Identification of novel and potent PROTACs targeting FAK for non-small cell lung cancer: Design, synthesis, and biological study

PROTAC targeted protein degraders: the past is prologue

(2022) Miklós Békés et al.   NATURE REVIEWS DRUG DISCOVERY

The state of the art of PROTAC technologies for drug discovery

(2022) Chao Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Frontiers in PROTACs

(2021) Gregory R. Hughes et al.   DRUG DISCOVERY TODAY

Discovery and Characterisation of Highly Cooperative FAK‐Degrading PROTACs

(2021) Robert P. Law et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery of novel BTK PROTACs for B-Cell lymphomas

(2021) Yunpeng Zhao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Developments of CRBN-based PROTACs as potential therapeutic agents

(2021) Chao Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

FAK-targeting PROTAC demonstrates enhanced antitumor activity against KRAS mutant non-small cell lung cancer

(2021) Jinyuan Liu et al.   EXPERIMENTAL CELL RESEARCH

FAK Regulates VEGFR2 Expression and Promotes Angiogenesis in Triple-Negative Breast Cancer

(2021) Jun-Ping Shiau et al.   Biomedicines

Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery

(2020) George M. Burslem et al.   CELL

FAK-targeted and combination therapies for the treatment of cancer: an overview of phase I and II clinical trials

(2020) Atish Mohanty et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

FAK-targeting PROTAC as a chemical tool for the investigation of non-enzymatic FAK function in mice

(2020) Hongying Gao et al.   Protein & Cell

PROTAC: A promising technology for cancer treatment

(2020) Xin Zhou et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A multi-kinase inhibitor APG-2449 enhances the antitumor effect of ibrutinib in esophageal squamous cell carcinoma via EGFR/FAK pathway inhibition

(2020) Qiu-Yun Luo et al.   BIOCHEMICAL PHARMACOLOGY

Focal adhesion kinase: Insight into its roles and therapeutic potential in oesophageal cancer

(2020) Yumeng Zhang et al.   CANCER LETTERS

Proteolysis targeting chimera (PROTAC) in drug discovery paradigm: Recent progress and future challenges

(2020) Shenxin Zeng et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The PROTAC technology in drug development

(2019) Yutian Zou et al.   CELL BIOCHEMISTRY AND FUNCTION

Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions

(2019) Johannes Popow et al.   JOURNAL OF MEDICINAL CHEMISTRY

Neoadjuvant Chemotherapy with Gemcitabine Plus Nab-Paclitaxel for Borderline Resectable Pancreatic Cancer Potentially Improves Survival and Facilitates Surgery

(2019) Yoshihiro Miyasaka et al.   ANNALS OF SURGICAL ONCOLOGY

A phase Ib dose-finding, pharmacokinetic study of the focal adhesion kinase inhibitor GSK2256098 and trametinib in patients with advanced solid tumours

(2019) Gabriel Mak et al.   BRITISH JOURNAL OF CANCER

The roles of nuclear focal adhesion kinase (FAK) on Cancer: a focused review

(2019) Jin Zhou et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Lenalidomide maintenance for diffuse large B‐cell lymphoma patients responding to R‐CHOP: quality of life, dosing, and safety results from the randomised controlled REMARC study

(2019) Catherine Thieblemont et al.   BRITISH JOURNAL OF HAEMATOLOGY

Design, Synthesis, and Evaluation of Highly Potent FAK-Targeting PROTACs

(2019) Hongying Gao et al.   ACS Medicinal Chemistry Letters

Design, synthesis, biological evaluation and molecular docking study of novel thieno[3,2-d]pyrimidine derivatives as potent FAK inhibitors

(2019) Ruifeng Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The FAK inhibitor BI 853520 inhibits spheroid formation and orthotopic tumor growth in malignant pleural mesothelioma

(2018) Viktoria Laszlo et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Addressing Kinase-Independent Functions of Fak via PROTAC-Mediated Degradation

(2018) Philipp M. Cromm et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Somatic Mutations and Splicing Variants of Focal Adhesion Kinase in Non–Small Cell Lung Cancer

(2017) Bo Zhou et al.   JNCI-Journal of the National Cancer Institute

Somatic Mutations and Splicing Variants of Focal Adhesion Kinase in Non–Small Cell Lung Cancer

(2017) Bo Zhou et al.   JNCI-Journal of the National Cancer Institute

Safety and efficacy of pomalidomide plus low-dose dexamethasone in STRATUS (MM-010): a phase 3b study in refractory multiple myeloma

(2016) M. A. Dimopoulos et al.   BLOOD

Molecular Pathways: Endothelial Cell FAK--A Target for Cancer Treatment

(2016) M. Roy-Luzarraga et al.   CLINICAL CANCER RESEARCH

CT-707, a Novel FAK Inhibitor, Synergizes with Cabozantinib to Suppress Hepatocellular Carcinoma by Blocking Cabozantinib-Induced FAK Activation

(2016) Dan-Dan Wang et al.   MOLECULAR CANCER THERAPEUTICS

A small molecule FAK kinase inhibitor, GSK2256098, inhibits growth and survival of pancreatic ductal adenocarcinoma cells

(2014) Jianliang Zhang et al.   CELL CYCLE

Role of Focal Adhesion Kinase in Regulating YB–1–Mediated Paclitaxel Resistance in Ovarian Cancer

(2013) Yu Kang et al.   JNCI-Journal of the National Cancer Institute

Anti-tumor effect of a novel FAK inhibitor TAE226 against human oral squamous cell carcinoma

(2012) Naito Kurio et al.   ORAL ONCOLOGY

Anti-tumor effect in human breast cancer by TAE226, a dual inhibitor for FAK and IGF-IR in vitro and in vivo

(2011) Naito Kurio et al.   EXPERIMENTAL CELL RESEARCH

PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments

(2010) Isabelle Tanjoni et al.   CANCER BIOLOGY & THERAPY

The FERM domain: organizing the structure and function of FAK

(2010) Margaret C. Frame et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY