Artemisinin relieves osteoarthritis by activating mitochondrial autophagy through reducing TNFSF11 expression and inhibiting PI3K/AKT/mTOR signaling in cartilage

The Efficacy and Safety of the mTOR Signaling Pathway Activator, MHY1485, for in vitro Activation of Human Ovarian Tissue

(2021) Shuang Wu et al.   Frontiers in Genetics

Autophagy receptors as viral targets

(2021) Päivi Ylä-Anttila   CELLULAR & MOLECULAR BIOLOGY LETTERS

KLF4, negatively regulated by miR-7, suppresses osteoarthritis development via activating TGF-β1 signaling

(2021) Jin Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The PI3K/AKT/mTOR signaling pathway in osteoarthritis: a narrative review

(2020) K. Sun et al.   OSTEOARTHRITIS AND CARTILAGE

Roles of the PI3K/AKT/mTOR signalling pathways in neurodegenerative diseases and tumours

(2020) Fei Xu et al.   Cell and Bioscience

The birth of artemisinin

(2020) Nan Ma et al.   PHARMACOLOGY & THERAPEUTICS

Osteoclast differentiation by RANKL and OPG signaling pathways

(2020) Nobuyuki Udagawa et al.   JOURNAL OF BONE AND MINERAL METABOLISM

The Role of Autophagy in Osteoarthritis

(2020) Ran Duan et al.   Frontiers in Cell and Developmental Biology

Osteoarthritis year in review 2020: epidemiology & therapy

(2020) G. Peat et al.   OSTEOARTHRITIS AND CARTILAGE

Changes in Autophagy Levels in Rat Myocardium During Exercise Preconditioning-Initiated Cardioprotective Effects

(2019) Ji-Yong Li et al.   International Heart Journal

Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis

(2019) Guo-Qing Chen et al.   CELL DEATH AND DIFFERENTIATION

IL-1β Damages Fibrocartilage and Upregulates MMP-13 Expression in Fibrochondrocytes in the Condyle of the Temporomandibular Joint

(2019) Hessam Tabeian et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

An updated algorithm recommendation for the management of knee osteoarthritis from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO)

(2019) Olivier Bruyère et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Regulatory Effects and Interactions of the Wnt and OPG-RANKL-RANK Signaling at the Bone-Cartilage Interface in Osteoarthritis

(2019) Béla Kovács et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Aucubin Protects Chondrocytes Against IL-1β-Induced Apoptosis In Vitro And Inhibits Osteoarthritis In Mice Model

(2019) Bo-wei Wang et al.   Drug Design Development and Therapy

Degrading products of chondroitin sulfate can induce hypertrophy-like changes and MMP-13/ADAMTS5 production in chondrocytes

(2019) Youn-Kwan Jung et al.   Scientific Reports

Osteoarthritis

(2019) Benjamin Abramoff et al.   MEDICAL CLINICS OF NORTH AMERICA

Mesenchymal stem cell-derived extracellular matrix enhances chondrogenic phenotype of and cartilage formation by encapsulated chondrocytes in vitro and in vivo

(2018) Yuanheng Yang et al.   Acta Biomaterialia

Induction of autophagy by depolarization of mitochondria

(2018) Konstantin G. Lyamzaev et al.   Autophagy

Effects of Artesunate on chondrocyte proliferation, apoptosis and autophagy through the PI3K/AKT/mTOR signaling pathway in rat models with rheumatoid arthritis

(2018) Fa-Bo Feng et al.   BIOMEDICINE & PHARMACOTHERAPY

Artemisinin and Artemisia annua leaves alleviate Eimeria tenella infection by facilitating apoptosis of host cells and suppressing inflammatory response

(2018) JinYing Jiao et al.   VETERINARY PARASITOLOGY

Osteoarthritis year in review 2018: clinical

(2018) L.A. Mandl   OSTEOARTHRITIS AND CARTILAGE

Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain

(2018) Shouan Zhu et al.   JOURNAL OF CLINICAL INVESTIGATION

Artesunate inhibits RANKL-induced osteoclastogenesis and bone resorption in vitro and prevents LPS-induced bone loss in vivo

(2017) Cheng-Ming Wei et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Autophagy in osteoarthritis

(2016) Hyelin Jeon et al.   CONNECTIVE TISSUE RESEARCH

Dihydroartemisinin, an Anti-Malaria Drug, Suppresses Estrogen Deficiency-Induced Osteoporosis, Osteoclast Formation, and RANKL-Induced Signaling Pathways

(2016) Lin Zhou et al.   JOURNAL OF BONE AND MINERAL RESEARCH

A consensus statement on the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) algorithm for the management of knee osteoarthritis—From evidence-based medicine to the real-life setting

(2016) Olivier Bruyère et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Hormesis, cell death and aging

(2016) Isabelle Martins et al.   Aging-US

Biomarkers of Chondrocyte Apoptosis and Autophagy in Osteoarthritis

(2015) Giuseppe Musumeci et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Osteoarthritis Pathogenesis: A Review of Molecular Mechanisms

(2014) Bingjiang Xia et al.   CALCIFIED TISSUE INTERNATIONAL

Destabilization of the medial meniscus leads to subchondral bone defects and site-specific cartilage degeneration in an experimental rat model

(2014) H. Iijima et al.   OSTEOARTHRITIS AND CARTILAGE

Functions of the osteocyte network in the regulation of bone mass

(2013) Toshihisa Komori   CELL AND TISSUE RESEARCH

Diagnosis and Treatment of Osteoarthritis

(2013) Rafaelani L. Taruc-Uy et al.   PRIMARY CARE

Regulation of PI-3-Kinase and Akt Signaling in T Lymphocytes and Other Cells by TNFR Family Molecules

(2013) Takanori So et al.   Frontiers in Immunology

RANKL Induces Organized Lymph Node Growth by Stromal Cell Proliferation

(2011) E. Hess et al.   JOURNAL OF IMMUNOLOGY

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Differential modulation of RANKL isoforms by human osteoarthritic subchondral bone osteoblasts: Influence of osteotropic factors

(2008) Steeve Kwan Tat et al.   BONE

Experimental Therapy of Hepatoma with Artemisinin and Its Derivatives: In vitro and In vivo Activity, Chemosensitization, and Mechanisms of Action

(2008) J. Hou et al.   CLINICAL CANCER RESEARCH

The Interleukin 1β Pathway in the Pathogenesis of Osteoarthritis

(2008) Massoud Daheshia et al.   JOURNAL OF RHEUMATOLOGY