Rapid phenotyping of knockout mice to identify genetic determinants of bone strength

Orthology for comparative genomics in the mouse genome database

(2015) Mary E. Dolan et al.   MAMMALIAN GENOME

Collaborative Cross and Diversity Outbred data resources in the Mouse Phenome Database

(2015) Molly A. Bogue et al.   MAMMALIAN GENOME

Novel therapies for osteoporosis

(2015) Polyzois Makras et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Whole‐genome sequencing identifies EN1 as a determinant of bone density and fracture

(2015) Hou‐Feng Zheng et al.   NATURE

Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics

(2015) Martin Hrabě de Angelis et al.   NATURE GENETICS

Osteopetrosis and Its Relevance for the Discovery of New Functions Associated with the Skeleton

(2015) Amélie E. Coudert et al.   International Journal of Endocrinology

Applying the ARRIVE Guidelines to an In Vivo Database

(2015) Natasha A. Karp et al.   PLOS BIOLOGY

Integrative Analysis of Transcriptomic and Epigenomic Data to Reveal Regulation Patterns for BMD Variation

(2015) Ji-Gang Zhang et al.   PLoS One

RNA sequencing: current and prospective uses in metabolic research

(2014) Petter Vikman et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

CRISPR-Cas systems for editing, regulating and targeting genomes

(2014) Jeffry D Sander et al.   NATURE BIOTECHNOLOGY

Fracture mortality: associations with epidemiology and osteoporosis treatment

(2014) Sebastian E. Sattui et al.   Nature Reviews Endocrinology

Odanacatib for the treatment of postmenopausal osteoporosis: development history and design and participant characteristics of LOFT, the Long-Term Odanacatib Fracture Trial

(2014) H. G. Bone et al.   OSTEOPOROSIS INTERNATIONAL

Ten years of next-generation sequencing technology

(2014) Erwin L. van Dijk et al.   TRENDS IN GENETICS

Unveiling the mysteries of the genetics of osteoporosis

(2014) N. Alonso et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes

(2013) Jacqueline K. White et al.   CELL

PLS3 Mutations in X-Linked Osteoporosis with Fractures

(2013) Fleur S. van Dijk et al.   NEW ENGLAND JOURNAL OF MEDICINE

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data

(2013) Gautier Koscielny et al.   NUCLEIC ACIDS RESEARCH

Nationwide registry-based analysis of cardiovascular risk factors and adverse outcomes in patients treated with strontium ranelate

(2013) B. Abrahamsen et al.   OSTEOPOROSIS INTERNATIONAL

ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering

(2013) Thomas Gaj et al.   TRENDS IN BIOTECHNOLOGY

Genome-wide approaches for identifying genetic risk factors for osteoporosis

(2013) Shuyan Wu et al.   Genome Medicine

Pervasive Transcription of the Human Genome Produces Thousands of Previously Unidentified Long Intergenic Noncoding RNAs

(2013) Matthew J. Hangauer et al.   PLoS Genetics

Osteoporosis in the European Union: medical management, epidemiology and economic burden

(2013) E. Hernlund et al.   Archives of Osteoporosis

Five Years of GWAS Discovery

(2012) Peter M. Visscher et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Activation of resorption in fatigue-loaded bone involves both apoptosis and active pro-osteoclastogenic signaling by distinct osteocyte populations

(2012) Oran D. Kennedy et al.   BONE

High-Resolution Genetic Mapping Using the Mouse Diversity Outbred Population

(2012) Karen L. Svenson et al.   GENETICS

Mouse genetic and phenotypic resources for human genetics

(2012) Paul N. Schofield et al.   HUMAN MUTATION

Beyond knockouts: cre resources for conditional mutagenesis

(2012) Stephen A. Murray et al.   MAMMALIAN GENOME

The International Mouse Phenotyping Consortium: past and future perspectives on mouse phenotyping

(2012) Steve D. M. Brown et al.   MAMMALIAN GENOME

The mammalian gene function resource: the international knockout mouse consortium

(2012) Allan Bradley et al.   MAMMALIAN GENOME

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

(2012) Karol Estrada et al.   NATURE GENETICS

Bench to bedside: elucidation of the OPG–RANK–RANKL pathway and the development of denosumab

(2012) David L. Lacey et al.   NATURE REVIEWS DRUG DISCOVERY

Genetics of osteoporosis from genome-wide association studies: advances and challenges

(2012) J. Brent Richards et al.   NATURE REVIEWS GENETICS

Transgenic Mice for a Tamoxifen-Induced, Conditional Expression of the Cre Recombinase in Osteoclasts

(2012) Maria Arantzazu Sanchez-Fernandez et al.   PLoS One

Rapid-Throughput Skeletal Phenotyping of 100 Knockout Mice Identifies 9 New Genes That Determine Bone Strength

(2012) J. H. Duncan Bassett et al.   PLoS Genetics

Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading

(2011) Xiaolin Tu et al.   BONE

Mouse models and the interpretation of human GWAS in type 2 diabetes and obesity

(2011) R. D. Cox et al.   Disease Models & Mechanisms

An integrative study ascertained SOD2 as a susceptibility gene for osteoporosis in Chinese

(2011) Fei-Yan Deng et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The Genetics of Bone Loss: Challenges and Prospects

(2011) Braxton D. Mitchell et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Targeted ablation of the PTH/PTHrP receptor in osteocytes impairs bone structure and homeostatic calcemic responses

(2011) William F Powell et al.   JOURNAL OF ENDOCRINOLOGY

Peripheral Blood Monocyte-expressedANXA2Gene is Involved in Pathogenesis of Osteoporosis in Humans

(2011) Fei-Yan Deng et al.   MOLECULAR & CELLULAR PROTEOMICS

A conditional knockout resource for the genome-wide study of mouse gene function

(2011) William C. Skarnes et al.   NATURE

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

(2011) Tomoki Nakashima et al.   NATURE MEDICINE

Epigenetic influences in the developmental origins of osteoporosis

(2011) C. Holroyd et al.   OSTEOPOROSIS INTERNATIONAL

Genome-Wide Association Study Using Extreme Truncate Selection Identifies Novel Genes Affecting Bone Mineral Density and Fracture Risk

(2011) Emma L. Duncan et al.   PLoS Genetics

Prioritizing GWAS Results: A Review of Statistical Methods and Recommendations for Their Application

(2010) Rita M. Cantor et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Cellular and Molecular Mechanisms of Bone Remodeling

(2010) Liza J. Raggatt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Changes in axial bone density with age: A twin study

(2010) Paul J. Kelly et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Segregation analysis and variance components analysis of bone mineral density in healthy families

(2010) René Guéguen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Guidelines for assessment of bone microstructure in rodents using micro-computed tomography

(2010) Mary L Bouxsein et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Secretome Analysis of Human BMSCs and Identification of SMOC1 as an Important ECM Protein in Osteoblast Differentiation

(2010) Young-Ae Choi et al.   JOURNAL OF PROTEOME RESEARCH

Genomewide Association Studies and Assessment of the Risk of Disease

(2010) Teri A. Manolio   NEW ENGLAND JOURNAL OF MEDICINE

Optimal bone strength and mineralization requires the type 2 iodothyronine deiodinase in osteoblasts

(2010) J. H. D. Bassett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PPIB Mutations Cause Severe Osteogenesis Imperfecta

(2009) Fleur S. van Dijk et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A microarray based identification of osteoporosis-related genes in primary culture of human osteoblasts

(2009) Zoran Trošt et al.   BONE

Adverse Effects of Bisphosphonates: Implications for Osteoporosis Management

(2009) Kurt A. Kennel et al.   MAYO CLINIC PROCEEDINGS

Human genetic variation and its contribution to complex traits

(2009) Kelly A. Frazer et al.   NATURE REVIEWS GENETICS

Excess mortality following hip fracture: a systematic epidemiological review

(2009) B. Abrahamsen et al.   OSTEOPOROSIS INTERNATIONAL

Human Osteoclast-Poor Osteopetrosis with Hypogammaglobulinemia due to TNFRSF11A (RANK) Mutations

(2008) Matteo M. Guerrini et al.   AMERICAN JOURNAL OF HUMAN GENETICS

CRTAPandLEPRE1mutations in recessive osteogenesis imperfecta

(2008) Dustin Baldridge et al.   HUMAN MUTATION

A Lack of Thyroid Hormones Rather than Excess Thyrotropin Causes Abnormal Skeletal Development in Hypothyroidism

(2007) J. H. Duncan Bassett et al.   MOLECULAR ENDOCRINOLOGY