Coupling chemical biology and vibrational spectroscopy for studies of amyloids in vitro and in cells

Terminal Alkynes as Raman Probes of α‐Synuclein in Solution and in Cells

(2020) Jessica D. Flynn et al.   CHEMBIOCHEM

Discriminating α-synuclein strains in Parkinson’s disease and multiple system atrophy

(2020) Mohammad Shahnawaz et al.   NATURE

The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure

(2020) David R. Boyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Live-Cell Imaging and Quantification of PolyQ Aggregates by Stimulated Raman Scattering of Selective Deuterium Labeling

(2020) Kun Miao et al.   ACS Central Science

New insights on the structure of alpha-synuclein fibrils using cryo-electron microscopy

(2020) Ricardo Guerrero-Ferreira et al.   CURRENT OPINION IN NEUROBIOLOGY

Structures of α-synuclein filaments from multiple system atrophy

(2020) Manuel Schweighauser et al.   NATURE

A Different hIAPP Polymorph Is Observed in Human Serum Than in Aqueous Buffer: Demonstration of a New Method for Studying Amyloid Fibril Structure Using Infrared Spectroscopy

(2020) Caitlyn R. Fields et al.   Journal of Physical Chemistry Letters

Cryo-EM structures of tau filaments

(2020) Sjors HW Scheres et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Raman spectral imaging of 13C2H15N-labeled α-synuclein amyloid fibrils in cells

(2020) Matthew D. Watson et al.   BIOPHYSICAL CHEMISTRY

Amyloid found in human cataracts with two-dimensional infrared spectroscopy

(2019) Ariel M. Alperstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutamine Side Chain 13C═18O as a Nonperturbative IR Probe of Amyloid Fibril Hydration and Assembly

(2019) Haifan Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural Insights into α-Synuclein Fibril Polymorphism: Effects of Parkinson's Disease-Related C-Terminal Truncations

(2019) Xiaodan Ni et al.   JOURNAL OF MOLECULAR BIOLOGY

Monolayer Sensitivity Enables a 2D IR Spectroscopic Immuno-biosensor for Studying Protein Structures: Application to Amyloid Polymorphs

(2019) Joshua S. Ostrander et al.   Journal of Physical Chemistry Letters

N-Terminal Acetylation Affects α-Synuclein Fibril Polymorphism

(2019) Matthew D. Watson et al.   BIOCHEMISTRY

Playing with the Molecules of Life

(2018) Douglas D. Young et al.   ACS Chemical Biology

Raman fingerprints of amyloid structures

(2018) Jessica D. Flynn et al.   CHEMICAL COMMUNICATIONS

Ultrafast Hydrogen-Bonding Dynamics in Amyloid Fibrils

(2018) Ileana M. Pazos et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Site-specific detection of protein secondary structure using 2D IR dihedral indexing: a proposed assembly mechanism of oligomeric hIAPP

(2018) Michał Maj et al.   Chemical Science

Cryo-EM structure of alpha-synuclein fibrils

(2018) Ricardo Guerrero-Ferreira et al.   eLife

Import and Export of Misfolded α-Synuclein

(2018) Lilia Rodriguez et al.   Frontiers in Neuroscience

A structural model of the hierarchical assembly of an amyloid nanosheet by an infrared probe technique

(2018) Baohuan Jia et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel

(2018) Binsen Li et al.   Nature Communications

Toxic Amyloid Tape: A Novel Mixed Antiparallel/Parallel β-Sheet Structure Formed by Amyloid β-Protein on GM1 Clusters

(2018) Yuki Okada et al.   ACS Chemical Neuroscience

Segmental 13 C-Labeling and Raman Microspectroscopy of α-Synuclein Amyloid Formation

(2018) Jessica D. Flynn et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural Polymorphs Suggest Competing Pathways for the Formation of Amyloid Fibrils That Diverge from a Common Intermediate Species

(2018) Lauren E. Buchanan et al.   BIOCHEMISTRY

Structural features of α-synuclein amyloid fibrils revealed by Raman spectroscopy

(2017) Jessica D. Flynn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Not All β-Sheets Are the Same: Amyloid Infrared Spectra, Transition Dipole Strengths, and Couplings Investigated by 2D IR Spectroscopy

(2017) Justin P. Lomont et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Monomeric Huntingtin Exon 1 Has Similar Overall Structural Features for Wild-Type and Pathological Polyglutamine Lengths

(2017) John B. Warner et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Free Energy Barrier Caused by the Refolding of an Oligomeric Intermediate Controls the Lag Time of Amyloid Formation by hIAPP

(2017) Arnaldo L. Serrano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Surface-Sensitive and Surface-Specific Ultrafast Two-Dimensional Vibrational Spectroscopy

(2016) Jan Philip Kraack et al.   CHEMICAL REVIEWS

Applications of two-dimensional infrared spectroscopy

(2015) Amanda L. Le Sueur et al.   ANALYST

Fast Helix Formation in the B Domain of Protein A Revealed by Site-Specific Infrared Probes

(2015) Caitlin M. Davis et al.   BIOCHEMISTRY

pH-Driven Polymorphism of Insulin Amyloid-Like Fibrils

(2015) Tomas Sneideris et al.   PLoS One

Polyglutamine (PolyQ) Diseases: Genetics to Treatments

(2014) Hueng-Chuen Fan et al.   CELL TRANSPLANTATION

How to Get Insight into Amyloid Structure and Formation from Infrared Spectroscopy

(2014) Sean D. Moran et al.   Journal of Physical Chemistry Letters

Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases

(2014) Jing L Guo et al.   NATURE MEDICINE

Live-cell imaging of alkyne-tagged small biomolecules by stimulated Raman scattering

(2014) Lu Wei et al.   NATURE METHODS

ATR-FTIR: A “rejuvenated” tool to investigate amyloid proteins

(2013) Rabia Sarroukh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Ribonuclease S Dynamics Measured Using a Nitrile Label with 2D IR Vibrational Echo Spectroscopy

(2012) Sayan Bagchi et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Conformational Dynamics and Stability of HP35 Studied with 2D IR Vibrational Echoes

(2012) Jean K. Chung et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Two-dimensional IR spectroscopy and segmental 13C labeling reveals the domain structure of human  D-crystallin amyloid fibrils

(2012) S. D. Moran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Azidohomoalanine: A Conformationally Sensitive IR Probe of Protein Folding, Protein Structure, and Electrostatics

(2010) Humeyra Taskent-Sezgin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Residue-Specific, Real-Time Characterization of Lag-Phase Species and Fibril Growth During Amyloid Formation: A Combined Fluorescence and IR Study of p-Cyanophenylalanine Analogs of Islet Amyloid Polypeptide

(2010) Peter Marek et al.   JOURNAL OF MOLECULAR BIOLOGY

The Common Architecture of Cross-β Amyloid

(2009) Thomas R. Jahn et al.   JOURNAL OF MOLECULAR BIOLOGY

Parkinson's disease

(2009) Andrew J Lees et al.   LANCET

Amide I Two-Dimensional Infrared Spectroscopy of Proteins

(2008) Ziad Ganim et al.   ACCOUNTS OF CHEMICAL RESEARCH

Two-color labeling of temporally defined protein populations in mammalian cells

(2008) Kimberly E. Beatty et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

β-Azidoalanine as an IR Probe: Application to Amyloid Aβ(16-22) Aggregation

(2008) Kwang-Im Oh et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Label-Free Biomedical Imaging with High Sensitivity by Stimulated Raman Scattering Microscopy

(2008) Christian W. Freudiger et al.   SCIENCE

Mechanisms of Protein Fibril Formation: Nucleated Polymerization with Competing Off-Pathway Aggregation

(2007) Evan T. Powers et al.   BIOPHYSICAL JOURNAL

FTIR reveals structural differences between native β-sheet proteins and amyloid fibrils

(2004) Giorgia Zandomeneghi et al.   PROTEIN SCIENCE