Characterization and impact of peptide physicochemical properties on oral and subcutaneous delivery
出版年份 2022 全文链接
标题
Characterization and impact of peptide physicochemical properties on oral and subcutaneous delivery
作者
关键词
-
出版物
ADVANCED DRUG DELIVERY REVIEWS
Volume 186, Issue -, Pages 114322
出版商
Elsevier BV
发表日期
2022-05-06
DOI
10.1016/j.addr.2022.114322
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- A Bidirectional Permeability Assay for beyond Rule of 5 Compounds
- (2021) Yunhai Cui et al. Pharmaceutics
- Development of an orally delivered GLP-1 receptor agonist through peptide engineering and drug delivery to treat chronic disease
- (2021) Sergei Pechenov et al. Scientific Reports
- Self-Assembly of Exendin-4-Derived Dual Peptide Agonists is Mediated by Acylation and Correlated to the Length of Conjugated Fatty Acyl Chains
- (2020) Martin Wolff et al. MOLECULAR PHARMACEUTICS
- Zwitterionic micelles efficiently deliver oral insulin without opening tight junctions
- (2020) Xiangfei Han et al. Nature Nanotechnology
- Robotic screening of intestinal drug absorption
- (2020) Abdul W. Basit et al. Nature Biomedical Engineering
- Robotically handled whole-tissue culture system for the screening of oral drug formulations
- (2020) Thomas von Erlach et al. Nature Biomedical Engineering
- The Connexin 43 Regulator Rotigaptide Reduces Cytokine-Induced Cell Death in Human Islets
- (2020) Seyed Mojtaba Ghiasi et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Molecular engineering of safe and efficacious oral basal insulin
- (2020) Frantisek Hubálek et al. Nature Communications
- Organoids to Study Intestinal Nutrient Transport, Drug Uptake and Metabolism – Update to the Human Model and Expansion of Applications
- (2020) Tamara Zietek et al. Frontiers in Bioengineering and Biotechnology
- Subcutaneous delivery of biotherapeutics: challenges at the injection site
- (2019) Joana A. D. Sequeira et al. Expert Opinion on Drug Delivery
- Intestinal Permeation Enhancers for Oral Delivery of Macromolecules: A Comparison between Salcaprozate Sodium (SNAC) and Sodium Caprate (C10)
- (2019) Caroline Twarog et al. Pharmaceutics
- Peptide-oligourea hybrids analogue of GLP-1 with improved action in vivo
- (2019) Juliette Fremaux et al. Nature Communications
- ENHANZE® drug delivery technology: a novel approach to subcutaneous administration using recombinant human hyaluronidase PH20
- (2019) Kenneth W. Locke et al. DRUG DELIVERY
- Mechanisms Influencing The Disposition Of Monoclonal Antibodies And Peptides
- (2019) Amita Datta-Mannan DRUG METABOLISM AND DISPOSITION
- The Discovery and Development of Liraglutide and Semaglutide
- (2019) Lotte Bjerre Knudsen et al. Frontiers in Endocrinology
- Hydrophobic ion-pairs and lipid-based nanocarrier systems: The perfect match for delivery of BCS class 3 drugs
- (2019) Thi Nhu Quynh Phan et al. JOURNAL OF CONTROLLED RELEASE
- Proteolysis and Oxidation of Therapeutic Proteins After Intradermal or Subcutaneous Administration
- (2019) Ninad Varkhede et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Striving Towards the Perfect In Vitro Oral Drug Absorption Model
- (2019) John P. Gleeson et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Subcutaneous Injection of Drugs: Literature Review of Factors Influencing Pain Sensation at the Injection Site
- (2019) Iris Usach et al. ADVANCES IN THERAPY
- Thrifty, Rapid Intestinal Monolayers (TRIM) Using Caco-2 Epithelial Cells for Oral Drug Delivery Experiments
- (2019) Nicholas G. Lamson et al. PHARMACEUTICAL RESEARCH
- Advances in oral peptide therapeutics
- (2019) Daniel J. Drucker NATURE REVIEWS DRUG DISCOVERY
- SEDDS: A game changing approach for the oral administration of hydrophilic macromolecular drugs
- (2018) Arshad Mahmood et al. ADVANCED DRUG DELIVERY REVIEWS
- Peptide chemistry toolbox – Transforming natural peptides into peptide therapeutics
- (2018) Miloš Erak et al. BIOORGANIC & MEDICINAL CHEMISTRY
- In vivo evaluation of an oral self-emulsifying drug delivery system (SEDDS) for exenatide
- (2018) Claudia Menzel et al. JOURNAL OF CONTROLLED RELEASE
- Impact of different hydrophobic ion pairs of octreotide on its oral bioavailability in pigs
- (2018) Sonja Bonengel et al. JOURNAL OF CONTROLLED RELEASE
- A liquid chromatography high-resolution mass spectrometry in vitro assay to assess metabolism at the injection site of subcutaneously administered therapeutic peptides
- (2018) Simone Esposito et al. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
- Enhancing oral bioavailability of cyclic RGD hexa-peptides by the Lipophilic Prodrug Charge Masking approach: Redirection of peptide intestinal permeability from paracellular to transcellular pathway
- (2018) Adi Schumacher-Klinger et al. MOLECULAR PHARMACEUTICS
- Discovery of a long-acting glucagon-like peptide-1 analog with enhanced aggregation propensity
- (2018) Mitsuaki Takeuchi et al. PEPTIDES
- In silico approaches for predicting the half-life of natural and modified peptides in blood
- (2018) Deepika Mathur et al. PLoS One
- Orally active peptides - is there a magic bullet?
- (2018) Andreas F. B. Räder et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- An intestinal paracellular pathway biased toward positively-charged macromolecules
- (2018) Khaled Almansour et al. JOURNAL OF CONTROLLED RELEASE
- Oral peptide delivery: Translational challenges due to physiological effects
- (2018) Puneet Tyagi et al. JOURNAL OF CONTROLLED RELEASE
- Transcellular stomach absorption of a derivatized glucagon-like peptide-1 receptor agonist
- (2018) Stephen T. Buckley et al. Science Translational Medicine
- Novel strategies in the oral delivery of antidiabetic peptide drugs – Insulin, GLP 1 and its analogs
- (2017) Ruba Ismail et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- If Euhydric and Isotonic Do Not Work, What Are Acceptable pH and Osmolality for Parenteral Drug Dosage Forms?
- (2017) Dieter Roethlisberger et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Differential stability of therapeutic peptides with different proteolytic cleavage sites in blood, plasma and serum
- (2017) Roland Böttger et al. PLoS One
- THPdb: Database of FDA-approved peptide and protein therapeutics
- (2017) Salman Sadullah Usmani et al. PLoS One
- Design of Potent and Proteolytically Stable Oxyntomodulin Analogs
- (2016) Avinash Muppidi et al. ACS Chemical Biology
- Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues
- (2016) P. Lundquist et al. ADVANCED DRUG DELIVERY REVIEWS
- A Helix-Stabilizing Linker Improves Subcutaneous Bioavailability of a Helical Peptide Independent of Linker Lipophilicity
- (2016) Liang Zhang et al. BIOCONJUGATE CHEMISTRY
- Insights into Protein–Ligand Interactions: Mechanisms, Models, and Methods
- (2016) Xing Du et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The molecular basis for the prolonged blood circulation of lipidated incretin peptides: Peptide oligomerization or binding to serum albumin?
- (2016) Ying Wang et al. JOURNAL OF CONTROLLED RELEASE
- Dulaglutide: A Review in Type 2 Diabetes
- (2015) Celeste B. Burness et al. BIODRUGS
- High metabolic in vivo stability and bioavailability of a palmitoylated ghrelin receptor ligand assessed by mass spectrometry
- (2015) Katja B. Kostelnik et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Oligomerization of a Glucagon-like Peptide 1 Analog: Bridging Experiment and Simulations
- (2015) Tine M. Frederiksen et al. BIOPHYSICAL JOURNAL
- Peptide Backbone Composition and Protease Susceptibility: Impact of Modification Type, Position, and Tandem Substitution
- (2015) Halina M. Werner et al. CHEMBIOCHEM
- Peptide therapeutics: current status and future directions
- (2015) Keld Fosgerau et al. DRUG DISCOVERY TODAY
- A novel in vitro method to model the fate of subcutaneously administered biopharmaceuticals and associated formulation components
- (2015) Hanne M. Kinnunen et al. JOURNAL OF CONTROLLED RELEASE
- Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide
- (2015) Jesper Lau et al. JOURNAL OF MEDICINAL CHEMISTRY
- Direct In Vivo Human Intestinal Permeability (Peff) Determined with Different Clinical Perfusion and Intubation Methods
- (2015) David Dahlgren et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Toward Oral Delivery of Biopharmaceuticals: An Assessment of the Gastrointestinal Stability of 17 Peptide Drugs
- (2015) Jie Wang et al. MOLECULAR PHARMACEUTICS
- From sewer to saviour — targeting the lymphatic system to promote drug exposure and activity
- (2015) Natalie L. Trevaskis et al. NATURE REVIEWS DRUG DISCOVERY
- An in silico platform for predicting, screening and designing of antihypertensive peptides
- (2015) Ravi Kumar et al. Scientific Reports
- Physicochemical and Formulation Developability Assessment for Therapeutic Peptide Delivery—A Primer
- (2014) Annette Bak et al. AAPS Journal
- Strategic Approaches to Optimizing Peptide ADME Properties
- (2014) Li Di AAPS Journal
- Oral Druggable Space beyond the Rule of 5: Insights from Drugs and Clinical Candidates
- (2014) Bradley Croy Doak et al. CHEMISTRY & BIOLOGY
- Improving the outcomes of biopharmaceutical delivery via the subcutaneous route by understanding the chemical, physical and physiological properties of the subcutaneous injection site
- (2014) Hanne M. Kinnunen et al. JOURNAL OF CONTROLLED RELEASE
- A Novel Suspension Formulation Enhances Intestinal Absorption of Macromolecules Via Transient and Reversible Transport Mechanisms
- (2014) Shmuel Tuvia et al. PHARMACEUTICAL RESEARCH
- Acylation of Glucagon-Like Peptide-2: Interaction with Lipid Membranes and In Vitro Intestinal Permeability
- (2014) Sofie Trier et al. PLoS One
- Pharmacokinetics of PEGylated Recombinant Human Erythropoietin in Rats
- (2014) Xiaohan Cao et al. Journal of Analytical Methods in Chemistry
- Drug Discovery and Regulatory Considerations for Improving In Silico and In Vitro Predictions that Use Caco-2 as a Surrogate for Human Intestinal Permeability Measurements
- (2013) Caroline A. Larregieu et al. AAPS Journal
- Impact of fluorination on proteolytic stability of peptides in human blood plasma
- (2013) Vivian Asante et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Spatial Configuration and Composition of Charge Modulates Transport into a Mucin Hydrogel Barrier
- (2013) Leon D. Li et al. BIOPHYSICAL JOURNAL
- Pharmacokinetics of Oral Recombinant Human Parathyroid Hormone [rhPTH(1–31)NH2] in Postmenopausal Women with Osteoporosis
- (2013) Amy Sturmer et al. CLINICAL PHARMACOKINETICS
- Pharmacokinetics and Pharmacokinetic–Pharmacodynamic Correlations of Therapeutic Peptides
- (2013) Lei Diao et al. CLINICAL PHARMACOKINETICS
- Future directions for peptide therapeutics development
- (2013) Allan A. Kaspar et al. DRUG DISCOVERY TODAY
- A systematic multitechnique approach for detection and characterization of reversible self-association during formulation development of therapeutic antibodies
- (2013) Reza Esfandiary et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- In Vitro Protein Binding of Liraglutide in Human Plasma Determined by Reiterated Stepwise Equilibrium Dialysis
- (2013) Anne Plum et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Crystal Structure of an HSA/FcRn Complex Reveals Recycling by Competitive Mimicry of HSA Ligands at a pH-Dependent Hydrophobic Interface
- (2013) Michael M. Schmidt et al. STRUCTURE
- Mechanistic Determinants of Biotherapeutics Absorption Following SC Administration
- (2012) Wolfgang F. Richter et al. AAPS Journal
- The Future of Peptide-based Drugs
- (2012) David J. Craik et al. Chemical Biology & Drug Design
- Lymphatic trafficking kinetics and near-infrared imaging using star polymer architectures with controlled anionic character
- (2012) Taryn R. Bagby et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Protein aggregation: Mechanisms and functional consequences
- (2012) Gaetano Invernizzi et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Design of the Novel Protraction Mechanism of Insulin Degludec, an Ultra-long-Acting Basal Insulin
- (2012) Ib Jonassen et al. PHARMACEUTICAL RESEARCH
- Engineering neonatal Fc receptor-mediated recycling and transcytosis in recombinant proteins by short terminal peptide extensions
- (2012) J. T. Sockolosky et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Photocrosslinked poly(ester anhydride)s for peptide delivery: Effect of oligomer hydrophobicity on PYY3-36 delivery
- (2011) Juha Mönkäre et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Long-Acting Lipidated Analogue of Human Pancreatic Polypeptide Is Slowly Released into Circulation
- (2011) Kathrin Bellmann-Sickert et al. JOURNAL OF MEDICINAL CHEMISTRY
- Analysis of protein-ligand interactions by fluorescence polarization
- (2011) Ana M Rossi et al. Nature Protocols
- Taylor Dispersion Analysis Compared to Dynamic Light Scattering for the Size Analysis of Therapeutic Peptides and Proteins and Their Aggregates
- (2011) Andrea Hawe et al. PHARMACEUTICAL RESEARCH
- Glycosylation of Therapeutic Proteins
- (2010) Ricardo J. Solá et al. BIODRUGS
- Hydrophobicity - Shake Flasks, Protein Folding and Drug Discovery
- (2010) Aurijit Sarkar et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Engineering and characterization of the long-acting glucagon-like peptide-1 analogue LY2189265, an Fc fusion protein
- (2010) Wolfgang Glaesner et al. DIABETES-METABOLISM RESEARCH AND REVIEWS
- Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic
- (2010) G. H. Bird et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- To protect peptide pharmaceuticals against peptidases
- (2010) R. Rink et al. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
- Safety and efficacy of sodium caprate in promoting oral drug absorption: from in vitro to the clinic
- (2009) Sam Maher et al. ADVANCED DRUG DELIVERY REVIEWS
- Rapid Profiling of Peptide Stability in Proteolytic Environments
- (2009) Hans H. Gorris et al. ANALYTICAL CHEMISTRY
- Peptide Retention Standards and Hydrophobicity Indexes in Reversed-Phase High-Performance Liquid Chromatography of Peptides
- (2009) Oleg V. Krokhin et al. ANALYTICAL CHEMISTRY
- Synthetic therapeutic peptides: science and market
- (2009) Patrick Vlieghe et al. DRUG DISCOVERY TODAY
- Evaluation of intestinal absorption and mucosal toxicity using two promoters. II. Rat instillation and perfusion studies
- (2009) Sam Maher et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Degarelix: a novel gonadotropin-releasing hormone blocker for the treatment of prostate cancer
- (2009) John Anderson Future Oncology
- A recombinant polypeptide extends the in vivo half-life of peptides and proteins in a tunable manner
- (2009) Volker Schellenberger et al. NATURE BIOTECHNOLOGY
- Lack of coupling between secondary structure formation and collapse in a model polypeptide that mimics early folding intermediates, the F2 fragment of the Escherichia coli tryptophan-synthase β chain
- (2009) Klaus Gast et al. PROTEIN SCIENCE
- Barrier properties of mucus
- (2008) Richard A. Cone ADVANCED DRUG DELIVERY REVIEWS
- Hydrophilic interaction liquid chromatography (HILIC) in proteomics
- (2008) Paul J. Boersema et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- Improving Oral Bioavailability of Peptides by Multiple N-Methylation: Somatostatin Analogues
- (2008) Eric Biron et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Degarelix: A Novel Gonadotropin-Releasing Hormone (GnRH) Receptor Blocker—Results from a 1-yr, Multicentre, Randomised, Phase 2 Dosage-Finding Study in the Treatment of Prostate Cancer
- (2008) Hendrik Van Poppel et al. EUROPEAN UROLOGY
- Extrinsic Fluorescent Dyes as Tools for Protein Characterization
- (2008) Andrea Hawe et al. PHARMACEUTICAL RESEARCH
- Properties of the Glomerular Barrier and Mechanisms of Proteinuria
- (2008) Börje Haraldsson et al. PHYSIOLOGICAL REVIEWS
- Reduction of IgG in nonhuman primates by a peptide antagonist of the neonatal Fc receptor FcRn
- (2008) A. R. Mezo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A versatile peptide pI calculator for phosphorylated and N-terminal acetylated peptides experimentally tested using peptide isoelectric focusing
- (2008) Sharon Gauci et al. PROTEOMICS
- Preparation, Characterization, and Application of Biotinylated and Biotin−PEGylated Glucagon-Like Peptide-1 Analogues for Enhanced Oral Delivery
- (2007) Su Young Chae et al. BIOCONJUGATE CHEMISTRY
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started