S-palmitoylation of PCSK9 induces sorafenib resistance in liver cancer by activating the PI3K/AKT pathway

PCSK9 promotes tumor growth by inhibiting tumor cell apoptosis in hepatocellular carcinoma

(2021) Shi-Zhe Zhang et al.   Experimental Hematology & Oncology

PCSK9 and cancer: Rethinking the link

(2021) Khadijeh Mahboobnia et al.   BIOMEDICINE & PHARMACOTHERAPY

A transient amphipathic helix in the prodomain of PCSK9 facilitates binding to low-density lipoprotein particles

(2020) Samantha K. Sarkar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GPS-Palm: a deep learning-based graphic presentation system for the prediction of S-palmitoylation sites in proteins

(2020) Wanshan Ning et al.   BRIEFINGS IN BIOINFORMATICS

RNA m 6 A methylation regulates sorafenib resistance in liver cancer through FOXO 3‐mediated autophagy

(2020) Ziyou Lin et al.   EMBO JOURNAL

FBXO22 degrades nuclear PTEN to promote tumorigenesis

(2020) Meng-Kai Ge et al.   Nature Communications

Mechanism of PRL2 phosphatase-mediated PTEN degradation and tumorigenesis

(2020) Qinglin Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diallyl disulfide improves lipid metabolism by inhibiting PCSK9 expression and increasing LDL uptake via PI3K/Akt-SREBP2 pathway in HepG2 cells

(2020) Ya-Ru Wu et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Inhibiting PD-L1 palmitoylation enhances T-cell immune responses against tumours

(2019) Han Yao et al.   Nature Biomedical Engineering

Decreased IL-6 induces sensitivity of hepatocellular carcinoma cells to sorafenib

(2019) Jing Yang et al.   PATHOLOGY RESEARCH AND PRACTICE

Targeting the IL-1β/EHD1/TUBB3 axis overcomes resistance to EGFR-TKI in NSCLC

(2019) Jian Huang et al.   ONCOGENE

PCSK9 Inhibitors: Mechanisms of Action, Metabolic Effects, and Clinical Outcomes

(2018) Connie N. Hess et al.   Annual Review of Medicine

microRNA-19a-3p promotes tumor metastasis and chemoresistance through the PTEN/Akt pathway in hepatocellular carcinoma

(2018) Xue-Mei Jiang et al.   BIOMEDICINE & PHARMACOTHERAPY

HRD1-mediated PTEN degradation promotes cell proliferation and hepatocellular carcinoma progression

(2018) Liu Liu et al.   CELLULAR SIGNALLING

Targeting EHMT2 reverses EGFR-TKI resistance in NSCLC by epigenetically regulating the PTEN/AKT signaling pathway

(2018) Lihui Wang et al.   Cell Death & Disease

Phosphorylated RB Promotes Cancer Immunity by Inhibiting NF-κB Activation and PD-L1 Expression

(2018) Xin Jin et al.   MOLECULAR CELL

PCSK9 regulates apoptosis in human lung adenocarcinoma A549 cells via endoplasmic reticulum stress and mitochondrial signaling pathways

(2017) Xiaohui Xu et al.   Experimental and Therapeutic Medicine

Identification and dynamics of the human ZDHHC16-ZDHHC6 palmitoylation cascade

(2017) Laurence Abrami et al.   eLife

ZDHHC16 modulates FGF/ERK dependent proliferation of neural stem/progenitor cells in the zebrafish telencephalon

(2016) Wei Shi et al.   Developmental Neurobiology

Metallothionein-1G facilitates sorafenib resistance through inhibition of ferroptosis

(2016) Xiaofang Sun et al.   HEPATOLOGY

ADRB2 signaling promotes HCC progression and sorafenib resistance by inhibiting autophagic degradation of HIF1α

(2016) Fu-Quan Wu et al.   JOURNAL OF HEPATOLOGY

Galectin-1 induces hepatocellular carcinoma EMT and sorafenib resistance by activating FAK/PI3K/AKT signaling

(2016) P-F Zhang et al.   Cell Death & Disease

Dual Shp2 and Pten Deficiencies Promote Non-alcoholic Steatohepatitis and Genesis of Liver Tumor-Initiating Cells

(2016) Xiaolin Luo et al.   Cell Reports

Dysregulation of AKT Pathway by SMYD2-Mediated Lysine Methylation on PTEN

(2015) Makoto Nakakido et al.   NEOPLASIA

Proprotein Convertase Subtilisin/Kexin Type 9 Deficiency Reduces Melanoma Metastasis in Liver

(2015) Xiaowei Sun et al.   NEOPLASIA

Cholesteryl Ester Accumulation Induced by PTEN Loss and PI3K/AKT Activation Underlies Human Prostate Cancer Aggressiveness

(2014) Shuhua Yue et al.   Cell Metabolism

PCSK9 and LDLR degradation

(2014) Thomas A. Lagace   CURRENT OPINION IN LIPIDOLOGY

Hepatocellular carcinoma: clinical frontiers and perspectives

(2014) Jordi Bruix et al.   GUT

Sorafenib/Regorafenib and Lapatinib Interact to kill CNS Tumor Cells

(2014) Hossein A. Hamed et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Inhibition of Akt Reverses the Acquired Resistance to Sorafenib by Switching Protective Autophagy to Autophagic Cell Death in Hepatocellular Carcinoma

(2014) B. Zhai et al.   MOLECULAR CANCER THERAPEUTICS

Akt and mTORC1 Have Different Roles During Liver Tumorigenesis in Mice

(2013) Heidi L. Kenerson et al.   GASTROENTEROLOGY

The functions and regulation of the PTEN tumour suppressor

(2012) Min Sup Song et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PTEN Enhances the Sensitivity of Human Hepatocellular Carcinoma Cells to Sorafenib

(2012) Zhi-Ping Ruan et al.   ONCOLOGY RESEARCH

Expansion of Hepatic Tumor Progenitor Cells in Pten-Null Mice Requires Liver Injury and Is Reversed by Loss of AKT2

(2010) Vivian A. Galicia et al.   GASTROENTEROLOGY

PTEN and the PI3-Kinase Pathway in Cancer

(2008) Nader Chalhoub et al.   Annual Review of Pathology-Mechanisms of Disease

Proprotein convertase subtilisin/kexin type 9 (PCSK9): Hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration

(2008) Ahmed Zaid et al.   HEPATOLOGY

Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial

(2008) Ann-Lii Cheng et al.   LANCET ONCOLOGY

CSS-Palm 2.0: an updated software for palmitoylation sites prediction

(2008) J. Ren et al.   PROTEIN ENGINEERING DESIGN & SELECTION