Expression of phenylalanine ammonia lyase as an intracellularly free and extracellularly cell surface-immobilized enzyme on a gut microbe as a live biotherapeutic for phenylketonuria

A modified pCas/pTargetF system for CRISPR-Cas9-assisted genome editing in Escherichia coli

(2021) Qi Li et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Improvement of a synthetic live bacterial therapeutic for phenylketonuria with biosensor-enabled enzyme engineering

(2021) Kristin J. Adolfsen et al.   Nature Communications

Comprehensive study on Escherichia coli genomic expression: Does position really matter?

(2020) Anke R. Goormans et al.   METABOLIC ENGINEERING

Enhanced genome editing to ameliorate a genetic metabolic liver disease through co-delivery of adeno-associated virus receptor

(2020) Shuming Yin et al.   Science China-Life Sciences

An engineered E. coli Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans

(2019) Caroline B. Kurtz et al.   Science Translational Medicine

A Synthetic Plasmid Toolkit for Shewanella oneidensis MR-1

(2019) Yingxiu Cao et al.   Frontiers in Microbiology

Phase I clinical evaluation of CNSA-001 (sepiapterin), a novel pharmacological treatment for phenylketonuria and tetrahydrobiopterin deficiencies, in healthy volunteers

(2019) Neil Smith et al.   MOLECULAR GENETICS AND METABOLISM

Pegvaliase: First Global Approval

(2018) Anthony Markham   BIODRUGS

Phenylalanine ammonia lyase (PAL): From discovery to enzyme substitution therapy for phenylketonuria

(2018) Harvey L. Levy et al.   MOLECULAR GENETICS AND METABOLISM

Development of a synthetic live bacterial therapeutic for the human metabolic disease phenylketonuria

(2018) Vincent M Isabella et al.   NATURE BIOTECHNOLOGY

Neuropsychiatric comorbidities in adults with phenylketonuria: A retrospective cohort study

(2017) Deborah A. Bilder et al.   MOLECULAR GENETICS AND METABOLISM

Genetically engineered probiotic for the treatment of phenylketonuria (PKU); assessment of a novel treatment in vitro and in the PAHenu2 mouse model of PKU

(2017) Katherine E. Durrer et al.   PLoS One

Surface Immobilization of Human Arginase-1 with an Engineered Ice Nucleation Protein Display System in E. coli

(2016) Zhen Zhang et al.   PLoS One

Display of Fungi Xylanase on Escherichia coli Cell Surface and Use of the Enzyme in Xylan Biodegradation

(2015) Wei Qu et al.   CURRENT MICROBIOLOGY

Fungal and Plant Phenylalanine Ammonia-lyase

(2012) Min Woo Hyun et al.   MYCOBIOLOGY

Construction of Xylose Dehydrogenase Displayed on the Surface of Bacteria Using Ice Nucleation Protein for Sensitive d-Xylose Detection

(2011) Bo Liang et al.   ANALYTICAL CHEMISTRY

Preparation of Ca-Alginate Microparticles and Its Application for Phenylketonuria Oral Therapy

(2011) Yueling Zhang et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

Phenylketonuria: a 21st century perspective

(2010) Francjan J. van Spronsen   Nature Reviews Endocrinology

Efficient cell surface display of organophosphorous hydrolase using N-terminal domain of ice nucleation protein in Escherichia coli

(2008) Dong Gyun Kang et al.   KOREAN JOURNAL OF CHEMICAL ENGINEERING