Article
Biochemistry & Molecular Biology
Yue Pu, Yao Wu, Yan Zhou, Li-hong Wan
Summary: Azithromycin (AZM) targets RACK1 to inhibit TGF-beta 1 mediated EMT in bronchial epithelial cells, leading to the suppression of cell migration and reversal of EMT.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Immunology
Danxue Qin, Peiqiang Liu, Huiqin Zhou, Jing Jin, Wanyang Gong, Kunyu Liu, Siyuan Chen, Jingyu Huang, Wenjun Fan, Zezhang Tao, Yu Xu
Summary: Chronic rhinosinusitis with nasal polyps (CRSwNP) is caused by prolonged inflammation of the paranasal sinus mucosa. In this study, TIM-4 was found to be increased in the sinonasal mucosa of CRSwNP patients, especially in macrophages. TIM-4 was positively correlated with clinical scores and inhibition of TIM-4 reduced polyp formation and EMT.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Xinjia Han, Chunfang Cai, Jiezhen Huang, Qiufen Li, Liu Huang, Qingshan Xuan, Jinying Yang
Summary: Nicotine has been shown to have regulatory effects on the TGF-beta 1/Smad3 pathway in a PTB-like model, promoting fibroblast-myofibroblast differentiation and inhibiting premature cervical ripening, ultimately improving pregnancy outcomes.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Lauren A. Griggs, Christopher A. Lemmon
Summary: Epithelial to Mesenchymal Transition (EMT) is a process in which epithelial cells transition to a motile and invasive mesenchymal phenotype. The EMT process is associated with an increase in fibronectin (FN) assembly and the localization of Transforming Growth Factor-beta 1 (TGF-beta 1) to FN fibrils. This study investigated the spatial gradients of EMT and FN fibrillogenesis in mammary epithelial cells cultured on square micropatterns in response to TGF-beta 1. The results showed that increasing TGF-beta 1 concentration induced a spatial gradient of both E-Cadherin and FN fibrils, and inhibition of FN fibril assembly globally reduced both E-Cadherin-containing adherens junctions and FN fibrillogenesis, but did not eliminate the spatial gradients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Rohan Reddy Nagavally, Siddharth Sunilkumar, Mumtaz Akhtar, Louis D. Trombetta, Sue M. Ford
Summary: Chrysin demonstrates nephroprotective effects against CsA-induced renal dysfunction and fibrosis by inhibiting TGF-beta(1)-dependent EMT in proximal tubule cells through modulation of Smad-dependent and independent signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Long Xu, Jian Wang, Buhan Liu, Jiaying Fu, Yuanxin Zhao, Sihang Yu, Luyan Shen, Xiaoyu Yan, Jing Su
Summary: Epithelial ovarian cancer has the highest mortality rate among gynecological malignant tumors, largely due to metastasis. This study found that HDAC9 plays different roles in different histological subtypes of ovarian cancer and may be a potential target for personalized treatment.
Article
Pharmacology & Pharmacy
Hyesook Lee, Jung-Hwa Han, Yun Jeong Kang, Hyun Hwangbo, Aeseon Yoon, Hyung-Sik Kim, Dongjun Lee, Soo Yong Lee, Byung Hyun Choi, Jae-Joon Kim, Seo Rin Kim, Yung Hyun Choi, Jin Hur
Summary: This study found that recombinant human cluster of differentiation 82 (rhCD82) can inhibit epithelial-mesenchymal transition (EMT) in retinal pigment epithelial (RPE) cells induced by transforming growth factor-beta (TGF-beta) 1, by interacting with TGF-beta receptors and integrins. This provides new insights into the potential therapeutic strategy of using CD82 in fibrotic retinal disorders.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Xiaoxiao Xu, Chuang Ma, Hang Wu, Yuanqiao Ma, Zejin Liu, Peijie Zhong, Chaolei Jin, Wenjuan Ning, Xiao Wu, Yijie Zhang, Jichang Han, Junpeng Wang
Summary: This study explored the impact of fructose on pulmonary fibrosis and the underlying mechanisms. The results showed that high fructose promoted the fibrotic phenotype and epithelial-mesenchymal transition of lung epithelial cells, which was associated with oxidative stress and the activation of TGF-beta 1.
FRONTIERS IN NUTRITION
(2022)
Article
Plant Sciences
Jing Liu, Dongyang Gao, Qi Ding, Binbin Zhang, Wenxiang Zhu, Yuanyuan Shi
Summary: The study proved that Sparganii Rhizoma (SR) has significant therapeutic effects against pulmonary fibrosis (PF) by inhibiting fibroblast differentiation and epithelial-mesenchymal transition. This provides a new idea and approach for the treatment of PF with traditional Chinese medicine.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Genetics & Heredity
Mi-Gyeong Gwon, Hyun-Jin An, Hyemin Gu, Young-Ah Kim, Sang Mi Han, Kwan-Kyu Park
Summary: Renal fibrosis is a progressive and chronic process that affects patients with chronic kidney disease, leading to irreversible failure of renal function. TGF-beta 1 signaling plays a key role in inducing myofibroblast activation and extracellular matrix production in renal fibrosis. Apamin has been shown to have a beneficial effect in inhibiting renal fibrosis through the modulation of TGF-beta 1 signaling pathways.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Multidisciplinary Sciences
Zhikai Ye, Wenbo Li, Zhenlong Jiang, Erkang Wang, Jin Wang
Summary: An intermediate state with high pluripotency appears to be necessary in the trans-differentiation from fibroblasts to myofibroblasts. This intermediate state exhibits characteristics similar to early reprogramming, such as accelerated cell cycle, metabolic switching, enhanced anti-apoptotic ability, and pluripotency, which change as the trans-differentiation process advances.
Article
Medicine, Research & Experimental
Jingjing Qiu, Yanmei Wang, Wentao Guo, Ling Xu, Yakui Mou, Limei Cui, Fengchan Han, Yan Sun
Summary: The study investigated the role of TGF-beta 1-mediated epithelial-mesenchymal transition (EMT) in the pathogenesis of tympanosclerosis, finding that it plays an important role by activating the EMT pathway and causing a transformation of middle ear mucosal epithelial cells. Rats with tympanosclerosis models exhibited inflammation, fibrosis, and cell infiltration, along with significant changes in the expression levels of EMT-associated proteins.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Cell Biology
Yilei Cui, Hao Yang, Silu Shi, Xiyuan Ping, Sifan Zheng, Xiajing Tang, Xiaoning Yu, Xingchao Shentu
Summary: This study explores the regulation mechanism of TGF-beta 2 in posterior capsule opacification (PCO) formation through its autophagic functions. The results suggest that TP53INP2 plays an important role in TGF-beta 2-induced autophagy during epithelial-mesenchymal transition (EMT), and it may be a potential target for pharmacological treatment of PCO.
Article
Pharmacology & Pharmacy
Minli Huang, Mengru Fu, Jia Wang, Chunhua Xia, Hong Zhang, Yuqing Xiong, Jiake He, Jianming Liu, Bingchen Liu, Siyi Pan, Fanglan Liu
Summary: Cancer-associated fibroblasts (CAFs) play a crucial role in breast cancer initiation, metastasis, and invasion. This study investigated the requirement of autophagy and FAP-alpha in breast cancer cell invasion and metastasis, finding that both are necessary. Targeting autophagy or FAP-alpha individually may be a potential approach to improve the prognosis of human breast cancer.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Oncology
Feifeng Lan, Menghua Chen, Xiaowei Xie, Yanyan Mo, Fengti Chen, Renbin Huang, Wenqi Liu
Summary: YLSPS, derived from the root of Millettia pulchra var. laxior, exhibits anticancer effects in lung cancer cells by reversing EMT and inhibiting the TGF-beta 1-induced ERK signaling pathway. YLSPS significantly inhibits the growth of xenograft tumors and reduces the levels of proteins associated with EMT. Importantly, YLSPS has fewer toxic side effects than cisplatin.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)