Editorial Material
Oncology
Sherin J. Rouhani, Christine M. Bestvina
Summary: This article provides an overview of the trial of pembrolizumab plus next line chemotherapy and places it in the context of evaluating different strategies for extending the benefit of immunotherapy after disease progression. It also includes a summary of other immunotherapy-based combinations currently under investigation.
Review
Ecology
Carl Wunsch
Summary: The field of oceanography has undergone a significant transformation, transitioning from mechanical instruments to modern electronic technologies. It is now understood that the ocean is a highly turbulent fluid system interacting globally. Research in oceanography requires large teams and diverse research instruments.
ANNUAL REVIEW OF MARINE SCIENCE, VOL 13, 2021
(2021)
Editorial Material
Hematology
Andreas Margraf, Alexander Zarbock
Summary: The authors elegantly demonstrate that kindlin-3 recruitment to the membrane precedes integrin high-affinity activation and is dependent on the pleckstrin homology (PH) domain within kindlin-3.
Review
Cell Biology
Elias T. Spiliotis, Ilona A. Kesisova
Summary: This study reviews the mechanism of intracellular long-range transport of membrane vesicles and organelles by microtubule motors. It highlights the spatial control of microtubule-dependent membrane traffic by septins, a unique family of GTPases, and how they regulate motor interactions with microtubules and membrane cargo for specific movement and directionality.
TRENDS IN CELL BIOLOGY
(2021)
Reprint
Anesthesiology
Lawrence J. Saidman
Summary: The minimum alveolar concentration (MAC) is a standard for measuring the depth of anesthesia, allowing for comparison of the pharmacologic effects of inhaled anesthetics. Rare side effects of volatile anesthetics include malignant hyperthermia, which can be monitored using blood gas devices.
Review
Cell Biology
Ulises Ahumada-Castro, Galdo Bustos, Eduardo Silva-Pavez, Andrea Puebla-Huerta, Alenka Lovy, Cesar Cardenas
Summary: Recent studies have shown that cross-organelle communication plays a significant role in metabolism, with calcium ions playing a crucial role in this process, especially in cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Environmental Sciences
Robert L. Cook, William G. Sanderson, Colin G. Moore, Dan B. Harries
Summary: This study is the first to explore the impact of seasonality and location on temperate marine restoration projects. Results showed that materials deployed in July had up to three times higher settlement rates for the rare biogenic species Serpula vermicularis. The timing and location of restoration efforts can significantly affect the success of a project.
MARINE POLLUTION BULLETIN
(2021)
Review
Immunology
Linyan Tang, Chao Liu, Peter Rosenberger
Summary: Platelets are anucleate blood cells derived from megakaryocytes, and they play important roles in hemostasis, inflammation, and host defense. The cytoskeleton plays a crucial role in platelet functions, including intracellular calcium flux, phospholipid translocation, granule release, and shape change necessary for adhesion and aggregation. Neuronal guidance proteins (NGPs) not only guide neuronal axon navigation but also modulate platelet function by rearranging the cytoskeleton. This review focuses on the roles of NGPs in platelet formation and activation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Surgery
Kalli L. Devecki, Sergey Kozyr, Marie Crandall, Brian K. Yorkgitis
Summary: This study found that implementing an expedited trauma transfer protocol led to reduced time of arrival to definitive care and decreased advanced imaging done prior to transfer for transferred trauma patients. However, there was no associated decrease in mortality or length of stay among these patients. Further research is needed to examine pre-hospital transport and hospital choice decisions to improve care provided to trauma patients.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Pawel Roszak, Jung-Ok Heo, Bernhard Blob, Koichi Toyokura, Yuki Sugiyama, Maria Angels de Luis Balaguer, Winnie W. Y. Lau, Fiona Hamey, Jacopo Cirrone, Ewelina Madej, Alida M. Bouatta, Xin Wang, Marjorie Guichard, Robertas Ursache, Hugo Tavares, Kevin Verstaen, Jos Wendrich, Charles W. Melnyk, Yoshihisa Oda, Dennis Shasha, Sebastian E. Ahnert, Yvan Saeys, Bert De Rybel, Renze Heidstra, Ben Scheres, Guido Grossmann, Ari Pekka Mahonen, Philipp Denninger, Berthold Gottgens, Rosangela Sozzani, Kenneth D. Birnbaum, Yrjo Helariutta
Summary: In plant meristems, tissue-wide maturation gradients in coordination with specialized cell networks establish developmental phases for indeterminate growth. Single-cell transcriptomics was used to reconstruct the developmental trajectory of protophloem in Arabidopsis thaliana roots, revealing the role of PHLOEM EARLY DNA-BINDING-WITH-ONE-FINGER (PEAR) transcription factors in lineage bifurcation and differentiation.
Article
Microbiology
Hongjae Park, Tanja Shabarova, Michaela M. Salcher, Lenka Kosova, Pavel Rychtecky, Indranil Mukherjee, Karel Simek, Petr Porcal, Jaromir Seda, Petr Znachor, Vojtech Kasalicky
Summary: This study investigates the spatiotemporal dynamics of planktonic microbial communities in freshwater ecosystems and proposes a new model of bacterial community assembly. The findings reveal site-specific occurrence and microdiversification of bacteria, as well as recurrent bacterial seasonal patterns.
Article
Psychology, Experimental
Sage E. P. Boettcher, Nir Shalev, Jeremy M. Wolfe, Anna C. Nobre
Summary: The study shows that participants in dynamic visual search tasks can utilize spatiotemporal regularities within the environment to guide their performance. Predictability in both space and time significantly improves search performance, primarily due to robust long-term representations of these regularities.
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-GENERAL
(2022)
Article
Gastroenterology & Hepatology
Brindusa Truta
Summary: Therapeutic drug monitoring (TDM) is an important tool for determining the therapeutic efficacy of biologics in treating inflammatory bowel disease (IBD). However, its implementation in clinical practice faces challenges, and there is potential for proactive TDM to have a significant impact on the management of specific groups of IBD patients.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Environmental Sciences
Serena R. Wright, David Righton, Joachim Naulaerts, Robert J. Schallert, Chris A. Griffiths, Taylor Chapple, Daniel Madigan, Vladimir Laptikhovsky, Victoria Bendall, Rhys Hobbs, Doug Beare, Elizabeth Clingham, Barbara Block, Martin A. Collins
Summary: The study investigated the behavior of yellowfin tuna using satellite tags in the South Atlantic Ocean around St Helena, finding that their behavior varies seasonally and with depth, impacting the catchability of the fish by local fishing fleets.
FRONTIERS IN MARINE SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Karen Velandia, James B. Reid, Eloise Foo
Summary: This review analyzes the role of plant hormones, including auxin, cytokinin, brassinosteroids, ethylene, and gibberellins, during the process of infection and organogenesis in legume plants. The findings suggest that these hormones have differential roles in the epidermal infection and cortical nodule initiation, development, and function. While most hormones suppress infection events, they promote nodule organogenesis, except for ethylene which suppresses nodule initiation.
PLANT COMMUNICATIONS
(2022)
