Ononin alleviates endoplasmic reticulum stress in doxorubicin-induced cardiotoxicity by activating SIRT3

Study of ER stress and apoptotic proteins in the heart and tumor exposed to doxorubicin

(2021) Ashim K. Bagchi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Pinocembrin inhibited cardiomyocyte pyroptosis against doxorubicin-induced cardiac dysfunction via regulating Nrf2/Sirt3 signaling pathway

(2021) Jiwei Gu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Salidroside alleviates liver inflammation in furan-induced mice by regulating oxidative stress and endoplasmic reticulum stress

(2021) Yuan Yuan et al.   TOXICOLOGY

Ononin alleviates H2O2‑induced cardiomyocyte apoptosis and improves cardiac function by activating the AMPK/mTOR/autophagy pathway

(2021) Rongrong Pan et al.   Experimental and Therapeutic Medicine

Melatonin Attenuates Anoxia/Reoxygenation Injury by Inhibiting Excessive Mitophagy Through the MT2/SIRT3/FoxO3a Signaling Pathway in H9c2 Cells

(2020) Jinjing Wu et al.   Drug Design Development and Therapy

Endoplasmic reticulum stress in doxorubicin-induced cardiotoxicity may be therapeutically targeted by natural and chemical compounds: A review

(2020) Fatemeh Yarmohammadi et al.   PHARMACOLOGICAL RESEARCH

The anti-inflammatory effects of formononetin and ononin on lipopolysaccharide-induced zebrafish models based on lipidomics and targeted transcriptomics

(2019) Liyu Luo et al.   Metabolomics

Chemical Discrimination of Astragalus mongholicus and Astragalus membranaceus Based on Metabolomics Using UHPLC-ESI-Q-TOF-MS/MS Approach

(2019) Yumei Wang et al.   MOLECULES

Calycosin-7-O-β-D-glucoside Attenuates OGD/R-Induced Damage by Preventing Oxidative Stress and Neuronal Apoptosis via the SIRT1/FOXO1/PGC-1α Pathway in HT22 Cells

(2019) Xiangli Yan et al.   NEURAL PLASTICITY

Doxorubicin and its proarrhythmic effects: A comprehensive review of the evidence from experimental and clinical studies

(2019) Juthipong Benjanuwattra et al.   PHARMACOLOGICAL RESEARCH

The unfolded protein response in ischemic heart disease

(2018) Xiaoding Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Activation of AMPK-SIRT3 Signaling is Chondroprotective by Preserving Mitochondrial DNA Integrity and Function

(2018) Liang-Yu Chen et al.   OSTEOARTHRITIS AND CARTILAGE

GADD45β-I attenuates oxidative stress and apoptosis via Sirt3-mediated inhibition of ER stress in osteoarthritis chondrocytes

(2018) Zhi Zhang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Anti-inflammatory effects of ononin on lipopolysaccharide-stimulated RAW 264.7 cells

(2017) Lin Dong et al.   MOLECULAR IMMUNOLOGY

A novel combination of four flavonoids derived from Astragali Radix relieves the symptoms of cyclophosphamide-induced anemic rats

(2017) Li Zhang et al.   FEBS Open Bio

Cardiotoxicity with rituximab, cyclophosphamide, non-pegylated liposomal doxorubicin, vincristine and prednisolone compared to rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone in frontline treatment of patients with diffuse large B-cell lymphoma

(2016) Michael A. Fridrik et al.   EUROPEAN JOURNAL OF CANCER

Alginate Oligosaccharide Prevents Acute Doxorubicin Cardiotoxicity by Suppressing Oxidative Stress and Endoplasmic Reticulum-Mediated Apoptosis

(2016) Jun-Jie Guo et al.   Marine Drugs

Isoflavones: Anti-Inflammatory Benefit and Possible Caveats

(2016) Jie Yu et al.   Nutrients

Sirtuin-3 (SIRT3) Protein Attenuates Doxorubicin-induced Oxidative Stress and Improves Mitochondrial Respiration in H9c2 Cardiomyocytes

(2015) Kyle G. Cheung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CHOP deficiency prevents methylglyoxal-induced myocyte apoptosis and cardiac dysfunction

(2015) Dae-Hwan Nam et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Physical exercise prior and during treatment reduces sub-chronic doxorubicin-induced mitochondrial toxicity and oxidative stress

(2015) Inês Marques-Aleixo et al.   MITOCHONDRION

Isoflavones: Chemistry, Analysis, Functions and Effects on Health and Cancer

(2014) Kwang-Pil Ko   Asian Pacific Journal of Cancer Prevention

Doxorubicin-Induced Cardiotoxicity: From Bioenergetic Failure and Cell Death to Cardiomyopathy

(2013) Filipa S. Carvalho et al.   MEDICINAL RESEARCH REVIEWS

SIRT3 protects from hypoxia and staurosporine-mediated cell death by maintaining mitochondrial membrane potential and intracellular pH

(2012) L Pellegrini et al.   CELL DEATH AND DIFFERENTIATION

Mutant SOD1G93A triggers mitochondrial fragmentation in spinal cord motor neurons: Neuroprotection by SIRT3 and PGC-1α

(2012) Wenjun Song et al.   NEUROBIOLOGY OF DISEASE

The interactions between doxorubicin and amphiphilic and acidic β-sheet peptides towards drug delivery hydrogels

(2011) Shlomo Zarzhitsky et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

SIRT3 Is a Stress-Responsive Deacetylase in Cardiomyocytes That Protects Cells from Stress-Mediated Cell Death by Deacetylation of Ku70

(2008) N. R. Sundaresan et al.   MOLECULAR AND CELLULAR BIOLOGY