Wound healing, fibroblast heterogeneity, and fibrosis

Multi-omic analysis reveals divergent molecular events in scarring and regenerative wound healing

(2022) Shamik Mascharak et al.   Cell Stem Cell

MBNL1 drives dynamic transitions between fibroblasts and myofibroblasts in cardiac wound healing

(2022) Darrian Bugg et al.   Cell Stem Cell

Disrupting mechanotransduction decreases fibrosis and contracture in split-thickness skin grafting

(2022) Kellen Chen et al.   Science Translational Medicine

NUAK1 promotes organ fibrosis via YAP and TGF-β/SMAD signaling

(2022) Tianzhou Zhang et al.   Science Translational Medicine

Developmental cell programs are co-opted in inflammatory skin disease

(2021) Gary Reynolds et al.   SCIENCE

Skin organoids: A new human model for developmental and translational research

(2021) Jiyoon Lee et al.   EXPERIMENTAL DERMATOLOGY

ArchR is a scalable software package for integrative single-cell chromatin accessibility analysis

(2021) Jeffrey M. Granja et al.   NATURE GENETICS

Mechanical stretch promotes hypertrophic scar formation through mechanically activated cation channel Piezo1

(2021) Jiahao He et al.   Cell Death & Disease

Inference and analysis of cell-cell communication using CellChat

(2021) Suoqin Jin et al.   Nature Communications

Tissue Mechanics in Haired Murine Skin: Potential Implications for Skin Aging

(2021) Hans I-Chen Harn et al.   Frontiers in Cell and Developmental Biology

Single-cell dual-omics reveals the transcriptomic and epigenomic diversity of cardiac non-myocytes

(2021) Li Wang et al.   CARDIOVASCULAR RESEARCH

Cross-tissue organization of the fibroblast lineage

(2021) Matthew B. Buechler et al.   NATURE

Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring

(2021) Shamik Mascharak et al.   SCIENCE

Fibroblasts: Origins, definitions, and functions in health and disease

(2021) Maksim V. Plikus et al.   CELL

The triumphs and limitations of computational methods for scRNA-seq

(2021) Peter V. Kharchenko   NATURE METHODS

CODEX multiplexed tissue imaging with DNA-conjugated antibodies

(2021) Sarah Black et al.   Nature Protocols

Disrupting biological sensors of force promotes tissue regeneration in large organisms

(2021) Kellen Chen et al.   Nature Communications

Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases

(2021) Cheng-Cheng Deng et al.   Nature Communications

Epithelial-to-Mesenchymal Transition in Fibrosis: Concepts and Targeting Strategies

(2021) Sara Lovisa   Frontiers in Pharmacology

Modulating cellular responses to mechanical forces to promote wound regeneration

(2021) Shamik Mascharak et al.   Advances in Wound Care

A Novel Xenograft Model Demonstrates Human Fibroblast Behavior During Skin Wound Repair and Fibrosis

(2021) Mimi Borrelli et al.   Advances in Wound Care

Resolving the intertwining of inflammation and fibrosis in human heart failure at single-cell level

(2021) Man Rao et al.   BASIC RESEARCH IN CARDIOLOGY

Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction

(2021) Vaibhao Janbandhu et al.   Cell Stem Cell

Integrated spatial multiomics reveals fibroblast fate during tissue repair

(2021) Deshka S. Foster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stem cells expand potency and alter tissue fitness by accumulating diverse epigenetic memories

(2021) Kevin Andrew Uy Gonzales et al.   SCIENCE

PDGFRα and αSMA mark two distinct mesenchymal cell populations involved in parenchymal and vascular remodeling in pulmonary fibrosis

(2020) Valentina Biasin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Deciphering the functional heterogeneity of skin fibroblasts using single‐cell RNA sequencing

(2020) Vera Vorstandlechner et al.   FASEB JOURNAL

Origin and functional heterogeneity of fibroblasts

(2020) Valerie S. LeBleu et al.   FASEB JOURNAL

Single-cell transcriptome analysis of human skin identifies novel fibroblast subpopulation and enrichment of immune subsets in atopic dermatitis

(2020) Helen He et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair

(2020) Brett A. Shook et al.   Cell Stem Cell

Molecular Mechanisms of Hair Growth and Regeneration: Current Understanding and Novel Paradigms

(2020) Khosrow Siamak Houschyar et al.   DERMATOLOGY

Experimental models and methods for cutaneous wound healing assessment

(2020) Daniela S. Masson-Meyers et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Cancer associated fibroblast FAK regulates malignant cell metabolism

(2020) Fevzi Demircioglu et al.   Nature Communications

Phagocytosis of Wnt inhibitor SFRP4 by late wound macrophages drives chronic Wnt activity for fibrotic skin healing

(2020) Denise Gay et al.   Science Advances

Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts during Wound Healing

(2020) Sepideh Abbasi et al.   Cell Stem Cell

Understanding the impact of fibroblast heterogeneity on skin fibrosis

(2020) Michelle F. Griffin et al.   Disease Models & Mechanisms

Hair-bearing human skin generated entirely from pluripotent stem cells

(2020) Jiyoon Lee et al.   NATURE

Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination

(2020) Lars Muhl et al.   Nature Communications

Dissecting Fibroblast Heterogeneity in Health and Fibrotic Disease

(2020) Tanya J Shaw et al.   Current Rheumatology Reports

Single-cell transcriptomes of the human skin reveal age-related loss of fibroblast priming

(2020) Llorenç Solé-Boldo et al.   Communications Biology

Machine learning integration of scleroderma histology and gene expression identifies fibroblast polarisation as a hallmark of clinical severity and improvement

(2020) Kimberly Showalter et al.   ANNALS OF THE RHEUMATIC DISEASES

Single-Cell RNA-seq Analysis Reveals a Crucial Role for Collagen Triple Helix Repeat Containing 1 (CTHRC1) Cardiac Fibroblasts after Myocardial Infarction

(2020) Adrian Ruiz-Villalba et al.   CIRCULATION

Lef1 expression in fibroblasts maintains developmental potential in adult skin to regenerate wounds

(2020) Quan M Phan et al.   eLife

Single‐cell transcriptomic analysis of small and large wounds reveals the distinct spatial organization of regenerative fibroblasts

(2020) Quan M. Phan et al.   EXPERIMENTAL DERMATOLOGY

Artificial intelligence identifies inflammation and confirms fibroblast foci as prognostic tissue biomarkers in idiopathic pulmonary fibrosis

(2020) Kati Mäkelä et al.   HUMAN PATHOLOGY

Fibrosis: from mechanisms to medicines

(2020) Neil C. Henderson et al.   NATURE

The Spectrum of Scarring in Craniofacial Wound Repair

(2019) Heather E. desJardins-Park et al.   Frontiers in Physiology

Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds

(2019) Christian F. Guerrero-Juarez et al.   Nature Communications

A novel spheroid-based co-culture model mimics loss of keratinocyte differentiation, melanoma cell invasion, and drug-induced selection of ABCB5-expressing cells

(2019) Julia Klicks et al.   BMC CANCER

Single Cell RNA Sequencing Identifies Subsets of Hepatic Stellate Cells and Myofibroblastsin Liver Fibrosis

(2019) Oliver Krenkel et al.   Cells

Primary Human Fibroblasts in Culture Switch to a Myofibroblast-Like Phenotype Independently of TGF Beta

(2019) Ulrike Baranyi et al.   Cells

Single-cell analysis reveals fibroblast heterogeneity and myofibroblasts in systemic sclerosis-associated interstitial lung disease

(2019) Eleanor Valenzi et al.   ANNALS OF THE RHEUMATIC DISEASES

Hippo pathway deletion in adult resting cardiac fibroblasts initiates a cell state transition with spontaneous and self-sustaining fibrosis

(2019) Yang Xiao et al.   GENES & DEVELOPMENT

Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis

(2019) Xuelian Xiong et al.   MOLECULAR CELL

CD163 overexpression using a macrophage-directed gene therapy approach improves wound healing in ex vivo and in vivo human skin models

(2019) David Wilson Ferreira et al.   IMMUNOBIOLOGY

Defining Transcriptional Signatures of Human Hair Follicle Cell States

(2019) Rie Takahashi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Resolving the fibrotic niche of human liver cirrhosis at single-cell level

(2019) P. Ramachandran et al.   NATURE

Patch repair of deep wounds by mobilized fascia

(2019) Donovan Correa-Gallegos et al.   NATURE

Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis

(2019) Andrew J. Haak et al.   Science Translational Medicine

Single-Cell Transcriptomics Uncovers Zonation of Function in the Mesenchyme during Liver Fibrosis

(2019) Ross Dobie et al.   Cell Reports

Circuit Design Features of a Stable Two-Cell System

(2018) Xu Zhou et al.   CELL

Direct In Vivo Reprogramming with Sendai Virus Vectors Improves Cardiac Function after Myocardial Infarction

(2018) Kazutaka Miyamoto et al.   Cell Stem Cell

Fibrocyte migration, differentiation and apoptosis during the corneal wound healing response to injury

(2018) Luciana Lassance et al.   EXPERIMENTAL EYE RESEARCH

Fibroblast heterogeneity: implications for human disease

(2018) Magnus D. Lynch et al.   JOURNAL OF CLINICAL INVESTIGATION

The perivascular origin of pathological fibroblasts

(2018) Selene E. Di Carlo et al.   JOURNAL OF CLINICAL INVESTIGATION

Skin wound healing in humans and mice: Challenges in translational research

(2018) Helena D. Zomer et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Controlled Delivery of a Focal Adhesion Kinase Inhibitor Results in Accelerated Wound Closure with Decreased Scar Formation

(2018) Kun Ma et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

SFRP2/DPP4 and FMO1/LSP1 Define Major Fibroblast Populations in Human Skin

(2018) Tracy Tabib et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations

(2018) Christina Philippeos et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The WNT signaling pathways in wound healing and fibrosis

(2018) Olivier Burgy et al.   MATRIX BIOLOGY

PDGF in organ fibrosis

(2018) Barbara Mara Klinkhammer et al.   MOLECULAR ASPECTS OF MEDICINE

Two succeeding fibroblastic lineages drive dermal development and the transition from regeneration to scarring

(2018) Dongsheng Jiang et al.   NATURE CELL BIOLOGY

Embryonic skin development and repair

(2018) Michael S. Hu et al.   Organogenesis

Single-Cell Deconvolution of Fibroblast Heterogeneity in Mouse Pulmonary Fibrosis

(2018) Ting Xie et al.   Cell Reports

The Role of Macrophages in Acute and Chronic Wound Healing and Interventions to Promote Pro-wound Healing Phenotypes

(2018) Paulina Krzyszczyk et al.   Frontiers in Physiology

Functions of Vγ4 T Cells and Dendritic Epidermal T Cells on Skin Wound Healing

(2018) Yashu Li et al.   Frontiers in Immunology

Mechanical Forces in Cutaneous Wound Healing: Emerging Therapies to Minimize Scar Formation

(2018) Leandra A. Barnes et al.   Advances in Wound Care

Deep Profiling of Mouse Splenic Architecture with CODEX Multiplexed Imaging

(2018) Yury Goltsev et al.   CELL

Neonatal Heart Regeneration

(2018) Nicholas T. Lam et al.   CIRCULATION

Lineage identity and location within the dermis determine the function of papillary and reticular fibroblasts in human skin

(2018) Ana Korosec et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Research Techniques Made Simple: Animal Models of Wound Healing

(2018) Ayman Grada et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Fibroblasts and wound healing: an update

(2018) Heather E desJardins-Park et al.   Regenerative Medicine

Developmental barcoding of whole mouse via homing CRISPR

(2018) Reza Kalhor et al.   SCIENCE

Genome Editing of Pigs for Agriculture and Biomedicine

(2018) Huaqiang Yang et al.   Frontiers in Genetics

Myofibroblast proliferation and heterogeneity are supported by macrophages during skin repair

(2018) Brett A. Shook et al.   SCIENCE

Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing

(2018) Chae Ho Lim et al.   Nature Communications

Motor neuron degeneration, severe myopathy and TDP-43 increase in a transgenic pig model of SOD1-linked familiar ALS

(2018) Paola Crociara et al.   NEUROBIOLOGY OF DISEASE

The tension biology of wound healing

(2017) Hans I-Chen Harn et al.   EXPERIMENTAL DERMATOLOGY

Human Dermal Fibroblast Subpopulations Display Distinct Gene Signatures Related to Cell Behaviors and Matrisome

(2017) Pauline Nauroy et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Inflammatory memory sensitizes skin epithelial stem cells to tissue damage

(2017) Shruti Naik et al.   NATURE

Polylox barcoding reveals haematopoietic stem cell fates realized in vivo

(2017) Weike Pei et al.   NATURE

Subjectivity in primary headaches: insight the causes

(2017) Gennaro Bussone   NEUROLOGICAL SCIENCES

Modeling Physiological Events in 2D vs. 3D Cell Culture

(2017) Kayla Duval et al.   PHYSIOLOGY

Regeneration of fat cells from myofibroblasts during wound healing

(2017) Maksim V. Plikus et al.   SCIENCE

Dermal fibroblast in cutaneous development and healing

(2017) Venkata Thulabandu et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Epithelial-mesenchymal transition in tissue repair and fibrosis

(2016) Rivka C. Stone et al.   CELL AND TISSUE RESEARCH

Direct Reprogramming of Hepatic Myofibroblasts into Hepatocytes In Vivo Attenuates Liver Fibrosis

(2016) Guangqi Song et al.   Cell Stem Cell

In Vivo Hepatic Reprogramming of Myofibroblasts with AAV Vectors as a Therapeutic Strategy for Liver Fibrosis

(2016) Milad Rezvani et al.   Cell Stem Cell

Transcription factor TBX4 regulates myofibroblast accumulation and lung fibrosis

(2016) Ting Xie et al.   JOURNAL OF CLINICAL INVESTIGATION

CD301b+ Macrophages Are Essential for Effective Skin Wound Healing

(2016) Brett Shook et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Identification of an atypical monocyte and committed progenitor involved in fibrosis

(2016) Takashi Satoh et al.   NATURE

Liver fibrosis and hepatic stellate cells: Etiology, pathological hallmarks and therapeutic targets

(2016) Chong-Yang Zhang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis

(2016) Katherine Martin et al.   Nature Communications

Role of Bone Marrow-Derived Fibroblasts in Renal Fibrosis

(2016) Jingyin Yan et al.   Frontiers in Physiology

Single-Cell Transcriptomics Reveals that Differentiation and Spatial Signatures Shape Epidermal and Hair Follicle Heterogeneity

(2016) Simon Joost et al.   Cell Systems

Single-Cell Transcriptomics Bioinformatics and Computational Challenges

(2016) Olivier B. Poirion et al.   Frontiers in Genetics

The Hippo pathway effector YAP controls mouse hepatic stellate cell activation

(2015) Inge Mannaerts et al.   JOURNAL OF HEPATOLOGY

Identification and isolation of a dermal lineage with intrinsic fibrogenic potential

(2015) Y. Rinkevich et al.   SCIENCE

Live Fibroblast Harvest Reveals Surface Marker ShiftIn Vitro

(2015) Graham G. Walmsley et al.   TISSUE ENGINEERING PART C-METHODS

Understanding fibroblast heterogeneity in the skin

(2015) Ryan R. Driskell et al.   TRENDS IN CELL BIOLOGY

Tissue-Specific Signals Control Reversible Program of Localization and Functional Polarization of Macrophages

(2014) Yasutaka Okabe et al.   CELL

Developmental Heterogeneity of Cardiac Fibroblasts Does Not Predict Pathological Proliferation and Activation

(2014) Shah R. Ali et al.   CIRCULATION RESEARCH

Genetic evidence that Nkx2.2 and Pdgfra are major determinants of the timing of oligodendrocyte differentiation in the developing CNS

(2014) Q. Zhu et al.   DEVELOPMENT

Potential use of TNF-α inhibitors in systemic sclerosis

(2014) Giuseppe Murdaca et al.   Immunotherapy

A Randomized Controlled Trial of the embrace Advanced Scar Therapy Device to Reduce Incisional Scar Formation

(2014) Michael T. Longaker et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Wound repair and regeneration: Mechanisms, signaling, and translation

(2014) S. A. Eming et al.   Science Translational Medicine

A statistical analysis of murine incisional and excisional acute wound models

(2014) David M. Ansell et al.   WOUND REPAIR AND REGENERATION

The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle

(2014) B. A. Morgan   Cold Spring Harbor Perspectives in Medicine

Fibroblasts in fibrosis: novel roles and mediators

(2014) Ryan T. Kendall et al.   Frontiers in Pharmacology

Myofibroblasts: Trust your heart and let fate decide

(2013) Jennifer Davis et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Fibrocytes develop outside the kidney but contribute to renal fibrosis in a mouse model

(2013) Barbara Reich et al.   KIDNEY INTERNATIONAL

Distinct fibroblast lineages determine dermal architecture in skin development and repair

(2013) Ryan R. Driskell et al.   NATURE

Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages

(2013) Takashi Satoh et al.   NATURE

Fgf9 from dermal γδ T cells induces hair follicle neogenesis after wounding

(2013) Denise Gay et al.   NATURE MEDICINE

The embrace Device Significantly Decreases Scarring following Scar Revision Surgery in a Randomized Controlled Trial

(2013) Angeline F. Lim et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

A Mechanomodulatory Device to Minimize Incisional Scar Formation

(2013) Victor W. Wong et al.   Advances in Wound Care

Endocardial and Epicardial Epithelial to Mesenchymal Transitions in Heart Development and Disease

(2012) Alexander von Gise et al.   CIRCULATION RESEARCH

Different Gene Expression Patterns in Human Papillary and Reticular Fibroblasts

(2012) David G. Janson et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Skin shedding and tissue regeneration in African spiny mice (Acomys)

(2012) Ashley W. Seifert et al.   NATURE

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

Multiple Roles and Interactions of Tbx4 and Tbx5 in Development of the Respiratory System

(2012) Ripla Arora et al.   PLoS Genetics

Improving Cutaneous Scar Formation by Controlling the Mechanical Environment

(2011) Geoffrey C. Gurtner et al.   ANNALS OF SURGERY

Lineage tracing demonstrates no evidence of cholangiocyte epithelial-to-mesenchymal transition in murine models of hepatic fibrosis

(2011) Andrew S. Chu et al.   HEPATOLOGY

The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C− monocytes

(2011) Richard N Hanna et al.   NATURE IMMUNOLOGY

Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling

(2011) Victor W Wong et al.   NATURE MEDICINE

Swine as Models in Biomedical Research and Toxicology Testing

(2011) M. M. Swindle et al.   VETERINARY PATHOLOGY

Extracellular Matrix Degradation and Remodeling in Development and Disease

(2011) P. Lu et al.   Cold Spring Harbor Perspectives in Biology

Acute liver failure is associated with elevated liver stiffness and hepatic stellate cell activation

(2010) Alexander Dechêne et al.   HEPATOLOGY

Differential Roles of Macrophages in Diverse Phases of Skin Repair

(2010) T. Lucas et al.   JOURNAL OF IMMUNOLOGY

Resolved: EMT Produces Fibroblasts in the Kidney

(2010) M. Zeisberg et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Scarless Fetal Wound Healing: A Basic Science Review

(2010) Barrett J. Larson et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Use of the parabiotic model in studies of cutaneous wound healing to define the participation of circulating cells

(2010) Guodong Song et al.   WOUND REPAIR AND REGENERATION

Limitations of the db/db mouse in translational wound healing research: Is the NONcNZO10 polygenic mouse model superior?

(2010) Robert C. Fang et al.   WOUND REPAIR AND REGENERATION

Reciprocal Requirements for EDA/EDAR/NF-κB and Wnt/β-Catenin Signaling Pathways in Hair Follicle Induction

(2009) Yuhang Zhang et al.   DEVELOPMENTAL CELL

Mesenchymal Stem Cells Can Participate in Ischemic Neovascularization

(2009) Cynthia Hamou et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

A dermal HOX transcriptional program regulates site-specific epidermal fate

(2008) J. L. Rinn et al.   GENES & DEVELOPMENT

Pivotal Advance: Th-1 cytokines inhibit, and Th-2 cytokines promote fibrocyte differentiation

(2008) D. D. Shao et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis

(2008) Masako Kohyama et al.   NATURE

Wound repair and regeneration

(2008) Geoffrey C. Gurtner et al.   NATURE