Cucurbitacin I exhibits anticancer efficacy through induction of apoptosis and modulation of JAK / STAT3 , MAPK / ERK , and AKT / mTOR signaling pathways in HepG2 cell line
出版年份 2022 全文链接
标题
Cucurbitacin I exhibits anticancer efficacy through induction of apoptosis and modulation of
JAK
/
STAT3
,
MAPK
/
ERK
, and
AKT
/
mTOR
signaling pathways in
HepG2
cell line
作者
关键词
-
出版物
JOURNAL OF FOOD BIOCHEMISTRY
Volume -, Issue -, Pages -
出版商
Wiley
发表日期
2022-07-22
DOI
10.1111/jfbc.14333
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Potential thiosemicarbazone‐based enzyme inhibitors: Assessment of antiproliferative activity, metabolic enzyme inhibition properties, and molecular docking calculations
- (2022) Hasan Yakan et al. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
- Simultaneous isolation and purification of cucurbitacin D and I from Ecballium elaterium (l.) A. Rich fruit juice
- (2020) Emir Tosun et al. Macedonian Journal of Chemistry and Chemical Engineering
- Cucurbitacin I induces apoptosis in ovarian cancer cells through oxidative stress and the p190B‑Rac1 signaling axis
- (2020) Ruli Li et al. Molecular Medicine Reports
- Mitogen-activated protein kinases are involved in cucurbitacin D-induced antitumor effects on adult T-cell leukemia cells
- (2020) Duo Wang et al. INVESTIGATIONAL NEW DRUGS
- Cancer Metabolism: Phenotype, Signaling and Therapeutic Targets
- (2020) Jae Hyung Park et al. Cells
- Preliminary phytochemical analysis and evaluation of in vitro antioxidant, antiproliferative, antidiabetic, and anticholinergics effects of endemic Gypsophila taxa from Turkey
- (2019) Ahmet Altay et al. JOURNAL OF FOOD BIOCHEMISTRY
- Hepatocellular carcinoma: Mechanisms of progression and immunotherapy
- (2019) Yu Jiang et al. WORLD JOURNAL OF GASTROENTEROLOGY
- Combination of aloin and metformin enhances the antitumor effect by inhibiting the growth and invasion and inducing apoptosis and autophagy in hepatocellular carcinoma through PI3K/AKT/mTOR pathway
- (2019) Ruijie Sun et al. Cancer Medicine
- Cucurbitacin I induces pro-death autophagy in A549 cells via the ERK-mTOR-STAT3 signaling pathway
- (2018) Yinyun Ni et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Cucurbitacin I induces cancer cell death through the endoplasmic reticulum stress pathway
- (2018) He Li et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Cucurbitacin B Induces Hypoglycemic Effect in Diabetic Mice by Regulation of AMP-Activated Protein Kinase Alpha and Glucagon-Like Peptide-1 via Bitter Taste Receptor Signaling
- (2018) Kang-Hoon Kim et al. Frontiers in Pharmacology
- Separation of cucurbitane triterpenoids from bitter melon drinks and determination of partition coefficients using vortex-assisted dispersive liquid-phase microextraction followed by UHPLC analysis
- (2017) Shuang Hu et al. JOURNAL OF SEPARATION SCIENCE
- Antitumor effectiveness of a combined therapy with a new cucurbitacin B derivative and paclitaxel on a human lung cancer xenograft model
- (2017) Lucas Lourenço Marostica et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Hepatocellular carcinoma
- (2016) Josep M. Llovet et al. Nature Reviews Disease Primers
- Synergistic Antiproliferative Effects of a New Cucurbitacin B Derivative and Chemotherapy Drugs on Lung Cancer Cell Line A549
- (2015) Lucas Lourenço Marostica et al. CHEMICAL RESEARCH IN TOXICOLOGY
- SEARCH: A Phase III, Randomized, Double-Blind, Placebo-Controlled Trial of Sorafenib Plus Erlotinib in Patients With Advanced Hepatocellular Carcinoma
- (2015) Andrew X. Zhu et al. JOURNAL OF CLINICAL ONCOLOGY
- Linifanib Versus Sorafenib in Patients With Advanced Hepatocellular Carcinoma: Results of a Randomized Phase III Trial
- (2015) Calin Cainap et al. JOURNAL OF CLINICAL ONCOLOGY
- Erratum: Advances in targeted therapies for hepatocellular carcinoma in the genomic era
- (2015) Josep M. Llovet et al. Nature Reviews Clinical Oncology
- Cucurbitacin I inhibits cell migration and invasion and enhances chemosensitivity in colon cancer
- (2015) JUNMIN SONG et al. ONCOLOGY REPORTS
- Hepatoprotective and proapoptotic effect of Ecballium elaterium on CCl4-induced hepatotoxicity in rats
- (2015) El Moataz Bellah El Naggar et al. Asian Pacific Journal of Tropical Medicine
- In Vitro and In Vivo Antitumor Activity of a Novel Semisynthetic Derivative of Cucurbitacin B
- (2015) Izabella T. Silva et al. PLoS One
- Cucurbitacin-I inhibits Aurora kinase A, Aurora kinase B and survivin, induces defects in cell cycle progression and promotes ABT-737-induced cell death in a caspase-independent manner in malignant human glioma cells
- (2014) Daniel R Premkumar et al. CANCER BIOLOGY & THERAPY
- Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012
- (2014) Jacques Ferlay et al. INTERNATIONAL JOURNAL OF CANCER
- Effect of Everolimus on Survival in Advanced Hepatocellular Carcinoma After Failure of Sorafenib
- (2014) Andrew X. Zhu et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- NK Cells Are the Crucial Antitumor Mediators When STAT3-Mediated Immunosuppression Is Blocked in Hepatocellular Carcinoma
- (2014) Qiangjun Sui et al. JOURNAL OF IMMUNOLOGY
- Brivanib Versus Sorafenib As First-Line Therapy in Patients With Unresectable, Advanced Hepatocellular Carcinoma: Results From the Randomized Phase III BRISK-FL Study
- (2013) Philip J. Johnson et al. JOURNAL OF CLINICAL ONCOLOGY
- Sunitinib Versus Sorafenib in Advanced Hepatocellular Cancer: Results of a Randomized Phase III Trial
- (2013) Ann-Lii Cheng et al. JOURNAL OF CLINICAL ONCOLOGY
- Targeting Blockage of STAT3 in Hepatocellular Carcinoma Cells Augments NK Cell Functions via Reverse Hepatocellular Carcinoma-Induced Immune Suppression
- (2013) X. Sun et al. MOLECULAR CANCER THERAPEUTICS
- Cellular and molecular mechanisms of hepatocellular carcinoma: an update
- (2012) Rajagopal N. Aravalli et al. ARCHIVES OF TOXICOLOGY
- The cucurbitacins E, D and I: Investigation of their cytotoxicity toward human chondrosarcoma SW 1353 cell line and their biotransformation in man liver
- (2012) Suzanne Abbas et al. TOXICOLOGY LETTERS
- Signaling pathway/molecular targets and new targeted agents under development in hepatocellular carcinoma
- (2012) Masatoshi Kudo WORLD JOURNAL OF GASTROENTEROLOGY
- Cucurbitacin-I (JSI-124) activates the JNK/c-Jun signaling pathway independent of apoptosis and cell cycle arrest in B Leukemic Cells
- (2011) Ganchimeg Ishdorj et al. BMC CANCER
- Anticancer activity of botanical compounds in ancient fermented beverages (Review)
- (2010) McGovern INTERNATIONAL JOURNAL OF ONCOLOGY
- Inhibition of Constitutive Activation of STAT3 by Curcurbitacin-I (JSI-124) Sensitized Human B-Leukemia Cells to Apoptosis
- (2010) G. Ishdorj et al. MOLECULAR CANCER THERAPEUTICS
- The role of signaling pathways in the development and treatment of hepatocellular carcinoma
- (2010) S Whittaker et al. ONCOGENE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search