Metabolic analysis as a driver for discovery, diagnosis, and therapy

Spatially resolved isotope tracing reveals tissue metabolic activity

(2022) Lin Wang et al.   NATURE METHODS

The Purinosome: A Case Study for a Mammalian Metabolon

(2022) Anthony M. Pedley et al.   Annual Review of Biochemistry

Metabolomic profiling of rare cell populations isolated by flow cytometry from tissues

(2021) Andrew W DeVilbiss et al.   eLife

Brain glycogen serves as a critical glucosamine cache required for protein glycosylation

(2021) Ramon C. Sun et al.   Cell Metabolism

SpaceM reveals metabolic states of single cells

(2021) Luca Rappez et al.   NATURE METHODS

Metabolic perturbations sensitize triple-negative breast cancers to apoptosis induced by BH3 mimetics

(2021) Veerle W. Daniels et al.   Science Signaling

SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells

(2021) Ying Wang et al.   NATURE

The reactome pathway knowledgebase 2022

(2021) Marc Gillespie et al.   NUCLEIC ACIDS RESEARCH

1H magnetic resonance spectroscopy of 2H-to-1H exchange quantifies the dynamics of cellular metabolism in vivo

(2020) Laurie J. Rich et al.   Nature Biomedical Engineering

Integrated analysis of metabolomic profiling and exome data supplements sequence variant interpretation, classification, and diagnosis

(2020) Joseph T. Alaimo et al.   GENETICS IN MEDICINE

The role of exome sequencing in newborn screening for inborn errors of metabolism

(2020) Aashish N. Adhikari et al.   NATURE MEDICINE

Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition

(2020) Bryan Ngo et al.   Cancer Discovery

A PEROXO-Tag Enables Rapid Isolation of Peroxisomes from Human Cells

(2020) G. Jordan Ray et al.   iScience

Metabolic Imaging Detects Resistance to PI3Kα Inhibition Mediated by Persistent FOXM1 Expression in ER+ Breast Cancer

(2020) Susana Ros et al.   CANCER CELL

Immunometabolism in the Single-Cell Era

(2020) Maxim N. Artyomov et al.   Cell Metabolism

MCART1/SLC25A51 is required for mitochondrial NAD transport

(2020) Nora Kory et al.   Science Advances

SCENITH: A Flow Cytometry-Based Method to Functionally Profile Energy Metabolism with Single-Cell Resolution

(2020) Rafael J. Argüello et al.   Cell Metabolism

Functional Genomics In Vivo Reveal Metabolic Dependencies of Pancreatic Cancer Cells

(2020) Xiphias Ge Zhu et al.   Cell Metabolism

Functional Genomics Identifies Metabolic Vulnerabilities in Pancreatic Cancer

(2020) Douglas E. Biancur et al.   Cell Metabolism

Kinetic Modeling of 18F-(2S,4R)4-Fluoroglutamine in Mouse Models of Breast Cancer to Estimate Glutamine Pool Size as an Indicator of Tumor Glutamine Metabolism

(2020) Varsha Viswanath et al.   JOURNAL OF NUCLEAR MEDICINE

Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death

(2019) Javier Garcia-Bermudez et al.   NATURE

First Human Imaging Studies with the EXPLORER Total-Body PET Scanner*

(2019) Ramsey D. Badawi et al.   JOURNAL OF NUCLEAR MEDICINE

Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion

(2019) Isaac S. Harris et al.   Cell Metabolism

Functional Assessment of Lipoyltransferase-1 Deficiency in Cells, Mice, and Humans

(2019) Min Ni et al.   Cell Reports

Hyperpolarized MRI of Human Prostate Cancer Reveals Increased Lactate with Tumor Grade Driven by Monocarboxylate Transporter 1

(2019) Kristin L. Granlund et al.   Cell Metabolism

Gene loci associated with insulin secretion in islets from nondiabetic mice

(2019) Mark P. Keller et al.   JOURNAL OF CLINICAL INVESTIGATION

Metabolic landscape of the tumor microenvironment at single cell resolution

(2019) Zhengtao Xiao et al.   Nature Communications

Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours

(2018) Javier Garcia-Bermudez et al.   NATURE CELL BIOLOGY

Durable Remissions with Ivosidenib in IDH1-Mutated Relapsed or Refractory AML

(2018) Courtney D. DiNardo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations

(2018) Andrew M. Intlekofer et al.   NATURE

Deuterium metabolic imaging (DMI) for MRI-based 3D mapping of metabolism in vivo

(2018) Henk M. De Feyter et al.   Science Advances

Hyperpolarized 13C MRI: Path to Clinical Translation in Oncology

(2018) John Kurhanewicz et al.   NEOPLASIA

A CRISPR screen identifies a pathway required for paraquat-induced cell death

(2017) Colleen R Reczek et al.   Nature Chemical Biology

Genetically encoded fluorescent sensors reveal dynamic regulation of NADPH metabolism

(2017) Rongkun Tao et al.   NATURE METHODS

Rapid immunopurification of mitochondria for metabolite profiling and absolute quantification of matrix metabolites

(2017) Walter W Chen et al.   Nature Protocols

Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease

(2017) Marc S. Sabatine et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes

(2017) Monther Abu-Remaileh et al.   SCIENCE

Real-time quantitative analysis of metabolic flux in live cells using a hyperpolarized micromagnetic resonance spectrometer

(2017) Sangmoo Jeong et al.   Science Advances

Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism

(2016) Walter W. Chen et al.   CELL

Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer

(2016) Shawn M. Davidson et al.   Cell Metabolism

Hyperpolarized 13 C Metabolic MRI of the Human HeartNovelty and Significance

(2016) Charles H. Cunningham et al.   CIRCULATION RESEARCH

Prospective Longitudinal Analysis of 2-Hydroxyglutarate Magnetic Resonance Spectroscopy Identifies Broad Clinical Utility for the Management of Patients With IDH-Mutant Glioma

(2016) Changho Choi et al.   JOURNAL OF CLINICAL ONCOLOGY

Apollo-NADP+: a spectrally tunable family of genetically encoded sensors for NADP+

(2016) William D Cameron et al.   NATURE METHODS

An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis

(2015) Kıvanç Birsoy et al.   CELL

Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells

(2015) Lucas B. Sullivan et al.   CELL

Acetate Dependence of Tumors

(2014) Sarah A. Comerford et al.   CELL

Update on Time-of-Flight PET Imaging

(2014) S. Surti   JOURNAL OF NUCLEAR MEDICINE

Separating NADH and NADPH fluorescence in live cells and tissues using FLIM

(2014) Thomas S. Blacker et al.   Nature Communications

Optical Metabolic Imaging Identifies Glycolytic Levels, Subtypes, and Early-Treatment Response in Breast Cancer

(2013) A. J. Walsh et al.   CANCER RESEARCH

Chemistry and biochemistry of13C hyperpolarized magnetic resonance using dynamic nuclear polarization

(2013) Kayvan R. Keshari et al.   CHEMICAL SOCIETY REVIEWS

The Collaborative Cross: A Recombinant Inbred Mouse Population for the Systems Genetic Era

(2013) D. W. Threadgill et al.   ILAR JOURNAL

Direct assessment of hepatic mitochondrial oxidative and anaplerotic fluxes in humans using dynamic 13C magnetic resonance spectroscopy

(2013) Douglas E Befroy et al.   NATURE MEDICINE

Magnetic resonance imaging of tumor glycolysis using hyperpolarized 13C-labeled glucose

(2013) Tiago B Rodrigues et al.   NATURE MEDICINE

An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells

(2013) D. Rohle et al.   SCIENCE

Targeted Inhibition of Mutant IDH2 in Leukemia Cells Induces Cellular Differentiation

(2013) F. Wang et al.   SCIENCE

Metabolic Imaging of Patients with Prostate Cancer Using Hyperpolarized [1-13C]Pyruvate

(2013) S. J. Nelson et al.   Science Translational Medicine

PET Imaging of Glutaminolysis in Tumors by 18F-(2S,4R)4-Fluoroglutamine

(2011) B. P. Lieberman et al.   JOURNAL OF NUCLEAR MEDICINE

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

(2011) Richard Possemato et al.   NATURE

Human metabolic individuality in biomedical and pharmaceutical research

(2011) Karsten Suhre et al.   NATURE

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

(2011) Jason W Locasale et al.   NATURE GENETICS

Hyperpolarized 13C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging

(2011) K. R. Keshari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

(2010) Maria E. Figueroa et al.   CANCER CELL

Altered Brain Mitochondrial Metabolism in Healthy Aging as Assessed by in vivo Magnetic Resonance Spectroscopy

(2009) Fawzi Boumezbeur et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Hyperpolarized [2-13C]-Fructose: A Hemiketal DNP Substrate for In Vivo Metabolic Imaging

(2009) Kayvan R. Keshari et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

A genome-wide perspective of genetic variation in human metabolism

(2009) Thomas Illig et al.   NATURE GENETICS

Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome

(2009) Elaine R. Mardis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Production of hyperpolarized [1,4-13C2]malate from [1,4-13C2]fumarate is a marker of cell necrosis and treatment response in tumors

(2009) F. A. Gallagher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

(2008) Stefano Romeo et al.   NATURE GENETICS

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE

Genetics Meets Metabolomics: A Genome-Wide Association Study of Metabolite Profiles in Human Serum

(2008) Christian Gieger et al.   PLoS Genetics