Lymphatics and fibroblasts support intestinal stem cells in homeostasis and injury

Lymphatics act as a signaling hub to regulate intestinal stem cell activity

(2022) Rachel E. Niec et al.   Cell Stem Cell

Lymphangiocrine signals are required for proper intestinal repair after cytotoxic injury

(2022) Brisa Palikuqi et al.   Cell Stem Cell

A constant pool of Lgr5+ intestinal stem cells is required for intestinal homeostasis

(2021) Si Hui Tan et al.   Cell Reports

IL-1R1–dependent signaling coordinates epithelial regeneration in response to intestinal damage

(2021) Christian B. Cox et al.   Science Immunology

High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity

(2021) Miyeko D. Mana et al.   Cell Reports

Single-Cell Transcriptome Atlas of Murine Endothelial Cells

(2020) Joanna Kalucka et al.   CELL

Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient

(2020) Neil McCarthy et al.   Cell Stem Cell

Cellular and molecular architecture of the intestinal stem cell niche

(2020) Neil McCarthy et al.   NATURE CELL BIOLOGY

Lymphoangiocrine signals promote cardiac growth and repair

(2020) Xiaolei Liu et al.   NATURE

Distinct populations of crypt-associated fibroblasts act as signaling hubs to control colon homeostasis

(2020) Michael David Brügger et al.   PLOS BIOLOGY

IL-1 and TNFα Contribute to the Inflammatory Niche to Enhance Alveolar Regeneration

(2019) Hiroaki Katsura et al.   Stem Cell Reports

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Cutaneous wound healing in diabetic mice is improved by topical mineralocorticoid receptor blockade

(2019) Van Tuan Nguyen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium

(2019) Nalle Pentinmikko et al.   NATURE

Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet

(2019) Chia-Wei Cheng et al.   CELL

Lymphatic vessels interact dynamically with the hair follicle stem cell niche during skin regeneration in vivo

(2019) Daniel Peña‐Jimenez et al.   EMBO JOURNAL

Stem cell–driven lymphatic remodeling coordinates tissue regeneration

(2019) Shiri Gur-Cohen et al.   SCIENCE

R-spondin 3 promotes stem cell recovery and epithelial regeneration in the colon

(2019) Christine Harnack et al.   Nature Communications

Vascular endothelial growth factor signaling in development and disease

(2018) Sinem Karaman et al.   DEVELOPMENT

Expression of the Atypical Chemokine Receptor ACKR4 Identifies a Novel Population of Intestinal Submucosal Fibroblasts That Preferentially Expresses Endothelial Cell Regulators

(2018) Carolyn A. Thomson et al.   JOURNAL OF IMMUNOLOGY

PDGFRα+pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo

(2018) Gediminas Greicius et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells

(2018) D. J. Huels et al.   Nature Communications

Structural Remodeling of the Human Colonic Mesenchyme in Inflammatory Bowel Disease

(2018) James Kinchen et al.   CELL

Subepithelial telocytes are an important source of Wnts that supports intestinal crypts

(2018) Michal Shoshkes-Carmel et al.   NATURE

GLI1-expressing mesenchymal cells form the essential Wnt-secreting niche for colon stem cells

(2018) Bahar Degirmenci et al.   NATURE

Intestinal Lymphatic Endothelial Cells Produce R-Spondin3

(2018) Reiki Ogasawara et al.   Scientific Reports

Heavy-tailed prior distributions for sequence count data: removing the noise and preserving large differences

(2018) Anqi Zhu et al.   BIOINFORMATICS

Human Intestinal Organoids Maintain Self-Renewal Capacity and Cellular Diversity in Niche-Inspired Culture Condition

(2018) Masayuki Fujii et al.   Cell Stem Cell

Tales from the crypt: new insights into intestinal stem cells

(2018) Helmuth Gehart et al.   Nature Reviews Gastroenterology & Hepatology

Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal

(2017) Kelley S. Yan et al.   NATURE

Salmon provides fast and bias-aware quantification of transcript expression

(2017) Rob Patro et al.   NATURE METHODS

CD34+mesenchymal cells are a major component of the intestinal stem cells niche at homeostasis and after injury

(2017) Igor Stzepourginski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stimulation of hair follicle stem cell proliferation through an IL-1 dependent activation of γδT-cells

(2017) Pedro Lee et al.   eLife

Visualization of a short-range Wnt gradient in the intestinal stem-cell niche

(2016) Henner F. Farin et al.   NATURE

High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

(2016) Semir Beyaz et al.   NATURE

Reg4+deep crypt secretory cells function as epithelial niche for Lgr5+stem cells in colon

(2016) Nobuo Sasaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-6 Stimulates Defective Angiogenesis

(2015) G. Gopinathan et al.   CANCER RESEARCH

The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength

(2014) W. de Lau et al.   GENES & DEVELOPMENT

Robust Cre-Mediated Recombination in Small Intestinal Stem Cells Utilizing the Olfm4 Locus

(2014) Jurian Schuijers et al.   Stem Cell Reports

LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling

(2013) Xiaomeng Wang et al.   NATURE

Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974

(2013) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipocalin 2 is a novel regulator of angiogenesis in human breast cancer

(2012) Jiang Yang et al.   FASEB JOURNAL

Redundant Sources of Wnt Regulate Intestinal Stem Cells and Promote Formation of Paneth Cells

(2012) Henner F. Farin et al.   GASTROENTEROLOGY

A conditional allele ofRspo3reveals redundant function of R-spondins during mouse limb development

(2012) Stanley Neufeld et al.   GENESIS

mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake

(2012) Ömer H. Yilmaz et al.   NATURE

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

Wnt2/2b and β-Catenin Signaling Are Necessary and Sufficient to Specify Lung Progenitors in the Foregut

(2009) Ashley M. Goss et al.   DEVELOPMENTAL CELL

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

(2009) David A. Barbie et al.   NATURE

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE