Structural advances in transcription elongation

Spt5 histone binding activity preserves chromatin during transcription by RNA polymerase II

(2022) Cecile Evrin et al.   EMBO JOURNAL

Assembly of RNA polymerase II transcription initiation complexes

(2022) Lucas Farnung et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Dynamic control of chromatin-associated m6A methylation regulates nascent RNA synthesis

(2022) Wenqi Xu et al.   MOLECULAR CELL

Structure of a transcribing RNA polymerase II–U1 snRNP complex

(2021) Suyang Zhang et al.   SCIENCE

Coupled Transcription-Translation in Prokaryotes: An Old Couple With New Surprises

(2021) Mikel Irastortza-Olaziregi et al.   Frontiers in Microbiology

NusG, an Ancient Yet Rapidly Evolving Transcription Factor

(2021) Bing Wang et al.   Frontiers in Microbiology

Structure of the catalytic core of the Integrator complex

(2021) Moritz M. Pfleiderer et al.   MOLECULAR CELL

The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer

(2021) Stephin J. Vervoort et al.   CELL

Structural basis of nucleosome transcription mediated by Chd1 and FACT

(2021) Lucas Farnung et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structures of the human Mediator and Mediator-bound preinitiation complex

(2021) Xizi Chen et al.   SCIENCE

Allosteric transcription stimulation by RNA polymerase II super elongation complex

(2021) Ying Chen et al.   MOLECULAR CELL

SPT5 stabilizes RNA polymerase II, orchestrates transcription cycles, and maintains the enhancer landscape

(2021) Shibin Hu et al.   MOLECULAR CELL

Structural basis of human transcription–DNA repair coupling

(2021) Goran Kokic et al.   NATURE

Structural basis of Integrator-mediated transcription regulation

(2021) Isaac Fianu et al.   SCIENCE

Integrator enforces the fidelity of transcriptional termination at protein-coding genes

(2021) Lucas Ferreira Dasilva et al.   Science Advances

Stepwise Promoter Melting by Bacterial RNA Polymerase

(2020) James Chen et al.   MOLECULAR CELL

Structure of complete Pol II–DSIF–PAF–SPT6 transcription complex reveals RTF1 allosteric activation

(2020) Seychelle M. Vos et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

In-cell architecture of an actively transcribing-translating expressome

(2020) Francis J. O’Reilly et al.   SCIENCE

Functionally uncoupled transcription–translation in Bacillus subtilis

(2020) Grace E. Johnson et al.   NATURE

Structural basis of transcription-translation coupling

(2020) Chengyuan Wang et al.   SCIENCE

Structural basis of transcription-translation coupling and collision in bacteria

(2020) Michael William Webster et al.   SCIENCE

Distinct Cdk9-phosphatase switches act at the beginning and end of elongation by RNA polymerase II

(2020) Pabitra K. Parua et al.   Nature Communications

Pre-termination Transcription Complex: Structure and Function

(2020) Zhitai Hao et al.   MOLECULAR CELL

Steps toward translocation-independent RNA polymerase inactivation by terminator ATPase ρ

(2020) Nelly Said et al.   SCIENCE

Structural insight into nucleosome transcription by RNA polymerase II with elongation factors

(2019) Haruhiko Ehara et al.   SCIENCE

Structural Basis for the Action of an All-Purpose Transcription Anti-termination Factor

(2019) Ferdinand Krupp et al.   MOLECULAR CELL

Promoter-proximal pausing of RNA polymerase II: a nexus of gene regulation

(2019) Leighton Core et al.   GENES & DEVELOPMENT

Selective kinase inhibition shows that Bur1 (Cdk9) phosphorylates the Rpb1 linker in vivo

(2019) Yujin Chun et al.   MOLECULAR AND CELLULAR BIOLOGY

Structural Basis of Transcription: RNA Polymerase Backtracking and Its Reactivation

(2019) Mo’men Abdelkareem et al.   MOLECULAR CELL

Mechanisms of Transcriptional Pausing in Bacteria

(2019) Jin Young Kang et al.   JOURNAL OF MOLECULAR BIOLOGY

Regulation of Bacterial Gene Expression by Transcription Attenuation

(2019) Charles L. Turnbough   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Structural visualization of key steps in nucleosome reorganization by human FACT

(2019) Kouta Mayanagi et al.   Scientific Reports

The nucleosome core particle remembers its position through DNA replication and RNA transcription

(2019) Gavin Schlissel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis of Q-dependent antitermination

(2019) Zhou Yin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FACT caught in the act of manipulating the nucleosome

(2019) Yang Liu et al.   NATURE

Structural Basis for Transcript Elongation Control by NusG Family Universal Regulators

(2018) Jin Young Kang et al.   CELL

RNA Polymerase Accommodates a Pause RNA Hairpin by Global Conformational Rearrangements that Prolong Pausing

(2018) Jin Young Kang et al.   MOLECULAR CELL

Structural Basis for NusA Stabilized Transcriptional Pausing

(2018) Xieyang Guo et al.   MOLECULAR CELL

Integrator subunit 4 is a ‘Symplekin-like’ scaffold that associates with INTS9/11 to form the Integrator cleavage module

(2018) Todd R Albrecht et al.   NUCLEIC ACIDS RESEARCH

Structure of a human catalytic step I spliceosome

(2018) Xiechao Zhan et al.   SCIENCE

Prespliceosome structure provides insights into spliceosome assembly and regulation

(2018) Clemens Plaschka et al.   NATURE

Structure of paused transcription complex Pol II–DSIF–NELF

(2018) Seychelle M. Vos et al.   NATURE

Structure of activated transcription complex Pol II–DSIF–PAF–SPT6

(2018) Seychelle M. Vos et al.   NATURE

CTD-dependent and -independent mechanisms govern co-transcriptional capping of Pol II transcripts

(2018) Melvin Noe Gonzalez et al.   Nature Communications

mRNA cap regulation in mammalian cell function and fate

(2018) Alison Galloway et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Structural basis of the nucleosome transition during RNA polymerase II passage

(2018) Tomoya Kujirai et al.   SCIENCE

Structure of transcribing RNA polymerase II-nucleosome complex

(2018) Lucas Farnung et al.   Nature Communications

Structural basis for the initiation of eukaryotic transcription-coupled DNA repair

(2017) Jun Xu et al.   NATURE

Cryo-EM structure of a human spliceosome activated for step 2 of splicing

(2017) Karl Bertram et al.   NATURE

Structure of a transcribing RNA polymerase II–DSIF complex reveals a multidentate DNA–RNA clamp

(2017) Carrie Bernecky et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Transcription–translation coupling: direct interactions of RNA polymerase with ribosomes and ribosomal subunits

(2017) Haitian Fan et al.   NUCLEIC ACIDS RESEARCH

Structure of the complete elongation complex of RNA polymerase II with basal factors

(2017) Haruhiko Ehara et al.   SCIENCE

Architecture of a transcribing-translating expressome

(2017) R. Kohler et al.   SCIENCE

Structure of a transcribing RNA polymerase II–DSIF complex reveals a multidentate DNA–RNA clamp

(2017) Carrie Bernecky et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A novel SH2 recognition mechanism recruits Spt6 to the doubly phosphorylated RNA polymerase II linker at sites of transcription

(2017) Matthew A Sdano et al.   eLife

CDK9-dependent RNA polymerase II pausing controls transcription initiation

(2017) Saskia Gressel et al.   eLife

P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates

(2016) Miriam Sansó et al.   GENES & DEVELOPMENT

Bacterial RNA polymerase can retain σ70throughout transcription

(2016) Timothy T. Harden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional termination in mammals: Stopping the RNA polymerase II juggernaut

(2016) N. J. Proudfoot   SCIENCE

TT-seq maps the human transient transcriptome

(2016) Björn Schwalb et al.   SCIENCE

Insights into HIV-1 proviral transcription from integrative structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex

(2016) Ursula Schulze-Gahmen et al.   eLife

Molecular Basis of Transcription-Coupled Pre-mRNA Capping

(2015) Fuensanta W. Martinez-Rucobo et al.   MOLECULAR CELL

Getting up to speed with transcription elongation by RNA polymerase II

(2015) Iris Jonkers et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanism of RNA polymerase II bypass of oxidative cyclopurine DNA lesions

(2015) Celine Walmacq et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcription factors TFIIF and TFIIS promote transcript elongation by RNA polymerase II by synergistic and independent mechanisms

(2014) V. Schweikhard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fission yeast RNA triphosphatase reads an Spt5 CTD code

(2014) Selom K. Doamekpor et al.   RNA

Integrator complex regulates NELF-mediated RNA polymerase II pause/release and processivity at coding genes

(2014) Bernd Stadelmayer et al.   Nature Communications

DSIF and NELF interact with Integrator to specify the correct post-transcriptional fate of snRNA genes

(2014) Junichi Yamamoto et al.   Nature Communications

Defining NELF-E RNA Binding in HIV-1 and Promoter-Proximal Pause Regions

(2014) John M. Pagano et al.   PLoS Genetics

Mechanism of Translesion Transcription by RNA Polymerase II and Its Role in Cellular Resistance to DNA Damage

(2012) Celine Walmacq et al.   MOLECULAR CELL

Structure and function of the initially transcribing RNA polymerase II–TFIIB complex

(2012) Sarah Sainsbury et al.   NATURE

Initial transcribed region sequences influence the composition and functional properties of the bacterial elongation complex

(2011) P. Deighan et al.   GENES & DEVELOPMENT

Bacterial Transcription Terminators: The RNA 3′-End Chronicles

(2011) Jason M. Peters et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural basis of RNA polymerase II backtracking, arrest and reactivation

(2011) Alan C. M. Cheung et al.   NATURE

The elongation rate of RNA polymerase determines the fate of transcribed nucleosomes

(2011) Lacramioara Bintu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The nucleotide addition cycle of RNA polymerase is controlled by two molecular hinges in the Bridge Helix domain

(2010) Robert OJ Weinzierl   BMC BIOLOGY

The Human PAF1 Complex Acts in Chromatin Transcription Elongation Both Independently and Cooperatively with SII/TFIIS

(2010) Jaehoon Kim et al.   CELL

Splicing-independent recruitment of U1 snRNP to a transcription unit in living cells

(2010) B. Spiluttini et al.   JOURNAL OF CELL SCIENCE

Mechanism of chromatin remodeling and recovery during passage of RNA polymerase II

(2009) Olga I Kulaeva et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism of sequence-specific pausing of bacterial RNA polymerase

(2009) M. L. Kireeva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nucleosomal Fluctuations Govern the Transcription Dynamics of RNA Polymerase II

(2009) C. Hodges et al.   SCIENCE