Akinesia and freezing caused by Na+leak-current channel (NALCN) deficiency corrected by pharmacological inhibition of K+channels and gap junctions

De Novo Mutations in NALCN Cause a Syndrome Characterized by Congenital Contractures of the Limbs and Face, Hypotonia, and Developmental Delay

(2015) Jessica X. Chong et al.   AMERICAN JOURNAL OF HUMAN GENETICS

UNC80mutation causes a syndrome of hypotonia, severe intellectual disability, dyskinesia and dysmorphism, similar to that caused by mutations in its interacting cation channelNALCN

(2015) Yonatan Perez et al.   JOURNAL OF MEDICAL GENETICS

The NCA sodium leak channel is required for persistent motor circuit activity that sustains locomotion

(2015) Shangbang Gao et al.   Nature Communications

Development of dalfampridine, a novel pharmacologic approach for treating walking impairment in multiple sclerosis

(2014) Andrew R. Blight et al.   Annals of the New York Academy of Sciences

Identification of novel small molecule modulators of K2P18.1 two-pore potassium channel

(2014) J. Kyle Bruner et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Food deprivation and nicotine correct akinesia and freezing in Na+-leak current channel (NALCN)-deficient strains ofCaenorhabditis elegans

(2014) K. Bonnett et al.   GENES BRAIN AND BEHAVIOR

The sodium leak channel, NALCN, in health and disease

(2014) Maud Cochet-Bissuel et al.   Frontiers in Cellular Neuroscience

Drug elucidation: invertebrate genetics sheds new light on the molecular targets of CNS drugs

(2014) Donard S. Dwyer et al.   Frontiers in Pharmacology

4-Aminopyridine improves freezing of gait in Parkinson’s disease

(2013) Corneliu C. Luca et al.   JOURNAL OF NEUROLOGY

Insulin/IGF-1 Signaling, including Class II/III PI3Ks, β-Arrestin and SGK-1, Is Required in C. elegans to Maintain Pharyngeal Muscle Performance during Starvation

(2013) Donard S. Dwyer et al.   PLoS One

New calcium channel agonists as potential therapeutics in Lambert-Eaton myasthenic syndrome and other neuromuscular diseases

(2012) Tyler B. Tarr et al.   Annals of the New York Academy of Sciences

Mitochondrial ATP-sensitive potassium channel activity and hypoxic preconditioning are independent of an inwardly rectifying potassium channel subunit inCaenorhabditis elegans

(2012) Andrew P. Wojtovich et al.   FEBS LETTERS

Sodium Leak Channels in Neuronal Excitability and Rhythmic Behaviors

(2011) Dejian Ren   NEURON

A Co-operative Regulation of Neuronal Excitability by UNC-7 Innexin and NCA/NALCN Leak Channel

(2011) Magali Bouhours et al.   Molecular Brain

A novel Caenorhabditis elegans allele, smn-1(cb131), mimicking a mild form of spinal muscular atrophy, provides a convenient drug screening platform highlighting new and pre-approved compounds

(2010) J. N. Sleigh et al.   HUMAN MOLECULAR GENETICS

Extracellular Calcium Controls Background Current and Neuronal Excitability via an UNC79-UNC80-NALCN Cation Channel Complex

(2010) Boxun Lu et al.   NEURON

A Putative Cation Channel, NCA-1, and a Novel Protein, UNC-80, Transmit Neuronal Activity in C. elegans

(2008) Edward Yeh et al.   PLOS BIOLOGY