Repurposing the Sphingosine-1-Phosphate Receptor Modulator Etrasimod as an Antibacterial Agent Against Gram-Positive Bacteria

Long-term Safety and Efficacy of Etrasimod for Ulcerative Colitis: Results from the Open-label Extension of the OASIS Study

(2021) Séverine Vermeire et al.   Journal of Crohns & Colitis

Sphingosine 1-Phosphate Receptor Modulators for Multiple Sclerosis

(2021) Reshmi Roy et al.   CNS DRUGS

Multisubstituted pyrimidines effectively inhibit bacterial growth and biofilm formation of Staphylococcus aureus

(2021) Riccardo Provenzani et al.   Scientific Reports

Brief Overview of Approaches and Challenges in New Antibiotic Development: A Focus On Drug Repurposing

(2021) Natalie K. Boyd et al.   Frontiers in Cellular and Infection Microbiology

4-4-(Anilinomethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-ylbenzoic acid derivatives as potent anti-gram-positive bacterial agents

(2021) Raj KC. Hansa et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Sphingosine 1-phosphate receptor modulators in multiple sclerosis and other conditions

(2021) Marisa P McGinley et al.   LANCET

Synthesis and Biological Evaluation of Fingolimod Derivatives as Antibacterial Agents

(2021) Matej Zore et al.   ACS Omega

Synthesis and biological evaluation of indole-based peptidomimetics as antibacterial agents against Gram-positive bacteria

(2021) Yongzhi Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antimicrobial Resistance in ESKAPE Pathogens

(2020) David M. P. De Oliveira et al.   CLINICAL MICROBIOLOGY REVIEWS

Optimization of a High-Throughput 384-Well Plate-Based Screening Platform with Staphylococcus aureus ATCC 25923 and Pseudomonas aeruginosa ATCC 15442 Biofilms

(2020) Shella Gilbert-Girard et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sphingosine kills bacteria by binding to cardiolipin

(2020) Rabea Verhaegh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis, molecular docking, antibacterial, antioxidant, and cytotoxicity activities of novel pyrido-cyclopenta[b]indole analogs

(2020) A. Amuthavalli et al.   SYNTHETIC COMMUNICATIONS

Chloroquine fumardiamides as novel quorum sensing inhibitors

(2020) Maja Beus et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Resistance of Gram-Positive Bacteria to Current Antibacterial Agents and Overcoming Approaches

(2020) Buthaina Jubeh et al.   MOLECULES

Screening of FDA-Approved Drugs Using a 384-Well Plate-Based Biofilm Platform: The Case of Fingolimod

(2020) Shella Gilbert-Girard et al.   Microorganisms

Drug repurposing for antimicrobial discovery

(2019) Maya A. Farha et al.   Nature Microbiology

Efficacy and Safety of Etrasimod in a Phase 2 Randomized Trial of Patients with Ulcerative Colitis

(2019) William J. Sandborn et al.   GASTROENTEROLOGY

An update on sphingosine-1-phosphate receptor 1 modulators

(2018) Alexander Marciniak et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Biofilms: Survival and defense strategy for pathogens

(2017) Ashutosh Kumar et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Modulators of Sphingosine-1-phosphate Pathway Biology: Recent Advances of Sphingosine-1-phosphate Receptor 1 (S1P1) Agonists and Future Perspectives

(2017) Alaric J. Dyckman   JOURNAL OF MEDICINAL CHEMISTRY

Antibacterial activity of ceramide and ceramide analogs against pathogenic Neisseria

(2017) Jérôme Becam et al.   Scientific Reports

Amiselimod, a novel sphingosine 1-phosphate receptor-1 modulator, has potent therapeutic efficacy for autoimmune diseases, with low bradycardia risk

(2016) Kunio Sugahara et al.   BRITISH JOURNAL OF PHARMACOLOGY

Lack of Sphingosine Causes Susceptibility to Pulmonary Staphylococcus Aureus Infections in Cystic Fibrosis

(2016) Shaghayegh Tavakoli Tabazavareh et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Indole Based Weapons to Fight Antibiotic Resistance: A Structure–Activity Relationship Study

(2016) Susan Lepri et al.   JOURNAL OF MEDICINAL CHEMISTRY

Flavones as Quorum Sensing Inhibitors Identified by a Newly Optimized Screening Platform Using Chromobacterium violaceum as Reporter Bacteria

(2016) Malena Skogman et al.   MOLECULES

Mechanism of Action and Resistance to Daptomycin in Staphylococcus aureus and Enterococci

(2016) William R. Miller et al.   Cold Spring Harbor Perspectives in Medicine

Anti-adherence and bactericidal activity of sphingolipids againstStreptococcus mutans

(2015) Nivedita Cukkemane et al.   EUROPEAN JOURNAL OF ORAL SCIENCES

Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate-1 Receptor

(2014) Daniel J. Buzard et al.   ACS Medicinal Chemistry Letters

On the essentiality of lipopolysaccharide to Gram-negative bacteria

(2013) Ge Zhang et al.   CURRENT OPINION IN MICROBIOLOGY

(+)-Dehydroabietic Acid, an Abietane-Type Diterpene, Inhibits Staphylococcus aureus Biofilms in Vitro

(2013) Adyary Fallarero et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Combining biofilm matrix measurements with biomass and viability assays in susceptibility assessments of antimicrobials against Staphylococcus aureus biofilms

(2012) Malena Elise Skogman et al.   JOURNAL OF ANTIBIOTICS

Current Concepts in Laboratory Testing to Guide Antimicrobial Therapy

(2012) Stephen G. Jenkins et al.   MAYO CLINIC PROCEEDINGS

Antibacterial Activity of Sphingoid Bases and Fatty Acids against Gram-Positive and Gram-Negative Bacteria

(2011) Carol L. Fischer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Resistance to Linezolid Caused by Modifications at Its Binding Site on the Ribosome

(2011) Katherine S. Long et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Biofilm development by clinical isolates ofStaphylococcusspp. from retrieved orthopedic prostheses

(2010) Jaime Esteban et al.   Acta Orthopaedica