Inhibition of fat accumulation, lipid dysmetabolism, cardiac inflammation, and improved nitric oxide signalling mediate the protective effects of lycopene against cardio-metabolic disorder in obese female rats

How does hepatic lipid accumulation lead to lipotoxicity in non-alcoholic fatty liver disease?

(2021) Yana Geng et al.   Hepatology International

Lycopene: A Critical Review of Digestion, Absorption, Metabolism, and Excretion

(2021) Joseph Arballo et al.   Antioxidants

Lycopene corrects metabolic syndrome and liver injury induced by high fat diet in obese rats through antioxidant, anti-inflammatory, antifibrotic pathways

(2021) Tarfa Albrahim et al.   BIOMEDICINE & PHARMACOTHERAPY

Elevated circulating high-sensitivity cardiac troponin t and cardiac remodeling in obesity

(2021) Jiaojiao Huang et al.   BMC Cardiovascular Disorders

Lycopene abrogates obesity-provoked hyperactivity of neurosignalling enzymes, oxidative stress and hypothalamic inflammation in female Wistar rats

(2021) Regina Ngozi Ugbaja et al.   NEUROCHEMISTRY INTERNATIONAL

Lycopene used as Anti-inflammatory Nanodrug for the Treatment of Rheumathoid Arthritis: Animal assay, Pharmacokinetics, ABC Transporter and Tissue Deposition

(2020) Vivian Meira Moia et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Lycopene attenuates body weight gain through induction of browning via regulation of peroxisome proliferator-activated receptor γ in high-fat diet-induced obese mice

(2020) Ruyuan Zhu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Lycopene prevents lipid accumulation in hepatocytes by stimulating PPARα and improving mitochondrial function

(2020) Jia Wang et al.   Journal of Functional Foods

Anticancer effects and possible mechanisms of lycopene intervention on N-methylbenzylnitrosamine induced esophageal cancer in F344 rats based on PPARγ1

(2020) Lingling Cui et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research*

(2020) Nathalie Percie du Sert et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Lycopene in human health

(2020) Mélanie Caseiro et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Lycopene-supplemented diet ameliorates metabolic syndrome induced by fructose in rats

(2020) Pedro Ferreira-Santos et al.   Journal of Functional Foods

Lycopene Exerts Neuroprotective Effects After Hypoxic–Ischemic Brain Injury in Neonatal Rats via the Nuclear Factor Erythroid-2 Related Factor 2/Nuclear Factor-κ-Gene Binding Pathway

(2020) Changchang Fu et al.   Frontiers in Pharmacology

Guarana supplementation attenuated obesity, insulin resistance, and adipokines dysregulation induced by a standardized human Western diet via brown adipose tissue activation

(2019) Rafael Calixto Bortolin et al.   PHYTOTHERAPY RESEARCH

Lycopene supplementation attenuates western diet-induced body weight gain through increasing the expressions of thermogenic/mitochondrial functional genes and improving insulin resistance in the adipose tissue of obese mice

(2019) Jia Wang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Lipotoxicity in Kidney, Heart, and Skeletal Muscle Dysfunction

(2019) Hiroshi Nishi et al.   Nutrients

Novel Insights Into the NLRP3 Inflammasome in Atherosclerosis

(2019) Ying Jin et al.   Journal of the American Heart Association

Cardiovascular risk and obesity

(2019) C. Cercato et al.   Diabetology & Metabolic Syndrome

Understanding the rise of cardiometabolic diseases in low- and middle-income countries

(2019) J. Jaime Miranda et al.   NATURE MEDICINE

Dietary Cholesterol and Cardiovascular Risk: A Science Advisory From the American Heart Association

(2019) Jo Ann S. Carson et al.   CIRCULATION

The IL-10-1082 (rs1800896) G allele is associated with a decreased risk of developing premature coronary artery disease and some IL-10 polymorphisms were associated with clinical and metabolic parameters. The GEA study

(2018) Rosalinda Posadas-Sánchez et al.   CYTOKINE

Bioactive Lipid Species and Metabolic Pathways in Progression and Resolution of Nonalcoholic Steatohepatitis

(2018) Giovanni Musso et al.   GASTROENTEROLOGY

Endothelial nitric oxide synthase gene polymorphisms and risk of erectile dysfunction: An updated meta-analysis of genetic association studies

(2018) Han-Xin Yao et al.   International Journal of Surgery

Role of Nitric Oxide in the Cardiovascular and Renal Systems

(2018) Ashfaq Ahmad et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Complex Interplay between Lipids, Immune System and Interleukins in Cardio-Metabolic Diseases

(2018) Stella Bernardi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lycopene rich extract from red guava ( Psidium guajava L.) displays anti-inflammatory and antioxidant profile by reducing suggestive hallmarks of acute inflammatory response in mice

(2017) Andreanne G. Vasconcelos et al.   FOOD RESEARCH INTERNATIONAL

A new animal diet based on human Western diet is a robust diet-induced obesity model: comparison to high-fat and cafeteria diets in term of metabolic and gut microbiota disruption

(2017) R C Bortolin et al.   INTERNATIONAL JOURNAL OF OBESITY

Effect of dry tomato peel supplementation on glucose tolerance, insulin resistance, and hepatic markers in mice fed high-saturated-fat/high-cholesterol diets

(2017) Sofiane Zidani et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Lycopene and risk of cardiovascular diseases: A meta-analysis of observational studies

(2017) Bo Song et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Anti-hyperlipidemic effect of rice bran polysaccharide and its potential mechanism in high-fat diet mice

(2017) Ying Nie et al.   Food & Function

Approach to asymptomatic creatine kinase elevation

(2016) S. MOGHADAM-KIA et al.   CLEVELAND CLINIC JOURNAL OF MEDICINE

Physiological Mechanisms of Weight Gain−Induced Steatosis in People With Obesity

(2016) Elisa Fabbrini et al.   GASTROENTEROLOGY

Endothelial dysfunction and cardiometabolic diseases: Role of long non-coding RNAs

(2016) Hai-Jian Sun et al.   LIFE SCIENCES

Inflammatory processes in cardiovascular disease: a route to targeted therapies

(2016) Neil Ruparelia et al.   Nature Reviews Cardiology

Lycopene Ameliorates Transplant Arteriosclerosis in Vascular Allograft Transplantation by Regulating the NO/cGMP Pathways and Rho-Associated Kinases Expression

(2016) Yunqiang He et al.   Oxidative Medicine and Cellular Longevity

Lycopene acts through inhibition of IκB kinase to suppress NF-κB signaling in human prostate and breast cancer cells

(2016) Emelia A. Assar et al.   TUMOR BIOLOGY

Inflammation and plaque vulnerability

(2015) G. K. Hansson et al.   JOURNAL OF INTERNAL MEDICINE

Molecular rationale delineating the role of lycopene as a potent HMG-CoA reductase inhibitor:in vitroandin silicostudy

(2015) Sahir Sultan Alvi et al.   NATURAL PRODUCT RESEARCH

Effects of red pitaya juice supplementation on cardiovascular and hepatic changes in high-carbohydrate, high-fat diet-induced metabolic syndrome rats

(2014) Nurul Shazini Ramli et al.   BMC Complementary and Alternative Medicine

The effect of lycopene on antioxidant status in rainbow trout (Oncorhynchus mykiss) reared under high stocking density

(2013) Kazim Sahin et al.   AQUACULTURE

Glycerol-3-phosphate Acyltransferase (GPAT)-1, but Not GPAT4, Incorporates Newly Synthesized Fatty Acids into Triacylglycerol and Diminishes Fatty Acid Oxidation

(2013) Angela A. Wendel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protective effect of lycopene on cardiac function and myocardial fibrosis after acute myocardial infarction in rats via the modulation of p38 and MMP-9

(2013) Xin Wang et al.   JOURNAL OF MOLECULAR HISTOLOGY

Dyslipidemia in Obesity: Mechanisms and Potential Targets

(2013) Boudewijn Klop et al.   Nutrients

Lipid Metabolism and Toxicity in the Heart

(2012) Ira J. Goldberg et al.   Cell Metabolism

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Thermodynamic and Structure Guided Design of Statin Based Inhibitors of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase

(2008) Ronald W. Sarver et al.   JOURNAL OF MEDICINAL CHEMISTRY