Complex mutation profiles in mismatch repair and ribonucleotide reductase mutants reveal novel repair substrate specificity of MutS homolog (MSH) complexes

A selection-based next generation sequencing approach to develop robust, genotype-specific mutation profiles in Saccharomyces cerevisiae

(2021) Natalie A Lamb et al.   G3-Genes Genomes Genetics

The repertoire of mutational signatures in human cancer

(2020) Ludmil B. Alexandrov et al.   NATURE

Human MutLγ, the MLH1–MLH3 heterodimer, is an endonuclease that promotes DNA expansion

(2020) Lyudmila Y. Kadyrova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spontaneous Polyploids and Antimutators Compete During the Evolution of Saccharomyces cerevisiae Mutator Cells

(2020) Maxwell A. Tracy et al.   GENETICS

Update on genetic predisposition to colorectal cancer and polyposis

(2019) Laura Valle et al.   MOLECULAR ASPECTS OF MEDICINE

Mutational signatures of DNA mismatch repair deficiency inC. elegansand human cancers

(2018) Bettina Meier et al.   GENOME RESEARCH

Validating the concept of mutational signatures with isogenic cell models

(2018) Xueqing Zou et al.   Nature Communications

Polymorphisms in DNA mismatch repair pathway genes predict toxicity and response to cisplatin chemoradiation in head and neck squamous cell carcinoma patients

(2018) Guilherme Augusto Silva Nogueira et al.   Oncotarget

MutationalPatterns: comprehensive genome-wide analysis of mutational processes

(2018) Francis Blokzijl et al.   Genome Medicine

A genetic screen pinpoints ribonucleotide reductase residues that sustain dNTP homeostasis and specifies a highly mutagenic type of dNTP imbalance

(2018) Tobias T Schmidt et al.   NUCLEIC ACIDS RESEARCH

Loss of MSH2 and MSH6 due to heterozygous germline defects in MSH3 and MSH6

(2017) Monika Morak et al.   Familial Cancer

Alterations in cellular metabolism triggered byURA7orGLN3inactivation cause imbalanced dNTP pools and increased mutagenesis

(2017) Tobias T. Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association of Distinct Mutational Signatures With Correlates of Increased Immune Activity in Pancreatic Ductal Adenocarcinoma

(2017) Ashton A. Connor et al.   JAMA Oncology

Exome Sequencing Identifies Biallelic MSH3 Germline Mutations as a Recessive Subtype of Colorectal Adenomatous Polyposis

(2016) Ronja Adam et al.   AMERICAN JOURNAL OF HUMAN GENETICS

DNA Replication—A Matter of Fidelity

(2016) Rais A. Ganai et al.   MOLECULAR CELL

A global genetic interaction network maps a wiring diagram of cellular function

(2016) M. Costanzo et al.   SCIENCE

Systematic Functional Annotation and Visualization of Biological Networks

(2016) Anastasia Baryshnikova   Cell Systems

Eukaryotic Mismatch Repair in Relation to DNA Replication

(2015) Thomas A. Kunkel et al.   Annual Review of Genetics

Quantifying the contributions of base selectivity, proofreading and mismatch repair to nuclear DNA replication in Saccharomyces cerevisiae

(2015) Jordan A. St Charles et al.   DNA REPAIR

Clock-like mutational processes in human somatic cells

(2015) Ludmil B Alexandrov et al.   NATURE GENETICS

Genome-wide analysis of the specificity and mechanisms of replication infidelity driven by imbalanced dNTP pools

(2015) Danielle L. Watt et al.   NUCLEIC ACIDS RESEARCH

EMAST is a Form of Microsatellite Instability That is Initiated by Inflammation and Modulates Colorectal Cancer Progression

(2015) John Carethers et al.   Genes

DNA Replication Error-Induced Extinction of Diploid Yeast

(2014) A. J. Herr et al.   GENETICS

C. eleganswhole-genome sequencing reveals mutational signatures related to carcinogens and DNA repair deficiency

(2014) Bettina Meier et al.   GENOME RESEARCH

Heterogeneous polymerase fidelity and mismatch repair bias genome variation and composition

(2014) Scott A. Lujan et al.   GENOME RESEARCH

Mispair-specific Recruitment of the Mlh1-Pms1 Complex Identifies Repair Substrates of theSaccharomyces cerevisiaeMsh2-Msh3 Complex

(2014) Anjana Srivatsan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies

(2014) Y Aye et al.   ONCOGENE

Mutational landscape of yeast mutator strains

(2014) Alexandre Serero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased and Imbalanced dNTP Pools Symmetrically Promote Both Leading and Lagging Strand Replication Infidelity

(2014) Robert J. Buckland et al.   PLoS Genetics

Emergence of DNA Polymerase   Antimutators That Escape Error-Induced Extinction in Yeast

(2013) L. N. Williams et al.   GENETICS

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

The MutSβ complex is a modulator of p53-driven tumorigenesis through its functions in both DNA double-strand break repair and mismatch repair

(2013) J M M van Oers et al.   ONCOGENE

MSH3 Mismatch Repair Protein Regulates Sensitivity to Cytotoxic Drugs and a Histone Deacetylase Inhibitor in Human Colon Carcinoma Cells

(2013) Jae Myung Park et al.   PLoS One

Mutation Rates, Spectra, and Genome-Wide Distribution of Spontaneous Mutations in Mismatch Repair Deficient Yeast

(2013) Gregory I. Lang et al.   G3-Genes Genomes Genetics

Different Roles of Eukaryotic MutS and MutL Complexes in Repair of Small Insertion and Deletion Loops in Yeast

(2013) Nina V. Romanova et al.   PLoS Genetics

Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype

(2012) Marta B Davidson et al.   EMBO JOURNAL

dNTP pools determine fork progression and origin usage under replication stress

(2012) Jérôme Poli et al.   EMBO JOURNAL

Mismatch Repair Balances Leading and Lagging Strand DNA Replication Fidelity

(2012) Scott A. Lujan et al.   PLoS Genetics

DNA building blocks: keeping control of manufacture

(2011) Anders Hofer et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Balancing eukaryotic replication asymmetry with replication fidelity

(2011) Thomas A Kunkel   CURRENT OPINION IN CHEMICAL BIOLOGY

MSH3 Mediates Sensitization of Colorectal Cancer Cells to Cisplatin, Oxaliplatin, and a Poly(ADP-ribose) Polymerase Inhibitor

(2011) Masanobu Takahashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiple Factors Insulate Msh2–Msh6 Mismatch Repair Activity from Defects in Msh2 Domain I

(2011) Charanya Kumar et al.   JOURNAL OF MOLECULAR BIOLOGY

A novel fluorescence-based assay for the rapid detection and quantification of cellular deoxyribonucleoside triphosphates

(2011) Peter M. Wilson et al.   NUCLEIC ACIDS RESEARCH

REVIGO Summarizes and Visualizes Long Lists of Gene Ontology Terms

(2011) Fran Supek et al.   PLoS One

Lynch syndrome-associated mutations in MSH2 alter DNA repair and checkpoint response functions in vivo

(2010) Adam S. Mastrocola et al.   HUMAN MUTATION

MutLα and Proliferating Cell Nuclear Antigen Share Binding Sites on MutSβ

(2010) Ravi R. Iyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mutation spectrum revealed by paired genome sequences from a lung cancer patient

(2010) William Lee et al.   NATURE

Quantitative analysis of fitness and genetic interactions in yeast on a genome scale

(2010) Anastasia Baryshnikova et al.   NATURE METHODS

Highly mutagenic and severely imbalanced dNTP pools can escape detection by the S-phase checkpoint

(2010) Dinesh Kumar et al.   NUCLEIC ACIDS RESEARCH

Mechanisms of mutagenesis in vivo due to imbalanced dNTP pools

(2010) D. Kumar et al.   NUCLEIC ACIDS RESEARCH

Mutator phenotypes due to DNA replication infidelity

(2010) Mercedes E. Arana et al.   SEMINARS IN CANCER BIOLOGY

Deficient DNA Mismatch Repair Is Common in Lynch Syndrome-Associated Colorectal Adenomas

(2009) Maria Simona Pino et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Genotype to phenotype: Analyzing the effects of inherited mutations in colorectal cancer families

(2009) Christopher D. Heinen   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Sequence context effect for hMSH2-hMSH6 mismatch-dependent activation

(2009) A. Mazurek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutation patterns in cancer genomes

(2009) A. F. Rubin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Broad Overexpression of Ribonucleotide Reductase Genes in Mice Specifically Induces Lung Neoplasms

(2008) X. Xu et al.   CANCER RESEARCH

The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases

(2008) Scott D McCulloch et al.   CELL RESEARCH