High levels of NRF2 sensitize temozolomide-resistant glioblastoma cells to ferroptosis via ABCC1/MRP1 upregulation

Ferroptosis in cancer therapy: a novel approach to reversing drug resistance

(2022) Chen Zhang et al.   Molecular Cancer

Transsulfuration, minor player or crucial for cysteine homeostasis in cancer

(2022) Hai-Feng Zhang et al.   TRENDS IN CELL BIOLOGY

Chinese Glioma Genome Atlas (CGGA): A Comprehensive Resource with Functional Genomic Data from Chinese Gliomas

(2021) Zheng Zhao et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Antioxidant responses related to temozolomide resistance in glioblastoma

(2021) José A. Campos-Sandoval et al.   NEUROCHEMISTRY INTERNATIONAL

Molecular analysis of the massive GSH transport mechanism mediated by the human Multidrug Resistant Protein 1/ABCC1

(2020) Rachad Nasr et al.   Scientific Reports

The Role of Erastin in Ferroptosis and Its Prospects in Cancer Therapy

(2020) Yuechen Zhao et al.   OncoTargets and Therapy

xCT inhibitor sulfasalazine depletes paclitaxel‑resistant tumor cells through ferroptosis in uterine serous carcinoma

(2020) Akiko Sugiyama et al.   Oncology Letters

A Potential Mechanism of Temozolomide Resistance in Glioma–Ferroptosis

(2020) Zhifang Hu et al.   Frontiers in Oncology

Ferroptosis-Related Gene Signature Predicts Glioma Cell Death and Glioma Patient Progression

(2020) Han-jie Liu et al.   Frontiers in Cell and Developmental Biology

Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy

(2020) Pranavi Koppula et al.   Protein & Cell

NRF2‐dependent stress defense in tumor antioxidant control and immune evasion

(2020) José Pedro Friedmann Angeli et al.   Pigment Cell & Melanoma Research

Revealing Temozolomide Resistance Mechanisms via Genome-Wide CRISPR Libraries

(2020) Clarissa Ribeiro Reily Rocha et al.   Cells

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

(2019) Matthew Dodson et al.   Redox Biology

A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity

(2019) Jennifer Yinuo Cao et al.   Cell Reports

Glioblastoma vs temozolomide: can the red queen race be won?

(2019) Anjali Arora et al.   CANCER BIOLOGY & THERAPY

Nrf2 and SQSTM1/p62 jointly contribute to mesenchymal transition and invasion in glioblastoma

(2019) Petri Pölönen et al.   ONCOGENE

Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation

(2019) Jiajun Zhu et al.   Cell Metabolism

The balance between NRF2/GSH antioxidant mediated pathway and DNA repair modulates cisplatin resistance in lung cancer cells

(2019) Matheus Molina Silva et al.   Scientific Reports

NRF2 and the Hallmarks of Cancer

(2018) Montserrat Rojo de la Vega et al.   CANCER CELL

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

(2018) Irina Ingold et al.   CELL

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

(2018) Behrouz Hassannia et al.   JOURNAL OF CLINICAL INVESTIGATION

Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer

(2018) Daiha Shin et al.   FREE RADICAL BIOLOGY AND MEDICINE

VDAC2 enables BAX to mediate apoptosis and limit tumor development

(2018) Hui San Chin et al.   Nature Communications

Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis

(2017) Z Fan et al.   Oncogenesis

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

Increased Expression of System x c − in Glioblastoma Confers an Altered Metabolic State and Temozolomide Resistance

(2016) Monika D. Polewski et al.   MOLECULAR CANCER RESEARCH

NRF2 and glutathione are key resistance mediators to temozolomide in glioma and melanoma cells

(2016) Clarissa Ribeiro Reily Rocha et al.   Oncotarget

Nrf2 is the key to chemotherapy resistance in MCF7 breast cancer cells under hypoxia

(2016) Jhih-Pu Syu et al.   Oncotarget

Erastin Disrupts Mitochondrial Permeability Transition Pore (mPTP) and Induces Apoptotic Death of Colorectal Cancer Cells

(2016) Haizhong Huo et al.   PLoS One

Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation

(2015) M Hayano et al.   CELL DEATH AND DIFFERENTIATION

Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death

(2015) Min-Young Kwon et al.   Oncotarget

Emerging Therapies for Glioblastoma

(2014) Alissa A. Thomas et al.   JAMA Neurology

The emerging role of the Nrf2-Keap1 signaling pathway in cancer

(2013) M. C. Jaramillo et al.   GENES & DEVELOPMENT

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Glutathione synthesis and its role in redox signaling

(2012) Hongqiao Zhang et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

HFE polymorphisms influence the response to chemotherapeutic agents via induction of p16INK4A

(2010) Sang Y. Lee et al.   INTERNATIONAL JOURNAL OF CANCER

Activation of AMP-activated Protein Kinase by Temozolomide Contributes to Apoptosis in Glioblastoma Cells via p53 Activation and mTORC1 Inhibition

(2010) Wen-bin Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nrf2 Enhances Cell Proliferation and Resistance to Anticancer Drugs in Human Lung Cancer

(2009) S. Homma et al.   CLINICAL CANCER RESEARCH

Intracellular redox status and oxidative stress: implications for cell proliferation, apoptosis, and carcinogenesis

(2008) José M. Matés et al.   ARCHIVES OF TOXICOLOGY

Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

(2008) X.-J. Wang et al.   CARCINOGENESIS