IL-6 accelerates renal fibrosis after acute kidney injury via DNMT1-dependent FOXO3a methylation and activation of Wnt/β-catenin pathway

Depleting microRNA-183-3p improves renal tubulointerstitial fibrosis after acute kidney injury via SIRT1/PUMA/FOXO3a deacetylation

(2021) Hunian Li et al.   LIFE SCIENCES

Endothelial progenitor cells-derived exosomal microRNA-21-5p alleviates sepsis-induced acute kidney injury by inhibiting RUNX1 expression

(2021) Yue Zhang et al.   Cell Death & Disease

Acute kidney injury and maladaptive tubular repair leading to renal fibrosis

(2020) Samuel M.-W. Yu et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Downregulated FOXO3a Associates With Poor Prognosis and Promotes Cell Invasion and Migration via WNT/β-catenin Signaling in Cervical Carcinoma

(2020) Yuejun Tian et al.   Frontiers in Oncology

WNT–β-catenin signalling — a versatile player in kidney injury and repair

(2020) Stefan J. Schunk et al.   Nature Reviews Nephrology

Interleukin 6 trans‐signaling is a critical driver of lung allograft fibrosis

(2020) David S. Wheeler et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Klotho recovery by genistein via promoter histone acetylation and DNA demethylation mitigates renal fibrosis in mice

(2019) Yanning Li et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

FABP4 contributes to renal interstitial fibrosis via mediating inflammation and lipid metabolism

(2019) Yujie Qiao et al.   Cell Death & Disease

Wnt/β‐catenin/RAS signaling mediates age‐related renal fibrosis and is associated with mitochondrial dysfunction

(2019) Jinhua Miao et al.   AGING CELL

Downregulation of FOXO3a by DNMT1 promotes breast cancer stem cell properties and tumorigenesis

(2019) Hao Liu et al.   CELL DEATH AND DIFFERENTIATION

Acute kidney injury

(2019) Claudio Ronco et al.   LANCET

Factors affecting the transition of acute kidney injury to chronic kidney disease: Potential mechanisms and future perspectives

(2019) Jeremiah Ogbadu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mechanisms of Renal Fibrosis

(2018) Benjamin D. Humphreys   Annual Review of Physiology

IL-6 trans-signalling contributes to aldosterone-induced cardiac fibrosis

(2018) Chia-Hung Chou et al.   CARDIOVASCULAR RESEARCH

miR-185 affected the EMT, cell viability and proliferation via DNMT1/MEG3 pathway in TGF-β1-induced renal fibrosis

(2018) Rong Xue et al.   CELL BIOLOGY INTERNATIONAL

Structural Basis of DNMT1 and DNMT3A-Mediated DNA Methylation

(2018) Wendan Ren et al.   Genes

Decreased Tissue COX5B Expression and Mitochondrial Dysfunction during Sepsis-Induced Kidney Injury in Rats

(2017) Jochen Hinkelbein et al.   Oxidative Medicine and Cellular Longevity

FOXO3a modulates WNT/β-catenin signaling and suppresses epithelial-to-mesenchymal transition in prostate cancer cells

(2015) Hao Liu et al.   CELLULAR SIGNALLING

Tempol Attenuates Renal Fibrosis in Mice with Unilateral Ureteral Obstruction: The Role of PI3K-Akt-FoxO3a Signaling

(2014) Hye Eun Yoon et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

IL-6 in Inflammation, Immunity, and Disease

(2014) T. Tanaka et al.   Cold Spring Harbor Perspectives in Biology

4-Chlorobenzoyl berbamine, a novel berbamine derivative, induces apoptosis in multiple myeloma cells through the IL-6 signal transduction pathway and increases FOXO3a-Bim expression

(2013) JIA-KUN SHEN et al.   ONCOLOGY REPORTS

Interleukin 6 Underlies Angiotensin II–Induced Hypertension and Chronic Renal Damage

(2011) Weiru Zhang et al.   HYPERTENSION