Review
Geriatrics & Gerontology
Charles Phillipe de Lucena Alves, Samuel Brito de Almeida, Danielle Pessoa Lima, Pedro Braga Neto, Ana Lucia Miranda, Todd Manini, Lara Vlietstra, Debra L. Waters, Renata Moraes Bielemann, Rosaly Correa-de-Araujo, Ana Paula Fayh, Eduardo Caldas Costa
Summary: This scoping review aimed to map out definitions and assessment methods of muscle quality in older adults. A total of 96 articles were included, revealing a substantial heterogeneity of definitions and assessment methods across functional and morphological domains. Standardizing the definition of muscle quality may help utilize it as a potential marker of skeletal muscle health in older adults.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2023)
Article
Multidisciplinary Sciences
Young-Ah Choi, Jung Soo Lee, Yeo Hyung Kim
Summary: We investigated the association between physical activity level and dynapenia in older adults with COPD and found that higher physical activity levels were associated with lower odds of dynapenia. This association was observed only in male patients and individuals with normal weight.
SCIENTIFIC REPORTS
(2022)
Article
Nutrition & Dietetics
Hyeonmok Kim, Sun Hee Beom, Tae Ho Kim, Beom-Jun Kim
Summary: This study explored the relationship between water intake and hand grip strength in older adults, finding that the correlation between water intake and hand grip strength may not be significant, potentially influenced by other factors such as age, body size, and resistance exercise.
Article
Endocrinology & Metabolism
Agnieszka Guligowska, Zuzanna Chrzastek, Marek Pawlikowski, Malgorzata Piglowska, Hanna Pisarek, Katarzyna Winczyk, Tomasz Kostka
Summary: Researchers found that hormone levels in older adults are closely related to sarcopenia indicators, especially gonadotropins, sex hormones, and DHEAS. These findings may potentially alter prevention and treatment strategies for sarcopenia.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Geriatrics & Gerontology
Je Hyun Seo, Young Lee
Summary: This study found that moderate to vigorous physical activity (PA) is associated with higher skeletal muscle mass and muscle strength in older adults. Specifically, engaging in high-intensity PA is positively correlated with the prevention of sarcopenia.
Article
Geriatrics & Gerontology
Tao -Chun Peng, Jeng-Min Chiou, Ta-Fu Chen, Yen-Ching Chen, Jen-Hau Chen
Summary: This study examined the associations of sarcopenia and its components with specific domains of cognitive impairment. The results showed that severe sarcopenia was associated with cognitive impairment in older adults, while low grip strength was associated with cognitive impairment in men but not in women.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2023)
Article
Geriatrics & Gerontology
Jessica Chan, Yi-Chien Lu, Melissa Min-Szu Yao, Russell Oliver Kosik
Summary: There is a correlation between hand grip strength (HGS) and muscle mass, and both decline with advancing age in both sexes, albeit with a stronger correlation in men.
Article
Immunology
Tung-Wei Kao, Tao-Chun Peng, Wei-Liang Chen, Yu-Chiao Chi, Chi-Ling Chen, Wei-Shiung Yang
Summary: The study found a positive association between serum leptin levels and the risk of dynapenia, while a negative association was observed with the risk of sarcopenia in both male and female elderly individuals. Further investigation is needed to understand the biological mechanisms underlying these associations.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Nutrition & Dietetics
Mirta Crovetto Mattassi, Camila Henriquez Mella, Lissette Perez Bocaz
Summary: This study investigated sarcopenia and nutritional status in Chilean older adults aged 65 and older. The results showed that nearly 50% of the participants had probable sarcopenia, with obese individuals having a higher risk. There is an association between nutritional status and sarcopenia.
Article
Multidisciplinary Sciences
Melissa J. Benton, Jefferson M. Spicher, Amy L. Silva-Smith
Summary: Among older adults, handgrip strength is commonly used as an indicator of frailty and sarcopenia. However, this study found that there is poor agreement between the two most frequently used handgrip dynamometers, indicating a lack of validity. Standardization and device-specific cutoff points are needed for accurate diagnosis.
Article
Nutrition & Dietetics
Masafumi Nozoe, Hiroki Kubo, Masashi Kanai, Miho Yamamoto, Shinichi Shimada, Kyoshi Mase
Summary: This study investigated the relationships between pre-stroke sarcopenia risk and comorbidities with lower extremity muscle strength in older patients with acute stroke. It found that pre-stroke sarcopenia and diabetes mellitus were negatively associated with lower extremity muscle strength, providing useful information for clinicians.
Article
Nutrition & Dietetics
Pablo Jorge Marcos-Pardo, Noelia Gonzalez-Galvez, Abraham Lopez-Vivancos, Alejandro Espeso-Garcia, Luis Manuel Martinez-Aranda, Gemma Maria Gea-Garcia, Francisco Javier Orquin-Castrillon, Ana Carbonell-Baeza, Jose Daniel Jimenez-Garcia, Daniel Velazquez-Diaz, Cristina Cadenas-Sanchez, Emanuele Isidori, Chiara Fossati, Fabio Pigozzi, Lorenzo Rum, Catherine Norton, Audrey Tierney, Ilvis Abelkalns, Agita Klempere-Sipjagina, Juris Porozovs, Heikki Hannola, Niko Niemisalo, Leo Hokka, David Jimenez-Pavon, Raquel Vaquero-Cristobal
Summary: The study determined the prevalence of sarcopenia among European middle-aged and older adults, finding that factors such as being male, age under 65, lower BMI, high levels of vigorous physical activity, and dietary habits could affect the risk of developing sarcopenia.
Review
Nutrition & Dietetics
Anna Izzo, Elena Massimino, Gabriele Riccardi, Giuseppe Della Pepa
Summary: Type 2 diabetes mellitus is a major health burden for the elderly, affecting approximately 25% of those over 65 years old. Sarcopenia, characterized by loss of skeletal muscle mass and function, has been identified as a new complication in elderly individuals with T2DM. It is important for researchers and clinicians to understand the risk factors and associations of sarcopenia in T2DM patients in order to provide appropriate therapeutic interventions.
Article
Geriatrics & Gerontology
Bo Kyung Koo, Seoil Moon, Min Kyong Moon
Summary: In older patients with long-standing T2DM, low handgrip strength and insulin resistance were identified as independent risk factors for aggravated glycemic control. These findings emphasize the importance of muscle strength and insulin sensitivity in managing diabetes in older adults.
Article
Geriatrics & Gerontology
Sebastiaan Dalle, Jolan Dupont, Lenore Dedeyne, Sabine Verschueren, Jos Tournoy, Evelien Gielen, Katrien Koppo
Summary: This study compared the protein expression profiles between older adults with preserved and low muscle strength, and found differences in catabolic, mitochondrial, stress-related, and myogenic pathways. The increased stress factors in the low muscle strength group may reflect the deterioration of tissue homeostasis, while the upregulation of myogenic markers in this group may be an attempt to compensate for the gradual loss in muscle quantity and quality.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Endocrinology & Metabolism
Mehmet Selman Ontan, Ozge Dokuzlar, Esra Ates Bulut, Pinar Soysal, Ahmet Turan Isik
Summary: This study revealed that probable sarcopenia and severe sarcopenia are associated with osteoporosis in older adults. Furthermore, low muscle strength, or dynapenia, is related to femoral neck osteopenia and osteoporosis.
JOURNAL OF BONE AND MINERAL METABOLISM
(2021)
Article
Geriatrics & Gerontology
Eral Idil, Ali Ekrem Aydin, Esra Ates Bulut, Ahmet Turan Isik
Summary: This study aimed to investigate the impact of drug rationalization on comprehensive geriatric assessment parameters. The results showed that medication optimization improved depression, mobility, and nutritional status, while maintaining cognitive function, activities of daily living, and gait speed. Increasing the number of drugs was associated with lower mobility and functionality.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2021)
Article
Clinical Neurology
Ahmet Turan Isik, Neziha Erken, Idil Yavuz, Derya Kaya, Mehmet Selman Ontan, Esra Ates Bulut, Fatma Sena Dost
Summary: The meta-analysis reveals a higher prevalence of orthostatic hypotension in Alzheimer's disease patients, with a risk approximately 2.5 times higher compared to healthy controls. Therefore, evaluating postural blood pressure changes should be a crucial follow-up and treatment goal for individuals with AD.
NEUROLOGICAL SCIENCES
(2022)
Article
Geriatrics & Gerontology
Esra Ates Bulut, Ahmet Turan Isik
Summary: Despite evidence showing older adults are vulnerable to drug misuse and abuse, there is insufficient information on screening, evaluation, diagnosis, and treatment. It is important to increase awareness among healthcare professionals caring for older patients about drug misuse and abuse.
CLINICS IN GERIATRIC MEDICINE
(2022)
Article
Clinical Neurology
Fatma Sena Dost, Derya Kaya, Mehmet Selman Ontan, Neziha Erken, Esra Ates Bulut, Ali Ekrem Aydin, Ahmet Turan Isik
Summary: This study found that Theracurmin may be a therapeutic option for elderly patients with Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI), providing stabilization of the disease course by preventing progressive loss in cognitive functions and activities of daily living (ADLs).
CURRENT ALZHEIMER RESEARCH
(2021)
Article
Nutrition & Dietetics
Esra Ates Bulut, Neziha Erken, Derya Kaya, Fatma Sena Dost, Ahmet Turan Isik
Summary: Anticholinergic drugs have negative effects on the nutrition of older adults, but this impact has not been extensively studied in the literature.
FRONTIERS IN NUTRITION
(2022)
Article
Geriatrics & Gerontology
Fatma Sena Dost, Esra Ates Bulut, Ozge Dokuzlar, Derya Kaya, Feyza Mutlay, Besra Hazal Yesil Gurel, Ahmet Turan Isik
Summary: This study aimed to investigate the relationship between sarcopenia and dementia with Lewy body (DLB) in older adults. The results showed that sarcopenia is common in patients with DLB and Alzheimer's disease (AD), and is closely related to low muscle strength and slow gait speed in DLB patients.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Neziha Erken, Fatma Sena Dost, Esra Ates Bulut, Ahmet Turan Isik
Summary: This study aimed to demonstrate the validity of plantar flexion strength (PFS) in diagnosing probable sarcopenia and investigating its relationship with comprehensive geriatric assessment (CGA), while determining appropriate cutoff values for PFS. Associations between probable sarcopenia identified by PFS and CGA parameters were found, showing its potential usefulness in evaluating sarcopenia in older adults.
POSTGRADUATE MEDICINE
(2022)
Article
Geriatrics & Gerontology
Neziha Erken, Derya Kaya, Fatma Sena Dost, Esra Ates Bulut, Ahmet Turan Isik
Summary: The widespread use of antidepressants in older adults increases the clinical concern for serotonin syndrome, and physicians should be aware of this drug-related complication in older patients.
Article
Geriatrics & Gerontology
Kubra Canaslan, Esra Ates Bulut, Suleyman Emre Kocyigit, Ali Ekrem Aydin, Ahmet Turan Isik
Summary: This study evaluated the relationship between comorbidity indices and common geriatric syndromes and found that none of the indices is sufficient to use alone in geriatric practice. New indices should be developed considering the complexity of geriatric cases and the limitations of existing indices.
Article
Psychiatry
Kubra Altunkalem Seydi, Esra Ates Bulut, Idil Yavuz, Hemrin Kavak, Derya Kaya, Ahmet Turan Isik
Summary: This study aimed to demonstrate the feasibility and effectiveness of telemedicine in delivering healthcare services to elderly patients during the pandemic. Results showed that most emails were sent by proxies, with patients facing challenges mostly related to cognitive diseases. Telemedicine can effectively address issues in geriatric practice, preventing infections and unnecessary hospitalizations.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Geriatrics & Gerontology
Esra Ates Bulut, Suade Ozlem Badak, Huseyin Aksoy, Ayse Fadiloglu, Ahmet Turan Isik
Summary: This study investigated the knowledge and attitudes of physicians in Turkey towards vaccination schemes for older adults. The results showed that there is a need to improve the awareness of healthcare professionals regarding routine vaccination schedules. Furthermore, the recommendation rates for certain vaccines decreased after the COVID-19 pandemic.
CLINICAL INTERVENTIONS IN AGING
(2022)
Article
Clinical Neurology
Derya Kaya, Besra Hazal Yesil Gurel, Burcu Akpinar Soylemez, Fatma Sena Dost, Ozge Dokuzlar, Feyza Mutlay, Esra Ates Bulut, Kadriye Petek, Angel Bernardo Golimstok, Ahmet Turan Isik
Summary: The Turkish version of the ALBA screening instrument (ASI-T) has been proven to be a reliable and effective tool for screening Lewy body dementia (LBD). It has the ability to distinguish LBD patients from controls or those with Alzheimer's Disease (AD).
APPLIED NEUROPSYCHOLOGY-ADULT
(2022)
Article
Geriatrics & Gerontology
Ahmet Turan Isik, Suleyman Emre Kocyigit, Derya Kaya, Fatma Sena Dost Gunay, Neziha Erken, Ozge Dokuzlar, Ali Ekrem Aydin, Esra Ates Bulut
Summary: The study reveals that elderly patients with DLB, AD, and VaD often experience OH, with diastolic OH potentially playing a role in the development of VaD. Therefore, it is crucial to consider potential complications of OH and evaluate it in the follow-up and management of these patients.
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
(2021)