Parkinson’s disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes

pH regulates potassium conductance and drives a constitutive proton current in human TMEM175

(2022) Wang Zheng et al.   Science Advances

A growth-factor-activated lysosomal K+ channel regulates Parkinson’s pathology

(2021) Jinhong Wie et al.   NATURE

Translocation of TMEM175 Lysosomal Potassium Channel to the Plasma Membrane by Dynasore Compounds

(2021) Enikő Pergel et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structural basis for ion selectivity in TMEM175 K+ channels

(2020) Janine D Brunner et al.   eLife

Gating and selectivity mechanisms for the lysosomal K+ channel TMEM175

(2020) SeCheol Oh et al.   eLife

Targeted sequencing of Parkinson’s disease loci genes highlights SYT11, FGF20 and other associations

(2020) Uladzislau Rudakou et al.   BRAIN

Mutation analysis of TMEM family members for early-onset Parkinson’s disease in Chinese population

(2020) ChunYu Li et al.   NEUROBIOLOGY OF AGING

Parkinson's disease age at onset genome‐wide association study: Defining heritability, genetic loci, and α‐synuclein mechanisms

(2019) Cornelis Blauwendraat et al.   MOVEMENT DISORDERS

PAC, an evolutionarily conserved membrane protein, is a proton-activated chloride channel

(2019) Junhua Yang et al.   SCIENCE

Structural and functional characterization of an otopetrin family proton channel

(2019) Qingfeng Chen et al.   eLife

Lysosomal Storage and Albinism Due to Effects of a De Novo CLCN7 Variant on Lysosomal Acidification

(2019) Elena-Raluca Nicoli et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Functionalization of the TMEM175 p.M393T Variant as a risk factor for Parkinson Disease

(2019) Sarah Jinn et al.   HUMAN MOLECULAR GENETICS

Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes

(2019) Sarah H. Shahmoradian et al.   NATURE NEUROSCIENCE

Lysosomes as a therapeutic target

(2019) Srinivasa Reddy Bonam et al.   NATURE REVIEWS DRUG DISCOVERY

Genetic, Structural, and Functional Evidence Link TMEM175 to Synucleinopathies

(2019) Lynne Krohn et al.   ANNALS OF NEUROLOGY

Lysosomes as dynamic regulators of cell and organismal homeostasis

(2019) Andrea Ballabio et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Agonist-specific voltage-dependent gating of lysosomal two-pore Na+ channels

(2019) Xiaoli Zhang et al.   eLife

An evolutionarily conserved gene family encodes proton-selective ion channels

(2018) Yu-Hsiang Tu et al.   SCIENCE

NUFIP1 is a ribosome receptor for starvation-induced ribophagy

(2018) Gregory A. Wyant et al.   SCIENCE

Lysosomal Ion Channels as Decoders of Cellular Signals

(2018) Ping Li et al.   TRENDS IN BIOCHEMICAL SCIENCES

A voltage-dependent K+channel in the lysosome is required for refilling lysosomal Ca2+stores

(2017) Wuyang Wang et al.   JOURNAL OF CELL BIOLOGY

The lysosomal potassium channel TMEM175 adopts a novel tetrameric architecture

(2017) Changkeun Lee et al.   NATURE

A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci

(2017) Diana Chang et al.   NATURE GENETICS

Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes

(2017) Cheng-Chang Chen et al.   Nature Protocols

TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation

(2017) Sarah Jinn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ligand- and voltage-gated Ca2+channels differentially regulate the mode of vesicular neuropeptide release in mammalian sensory neurons

(2017) Yeshi Wang et al.   Science Signaling

Ligand- and voltage-gated Ca2+channels differentially regulate the mode of vesicular neuropeptide release in mammalian sensory neurons

(2017) Yeshi Wang et al.   Science Signaling

Nanoparticles restore lysosomal acidification defects: Implications for Parkinson and other lysosomal-related diseases

(2016) Mathieu Bourdenx et al.   Autophagy

The position of lysosomes within the cell determines their luminal pH

(2016) Danielle E. Johnson et al.   JOURNAL OF CELL BIOLOGY

Soluble adenylyl cyclase is essential for proper lysosomal acidification

(2016) Nawreen Rahman et al.   JOURNAL OF GENERAL PHYSIOLOGY

Lysosomal Physiology

(2015) Haoxing Xu et al.   Annual Review of Physiology

TMEM175 Is an Organelle K + Channel Regulating Lysosomal Function

(2015) Chunlei Cang et al.   CELL

Purification and Characterization of Cathepsin B from the Muscle of Horse Mackerel Trachurus japonicus

(2015) Asami Yoshida et al.   Marine Drugs

Cysteine cathepsins are essential in lysosomal degradation of α-synuclein

(2015) Ryan P. McGlinchey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reconstituted Human TPC1 Is a Proton-Permeable Ion Channel and Is Activated by NAADP or Ca2+

(2014) S. J. Pitt et al.   Science Signaling

A High-Throughput Functional Screen Identifies Small Molecule Regulators of Temperature- and Mechano-Sensitive K2P Channels

(2013) Sviatoslav N. Bagriantsev et al.   ACS Chemical Biology

A model of lysosomal pH regulation

(2013) Yoichi Ishida et al.   JOURNAL OF GENERAL PHYSIOLOGY

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

TPC Proteins Are Phosphoinositide- Activated Sodium-Selective Ion Channels in Endosomes and Lysosomes

(2012) Xiang Wang et al.   CELL

Inducible Renitence Limits Listeria monocytogenes Escape from Vacuoles in Macrophages

(2012) Michael J. Davis et al.   JOURNAL OF IMMUNOLOGY

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release

(2012) Dongbiao Shen et al.   Nature Communications

Lysosomal Acidification Mechanisms

(2011) Joseph A. Mindell   Annual Review of Physiology

In situ Measurement of the Electrical Potential Across the Lysosomal Membrane Using FRET

(2011) Mirkka Koivusalo et al.   TRAFFIC

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

A cation counterflux supports lysosomal acidification

(2010) Benjamin E. Steinberg et al.   JOURNAL OF CELL BIOLOGY

The proteome of lysosomes

(2010) Bernd A. Schröder et al.   PROTEOMICS

Sensors and regulators of intracellular pH

(2009) Joseph R. Casey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo

(2009) Valerie Cullen et al.   Molecular Brain

The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel

(2008) Xian-Ping Dong et al.   NATURE

The Cl-/H+ antiporter ClC-7 is the primary chloride permeation pathway in lysosomes

(2008) Austin R. Graves et al.   NATURE

Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity

(2008) Liyan Qiao et al.   Molecular Brain