Development of a synthetic live bacterial therapeutic for the human metabolic disease phenylketonuria

The impact of phenylalanine levels on cognitive outcomes in adults with phenylketonuria: Effects across tasks and developmental stages.

(2017) Cristina Romani et al.   NEUROPSYCHOLOGY

Engineered probiotic Escherichia coli can eliminate and prevent Pseudomonas aeruginosa gut infection in animal models

(2017) In Young Hwang et al.   Nature Communications

Engineered Probiotic for the Inhibition of Salmonella via Tetrathionate-Induced Production of Microcin H47

(2017) Jacob D. Palmer et al.   ACS Infectious Diseases

Formulation and PEGylation optimization of the therapeutic PEGylated phenylalanine ammonia lyase for the treatment of phenylketonuria

(2017) Sean M. Bell et al.   PLoS One

Genetically engineered probiotic for the treatment of phenylketonuria (PKU); assessment of a novel treatment in vitro and in the PAHenu2 mouse model of PKU

(2017) Katherine E. Durrer et al.   PLoS One

Structure-Function Relationships in l-Amino Acid Deaminase, a Flavoprotein Belonging to a Novel Class of Biotechnologically Relevant Enzymes

(2016) Paolo Motta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two-Step Production of Phenylpyruvic Acid from L-Phenylalanine by Growing and Resting Cells of Engineered Escherichia coli: Process Optimization and Kinetics Modeling

(2016) Ying Hou et al.   PLoS One

Genetically Engineered Escherichia coli Nissle 1917 Synbiotics Reduce Metabolic Effects Induced by Chronic Consumption of Dietary Fructose

(2016) Chaudhari Archana Somabhai et al.   PLoS One

Production of phenylpyruvic acid from l-phenylalanine using an l-amino acid deaminase from Proteus mirabilis: comparison of enzymatic and whole-cell biotransformation approaches

(2015) Ying Hou et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Long-term safety and efficacy of sapropterin: The PKUDOS registry experience

(2015) Nicola Longo et al.   MOLECULAR GENETICS AND METABOLISM

Biocontainment of genetically modified organisms by synthetic protein design

(2015) Daniel J. Mandell et al.   NATURE

Programmable probiotics for detection of cancer in urine

(2015) Tal Danino et al.   Science Translational Medicine

Phenylalanine hydroxylase deficiency: diagnosis and management guideline

(2014)   GENETICS IN MEDICINE

Long-term developmental progression in infants and young children taking sapropterin for phenylketonuria: a two-year analysis of safety and efficacy

(2014) Nicola Longo et al.   GENETICS IN MEDICINE

Incorporation of therapeutically modified bacteria into gut microbiota inhibits obesity

(2014) Zhongyi Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

GeneGuard: A Modular Plasmid System Designed for Biosafety

(2014) Oliver Wright et al.   ACS Synthetic Biology

Building-in biosafety for synthetic biology

(2013) O. Wright et al.   MICROBIOLOGY-SGM

Psychiatric symptoms in adults with phenylketonuria

(2013) Deborah A. Bilder et al.   MOLECULAR GENETICS AND METABOLISM

Synthetic Biology Moving into the Clinic

(2011) W. C. Ruder et al.   SCIENCE

Translational Regulation of Gene Expression by an Anaerobically Induced Small Non-coding RNA in Escherichia coli

(2010) Anders Boysen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reprogramming of anaerobic metabolism by the FnrS small RNA

(2010) Sylvain Durand et al.   MOLECULAR MICROBIOLOGY

Survival of the probiotic Escherichia coli Nissle 1917 (EcN) in the gastrointestinal tract given in combination with oral mesalamine to healthy volunteers

(2009) Thai Hoa Joeres-Nguyen-Xuan et al.   INFLAMMATORY BOWEL DISEASES

Pathogenesis of cognitive dysfunction in phenylketonuria: Review of hypotheses☆

(2009) M.J. de Groot et al.   MOLECULAR GENETICS AND METABOLISM

Dietary Guidelines should reflect new understandings about adult protein needs

(2009) Donald K Layman   Nutrition & Metabolism

Clinical use of E. coli Nissle 1917 in inflammatory bowel disease

(2008) Michael Schultz   INFLAMMATORY BOWEL DISEASES

Preclinical evaluation of multiple species of PEGylated recombinant phenylalanine ammonia lyase for the treatment of phenylketonuria

(2008) C. N. Sarkissian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA