Mechanically active integrins target lytic secretion at the immune synapse to facilitate cellular cytotoxicity

Cytotoxic lymphocytes target characteristic biophysical vulnerabilities in cancer

(2021) Maria Tello-Lafoz et al.   IMMUNITY

NK cells integrate signals over large areas when building immune synapses but require local stimuli for degranulation

(2021) Quentin Verron et al.   Science Signaling

Centrioles control the capacity, but not the specificity, of cytotoxic T cell killing

(2020) Fella Tamzalit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanical Regulation of the Cytotoxic Activity of Natural Killer Cells

(2020) Lital Mordechay et al.   ACS Biomaterials-Science & Engineering

Nanobody-CD16 catch bond reveals NK cell mechanosensitivity

(2019) Cristina Gonzalez et al.   BIOPHYSICAL JOURNAL

Mitochondrial Entry of Cytotoxic Proteases: A New Insight into the Granzyme B Cell Death Pathway

(2019) Denis Martinvalet   Oxidative Medicine and Cellular Longevity

Microtubules at focal adhesions – a double-edged sword

(2019) Shailaja Seetharaman et al.   JOURNAL OF CELL SCIENCE

The Wiskott-Aldrich Syndrome Protein Contributes to the Assembly of the LFA-1 Nanocluster Belt at the Lytic Synapse

(2018) Raïssa Houmadi et al.   Cell Reports

A novel intracellular pool of LFA-1 is critical for asymmetric CD8+T cell activation and differentiation

(2017) Tara Capece et al.   JOURNAL OF CELL BIOLOGY

Different TCR-induced T lymphocyte responses are potentiated by stiffness with variable sensitivity

(2017) Michael Saitakis et al.   eLife

Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell Killing

(2016) Roshni Basu et al.   CELL

Dynamics of the actin cytoskeleton mediates receptor cross talk: An emerging concept in tuning receptor signaling

(2016) Pieta K. Mattila et al.   JOURNAL OF CELL BIOLOGY

T cell activation requires force generation

(2016) Kenneth H. Hu et al.   JOURNAL OF CELL BIOLOGY

Lipids implicated in the journey of a secretory granule: from biogenesis to fusion

(2016) Emeline Tanguy et al.   JOURNAL OF NEUROCHEMISTRY

DNA-based nanoparticle tension sensors reveal that T-cell receptors transmit defined pN forces to their antigens for enhanced fidelity

(2016) Yang Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mother Centriole Distal Appendages Mediate Centrosome Docking at the Immunological Synapse and Reveal Mechanistic Parallels with Ciliogenesis

(2015) Jane C. Stinchcombe et al.   CURRENT BIOLOGY

A Mechanical Switch Couples T Cell Receptor Triggering to the Cytoplasmic Juxtamembrane Regions of CD3ζζ

(2015) Mark S. Lee et al.   IMMUNITY

F-actin flow drives affinity maturation and spatial organization of LFA-1 at the immunological synapse

(2015) William A. Comrie et al.   JOURNAL OF CELL BIOLOGY

Cytoskeletal forces during signaling activation in Jurkat T-cells

(2015) King Lam Hui et al.   MOLECULAR BIOLOGY OF THE CELL

CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling

(2014) Randall J. Platt et al.   CELL

Accumulation of Dynamic Catch Bonds between TCR and Agonist Peptide-MHC Triggers T Cell Signaling

(2014) Baoyu Liu et al.   CELL

From lipid second messengers to molecular motors: microtubule-organizing center reorientation in T cells

(2014) Morgan Huse et al.   IMMUNOLOGICAL REVIEWS

A Dual Role for Talin in NK Cell Cytotoxicity: Activation of LFA-1-Mediated Cell Adhesion and Polarization of NK Cells

(2014) E. M. Mace et al.   JOURNAL OF IMMUNOLOGY

CD28 and CD3 have complementary roles in T-cell traction forces

(2014) Keenan T. Bashour et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA-based digital tension probes reveal integrin forces during early cell adhesion

(2014) Yun Zhang et al.   Nature Communications

Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL

(2014) Misty R Jenkins et al.   eLife

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes

(2014) Marianne Strazza et al.   Jove-Journal of Visualized Experiments

B Cell Activation Is Regulated by the Stiffness Properties of the Substrate Presenting the Antigens

(2013) Z. Wan et al.   JOURNAL OF IMMUNOLOGY

Cross Talk between CD3 and CD28 Is Spatially Modulated by Protein Lateral Mobility

(2013) K. T. Bashour et al.   MOLECULAR AND CELLULAR BIOLOGY

An initial and rapid step of lytic granule secretion precedes microtubule organizing center polarization at the cytotoxic T lymphocyte/target cell synapse

(2013) F. Bertrand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hedgehog Signaling Controls T Cell Killing at the Immunological Synapse

(2013) M. de la Roche et al.   SCIENCE

Mechanosensing in T Lymphocyte Activation

(2012) Edward Judokusumo et al.   BIOPHYSICAL JOURNAL

Substrate Rigidity Regulates Human T Cell Activation and Proliferation

(2012) R. S. O'Connor et al.   JOURNAL OF IMMUNOLOGY

Regulation of Integrin Activation

(2011) Chungho Kim et al.   Annual Review of Cell and Developmental Biology

Two modes of lytic granule fusion during degranulation by natural killer cells

(2011) Dongfang Liu et al.   IMMUNOLOGY AND CELL BIOLOGY

Inhibitory signaling blocks activating receptor clustering and induces cytoskeletal retraction in natural killer cells

(2011) Thushara P. Abeyweera et al.   JOURNAL OF CELL BIOLOGY

Centrosome docking at the immunological synapse is controlled by Lck signaling

(2011) Andy Tsun et al.   JOURNAL OF CELL BIOLOGY

Natural Killer Cell Lytic Granule Secretion Occurs through a Pervasive Actin Network at the Immune Synapse

(2011) Gregory D. Rak et al.   PLOS BIOLOGY

Remodelling of Cortical Actin Where Lytic Granules Dock at Natural Killer Cell Immune Synapses Revealed by Super-Resolution Microscopy

(2011) Alice C. N. Brown et al.   PLOS BIOLOGY

Cytotoxic immunological synapses

(2010) Michael L. Dustin et al.   IMMUNOLOGICAL REVIEWS

Forcing Switch from Short- to Intermediate- and Long-lived States of the αA Domain Generates LFA-1/ICAM-1 Catch Bonds

(2010) Wei Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane nanotubes facilitate long-distance interactions between natural killer cells and target cells

(2010) A. Chauveau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct Roles for the Actin Nucleators Arp2/3 and hDia1 during NK-Mediated Cytotoxicity

(2009) Boyd Butler et al.   CURRENT BIOLOGY

Genetic and cell biological analysis of integrin outside-in signaling

(2009) K. R. Legate et al.   GENES & DEVELOPMENT

Integrin-Dependent Organization and Bidirectional Vesicular Traffic at Cytotoxic Immune Synapses

(2009) Dongfang Liu et al.   IMMUNITY

Kinetics of Early T Cell Receptor Signaling Regulate the Pathway of Lytic Granule Delivery to the Secretory Domain

(2009) Allison M. Beal et al.   IMMUNITY

Localized diacylglycerol drives the polarization of the microtubule-organizing center in T cells

(2009) Emily J Quann et al.   NATURE IMMUNOLOGY

Mechanically Activated Integrin Switch Controls  5 1 Function

(2009) J. C. Friedland et al.   SCIENCE

Talin depletion reveals independence of initial cell spreading from integrin activation and traction

(2008) Xian Zhang et al.   NATURE CELL BIOLOGY