Heparin induces α-synuclein to form new fibril polymorphs with attenuated neuropathology

Hierarchical chemical determination of amyloid polymorphs in neurodegenerative disease

(2021) Dan Li et al.   Nature Chemical Biology

Anomalous collapses of Nares Strait ice arches leads to enhanced export of Arctic sea ice

(2021) G. W. K. Moore et al.   Nature Communications

Seeded assembly in vitro does not replicate the structures of α‐synuclein filaments from multiple system atrophy

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The expanding amyloid family: Structure, stability, function, and pathogenesis

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Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson's disease

(2021) Shengnan Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The N terminus of α-synuclein dictates fibril formation

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Structure-based classification of tauopathies

(2021) Yang Shi et al.   NATURE

Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains

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Discriminating α-synuclein strains in Parkinson’s disease and multiple system atrophy

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The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure

(2020) David R. Boyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

U1 snRNP regulates cancer cell migration and invasion in vitro

(2020) Jung-Min Oh et al.   Nature Communications

Amyloid structure determination in RELION-3.1

(2020) Sjors H. W. Scheres   Acta Crystallographica Section D-Structural Biology

Cryo-EM structure of full-length α-synuclein amyloid fibril with Parkinson’s disease familial A53T mutation

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Structures of α-synuclein filaments from multiple system atrophy

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A myosin-7B–dependent endocytosis pathway mediates cellular entry of α-synuclein fibrils and polycation-bearing cargos

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Parkinson’s disease-related phosphorylation at Tyr39 rearranges α-synuclein amyloid fibril structure revealed by cryo-EM

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Cryo-EM structures of tau filaments

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Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer’s and Pick’s diseases

(2019) Wenjuan Zhang et al.   eLife

Structures of fibrils formed by α-synuclein hereditary disease mutant H50Q reveal new polymorphs

(2019) David R. Boyer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

α-Synuclein strains target distinct brain regions and cell types

(2019) Angus Lau et al.   NATURE NEUROSCIENCE

Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts

(2019) Timo Strohäker et al.   Nature Communications

Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy

(2019) Ricardo Guerrero-Ferreira et al.   eLife

Glycosaminoglycans have variable effects on α-synuclein aggregation and differentially affect the activities of the resulting amyloid fibrils

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Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies

(2018) Chao Peng et al.   NATURE

Structural absorption by barbule microstructures of super black bird of paradise feathers

(2018) Dakota E. McCoy et al.   Nature Communications

Cryo-EM structure of alpha-synuclein fibrils

(2018) Ricardo Guerrero-Ferreira et al.   eLife

Amyloid fibril structure of α-synuclein determined by cryo-electron microscopy

(2018) Yaowang Li et al.   CELL RESEARCH

A new era for understanding amyloid structures and disease

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MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

Improvements to the APBS biomolecular solvation software suite

(2017) Elizabeth Jurrus et al.   PROTEIN SCIENCE

The Synucleinopathies: Twenty Years On

(2017) Michel Goedert et al.   Journal of Parkinsons Disease

Structural disorder of monomeric α-synuclein persists in mammalian cells

(2016) Francois-Xavier Theillet et al.   NATURE

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

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α-Synuclein strains cause distinct synucleinopathies after local and systemic administration

(2015) W. Peelaerts et al.   NATURE

Amyloid Polymorphism: Structural Basis and Neurobiological Relevance

(2015) Robert Tycko   NEURON

Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite–like aggregates

(2014) Laura A Volpicelli-Daley et al.   Nature Protocols

Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies

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Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

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Features and development ofCoot

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

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 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

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AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Membrane-Bound α-Synuclein Forms an Extended Helix: Long-Distance Pulsed ESR Measurements Using Vesicles, Bicelles, and Rodlike Micelles

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Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease

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