Discovery of a Transferrin Receptor 1-Binding Aptamer and Its Application in Cancer Cell Depletion for Adoptive T-Cell Therapy Manufacturing

Transferrin Receptor-Mediated Internalization and Intracellular Fate of Conjugates of a DNA Aptamer

(2022) Nan Zhang et al.   Molecular Therapy-Nucleic Acids

Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma

(2021) Nikhil C. Munshi et al.   NEW ENGLAND JOURNAL OF MEDICINE

A DNA Aptameric Ligand of Human Transferrin Receptor Generated by Cell-SELEX

(2021) Nan Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ciltacabtagene autoleucel, a B-cell maturation antigen-directed chimeric antigen receptor T-cell therapy in patients with relapsed or refractory multiple myeloma (CARTITUDE-1): a phase 1b/2 open-label study

(2021) Jesus G Berdeja et al.   LANCET

Enhanced in Vivo Blood–Brain Barrier Penetration by Circular Tau–Transferrin Receptor Bifunctional Aptamer for Tauopathy Therapy

(2020) Xiaowei Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

KTE-X19 CAR T-Cell Therapy in Relapsed or Refractory Mantle-Cell Lymphoma

(2020) Michael Wang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Biomaterials in Chimeric Antigen Receptor T-Cell Process Development

(2020) Ian I. Cardle et al.   ACCOUNTS OF CHEMICAL RESEARCH

Identification of a DNA Aptamer That Binds to Human Monocytes and Macrophages

(2020) Meilyn Sylvestre et al.   BIOCONJUGATE CHEMISTRY

Lisocabtagene maraleucel for patients with relapsed or refractory large B-cell lymphomas (TRANSCEND NHL 001): a multicentre seamless design study

(2020) Jeremy S Abramson et al.   LANCET

Cryo-EM structure of the human ferritin–transferrin receptor 1 complex

(2019) Linda Celeste Montemiglio et al.   Nature Communications

CD19 CAR T cell product and disease attributes predict leukemia remission durability

(2019) Olivia C. Finney et al.   JOURNAL OF CLINICAL INVESTIGATION

2B4 costimulatory domain enhancing cytotoxic ability of anti-CD5 chimeric antigen receptor engineered natural killer cells against T cell malignancies

(2019) Yingxi Xu et al.   Journal of Hematology & Oncology

Exploratory trial of a biepitopic CAR T-targeting B cell maturation antigen in relapsed/refractory multiple myeloma

(2019) Jie Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elucidation and Structural Modeling of CD71 as a Molecular Target for Cell-Specific Aptamer Binding

(2019) Xiaoqiu Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Traceless aptamer-mediated isolation of CD8+ T cells for chimeric antigen receptor T-cell therapy

(2019) Nataly Kacherovsky et al.   Nature Biomedical Engineering

G-Quadruplex-Forming Aptamers—Characteristics, Applications, and Perspectives

(2019) Carolina Roxo et al.   MOLECULES

A DNA G-quadruplex/i-motif hybrid

(2019) Betty Chu et al.   NUCLEIC ACIDS RESEARCH

Targeting T cell malignancies using CAR-based immunotherapy: challenges and potential solutions

(2019) Lauren C. Fleischer et al.   Journal of Hematology & Oncology

A guide to manufacturing CAR T cell therapies

(2018) Philipp Vormittag et al.   CURRENT OPINION IN BIOTECHNOLOGY

Cationic polymers for non-viral gene delivery to human T cells

(2018) Brynn R. Olden et al.   JOURNAL OF CONTROLLED RELEASE

An “off-the-shelf” fratricide-resistant CAR-T for the treatment of T cell hematologic malignancies

(2018) Matthew L Cooper et al.   LEUKEMIA

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

(2018) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

Optimizing Circulating Tumor Cells’ Capture Efficiency of Magnetic Nanogels by Transferrin Decoration

(2018) Catalina Biglione et al.   Polymers

Differences in Expansion Potential of Naive Chimeric Antigen Receptor T Cells from Healthy Donors and Untreated Chronic Lymphocytic Leukemia Patients

(2018) Jean-Marc Hoffmann et al.   Frontiers in Immunology

Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell

(2018) Marco Ruella et al.   NATURE MEDICINE

Long-term safety and activity of axicabtagene ciloleucel in refractory large B-cell lymphoma (ZUMA-1): a single-arm, multicentre, phase 1–2 trial

(2018) Frederick L Locke et al.   LANCET ONCOLOGY

CAR T-cells for T-cell malignancies: challenges in distinguishing between therapeutic, normal, and neoplastic T-cells

(2018) Marion Alcantara et al.   LEUKEMIA

Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma

(2018) Stephen J. Schuster et al.   NEW ENGLAND JOURNAL OF MEDICINE

Aptamers as targeted therapeutics: current potential and challenges

(2017) Jiehua Zhou et al.   NATURE REVIEWS DRUG DISCOVERY

Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma

(2017) Sattva S. Neelapu et al.   NEW ENGLAND JOURNAL OF MEDICINE

CAR-T cell manufacturing: time to put it in gear

(2017) Alexey Bersenev   TRANSFUSION

Autologous lymphapheresis for the production of chimeric antigen receptor T cells

(2017) Elizabeth S. Allen et al.   TRANSFUSION

Embracing proteins: structural themes in aptamer–protein complexes

(2016) Amy D Gelinas et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Myeloid cells in peripheral blood mononuclear cell concentrates inhibit the expansion of chimeric antigen receptor T cells

(2016) David F. Stroncek et al.   CYTOTHERAPY

DNA Aptamer Selected against Pancreatic Ductal Adenocarcinoma for in vivo Imaging and Clinical Tissue Recognition

(2015) Xiaoqiu Wu et al.   Theranostics

FASTAptamer: A Bioinformatic Toolkit for High-throughput Sequence Analysis of Combinatorial Selections

(2015) Khalid K Alam et al.   Molecular Therapy-Nucleic Acids

Transferrin Receptor-Mediated Endocytosis: A Useful Target for Cancer Therapy

(2014) Stephanie Tortorella et al.   JOURNAL OF MEMBRANE BIOLOGY

Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia

(2014) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structure analysis of free and bound states of an RNA aptamer against ribosomal protein S8 from Bacillus anthracis

(2014) Milya Davlieva et al.   NUCLEIC ACIDS RESEARCH

The role of hepatic transferrin receptor 2 in the regulation of iron homeostasis in the body

(2014) Christal A. Worthen et al.   Frontiers in Pharmacology

Cytometric evaluation of transferrin receptor 1 (CD71) in childhood acute lymphoblastic leukemia

(2012) Anna Płoszyńska et al.   FOLIA HISTOCHEMICA ET CYTOBIOLOGICA

Programmable Hydrogels for Controlled Cell Catch and Release Using Hybridized Aptamers and Complementary Sequences

(2012) Zhaoyang Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An RNA Alternative to Human Transferrin: A New Tool for Targeting Human Cells

(2012) Samantha E Wilner et al.   Molecular Therapy-Nucleic Acids

The intracellular trafficking pathway of transferrin

(2011) Kristine M. Mayle et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Aptamer-Based Multiplexed Proteomic Technology for Biomarker Discovery

(2011) Larry Gold et al.   PLoS One

NUPACK: Analysis and design of nucleic acid systems

(2010) Joseph N. Zadeh et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Development of DNA aptamers using Cell-SELEX

(2010) Kwame Sefah et al.   Nature Protocols

Efficient clinical-scale enrichment of lymphocytes for use in adoptive immunotherapy using a modified counterflow centrifugal elutriation program

(2009) Daniel J. Powell et al.   CYTOTHERAPY

MEME SUITE: tools for motif discovery and searching

(2009) T. L. Bailey et al.   NUCLEIC ACIDS RESEARCH

The Transferrin Receptor Modulates Hfe-Dependent Regulation of Hepcidin Expression

(2008) Paul J. Schmidt et al.   Cell Metabolism

Imino proton exchange rates imply an induced-fit binding mechanism for the VEGF165-targeting aptamer, Macugen

(2008) Joon-Hwa Lee et al.   FEBS LETTERS

Cell-Specific Aptamer Probes for Membrane Protein Elucidation in Cancer Cells

(2008) Dihua Shangguan et al.   JOURNAL OF PROTEOME RESEARCH