Biodegradable Ca 2+ Nanomodulators Activate Pyroptosis through Mitochondrial Ca 2+ Overload for Cancer Immunotherapy

Nitric Oxide Modulating Calcium Store for Ca 2+ ‐Initiated Cancer Therapy

(2021) Xu Chu et al.   ADVANCED FUNCTIONAL MATERIALS

A Multichannel Ca 2+ Nanomodulator for Multilevel Mitochondrial Destruction‐Mediated Cancer Therapy

(2021) Pan Zheng et al.   ADVANCED MATERIALS

Ultrasound-Augmented Mitochondrial Calcium Ion Overload by Calcium Nanomodulator to Induce Immunogenic Cell Death

(2021) Pan Zheng et al.   NANO LETTERS

A Robust ROS Generation Strategy for Enhanced Chemodynamic/Photodynamic Therapy via H 2 O 2 /O 2 Self‐Supply and Ca 2+ Overloading

(2021) Jie Shen et al.   ADVANCED FUNCTIONAL MATERIALS

Biodegradable Upconversion Nanoparticles Induce Pyroptosis for Cancer Immunotherapy

(2021) Binbin Ding et al.   NANO LETTERS

Nanoscale CaH2 materials for synergistic hydrogen-immune cancer therapy

(2021) Fei Gong et al.   Chem

Metal–Organic Framework Nanoparticles Induce Pyroptosis in Cells Controlled by the Extracellular pH

(2020) Evelyn Ploetz et al.   ADVANCED MATERIALS

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

(2020) Zhibin Zhang et al.   NATURE

A bioorthogonal system reveals antitumour immune function of pyroptosis

(2020) Qinyang Wang et al.   NATURE

Eliciting Immunogenic Cell Death via a Unitized Nanoinducer

(2020) Zan Dai et al.   NANO LETTERS

Implantable Bioresponsive Nanoarray Enhances Postsurgical Immunotherapy by Activating Pyroptosis and Remodeling Tumor Microenvironment

(2020) Hongjuan Zhao et al.   ADVANCED FUNCTIONAL MATERIALS

Cell Death Mediated by the Pyroptosis Pathway with the Aid of Nanotechnology: Prospects for Cancer Therapy

(2020) Dan Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Programming cell pyroptosis with biomimetic nanoparticles for solid tumor immunotherapy

(2020) Pengfei Zhao et al.   BIOMATERIALS

Na2S2O8 Nanoparticles Trigger Antitumor Immunotherapy through Reactive Oxygen Species Storm and Surge of Tumor Osmolarity

(2020) Yang Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemotherapeutic paclitaxel and cisplatin differentially induce pyroptosis in A549 lung cancer cells via caspase-3/GSDME activation

(2019) Cheng-cheng Zhang et al.   APOPTOSIS

Eukaryotic elongation factor-2 kinase regulates the cross-talk between autophagy and pyroptosis in doxorubicin-treated human melanoma cells in vitro

(2019) Pian Yu et al.   ACTA PHARMACOLOGICA SINICA

Metformin induces human esophageal carcinoma cell pyroptosis by targeting the miR-497/PELP1 axis

(2019) Lu Wang et al.   CANCER LETTERS

Calcium-Overload-Mediated Tumor Therapy by Calcium Peroxide Nanoparticles

(2019) Meng Zhang et al.   Chem

NaCl Nanoparticles as a Cancer Therapeutic

(2019) Wen Jiang et al.   ADVANCED MATERIALS

Epigenetics-Based Tumor Cells Pyroptosis for Enhancing the Immunological Effect of Chemotherapeutic Nanocarriers

(2019) Jin-Xuan Fan et al.   NANO LETTERS

Enhanced Intracellular Ca2+ Nanogenerator for Tumor-Specific Synergistic Therapy via Disruption of Mitochondrial Ca2+ Homeostasis and Photothermal Therapy

(2018) Lihua Xu et al.   ACS Nano

Mitochondrial Ca 2+ signaling

(2018) Trayambak Pathak et al.   PHARMACOLOGY & THERAPEUTICS

Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis 

(2018) Bo Zhou et al.   CELL RESEARCH

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE