期刊
FOOD RESEARCH INTERNATIONAL
卷 157, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.foodres.2022.111281
关键词
Salmo salar skin; Collagen hydrolysate; Anti-atherosclerosis; ApoE(-/-)mice; Anti-inflammatory peptides; Anti-platelet peptides; Joint effect
资金
- National Key Research and Development Program of China [2018YFD0901102]
- China Agriculture Research System of MOF and MARA [CARS-45]
This study found that collagen hydrolysate from salmon skin has anti-inflammatory and anti-platelet aggregation activities, and can attenuate the development of atherosclerosis. Two multifunctional peptides identified from the hydrolysate could be potential drugs or dietary supplements for the prevention of AS.
Atherosclerosis (AS) is the underlying condition in most cardiovascular diseases, which is blood vessel inflammation participated by many factors. Collagen hydrolysate from salmo salar skin (SCH) obtained in this study showed strong anti-inflammatory activity, protection of endothelial cell injury, antioxidant activity, and anti platelet aggregation activity in vitro, exhibiting a great potential of attenuating AS. In this study, multifunctional peptides FAGPPGGDGQPGAK and IAGPAGPRGPSGPA, which mainly showed strong anti-inflammatory activity, were identified from SCH after separation of ultrafiltration and column chromatography. Moreover, SCH (contained anti-platelet peptides and anti-inflammatory peptides) was observed to inhibit arterial intima thickening and plaques formation in apolipoprotein E-deficient (ApoE(-/-)) mice fed with high-fat diets without side effects, exhibiting a comparable effect with aspirin. SCH showed combined effect on regulating serum biomarkers of inflammation (IL-6 and TNF-alpha), endothelial injury (MCP-1), platelet activation (TXB2 and PF4) and oxidative stress (MDA and CAT). This research suggested SCH as a potential dietary supplement for the primary prevention of AS.
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