institute

β-elemene sensitizes hepatocellular carcinoma cells to oxaliplatin by preventing oxaliplatin-induced degradation of copper transporter 1

(2016) Xiaoqiang Li et al.   Scientific Reports

β-elemene inhibited expression of DNA methyltransferase 1 through activation of ERK1/2 and AMPKα signalling pathways in human lung cancer cells: the role of Sp1

(2015) ShunYu Zhao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Enhanced insulin signaling in density-enhanced phosphatase-1 (DEP-1) knockout mice

(2015) Janine Krüger et al.   Molecular Metabolism

Evaluation of In Vitro Activity of the Class I PI3K Inhibitor Buparlisib (BKM120) in Pediatric Bone and Soft Tissue Sarcomas

(2015) Jennifer L. Anderson et al.   PLoS One

β-elemene inhibits stemness, promotes differentiation and impairs chemoresistance to temozolomide in glioblastoma stem-like cells

(2014) TING-ZHUN ZHU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

MEDI-573, Alone or in Combination with Mammalian Target of Rapamycin Inhibitors, Targets the Insulin-like Growth Factor Pathway in Sarcomas

(2014) H. Zhong et al.   MOLECULAR CANCER THERAPEUTICS

Anticancer effects of β-elemene in gastric cancer cells and its potential underlying proteins: A proteomic study

(2014) JUN-SONG LIU et al.   ONCOLOGY REPORTS

β-Elemene enhances susceptibility to cisplatin in resistant ovarian carcinoma cells via downregulation of ERCC-1 and XIAP and inactivation of JNK

(2013) QUENTIN Q. LI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

EWS represses cofilin 1 expression by inducing nuclear retention of cofilin 1 mRNA

(2013) L Huang et al.   ONCOGENE

13,14-bis(cis-3,5-dimethyl-1-piperazinyl)-β-elemene, a novel β-elemene derivative, shows potent antitumor activities via inhibition of mTOR in human breast cancer cells

(2013) XIAO-FEI DING et al.   Oncology Letters

TCPTP Regulates SFK and STAT3 Signaling and Is Lost in Triple-Negative Breast Cancers

(2012) Benjamin J. Shields et al.   MOLECULAR AND CELLULAR BIOLOGY

AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity

(2011) Sarat Chandarlapaty et al.   CANCER CELL

Oncogenic Fusion Protein EWS/FLI1 Down-regulates Gene Expression by Both Transcriptional and Posttranscriptional Mechanisms

(2011) Kelly A. France et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efficacy of and resistance to anti-IGF-1R therapies in Ewing's sarcoma is dependent on insulin receptor signaling

(2011) C Garofalo et al.   ONCOGENE

A Phase I Study of Weekly R1507, A Human Monoclonal Antibody Insulin-like Growth Factor-I Receptor Antagonist, in Patients with Advanced Solid Tumors

(2010) R. Kurzrock et al.   CLINICAL CANCER RESEARCH

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

(2010) Gideon Bollag et al.   NATURE

Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia

(2010) Maria Kleppe et al.   NATURE GENETICS

Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo

(2010) C Algire et al.   ONCOGENE

Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy

(2010) D. B. Ulanet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IGF-1R targeted treatment of sarcoma

(2009) Jeffrey A Toretsky et al.   LANCET ONCOLOGY

Safety, pharmacokinetics, and preliminary activity of the anti-IGF-1R antibody figitumumab (CP-751,871) in patients with sarcoma and Ewing's sarcoma: a phase 1 expansion cohort study

(2009) David Olmos et al.   LANCET ONCOLOGY

Emerging role of insulin-like growth factor receptor inhibitors in oncology: early clinical trial results and future directions

(2009) A Gualberto et al.   ONCOGENE

The Type 1 Insulin-Like Growth Factor Receptor Pathway

(2008) M. M. Chitnis et al.   CLINICAL CANCER RESEARCH

Prediagnostic body-mass index, plasma C-peptide concentration, and prostate cancer-specific mortality in men with prostate cancer: a long-term survival analysis

(2008) Jing Ma et al.   LANCET ONCOLOGY

The Emerging Role of the Insulin-Like Growth Factor Pathway as a Therapeutic Target in Cancer

(2008) P. D. Ryan et al.   ONCOLOGIST