Directed evolution of adeno-associated virus for efficient gene delivery to microglia

Cx3Cr1-Cre induction leads to microglial activation and IFN-1 signaling caused by DNA damage in early postnatal brain

(2022) Vinaya Sahasrabuddhe et al.   Cell Reports

Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain

(2022) Samuel E. Marsh et al.   NATURE NEUROSCIENCE

AAV Targeting of Glial Cell Types in the Central and Peripheral Nervous System and Relevance to Human Gene Therapy

(2021) Simon J. O’Carroll et al.   Frontiers in Molecular Neuroscience

Multifaceted microglia — key players in primary brain tumour heterogeneity

(2021) Lily Keane et al.   Nature Reviews Neurology

Integrated analysis of multimodal single-cell data

(2021) Yuhan Hao et al.   CELL

Partial recovery of visual function in a blind patient after optogenetic therapy

(2021) José-Alain Sahel et al.   NATURE MEDICINE

Optimizing AAV2/6 microglial targeting identified enhanced efficiency in the photoreceptor degenerative environment

(2021) Margaret E. Maes et al.   Molecular Therapy-Methods & Clinical Development

Transduction catalysis: Doxorubicin amplifies rAAV-mediated gene expression in the cortex of higher-order vertebrates

(2021) Hongliang Gong et al.   iScience

A sensitive GRAB sensor for detecting extracellular ATP in vitro and in vivo

(2021) Zhaofa Wu et al.   NEURON

Human chimeric antigen receptor macrophages for cancer immunotherapy

(2020) Michael Klichinsky et al.   NATURE BIOTECHNOLOGY

Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity

(2020) Phi T. Nguyen et al.   CELL

Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPβ in Microglia

(2020) Ada Ndoja et al.   CELL

Novel Hexb-based tools for studying microglia in the CNS

(2020) Takahiro Masuda et al.   NATURE IMMUNOLOGY

A scalable SCENIC workflow for single-cell gene regulatory network analysis

(2020) Bram Van de Sande et al.   Nature Protocols

A new genetic strategy for targeting microglia in development and disease

(2020) Gabriel L McKinsey et al.   eLife

Negative feedback control of neuronal activity by microglia

(2020) Ana Badimon et al.   NATURE

Emerging Microglia Biology Defines Novel Therapeutic Approaches for Alzheimer’s Disease

(2020) Joseph W. Lewcock et al.   NEURON

Single-cell transcriptomics identifies divergent developmental lineage trajectories during human pituitary development

(2020) Shu Zhang et al.   Nature Communications

Microglial Gi-dependent dynamics regulate brain network hyperexcitability

(2020) Mario Merlini et al.   NATURE NEUROSCIENCE

CD22 blockade restores homeostatic microglial phagocytosis in ageing brains

(2019) John V. Pluvinage et al.   NATURE

Single-cell transcriptomic analysis of Alzheimer’s disease

(2019) Hansruedi Mathys et al.   NATURE

Targeting neuronal and glial cell types with synthetic promoter AAVs in mice, non-human primates and humans

(2019) Josephine Jüttner et al.   NATURE NEUROSCIENCE

Targeting microglia in brain disorders

(2019) Josef Priller et al.   SCIENCE

Microglial subtypes: diversity within the microglial community

(2019) Vassilis Stratoulias et al.   EMBO JOURNAL

Targeting microglia with lentivirus and AAV: Recent advances and remaining challenges

(2019) Margaret E. Maes et al.   NEUROSCIENCE LETTERS

Microglia Biology: One Century of Evolving Concepts

(2019) Marco Prinz et al.   CELL

Microglia/Brain Macrophages as Central Drivers of Brain Tumor Pathobiology

(2019) David H. Gutmann et al.   NEURON

Viral Strategies for Targeting the Central and Peripheral Nervous Systems

(2018) Claire N. Bedbrook et al.   Annual Review of Neuroscience

Isolation and Culture of Rodent Microglia to Promote a Dynamic Ramified Morphology in Serum-free Medium

(2018) Hannah Y. Collins et al.   Jove-Journal of Visualized Experiments

TREM2 — a key player in microglial biology and Alzheimer disease

(2018) Tyler K. Ulland et al.   Nature Reviews Neurology

Cell-type-specific and projection-specific brain-wide reconstruction of single neurons

(2018) Rui Lin et al.   NATURE METHODS

UMI-tools: modeling sequencing errors in Unique Molecular Identifiers to improve quantification accuracy

(2017) Tom Smith et al.   GENOME RESEARCH

SCENIC: single-cell regulatory network inference and clustering

(2017) Sara Aibar et al.   NATURE METHODS

Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures

(2017) Christopher J. Bohlen et al.   NEURON

Identification and Validation of Small Molecules That Enhance Recombinant Adeno-associated Virus Transduction following High-Throughput Screens

(2016) Sarah C. Nicolson et al.   JOURNAL OF VIROLOGY

Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain

(2016) Benjamin E Deverman et al.   NATURE BIOTECHNOLOGY

Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype

(2016) Xianli Shen et al.   NATURE IMMUNOLOGY

mScarlet: a bright monomeric red fluorescent protein for cellular imaging

(2016) Daphne S Bindels et al.   NATURE METHODS

A polarizing question: do M1 and M2 microglia exist?

(2016) Richard M Ransohoff   NATURE NEUROSCIENCE

New tools for studying microglia in the mouse and human CNS

(2016) Mariko L. Bennett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Microglia-specific targeting by novel capsid-modified AAV6 vectors

(2016) Awilda M Rosario et al.   Molecular Therapy-Methods & Clinical Development

Recombinant adeno-associated viral (rAAV) vectors mediate efficient gene transduction in cultured neonatal and adult microglia

(2015) Wei Su et al.   JOURNAL OF NEUROCHEMISTRY

In vivo genome editing using Staphylococcus aureus Cas9

(2015) F. Ann Ran et al.   NATURE

CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling

(2014) Randall J. Platt et al.   CELL

iRegulon: From a Gene List to a Gene Regulatory Network Using Large Motif and Track Collections

(2014) Rekin's Janky et al.   PLoS Computational Biology

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease

(2012) Alexander H. Stephan et al.   Annual Review of Neuroscience

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

AAV-Mediated Gene Targeting Is Significantly Enhanced by Transient Inhibition of Nonhomologous End Joining or the Proteasome In Vivo

(2012) Nicole K. Paulk et al.   HUMAN GENE THERAPY

The Threefold Protrusions of Adeno-Associated Virus Type 8 Are Involved in Cell Surface Targeting as Well as Postattachment Processing

(2012) C. Raupp et al.   JOURNAL OF VIROLOGY

Structural Insight into the Unique Properties of Adeno-Associated Virus Serotype 9

(2012) M. A. DiMattia et al.   JOURNAL OF VIROLOGY

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Proteasome Inhibitors Enhance Gene Delivery by AAV Virus Vectors Expressing Large Genomes in Hemophilia Mouse and Dog Models: A Strategy for Broad Clinical Application

(2010) Paul E Monahan et al.   MOLECULAR THERAPY

Fast unfolding of communities in large networks

(2008) Vincent D Blondel et al.   JOURNAL OF STATISTICAL MECHANICS-THEORY AND EXPERIMENT