Genetically Encoded Aryl Alkyne for Raman Spectral Imaging of Intracellular α-Synuclein Fibrils

Raman spectroscopy in cell biology and microbiology

(2021) Giuseppe Pezzotti   JOURNAL OF RAMAN SPECTROSCOPY

Imaging of α-Synuclein Aggregates in a Rat Model of Parkinson’s Disease Using Raman Microspectroscopy

(2021) Fide Sevgi et al.   Frontiers in Cell and Developmental Biology

Coupling chemical biology and vibrational spectroscopy for studies of amyloids in vitro and in cells

(2021) Matthew D. Watson et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Structural and Functional Insights into α-Synuclein Fibril Polymorphism

(2021) Surabhi Mehra et al.   Biomolecules

Terminal Alkynes as Raman Probes of α‐Synuclein in Solution and in Cells

(2020) Jessica D. Flynn et al.   CHEMBIOCHEM

The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure

(2020) David R. Boyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of α-synuclein filaments from multiple system atrophy

(2020) Manuel Schweighauser et al.   NATURE

A Different hIAPP Polymorph Is Observed in Human Serum Than in Aqueous Buffer: Demonstration of a New Method for Studying Amyloid Fibril Structure Using Infrared Spectroscopy

(2020) Caitlyn R. Fields et al.   Journal of Physical Chemistry Letters

Parkinson’s disease-related phosphorylation at Tyr39 rearranges α-synuclein amyloid fibril structure revealed by cryo-EM

(2020) Kun Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Raman spectral imaging of 13C2H15N-labeled α-synuclein amyloid fibrils in cells

(2020) Matthew D. Watson et al.   BIOPHYSICAL CHEMISTRY

Vibrational Approach to the Dynamics and Structure of Protein Amyloids

(2019) Haoqian Li et al.   MOLECULES

Amyloid found in human cataracts with two-dimensional infrared spectroscopy

(2019) Ariel M. Alperstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C-terminal α-synuclein truncations are linked to cysteine cathepsin activity in Parkinson’s disease

(2019) Ryan P. McGlinchey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Insights into α-Synuclein Fibril Polymorphism: Effects of Parkinson's Disease-Related C-Terminal Truncations

(2019) Xiaodan Ni et al.   JOURNAL OF MOLECULAR BIOLOGY

Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes

(2019) Sarah H. Shahmoradian et al.   NATURE NEUROSCIENCE

N-Terminal Acetylation Affects α-Synuclein Fibril Polymorphism

(2019) Matthew D. Watson et al.   BIOCHEMISTRY

Structures of fibrils formed by α-synuclein hereditary disease mutant H50Q reveal new polymorphs

(2019) David R. Boyer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Amyloid structures: much more than just a cross-β fold

(2019) Rodrigo Gallardo et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts

(2019) Timo Strohäker et al.   Nature Communications

Raman fingerprints of amyloid structures

(2018) Jessica D. Flynn et al.   CHEMICAL COMMUNICATIONS

Distinct α-Synuclein strains and implications for heterogeneity among α-Synucleinopathies

(2018) Chao Peng et al.   NEUROBIOLOGY OF DISEASE

Structural features of α-synuclein amyloid fibrils revealed by Raman spectroscopy

(2017) Jessica D. Flynn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The SH-SY5Y cell line in Parkinson’s disease research: a systematic review

(2017) Helena Xicoy et al.   Molecular Neurodegeneration

Aggregated Alpha-Synuclein Transfer Efficiently between Cultured Human Neuron-Like Cells and Localize to Lysosomes

(2017) Jakob Domert et al.   PLoS One

Raman spectroscopy: an evolving technique for live cell studies

(2016) Rachael Smith et al.   ANALYST

Rapid acquisition of mean Raman spectra of eukaryotic cells for a robust single cell classification

(2016) Iwan W. Schie et al.   ANALYST

Functionally different α-synuclein inclusions yield insight into Parkinson’s disease pathology

(2016) Christian C. Raiss et al.   Scientific Reports

Probing the effectiveness of spectroscopic reporter unnatural amino acids: a structural study

(2016) Andrew B. Dippel et al.   Acta Crystallographica Section D-Structural Biology

Amyloid Polymorphism: Structural Basis and Neurobiological Relevance

(2015) Robert Tycko   NEURON

Prion-like Mechanisms in the Pathogenesis of Tauopathies and Synucleinopathies

(2014) Michel Goedert et al.   Current Neurology and Neuroscience Reports

How to Get Insight into Amyloid Structure and Formation from Infrared Spectroscopy

(2014) Sean D. Moran et al.   Journal of Physical Chemistry Letters

Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite–like aggregates

(2014) Laura A Volpicelli-Daley et al.   Nature Protocols

Raman spectroscopy of proteins: a review

(2013) A. Rygula et al.   JOURNAL OF RAMAN SPECTROSCOPY

α-Synuclein in Central Nervous System and from Erythrocytes, Mammalian Cells, andEscherichia coliExists Predominantly as Disordered Monomer

(2012) Bruno Fauvet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alkyne-Tag Raman Imaging for Visualization of Mobile Small Molecules in Live Cells

(2012) Hiroyuki Yamakoshi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cell-selective labeling of bacterial proteomes with an orthogonal phenylalanine amino acid reporter

(2011) Markus Grammel et al.   CHEMICAL COMMUNICATIONS

Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus

(2011) Per Westermark et al.   PHYSIOLOGICAL REVIEWS

Improved Immunodetection of Endogenous α-Synuclein

(2011) Byung Rho Lee et al.   PLoS One

Probing Protein Folding Using Site-Specifically Encoded Unnatural Amino Acids as FRET Donors with Tryptophan

(2009) Shigeki J. Miyake-Stoner et al.   BIOCHEMISTRY

The Common Architecture of Cross-β Amyloid

(2009) Thomas R. Jahn et al.   JOURNAL OF MOLECULAR BIOLOGY

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of  -synuclein

(2009) P. Desplats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA