Androgen receptor-mediated CD8+ T cell stemness programs drive sex differences in antitumor immunity

Androgen receptor activity in T cells limits checkpoint blockade efficacy

(2022) Xiangnan Guan et al.   NATURE

Androgen conspires with the CD8 + T cell exhaustion program and contributes to sex bias in cancer

(2022) Hyunwoo Kwon et al.   Science Immunology

Inhibitory signaling sustains a distinct early memory CD8+ T cell precursor that is resistant to DNA damage

(2021) Jonathan B. Johnnidis et al.   Science Immunology

BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8+ T cells

(2021) Chen Yao et al.   NATURE IMMUNOLOGY

A cross-talk between CAR T cell subsets and the tumor microenvironment is essential for sustained cytotoxic activity

(2021) Morgane Boulch et al.   Science Immunology

Interpretation of T cell states from single-cell transcriptomics data using reference atlases

(2021) Massimo Andreatta et al.   Nature Communications

Sex-specific adipose tissue imprinting of regulatory T cells

(2020) Ajithkumar Vasanthakumar et al.   NATURE

Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer

(2020) Hae-Ock Lee et al.   NATURE GENETICS

Myeloid-derived suppressor cell subsets drive glioblastoma growth in a sex-specific manner

(2020) Defne Bayik et al.   Cancer Discovery

cGAS-STING–mediated DNA sensing maintains CD8+ T cell stemness and promotes antitumor T cell therapy

(2020) Wenwen Li et al.   Science Translational Medicine

Implications of Sex Differences in Immunity for SARS-CoV-2 Pathogenesis and Design of Therapeutic Interventions

(2020) Madeleine J. Bunders et al.   IMMUNITY

Endogenous Glucocorticoid Signaling Regulates CD8+ T Cell Differentiation and Development of Dysfunction in the Tumor Microenvironment

(2020) Nandini Acharya et al.   IMMUNITY

Sex differences in immune responses that underlie COVID-19 disease outcomes

(2020) Takehiro Takahashi et al.   NATURE

Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans

(2020) Giovanni Galletti et al.   NATURE IMMUNOLOGY

MEK inhibition reprograms CD8+ T lymphocytes into memory stem cells with potent antitumor effects

(2020) Vivek Verma et al.   NATURE IMMUNOLOGY

Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer

(2020) Sri Krishna et al.   SCIENCE

Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy

(2019) Imran Siddiqui et al.   IMMUNITY

Sex differences in GBM revealed by analysis of patient imaging, transcriptome, and survival data

(2019) Wei Yang et al.   Science Translational Medicine

T cell stemness and dysfunction in tumors are triggered by a common mechanism

(2019) Suman Kumar Vodnala et al.   SCIENCE

The transcription factor c-Myb regulates CD8+ T cell stemness and antitumor immunity

(2019) Sanjivan Gautam et al.   NATURE IMMUNOLOGY

Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

(2019) Brian C. Miller et al.   NATURE IMMUNOLOGY

c-Jun overexpression in CAR T cells induces exhaustion resistance

(2019) Rachel C. Lynn et al.   NATURE

A GPR174–CCL21 module imparts sexual dimorphism to humoral immunity

(2019) Ruozhu Zhao et al.   NATURE

esATAC: an easy-to-use systematic pipeline for ATAC-seq data analysis

(2018) Zheng Wei et al.   BIOINFORMATICS

A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

(2018) Livnat Jerby-Arnon et al.   CELL

Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

(2018) Moshe Sade-Feldman et al.   CELL

Androgen receptor functions as transcriptional repressor of cancer-associated fibroblast activation

(2018) Andrea Clocchiatti et al.   JOURNAL OF CLINICAL INVESTIGATION

T Cell Factor 1-Expressing Memory-like CD8 + T Cells Sustain the Immune Response to Chronic Viral Infections

(2016) Daniel T. Utzschneider et al.   IMMUNITY

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

(2016) I. Tirosh et al.   SCIENCE

Glucocorticoid Receptor Confers Resistance to Antiandrogens by Bypassing Androgen Receptor Blockade

(2013) Vivek K. Arora et al.   CELL

A Hormone-DNA Repair Circuit Governs the Response to Genotoxic Insult

(2013) J. F. Goodwin et al.   Cancer Discovery

Androgen Receptor Signaling Regulates DNA Repair in Prostate Cancers

(2013) W. R. Polkinghorn et al.   Cancer Discovery

Sex differences in resident immune cell phenotype underlie more efficient acute inflammatory responses in female mice

(2011) R. S. Scotland et al.   BLOOD

A human memory T cell subset with stem cell–like properties

(2011) Luca Gattinoni et al.   NATURE MEDICINE

Anti-androgens and androgen-depleting therapies in prostate cancer: new agents for an established target

(2009) Yu Chen et al.   LANCET ONCOLOGY

Sex differences in the Toll-like receptor–mediated response of plasmacytoid dendritic cells to HIV-1

(2009) Angela Meier et al.   NATURE MEDICINE

Phenotype and function of human T lymphocyte subsets: Consensus and issues

(2008) Victor Appay et al.   CYTOMETRY PART A

Batf3 Deficiency Reveals a Critical Role for CD8 + Dendritic Cells in Cytotoxic T Cell Immunity

(2008) K. Hildner et al.   SCIENCE