The structure and regulation of the E3 ubiquitin ligase HUWE1 and its biological functions in cancer
出版年份 2020 全文链接
标题
The structure and regulation of the E3 ubiquitin ligase HUWE1 and its biological functions in cancer
作者
关键词
-
出版物
INVESTIGATIONAL NEW DRUGS
Volume -, Issue -, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2020-02-01
DOI
10.1007/s10637-020-00894-6
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Ubiquitin Ligases in Cancer Immunotherapy – Balancing Antitumor and Autoimmunity
- (2019) Yu Fujita et al. TRENDS IN MOLECULAR MEDICINE
- Flavokawain B targets protein neddylation for enhancing the anti-prostate cancer effect of Bortezomib via Skp2 degradation
- (2019) Xuesen Li et al. Cell Communication and Signaling
- A phase I trial of palbociclib plus bortezomib in previously treated mantle cell lymphoma
- (2019) Peter Martin et al. LEUKEMIA & LYMPHOMA
- Mitofusins: Disease Gatekeepers and Hubs in Mitochondrial Quality Control by E3 Ligases
- (2019) Mafalda Escobar-Henriques et al. Frontiers in Physiology
- Non-proteolytic ubiquitination of Hexokinase 2 by HectH9 controls tumor metabolism and cancer stem cell expansion
- (2019) Hong-Jen Lee et al. Nature Communications
- LIMCH1 suppress the growth of lung cancer by interacting with HUWE1 to sustain p53 stability
- (2019) Yuanyuan Zhang et al. GENE
- Structural mechanisms of HECT-type ubiquitin ligases
- (2018) Sonja Lorenz BIOLOGICAL CHEMISTRY
- Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma
- (2018) Brian A. Walker et al. BLOOD
- NEDD8 — its role in the regulation of Cullin-RING ligases
- (2018) Claus Schwechheimer CURRENT OPINION IN PLANT BIOLOGY
- Hepatic PPARα function is controlled by polyubiquitination and proteasome-mediated degradation through the coordinated actions of PAQR3 and HUWE1
- (2018) Zilong Zhao et al. HEPATOLOGY
- β-Sheet Augmentation Is a Conserved Mechanism of Priming HECT E3 Ligases for Ubiquitin Ligation
- (2018) Magnus Jäckl et al. JOURNAL OF MOLECULAR BIOLOGY
- HUWE1 controls the development of non-small cell lung cancer through down-regulation of p53
- (2018) Dong Yang et al. Theranostics
- R1 Regulates Prostate Tumor Growth and Progression By Transcriptional Suppression of the E3 Ligase HUWE1 to Stabilize c-Myc
- (2018) Tzu-Ping Lin et al. MOLECULAR CANCER RESEARCH
- HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα
- (2018) Anthea Di Rita et al. Nature Communications
- Drosophila HUWE1 Ubiquitin Ligase Regulates Endoreplication and Antagonizes JNK Signaling During Salivary Gland Development
- (2018) Yifat Yanku et al. Cells
- NEDDylation promotes nuclear protein aggregation and protects the Ubiquitin Proteasome System upon proteotoxic stress
- (2018) Chantal M. Maghames et al. Nature Communications
- An integrated bioinformatics platform for investigating the human E3 ubiquitin ligase-substrate interaction network
- (2017) Yang Li et al. Nature Communications
- DNA damage-induced histone H1 ubiquitylation is mediated by HUWE1 and stimulates the RNF8-RNF168 pathway
- (2017) I. K. Mandemaker et al. Scientific Reports
- A conformational switch regulates the ubiquitin ligase HUWE1
- (2017) Bodo Sander et al. eLife
- Impaired oxidative stress response characterizes HUWE1-promoted X-linked intellectual disability
- (2017) Matthias Bosshard et al. Scientific Reports
- The ubiquitin–proteasome system and its potential application in hepatocellular carcinoma therapy
- (2016) Yan-Jie Chen et al. CANCER LETTERS
- HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation
- (2016) Kevin B Myant et al. EMBO Molecular Medicine
- HUWE1 interacts with PCNA to alleviate replication stress
- (2016) Katherine N Choe et al. EMBO REPORTS
- System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes
- (2016) Wei Zhang et al. MOLECULAR CELL
- The ubiquitin ligase Huwe1 regulates the maintenance and lymphoid commitment of hematopoietic stem cells
- (2016) Bryan King et al. NATURE IMMUNOLOGY
- Transposon mutagenesis identifies genes and cellular processes driving epithelial-mesenchymal transition in hepatocellular carcinoma
- (2016) Takahiro Kodama et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- K63-polyubiquitinated HAUSP deubiquitinates HIF-1α and dictates H3K56 acetylation promoting hypoxia-induced tumour progression
- (2016) Han-Tsang Wu et al. Nature Communications
- HUWE1 plays important role in mouse preimplantation embryo development and the dysregulation is associated with poor embryo development in humans
- (2016) L. J. Chen et al. Scientific Reports
- HUWE1 Ubiquitylates and Degrades the RAC Activator TIAM1 Promoting Cell-Cell Adhesion Disassembly, Migration, and Invasion
- (2015) Lynsey Vaughan et al. Cell Reports
- ATM and SIRT6/SNF2H Mediate Transient H2AX Stabilization When DSBs Form by Blocking HUWE1 to Allow Efficient γH2AX Foci Formation
- (2015) Yuko Atsumi et al. Cell Reports
- A specific E3 ligase/deubiquitinase pair modulates TBP protein levels during muscle differentiation
- (2015) Li Li et al. eLife
- HUWE1 interacts with BRCA1 and promotes its degradation in the ubiquitin–proteasome pathway
- (2014) Xiaozhen Wang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Bortezomib sensitizes non-small cell lung cancer to mesenchymal stromal cell-delivered inducible caspase-9-mediated cytotoxicity
- (2014) M Ando et al. CANCER GENE THERAPY
- Shh Signaling Protects Atoh1 from Degradation Mediated by the E3 Ubiquitin Ligase Huwe1 in Neural Precursors
- (2014) Antoine Forget et al. DEVELOPMENTAL CELL
- Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase
- (2014) S. Peter et al. EMBO Molecular Medicine
- Comprehensive molecular characterization of gastric adenocarcinoma
- (2014) Adam J. Bass et al. NATURE
- New insights into ubiquitin E3 ligase mechanism
- (2014) Christopher E Berndsen et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Peptide and small molecule inhibitors of HECT-type ubiquitin ligases
- (2014) Thomas Mund et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Huwe1-Mediated Ubiquitylation of Dishevelled Defines a Negative Feedback Loop in the Wnt Signaling Pathway
- (2014) R. E. A. de Groot et al. Science Signaling
- Bortezomib-induced apoptosis in cultured pancreatic cancer cells is associated with ceramide production
- (2013) Lei Gong et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Proteasome Inhibition Increases Recruitment of IκB Kinase β (IKKβ), S536P-p65, and Transcription Factor EGR1 to Interleukin-8 (IL-8) Promoter, Resulting in Increased IL-8 Production in Ovarian Cancer Cells
- (2013) Bipradeb Singha et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The MULE/HUWE1 E3 Ubiquitin Ligase Is a Tumor Suppressor
- (2013) Cancer Discovery
- Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3
- (2013) Hari B Kamadurai et al. eLife
- HUWE1 ubiquitinates MyoD and targets it for proteasomal degradation
- (2012) Tahel Noy et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- An open-label, single-arm, phase 2 (PX-171-004) study of single-agent carfilzomib in bortezomib-naive patients with relapsed and/or refractory multiple myeloma
- (2012) R. Vij et al. BLOOD
- An open-label, single-arm, phase 2 study of single-agent carfilzomib in patients with relapsed and/or refractory multiple myeloma who have been previously treated with bortezomib
- (2012) Ravi Vij et al. BRITISH JOURNAL OF HAEMATOLOGY
- A Landscape of Driver Mutations in Melanoma
- (2012) Eran Hodis et al. CELL
- Mule determines the apoptotic response to HDAC inhibitors by targeted ubiquitination and destruction of HDAC2
- (2011) J. Zhang et al. GENES & DEVELOPMENT
- Unraveling the Ubiquitome of the Human Malaria Parasite
- (2011) Nadia Ponts et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Regulation of oxidative DNA damage repair by DNA polymerase and MutYH by cross-talk of phosphorylation and ubiquitination
- (2011) E. Markkanen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- RING Domain E3 Ubiquitin Ligases
- (2009) Raymond J. Deshaies et al. Annual Review of Biochemistry
- Quantitative Proteomics Reveals the Function of Unconventional Ubiquitin Chains in Proteasomal Degradation
- (2009) Ping Xu et al. CELL
- Ubiquitin ligase ARF-BP1/Mule modulates base excision repair
- (2009) Jason L Parsons et al. EMBO JOURNAL
- A Structural Element within the HUWE1 HECT Domain Modulates Self-ubiquitination and Substrate Ubiquitination Activities
- (2009) Renuka K. Pandya et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Physiological functions of the HECT family of ubiquitin ligases
- (2009) Daniela Rotin et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The HECT Family of E3 Ubiquitin Ligases: Multiple Players in Cancer Development
- (2008) Francesca Bernassola et al. CANCER CELL
- Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1
- (2008) Steffi Herold et al. EMBO JOURNAL
- The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein
- (2008) Xudong Zhao et al. NATURE CELL BIOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now