ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodies

SARS-CoV-2 breakthrough infections elicit potent, broad, and durable neutralizing antibody responses

(2022) Alexandra C. Walls et al.   CELL

Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry

(2022) Young-Jun Park et al.   SCIENCE

A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection

(2022) Panpan Zhou et al.   Science Translational Medicine

The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV-2 variants of concern

(2022) Rana Abdelnabi et al.   Nature Communications

Structure, receptor recognition and antigenicity of the human coronavirus CCoV-HuPn-2018 spike glycoprotein

(2022) M. Alejandra Tortorici et al.   CELL

Structural diversity of the SARS-CoV-2 Omicron spike

(2022) Sophie M.-C. Gobeil et al.   MOLECULAR CELL

Inter-domain communication in SARS-CoV-2 spike proteins controls protease-triggered cell entry

(2022) Enya Qing et al.   Cell Reports

Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis

(2021) Bryan A. Johnson et al.   NATURE

Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection

(2021) Elizabeth M. Anderson et al.   CELL

SARS-CoV-2 S protein:ACE2 interaction reveals novel allosteric targets

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Structural basis for broad coronavirus neutralization

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Clonal analysis of immunodominance and cross-reactivity of the CD4 T cell response to SARS-CoV-2

(2021) Jun Siong Low et al.   SCIENCE

Cross-reactive serum and memory B-cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection

(2021) Ge Song et al.   Nature Communications

A conserved immunogenic and vulnerable site on the coronavirus spike protein delineated by cross-reactive monoclonal antibodies

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Novel Canine Coronavirus Isolated from a Hospitalized Pneumonia Patient, East Malaysia

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Lectins enhance SARS-CoV-2 infection and influence neutralizing antibodies

(2021) Florian A. Lempp et al.   NATURE

Broad sarbecovirus neutralization by a human monoclonal antibody

(2021) M. Alejandra Tortorici et al.   NATURE

SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape

(2021) Tyler N. Starr et al.   NATURE

Broad betacoronavirus neutralization by a stem helix–specific human antibody

(2021) Dora Pinto et al.   SCIENCE

Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodies

(2021) Claudia A. Jette et al.   Cell Reports

Comparing infectivity and virulence of emerging SARS-CoV-2 variants in Syrian hamsters

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Independent infections of porcine deltacoronavirus among Haitian children

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SARS-CoV-2 spike engagement of ACE2 primes S2′ site cleavage and fusion initiation

(2021) Shi Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice

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Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

Preclinical Development of a Fusion Peptide Conjugate as an HIV Vaccine Immunogen

(2020) Li Ou et al.   Scientific Reports

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells

(2020) Markus Hoffmann et al.   MOLECULAR CELL

Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody

(2020) Dora Pinto et al.   NATURE

Protocol and Reagents for Pseudotyping Lentiviral Particles with SARS-CoV-2 Spike Protein for Neutralization Assays

(2020) Katharine H. D. Crawford et al.   Viruses-Basel

Two linear epitopes on the SARS-CoV-2 spike protein that elicit neutralising antibodies in COVID-19 patients

(2020) Chek Meng Poh et al.   Nature Communications

Structure-based design of prefusion-stabilized SARS-CoV-2 spikes

(2020) Ching-Lin Hsieh et al.   SCIENCE

Broad neutralization of SARS-related viruses by human monoclonal antibodies

(2020) Anna Z. Wec et al.   SCIENCE

Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology

(2020) Luca Piccoli et al.   CELL

Favipiravir at high doses has potent antiviral activity in SARS-CoV-2−infected hamsters, whereas hydroxychloroquine lacks activity

(2020) Suzanne J. F. Kaptein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity

(2020) Ellen Shrock et al.   SCIENCE

Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms

(2020) M. Alejandra Tortorici et al.   SCIENCE

Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody Recognition

(2020) Allison J. Greaney et al.   Cell Host & Microbe

A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate

(2020) Lorena Sanchez-Felipe et al.   NATURE

A chimeric hemagglutinin-based universal influenza virus vaccine approach induces broad and long-lasting immunity in a randomized, placebo-controlled phase I trial

(2020) Raffael Nachbagauer et al.   NATURE MEDICINE

STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters

(2020) Robbert Boudewijns et al.   Nature Communications

Unexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion

(2019) Alexandra C. Walls et al.   CELL

Consistent elicitation of cross-clade HIV-neutralizing responses achieved in guinea pigs after fusion peptide priming by repetitive envelope trimer boosting

(2019) Cheng Cheng et al.   PLoS One

An antibody against the F glycoprotein inhibits Nipah and Hendra virus infections

(2019) Ha V. Dang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix

(2019) Dorothee Liebschner et al.   Acta Crystallographica Section D-Structural Biology

Repertoire-wide phylogenetic models of B cell molecular evolution reveal evolutionary signatures of aging and vaccination

(2019) Kenneth B. Hoehn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Near-Pan-neutralizing Antibodies against HIV-1 by Deconvolution of Plasma Humoral Responses

(2018) Mohammad Mohseni Sajadi et al.   CELL

A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein

(2018) Joshua Tan et al.   NATURE MEDICINE

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1

(2018) Kai Xu et al.   NATURE MEDICINE

Broad receptor engagement of an emerging global coronavirus may potentiate its diverse cross-species transmissibility

(2018) Wentao Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recent progress in broadly neutralizing antibodies to HIV

(2018) Devin Sok et al.   NATURE IMMUNOLOGY

Antibody-virus co-evolution in HIV infection: paths for HIV vaccine development

(2017) Mattia Bonsignori et al.   IMMUNOLOGICAL REVIEWS

Tectonic conformational changes of a coronavirus spike glycoprotein promote membrane fusion

(2017) Alexandra C. Walls et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen

(2017) Jesper Pallesen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

UCSF ChimeraX: Meeting modern challenges in visualization and analysis

(2017) Thomas D. Goddard et al.   PROTEIN SCIENCE

Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer

(2016) Alexandra C. Walls et al.   NATURE

Proteolytic processing of Middle East respiratory syndrome coronavirus spikes expands virus tropism

(2016) Jung-Eun Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody

(2016) R. Kong et al.   SCIENCE

Human Coronavirus HKU1 Spike Protein UsesO-Acetylated Sialic Acid as an Attachment Receptor Determinant and Employs Hemagglutinin-Esterase Protein as a Receptor-Destroying Enzyme

(2015) Xingchuan Huang et al.   JOURNAL OF VIROLOGY

Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection

(2015) Hadi M Yassine et al.   NATURE MEDICINE

A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen

(2015) A. Impagliazzo et al.   SCIENCE

Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein

(2014) Jean Kaoru Millet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How good are my data and what is the resolution?

(2013) Philip R. Evans et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Broadly Neutralizing Antiviral Antibodies

(2013) Davide Corti et al.   Annual Review of Immunology

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Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor

(2013) Xing-Yi Ge et al.   NATURE

Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC

(2013) V. Stalin Raj et al.   NATURE

Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

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IgBLAST: an immunoglobulin variable domain sequence analysis tool

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Broad and potent neutralization of HIV-1 by a gp41-specific human antibody

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Highly Conserved Protective Epitopes on Influenza B Viruses

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Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding

(2011) J. F. Scheid et al.   SCIENCE

A Neutralizing Antibody Selected from Plasma Cells That Binds to Group 1 and Group 2 Influenza A Hemagglutinins

(2011) D. Corti et al.   SCIENCE

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

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Acquisition of Complement Resistance through Incorporation of CD55/Decay-Accelerating Factor into Viral Particles Bearing Baculovirus GP64

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Clonal dissection of the human memory B-cell repertoire following infection and vaccination

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High-throughput isolation of immunoglobulin genes from single human B cells and expression as monoclonal antibodies

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Characterization of a Highly Conserved Domain within the Severe Acute Respiratory Syndrome Coronavirus Spike Protein S2 Domain with Characteristics of a Viral Fusion Peptide

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