A Novel Leucyl-tRNA Synthetase Inhibitor, MRX-6038, Expresses Anti-Mycobacterium abscessus Activity In Vitro and In Vivo

A Leucyl-tRNA Synthetase Inhibitor with Broad-Spectrum Anti-Mycobacterial Activity

(2021) Uday S. Ganapathy et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Eradication success for non-tuberculous mycobacteria in children with cystic fibrosis

(2021) Dominic A Hughes et al.   EUROPEAN RESPIRATORY JOURNAL

Stepwise pathogenic evolution of Mycobacterium abscessus

(2021) Josephine M. Bryant et al.   SCIENCE

Phage Therapy for Mycobacterium Abscessus and Strategies to Improve Outcomes

(2021) Abdolrazagh Hashemi Shahraki et al.   Microorganisms

Epetraborole Is Active against Mycobacterium abscessus

(2021) Uday S. Ganapathy et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Screening of the MMV Pandemic Response Box Reveals Epetraborole as A New Potent Inhibitor against Mycobacterium abscessus

(2021) Taeho Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structural Computational Analysis of the Natural History of Class I aminoacyl-tRNA Synthetases Suggests their Role in Establishing the Genetic Code

(2021) Pedro Henrique Lopes Ferreira Dantas et al.   JOURNAL OF MOLECULAR EVOLUTION

Uropathogenic Escherichia coli Shows Antibiotic Tolerance and Growth Heterogeneity in an In Vitro Model of Intracellular Infection

(2021) Ivana Kerkez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Efficacy of epetraborole against Mycobacterium abscessus is increased with norvaline

(2021) Jaryd R. Sullivan et al.   PLoS Pathogens

Non-tuberculous mycobacteria and the rise of Mycobacterium abscessus

(2020) Matt D. Johansen et al.   NATURE REVIEWS MICROBIOLOGY

Mycobacterium abscessus infection leads to enhanced production of type 1 interferon and NLRP3 inflammasome activation in murine macrophages via mitochondrial oxidative stress

(2020) Bo-Ram Kim et al.   PLoS Pathogens

Mycobacterium abscessus pulmonary disease: individual patient data meta-analysis

(2019) Nakwon Kwak et al.   EUROPEAN RESPIRATORY JOURNAL

Mycobacterium abscessus and antibiotic resistance: Same as it ever was

(2019) David E Griffith   CLINICAL INFECTIOUS DISEASES

Aminoacyl-tRNA Synthetases and tRNAs for an Expanded Genetic Code: What Makes them Orthogonal?

(2019) Sergey V. Melnikov et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Non-tuberculous mycobacterial pulmonary disease

(2019) Steven Cowman et al.   EUROPEAN RESPIRATORY JOURNAL

Clinical Efficacy and Adverse Effects of Antibiotics Used to Treat Mycobacterium abscessus Pulmonary Disease

(2019) Jianhui Chen et al.   Frontiers in Microbiology

Mycobacterium abscessus, an Emerging and Worrisome Pathogen among Cystic Fibrosis Patients

(2019) Degiacomi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

In Vitro Susceptibility Testing of GSK656 against Mycobacterium Species

(2019) Wenzhu Dong et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Is there a role for tedizolid in the treatment of non-tuberculous mycobacterial disease?

(2019) Mike Marvin Ruth et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Bi-allelic Mutations in Phe-tRNA Synthetase Associated with a Multi-system Pulmonary Disease Support Non-translational Function

(2018) Zhiwen Xu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Aminoacyl-tRNA synthetases, therapeutic targets for infectious diseases

(2018) Eun-Young Lee et al.   BIOCHEMICAL PHARMACOLOGY

Mycobacterium abscessus in patients with cystic fibrosis: low impact of inter-human transmission in Italy

(2017) Enrico Tortoli et al.   EUROPEAN RESPIRATORY JOURNAL

In vitro and in vivo activity of biapenem against drug-susceptible and rifampicin-resistant Mycobacterium tuberculosis

(2017) Amit Kaushik et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656)

(2017) Xianfeng Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

British Thoracic Society guidelines for the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD)

(2017) Charles S Haworth et al.   THORAX

Relationship between Antibiotic Susceptibility and Genotype in Mycobacterium abscessus Clinical Isolates

(2017) Bing Li et al.   Frontiers in Microbiology

Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase

(2016) Andrés Palencia et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium

(2016) Josephine M. Bryant et al.   SCIENCE

Bacterial Resistance to Leucyl-tRNA Synthetase Inhibitor GSK2251052 Develops during Treatment of Complicated Urinary Tract Infections

(2014) Karen O'Dwyer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mycobacterium abscessus

(2014) Jeana L. Benwill et al.   CURRENT OPINION IN INFECTIOUS DISEASES

A bridge between the aminoacylation and editing domains of leucyl-tRNA synthetase is crucial for its synthetic activity

(2014) Qian Huang et al.   RNA

Whole-genome sequencing to identify transmission of Mycobacterium abscessus between patients with cystic fibrosis: a retrospective cohort study

(2013) Josephine M Bryant et al.   LANCET

Leucine-specific domain modulates the aminoacylation and proofreading functional cycle of bacterial leucyl-tRNA synthetase

(2013) Wei Yan et al.   NUCLEIC ACIDS RESEARCH

Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase

(2012) Tracy L Keller et al.   Nature Chemical Biology

Assessment of Clarithromycin Susceptibility in Strains Belonging to theMycobacterium abscessusGroup byerm(41) andrrlSequencing

(2010) Sylvaine Bastian et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY