Discovery and Mechanistic Study of Mycobacterium tuberculosis PafA Inhibitors

Long-range electrostatic interactions significantly modulate the affinity of dynein for microtubules

(2022) Ashok Pabbathi et al.   BIOPHYSICAL JOURNAL

The Pup-Proteasome System Protects Mycobacteria from Antimicrobial Antifolates

(2021) Marissa B. Guzzo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Development of Tyrphostin Analogues to Study Inhibition of the Mycobacterium tuberculosis Pup Proteasome System**

(2021) Guido V. Janssen et al.   CHEMBIOCHEM

Functionalized Dioxonaphthoimidazoliums: A Redox Cycling Chemotype with Potent Bactericidal Activities against Mycobacterium tuberculosis

(2021) Kevin T. Fridianto et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structures of prokaryotic ubiquitin-like protein Pup in complex with depupylase Dop reveal the mechanism of catalytic phosphate formation

(2021) Hengjun Cui et al.   Nature Communications

Development and characterization of nanobubbles containing paclitaxel and survivin inhibitor YM155 against lung cancer

(2019) Yücel Başpınar et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Pupylated proteins are subject to broad proteasomal degradation specificity and differential depupylation

(2019) Juerg Laederach et al.   PLoS One

A selective membrane-targeting repurposed antibiotic with activity against persistent methicillin-resistant Staphylococcus aureus

(2019) Wooseong Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteasome accessory factor A (PafA) transferase activity makes sense in the light of its homology with glutamine synthetase

(2018) Nir Hecht et al.   JOURNAL OF MOLECULAR BIOLOGY

Anti-GD2 Immunoliposomes for Targeted Delivery of the Survivin Inhibitor Sepantronium Bromide (YM155) to Neuroblastoma Tumor Cells

(2018) Shima Gholizadeh et al.   PHARMACEUTICAL RESEARCH

Identification of Serine 119 as an Effective Inhibitor Binding Site of M. tuberculosis Ubiquitin-like Protein Ligase PafA Using Purified Proteins and M. smegmatis

(2018) He-Wei Jiang et al.   EBioMedicine

Mycobacterium tuberculosis Proteasome Accessory Factor A (PafA) Can Transfer Prokaryotic Ubiquitin-Like Protein (Pup) between Substrates

(2017) Susan Zhang et al.   mBio

An Extended Loop of the Pup Ligase, PafA, Mediates Interaction with Protein Targets

(2016) Ofir Regev et al.   JOURNAL OF MOLECULAR BIOLOGY

Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability

(2016) Adi Goldenzweig et al.   MOLECULAR CELL

Posttranslational regulation of coordinated enzyme activities in the Pup-proteasome system

(2016) Yifat Elharar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preclinical efficacy of the synthetic retinoid ST1926 for treating adult T-cell leukemia/lymphoma

(2014) H. El Hajj et al.   BLOOD

Survival of mycobacteria depends on proteasome-mediated amino acid recycling under nutrient limitation

(2014) Y. Elharar et al.   EMBO JOURNAL

Correction: Prokaryotic Ubiquitin-Like Protein (Pup) Proteome of Mycobacterium tuberculosis

(2014) Richard A. Festa et al.   PLoS One

Release of extracellular ATP by bacteria during growth

(2013) Roberto Mempin et al.   BMC MICROBIOLOGY

Crystal Structure of the Complex between Prokaryotic Ubiquitin-like Protein and Its Ligase PafA

(2013) Jonas Barandun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fluorescent Probes Reveal a Minimal Ligase Recognition Motif in the Prokaryotic Ubiquitin-like Protein from Mycobacterium tuberculosis

(2013) Denis Smirnov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structures of Pup ligase PafA and depupylase Dop from the prokaryotic ubiquitin-like modification pathway

(2012) Dennis Özcelik et al.   Nature Communications

Reconstitution of the Mycobacterium tuberculosis pupylation pathway in Escherichia coli

(2011) Francisca A Cerda-Maira et al.   EMBO REPORTS

The mycobacterial Mpa–proteasome unfolds and degrades pupylated substrates by engaging Pup's N-terminus

(2010) Frank Striebel et al.   EMBO JOURNAL

Dop functions as a depupylase in the prokaryotic ubiquitin-like modification pathway

(2010) Frank Imkamp et al.   EMBO REPORTS

Mycobacterial Ubiquitin-like Protein Ligase PafA Follows a Two-step Reaction Pathway with a Phosphorylated Pup Intermediate

(2010) Ethan Guth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prokaryotic Ubiquitin-like Protein (Pup) Is Coupled to Substrates via the Side Chain of Its C-Terminal Glutamate

(2010) Markus Sutter et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

“Depupylation” of Prokaryotic Ubiquitin-like Protein from Mycobacterial Proteasome Substrates

(2010) Kristin E. Burns et al.   MOLECULAR CELL

A distinct structural region of the prokaryotic ubiquitin-like protein (Pup) is recognized by the N-terminal domain of the proteasomal ATPase Mpa

(2009) Markus Sutter et al.   FEBS LETTERS

Bacterial ubiquitin-like modifier Pup is deamidated and conjugated to substrates by distinct but homologous enzymes

(2009) Frank Striebel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ubiquitin-Like Protein Involved in the Proteasome Pathway of Mycobacterium tuberculosis

(2008) M. J. Pearce et al.   SCIENCE