标题
Molecular and cellular biology of PCSK9: impact on glucose homeostasis
作者
关键词
-
出版物
JOURNAL OF DRUG TARGETING
Volume -, Issue -, Pages 1-13
出版商
Informa UK Limited
发表日期
2022-06-20
DOI
10.1080/1061186x.2022.2092622
参考文献
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- (2021) Bruce A. Warden et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Substantial PCSK9 inactivation in β-cells does not modify glucose homeostasis or insulin secretion in mice
- (2021) Marie-Line Peyot et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- The Diabetes Mellitus–Atherosclerosis Connection: The Role of Lipid and Glucose Metabolism and Chronic Inflammation
- (2020) Anastasia Poznyak et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Research progress on alternative non-classical mechanisms of PCSK9 in atherosclerosis in patients with and without diabetes
- (2020) Ying Tang et al. Cardiovascular Diabetology
- Special Issue “Diabetic Nephropathy: Diagnosis, Prevention and Treatment”
- (2020) Marta Ruiz-Ortega et al. Journal of Clinical Medicine
- High-Density Lipoproteins Are Bug Scavengers
- (2020) Olivier Meilhac et al. Biomolecules
- Sex-specific predictors of PCSK9 levels in a European population: The IMPROVE Study
- (2020) Nicola Ferri et al. ATHEROSCLEROSIS
- The role of the C-terminal domain of PCSK9 and SEC24 isoforms in PCSK9 secretion
- (2020) Shi-jun Deng et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Mechanisms of the Regulation and Dysregulation of Glucagon Secretion
- (2020) Arnold N. Onyango Oxidative Medicine and Cellular Longevity
- PCSK9 Variants in Familial Hypercholesterolemia: A Comprehensive Synopsis
- (2020) Qianyun Guo et al. Frontiers in Genetics
- The loss-of-function PCSK9Q152H variant increases ER chaperones GRP78 and GRP94 and protects against liver injury
- (2020) Paul F. Lebeau et al. JOURNAL OF CLINICAL INVESTIGATION
- Coming Back to Physiology: Extra Hepatic Functions of Proprotein Convertase Subtilisin/Kexin Type 9
- (2020) Klaus-Dieter Schlüter et al. Frontiers in Physiology
- Hepatic Glucagon Signaling Regulates PCSK9 and Low-Density Lipoprotein Cholesterol
- (2019) Stefano Spolitu et al. CIRCULATION RESEARCH
- Sex Differences Associated With Circulating PCSK9 in Patients Presenting With Acute Myocardial Infarction
- (2019) Zhong Zhang et al. Scientific Reports
- Epigenetics in Human Obesity and Type 2 Diabetes
- (2019) Charlotte Ling et al. Cell Metabolism
- Effect of Physical Activity on Plasma PCSK9 in Subjects With High Risk for Type 2 Diabetes
- (2019) Kari Antero Mäkelä et al. Frontiers in Physiology
- Gut Microbiome: Profound Implications for Diet and Disease
- (2019) Ronald D. Hills et al. Nutrients
- Surf4 regulates expression of proprotein convertase subtilisin/kexin type 9 (PCSK9) but is not required for PCSK9 secretion in cultured human hepatocytes
- (2019) Yishi Shen et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Identification of Regions in PCSK9 Important for Its Secretion
- (2018) Shijun Deng et al. ATHEROSCLEROSIS SUPPLEMENTS
- Role of PCSK9 in lipid metabolism and atherosclerosis
- (2018) Xiao-Long Lin et al. BIOMEDICINE & PHARMACOTHERAPY
- PCSK9 regulates expression of scavenger receptors and ox-LDL uptake in macrophages
- (2018) Zufeng Ding et al. CARDIOVASCULAR RESEARCH
- PCSK9 expression in the ischaemic heart and its relationship to infarct size, cardiac function, and development of autophagy
- (2018) Zufeng Ding et al. CARDIOVASCULAR RESEARCH
- PCSK9
- (2018) Michael D. Shapiro et al. CIRCULATION RESEARCH
- PCSK9 deficiency reduces insulin secretion and promotes glucose intolerance: the role of the low-density lipoprotein receptor
- (2018) Lorenzo Da Dalt et al. EUROPEAN HEART JOURNAL
- Loss-of-function PCSK9 mutants evade the unfolded protein response sensor GRP78 and fail to induce endoplasmic reticulum stress when retained
- (2018) Paul Lebeau et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- PCSK9 induces a pro-inflammatory response in macrophages
- (2018) Chiara Ricci et al. Scientific Reports
- DOUBLING OF HEMOGLOBIN A1C ON PCSK 9 INHIBITOR THERAPY
- (2018) Raafia Memon et al. AMERICAN JOURNAL OF MEDICINE
- C679X loss-of-function PCSK9 variant lowers fasting glucose levels in a black South African population: A longitudinal study
- (2018) Tinashe Chikowore et al. DIABETES RESEARCH AND CLINICAL PRACTICE
- The cargo receptor SURF4 promotes the efficient cellular secretion of PCSK9
- (2018) Brian T Emmer et al. eLife
- PPARγ overexpression regulates cholesterol metabolism in human L02 hepatocytes
- (2018) Tao Han et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- Hepatic HNF1 transcription factors control the induction of PCSK9 mediated by rosuvastatin in normolipidemic hamsters
- (2017) Bin Dong et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- PCSK9 and Atherosclerosis - Lipids and Beyond
- (2017) Michael D. Shapiro et al. Journal of Atherosclerosis and Thrombosis
- Predicting proprotein convertase subtilisin kexin type-9 loss of function mutations using plasma PCSK9 concentration
- (2017) Eric Wanneh et al. Journal of Clinical Lipidology
- Glucagon-induced extracellular cAMP regulates hepatic lipid metabolism
- (2017) Sihan Lv et al. JOURNAL OF ENDOCRINOLOGY
- Role of PCSK9 (proprotein convertase subtilisin/kexin type 9) beyond LDLR targeting: Focus on glucose metabolism
- (2017) G. Balzarotti et al. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
- Heparan sulfate proteoglycans present PCSK9 to the LDL receptor
- (2017) Camilla Gustafsen et al. Nature Communications
- Circulating Levels of Proprotein Convertase Subtilisin/Kexin Type 9 and Arterial Stiffness in a Large Population Sample: Data From the Brisighella Heart Study
- (2017) Massimiliano Ruscica et al. Journal of the American Heart Association
- Cardiovascular safety and efficacy of the PCSK9 inhibitor evolocumab in patients with and without diabetes and the effect of evolocumab on glycaemia and risk of new-onset diabetes: a prespecified analysis of the FOURIER randomised controlled trial
- (2017) Marc S Sabatine et al. Lancet Diabetes & Endocrinology
- PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study
- (2017) Amand F Schmidt et al. Lancet Diabetes & Endocrinology
- Long-term Low-Density Lipoprotein Cholesterol–Lowering Efficacy, Persistence, and Safety of Evolocumab in Treatment of Hypercholesterolemia
- (2017) Michael J. Koren et al. JAMA Cardiology
- Identification and in vitro characterization of two new PCSK9 Gain of Function variants found in patients with Familial Hypercholesterolemia
- (2017) Maria Donata Di Taranto et al. Scientific Reports
- PCSK9 knock-out mice are protected from neointimal formation in response to perivascular carotid collar placement
- (2016) Nicola Ferri et al. ATHEROSCLEROSIS
- TLR2 and TLR4 mediated host immune responses in major infectious diseases: a review
- (2016) Suprabhat Mukherjee et al. Brazilian Journal of Infectious Diseases
- Circulating Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Predicts Future Risk of Cardiovascular Events Independently of Established Risk FactorsCLINICAL PERSPECTIVE
- (2016) Karin Leander et al. CIRCULATION
- No effect of PCSK9 inhibitor alirocumab on the incidence of diabetes in a pooled analysis from 10 ODYSSEY Phase 3 studies
- (2016) Helen M. Colhoun et al. EUROPEAN HEART JOURNAL
- Association Between Low-Density Lipoprotein Cholesterol–Lowering Genetic Variants and Risk of Type 2 Diabetes
- (2016) Luca A. Lotta et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Enhanced pro-protein convertase subtilisin/kexin type 9 expression by C-reactive protein through p38MAPK-HNF1α pathway in HepG2 cells
- (2016) Chuan-Jue Cui et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Variation in PCSK9 and HMGCR and Risk of Cardiovascular Disease and Diabetes
- (2016) Brian A. Ference et al. NEW ENGLAND JOURNAL OF MEDICINE
- Adiponectin signaling and function in insulin target tissues
- (2016) Hong Ruan et al. Journal of Molecular Cell Biology
- Genistein upregulates LDLR levels via JNK-mediated activation of SREBP-2
- (2016) Medicia Kartawijaya et al. Food & Nutrition Research
- Trafficking Dynamics of PCSK9-Induced LDLR Degradation: Focus on Human PCSK9 Mutations and C-Terminal Domain
- (2016) Steve Poirier et al. PLoS One
- The Central Role of Proprotein Convertase Subtilisin/Kexin Type 9 in Septic Pathogen Lipid Transport and Clearance
- (2015) Keith R. Walley et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Molecular and cellular function of the proprotein convertase subtilisin/kexin type 9 (PCSK9)
- (2015) Rainer Schulz et al. BASIC RESEARCH IN CARDIOLOGY
- Cross-talk between LOX-1 and PCSK9 in vascular tissues
- (2015) Zufeng Ding et al. CARDIOVASCULAR RESEARCH
- Relationship between testosterone, estradiol and circulating PCSK9: Cross-sectional and interventional studies in humans
- (2015) T.C. Ooi et al. CLINICA CHIMICA ACTA
- Positive correlation of plasma PCSK9 levels with HbA1cin patients with type 2 diabetes
- (2015) Sheng-Hua Yang et al. DIABETES-METABOLISM RESEARCH AND REVIEWS
- The loss-of-function PCSK9 p.R46L genetic variant does not alter glucose homeostasis
- (2015) Amélie Bonnefond et al. DIABETOLOGIA
- Stairs instead of elevators at the workplace decreases PCSK9 levels in a healthy population
- (2015) Christel H. Kamani et al. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
- Association Between Familial Hypercholesterolemia and Prevalence of Type 2 Diabetes Mellitus
- (2015) Joost Besseling et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Suppressor of Cytokine Signaling-3 (SOCS-3) Induces Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) Expression in Hepatic HepG2 Cell Line
- (2015) Massimiliano Ruscica et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Familial hypercholesterolemia: PCSK9 InsLEU genetic variant and prediabetes/diabetes risk
- (2015) Yascara G. Luna Saavedra et al. Journal of Clinical Lipidology
- Reduction of circulating PCSK9 and LDL-C levels by liver-specific knockdown of HNF1α in normolipidemic mice
- (2015) Vikram Ravindra Shende et al. JOURNAL OF LIPID RESEARCH
- HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials
- (2015) Daniel I Swerdlow et al. LANCET
- Docosahexaenoic Acid Attenuates Cardiovascular Risk Factors via a Decline in Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Plasma Levels
- (2015) Celia Rodríguez-Pérez et al. LIPIDS
- GRP94 Regulates Circulating Cholesterol Levels through Blockade of PCSK9-Induced LDLR Degradation
- (2015) Steve Poirier et al. Cell Reports
- PCSK9 variation and association with blood pressure in African Americans: preliminary findings from the HyperGEN and REGARDS studies
- (2015) Ngan T. Tran et al. Frontiers in Genetics
- Association of plasma PCSK9 levels with white blood cell count and its subsets in patients with stable coronary artery disease
- (2014) Sha Li et al. ATHEROSCLEROSIS
- Sorting an LDL receptor with bound PCSK9 to intracellular degradation
- (2014) Trond P. Leren ATHEROSCLEROSIS
- PCSK9 levels in abdominally obese men: Association with cardiometabolic risk profile and effects of a one-year lifestyle modification program
- (2014) Benoit J. Arsenault et al. ATHEROSCLEROSIS
- The Hypercholesterolemia-Risk Gene SORT1 Facilitates PCSK9 Secretion
- (2014) Camilla Gustafsen et al. Cell Metabolism
- PCSK9
- (2014) Nabil G. Seidah et al. CIRCULATION RESEARCH
- The effect of insulin on circulating PCSK9 in postmenopausal obese women
- (2014) Zuhier Awan et al. CLINICAL BIOCHEMISTRY
- Circulating PCSK9 levels correlate with the serum LDL cholesterol level in newborn infants
- (2014) Shunsuke Araki et al. EARLY HUMAN DEVELOPMENT
- LDL Receptor and Pcsk9 Transcripts are Decreased in Liver of Ovariectomized Rats: Effects of Exercise Training
- (2014) E. Ngo Sock et al. HORMONE AND METABOLIC RESEARCH
- Isolation and characterization of the circulating truncated form of PCSK9
- (2014) Bomie Han et al. JOURNAL OF LIPID RESEARCH
- Influence of physiological changes in endogenous estrogen on circulating PCSK9 and LDL cholesterol
- (2014) Moumita Ghosh et al. JOURNAL OF LIPID RESEARCH
- PCSK9 is a critical regulator of the innate immune response and septic shock outcome
- (2014) K. R. Walley et al. Science Translational Medicine
- Variable effects of gender and Western diet on lipid and glucose homeostasis in aged PCSK9-deficient C57BL/6 mice 性别与西方饮食对CSK9基因缺陷的PC57BL/6老龄小鼠的脂质以及葡萄糖内稳态的不同影响
- (2014) Majambu Mbikay et al. Journal of Diabetes
- Regional Distribution and Metabolic Effect of PCSK9 insLEU and R46L Gene Mutations and apoE Genotype
- (2013) Zuhier Awan et al. CANADIAN JOURNAL OF CARDIOLOGY
- Serum Proprotein Convertase Subtilisin/Kexin Type 9 and Cell Surface Low-Density Lipoprotein Receptor
- (2013) Hagai Tavori et al. CIRCULATION
- Proprotein convertase subtilisin/kexin type 9 potentially influences cholesterol uptake in macrophages and reverse cholesterol transport
- (2013) Li Shen et al. FEBS LETTERS
- FoxO3 Transcription Factor and Sirt6 Deacetylase Regulate Low Density Lipoprotein (LDL)-cholesterol Homeostasis via Control of the Proprotein Convertase Subtilisin/Kexin Type 9 (Pcsk9) Gene Expression
- (2013) Rongya Tao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Characterization of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Trafficking Reveals a Novel Lysosomal Targeting Mechanism via Amyloid Precursor-like Protein 2 (APLP2)
- (2013) Rachel M. DeVay et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Plasma PCSK9 concentrations during an oral fat load and after short term high-fat, high-fat high-protein and high-fructose diets
- (2013) Bertrand Cariou et al. Nutrition & Metabolism
- The biology of PCSK9 from the endoplasmic reticulum to lysosomes: new and emerging therapeutics to control low-density lipoprotein cholesterol
- (2013) Gaétan Mayer et al. Drug Design Development and Therapy
- SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion
- (2013) Xiao-Wei Chen et al. eLife
- Identification and characterization of new gain-of-function mutations in the PCSK9 gene responsible for autosomal dominant hypercholesterolemia
- (2012) Marianne Abifadel et al. ATHEROSCLEROSIS
- Delineation of molecular pathways that regulate hepatic PCSK9 and LDL receptor expression during fasting in normolipidemic hamsters
- (2012) Minhao Wu et al. ATHEROSCLEROSIS
- The novel function of HINFP as a co-activator in sterol-regulated transcription ofPCSK9in HepG2 cells
- (2012) Hai Li et al. BIOCHEMICAL JOURNAL
- Furin-cleaved Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Is Active and Modulates Low Density Lipoprotein Receptor and Serum Cholesterol Levels
- (2012) Michael T. Lipari et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Peroxisome Proliferator-activated Receptor γ Activation by Ligands and Dephosphorylation Induces Proprotein Convertase Subtilisin Kexin Type 9 and Low Density Lipoprotein Receptor Expression
- (2012) Yajun Duan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Regulation of hepatic LDL receptors by mTORC1 and PCSK9 in mice
- (2012) Ding Ai et al. JOURNAL OF CLINICAL INVESTIGATION
- Endogenous Estrogens Lower Plasma PCSK9 and LDL Cholesterol But Not Lp(a) or Bile Acid Synthesis in Women
- (2011) Lena Persson et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Plasma proprotein convertase subtilisin kexin type 9 is not altered in subjects with impaired glucose metabolism and type 2 diabetes mellitus, but its relationship with non-HDL cholesterol and apolipoprotein B may be modified by type 2 diabetes mellitus: The CODAM study
- (2011) M.C.G.J. Brouwers et al. ATHEROSCLEROSIS
- Clinical aspects of PCSK9
- (2011) Bertrand Cariou et al. ATHEROSCLEROSIS
- Effect of the Mediterranean diet with and without weight loss on surrogate markers of cholesterol homeostasis in men with the metabolic syndrome
- (2011) Caroline Richard et al. BRITISH JOURNAL OF NUTRITION
- Novel Loss-of-Function PCSK9 Variant Is Associated with Low Plasma LDL Cholesterol in a French-Canadian Family and with Impaired Processing and Secretion in Cell Culture
- (2011) J. Mayne et al. CLINICAL CHEMISTRY
- Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH
- (2011) Paola Lo Surdo et al. EMBO REPORTS
- Sex Differences in Lipid and Lipoprotein Metabolism: It's Not Just about Sex Hormones
- (2011) Xuewen Wang et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Targeted Disruption of the Idol Gene Alters Cellular Regulation of the Low-Density Lipoprotein Receptor by Sterols and Liver X Receptor Agonists
- (2011) E. Scotti et al. MOLECULAR AND CELLULAR BIOLOGY
- Circulating Proprotein Convertase Subtilisin Kexin Type 9 Has a Diurnal Rhythm Synchronous With Cholesterol Synthesis and Is Reduced by Fasting in Humans
- (2010) Lena Persson et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Plasma proprotein convertase subtilisin–kexin type 9 does not change during 24h insulin infusion in healthy subjects and type 2 diabetic patients
- (2010) Paul J.W.H. Kappelle et al. ATHEROSCLEROSIS
- In VivoEvidence That Furin from Hepatocytes Inactivates PCSK9
- (2010) Rachid Essalmani et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Effects of the Prosegment and pH on the Activity of PCSK9
- (2010) Suzanne Benjannet et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Fasting reduces plasma proprotein convertase, subtilisin/kexin type 9 and cholesterol biosynthesis in humans
- (2010) Jeffrey D. Browning et al. JOURNAL OF LIPID RESEARCH
- Strong induction of PCSK9 gene expression through HNF1α and SREBP2: mechanism for the resistance to LDL-cholesterol lowering effect of statins in dyslipidemic hamsters
- (2010) Bin Dong et al. JOURNAL OF LIPID RESEARCH
- PCSK9 is expressed in pancreatic δ-cells and does not alter insulin secretion
- (2009) Cédric Langhi et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Plasma PCSK9 Is Associated with Age, Sex, and Multiple Metabolic Markers in a Population-Based Sample of Children and Adolescents
- (2009) A. Baass et al. CLINICAL CHEMISTRY
- PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities
- (2009) Majambu Mbikay et al. FEBS LETTERS
- Hepatocyte Nuclear Factor 1α Plays a Critical Role inPCSK9Gene Transcription and Regulation by the Natural Hypocholesterolemic Compound Berberine
- (2009) Hai Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Dissection of the Endogenous Cellular Pathways of PCSK9-induced Low Density Lipoprotein Receptor Degradation
- (2009) Steve Poirier et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Genetic and Metabolic Determinants of Plasma PCSK9 Levels
- (2009) Susan G. Lakoski et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Activation of the farnesoid X receptor represses PCSK9 expression in human hepatocytes
- (2008) Cédric Langhi et al. FEBS LETTERS
- Dual Mechanisms for the Fibrate-mediated Repression of Proprotein Convertase Subtilisin/Kexin Type 9
- (2008) Sanae Kourimate et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Plasma PCSK9 preferentially reduces liver LDL receptors in mice
- (2008) Aldo Grefhorst et al. JOURNAL OF LIPID RESEARCH
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