The giant E3 ligase HUWE1 is linked to tumorigenesis, spermatogenesis, intellectual disability, and inflammatory diseases

Ubiquitin ligase E3 HUWE1/MULE targets transferrin receptor for degradation and suppresses ferroptosis in acute liver injury

(2022) Yan Wu et al.   CELL DEATH AND DIFFERENTIATION

Beyond K48 and K63: non-canonical protein ubiquitination

(2021) Michal Tracz et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

PPARγ increases HUWE1 to attenuate NF-κB/p65 and sickle cell disease with pulmonary hypertension

(2021) Andrew J. Jang et al.   Blood Advances

Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition

(2021) Moritz Hunkeler et al.   MOLECULAR CELL

HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain

(2021) Daniel B. Grabarczyk et al.   Nature Chemical Biology

A Potential Role for HUWE1 in Modulating Cisplatin Sensitivity

(2021) Stijn Wenmaekers et al.   Cells

HUWE1 Causes an Immune Imbalance in Immune Thrombocytopenic Purpura by Reducing the Number and Function of Treg Cells Through the Ubiquitination Degradation of Ets-1

(2021) Jianqin Li et al.   Frontiers in Cell and Developmental Biology

HUWE1 promotes EGFR ubiquitination and degradation to protect against renal tubulointerstitial fibrosis

(2020) Qian Zhu et al.   FASEB JOURNAL

The structure and regulation of the E3 ubiquitin ligase HUWE1 and its biological functions in cancer

(2020) Xiaofeng Gong et al.   INVESTIGATIONAL NEW DRUGS

Roles of the HUWE1 ubiquitin ligase in nervous system development, function and disease

(2020) Andrew C. Giles et al.   Neural Development

TiPARP forms nuclear condensates to degrade HIF-1α and suppress tumorigenesis

(2020) Lu Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HUWE1-dependent DNA-PKcs neddylation modulates its autophosphorylation in DNA damage response

(2020) Zongpei Guo et al.   Cell Death & Disease

BRPF3-HUWE1-mediated regulation of MYST2 is required for differentiation and cell-cycle progression in embryonic stem cells

(2020) Hye In Cho et al.   CELL DEATH AND DIFFERENTIATION

The E3 ligase HUWE1 inhibition as a therapeutic strategy to target MYC in multiple myeloma

(2020) Lisa J. Crawford et al.   ONCOGENE

HUWE1 mediates inflammasome activation and promotes host defense against bacterial infection

(2020) Yu Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Protease Activity Profiling via Programmable Phage Display of Comprehensive Proteome-Scale Peptide Libraries

(2020) Gabriel D. Román-Meléndez et al.   Cell Systems

X-Linked Huwe1 Is Essential for Oocyte Maturation and Preimplantation Embryo Development

(2020) Alaa A. Eisa et al.   iScience

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape

(2019) Philipp Hubel et al.   NATURE IMMUNOLOGY

Exome sequencing reveals a novel splice site variant in HUWE1 gene in patients with suspected Say-Meyer syndrome

(2019) Babylakshmi Muthusamy et al.   European Journal of Medical Genetics

Meta‑analysis of gene expression alterations and clinical significance of the HECT domain‑containing ubiquitin ligase HUWE1 in cancer

(2019) Chen Su et al.   Oncology Letters

Non-proteolytic ubiquitination of Hexokinase 2 by HectH9 controls tumor metabolism and cancer stem cell expansion

(2019) Hong-Jen Lee et al.   Nature Communications

HUWE1 controls MCL1 stability to unleash AMBRA1-induced mitophagy

(2019) Flavie Strappazzon et al.   CELL DEATH AND DIFFERENTIATION

Direct regulation of Chk1 protein stability by E3 ubiquitin ligase HUWE1

(2019) Katelyn B. Cassidy et al.   FEBS Journal

HUWE1 upregulation has tumor suppressive effect in human prostate cancer cell lines through c-Myc

(2018) Huawei Qu et al.   BIOMEDICINE & PHARMACOTHERAPY

HUWE1 controls the development of non-small cell lung cancer through down-regulation of p53

(2018) Dong Yang et al.   Theranostics

HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα

(2018) Anthea Di Rita et al.   Nature Communications

mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux

(2018) Wei Wan et al.   MOLECULAR CELL

Huwe1 Regulates the Establishment and Maintenance of Spermatogonia by Suppressing DNA Damage Response

(2017) Kin Lam Fok et al.   ENDOCRINOLOGY

HUWE1 variants cause dominant X-linked intellectual disability: a clinical study of 21 patients

(2017) Stéphanie Moortgat et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

DNA damage-induced histone H1 ubiquitylation is mediated by HUWE1 and stimulates the RNF8-RNF168 pathway

(2017) I. K. Mandemaker et al.   Scientific Reports

Ubiquitin Ligase Huwe1 Modulates Spermatogenesis by Regulating Spermatogonial Differentiation and Entry into Meiosis

(2017) Rohini Bose et al.   Scientific Reports

Types of Ubiquitin Ligases

(2016) Francesca Ester Morreale et al.   CELL

HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation

(2016) Kevin B Myant et al.   EMBO Molecular Medicine

HUWE1 interacts with PCNA to alleviate replication stress

(2016) Katherine N Choe et al.   EMBO REPORTS

Tumour suppressive function of HUWE1 in thyroid cancer

(2016) Weiyuan Ma et al.   JOURNAL OF BIOSCIENCES

Ubiquitin chain diversity at a glance

(2016) Masato Akutsu et al.   JOURNAL OF CELL SCIENCE

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes

(2016) Wei Zhang et al.   MOLECULAR CELL

The K48-K63 Branched Ubiquitin Chain Regulates NF-κB Signaling

(2016) Fumiaki Ohtake et al.   MOLECULAR CELL

Return to quiescence of mouse neural stem cells by degradation of a proactivation protein

(2016) Noelia Urbán et al.   SCIENCE

K63-polyubiquitinated HAUSP deubiquitinates HIF-1α and dictates H3K56 acetylation promoting hypoxia-induced tumour progression

(2016) Han-Tsang Wu et al.   Nature Communications

HUWE1 mutations in Juberg-Marsidi and Brooks syndromes: the results of an X-chromosome exome sequencing study

(2016) Michael J Friez et al.   BMJ Open

The HECT domain ubiquitin ligase HUWE1 targets unassembled soluble proteins for degradation

(2016) Yue Xu et al.   Cell Discovery

HUWE1 plays important role in mouse preimplantation embryo development and the dysregulation is associated with poor embryo development in humans

(2016) L. J. Chen et al.   Scientific Reports

448 Clinical significance of HUWE1 expression in ovarian cancer

(2015) A. Podgorska et al.   EUROPEAN JOURNAL OF CANCER

DNA damage-induced activation of CUL4B targets HUWE1 for proteasomal degradation

(2015) Juan Yi et al.   NUCLEIC ACIDS RESEARCH

HUWE1 Ubiquitylates and Degrades the RAC Activator TIAM1 Promoting Cell-Cell Adhesion Disassembly, Migration, and Invasion

(2015) Lynsey Vaughan et al.   Cell Reports

ATM and SIRT6/SNF2H Mediate Transient H2AX Stabilization When DSBs Form by Blocking HUWE1 to Allow Efficient γH2AX Foci Formation

(2015) Yuko Atsumi et al.   Cell Reports

Huwe1 interacts with Gadd45b under oxygen-glucose deprivation and reperfusion injury in primary Rat cortical neuronal cells

(2015) Guo-qian He et al.   Molecular Brain

Shh Signaling Protects Atoh1 from Degradation Mediated by the E3 Ubiquitin Ligase Huwe1 in Neural Precursors

(2014) Antoine Forget et al.   DEVELOPMENTAL CELL

Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase

(2014) S. Peter et al.   EMBO Molecular Medicine

Quantitative Lys-ϵ-Gly-Gly (diGly) Proteomics Coupled with Inducible RNAi Reveals Ubiquitin-mediated Proteolysis of DNA Damage-inducible Transcript 4 (DDIT4) by the E3 Ligase HUWE1

(2014) Joel W. Thompson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New insights into ubiquitin E3 ligase mechanism

(2014) Christopher E Berndsen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Peptide and small molecule inhibitors of HECT-type ubiquitin ligases

(2014) Thomas Mund et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Huwe1-Mediated Ubiquitylation of Dishevelled Defines a Negative Feedback Loop in the Wnt Signaling Pathway

(2014) R. E. A. de Groot et al.   Science Signaling

HUWE1 interacts with BRCA1 and promotes its degradation in the ubiquitin–proteasome pathway

(2013) Xiaozhen Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15

(2013) S. Inoue et al.   GENES & DEVELOPMENT

Homeostatic defects in B cells deficient in the E3 ubiquitin ligase ARF-BP1 are restored by enhanced expression of MYC

(2013) Chen-Feng Qi et al.   LEUKEMIA RESEARCH

A Network of Substrates of the E3 Ubiquitin Ligases MDM2 and HUWE1 Control Apoptosis Independently of p53

(2013) M. Kurokawa et al.   Science Signaling

Obesity Promotes Liver Carcinogenesis via Mcl-1 Stabilization Independent of IL-6Rα Signaling

(2013) Sabine Gruber et al.   Cell Reports

Copy-Number Gains of HUWE1 Due to Replication- and Recombination-Based Rearrangements

(2012) Guy Froyen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

HUWE1 ubiquitinates MyoD and targets it for proteasomal degradation

(2012) Tahel Noy et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ubiquitination in signaling to and activation of IKK

(2012) Zhijian J. Chen   IMMUNOLOGICAL REVIEWS

Characterization of ARF-BP1/HUWE1 Interactions with CTCF, MYC, ARF and p53 in MYC-Driven B Cell Neoplasms

(2012) Chen-Feng Qi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The E3 ubiquitin ligase Mule acts through the ATM–p53 axis to maintain B lymphocyte homeostasis

(2012) Zhenyue Hao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Stress-Induced Phosphorylation and Proteasomal Degradation of Mitofusin 2 Facilitates Mitochondrial Fragmentation and Apoptosis

(2012) Guillaume P. Leboucher et al.   MOLECULAR CELL

Mule determines the apoptotic response to HDAC inhibitors by targeted ubiquitination and destruction of HDAC2

(2011) J. Zhang et al.   GENES & DEVELOPMENT

Regulation of oxidative DNA damage repair by DNA polymerase   and MutYH by cross-talk of phosphorylation and ubiquitination

(2011) E. Markkanen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

E3 ubiquitin ligase Mule ubiquitinates Miz1 and is required for TNF -induced JNK activation

(2010) Y. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The N-Myc-DLL3 Cascade Is Suppressed by the Ubiquitin Ligase Huwe1 to Inhibit Proliferation and Promote Neurogenesis in the Developing Brain

(2009) Xudong Zhao et al.   DEVELOPMENTAL CELL

Ubiquitin ligase ARF-BP1/Mule modulates base excision repair

(2009) Jason L Parsons et al.   EMBO JOURNAL

A Structural Element within the HUWE1 HECT Domain Modulates Self-ubiquitination and Substrate Ubiquitination Activities

(2009) Renuka K. Pandya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alterations of ubiquitin ligases in human cancer and their association with the natural history of the tumor

(2009) S Confalonieri et al.   ONCOGENE

Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1

(2008) Steffi Herold et al.   EMBO JOURNAL

The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein

(2008) Xudong Zhao et al.   NATURE CELL BIOLOGY

Diversity of degradation signals in the ubiquitin–proteasome system

(2008) Tommer Ravid et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY