Article
Oncology
Jiakai Hou, Yunfei Wang, Leilei Shi, Yuan Chen, Chunyu Xu, Arash Saeedi, Ke Pan, Ritu Bohat, Nicholas A. Egan, Jodi A. McKenzie, Rina M. Mbofung, Leila J. Williams, Zhenhuang Yang, Ming Sun, Xiaofang Liang, Jordi Rodon Ahnert, Navin Varadarajan, Cassian Yee, Yiwen Chen, Patrick Hwu, Weiyi Peng
Summary: This study used genome-wide CRISPR immune screens to identify immunosuppressive mechanisms in non-responders to cancer immunotherapy and integrated the results with multi-omics clinical data to evaluate the role of tumor intrinsic factors in regulating two key steps of cancer immunotherapy. Two distinct types of immune resistance regulators were revealed, with PRMT1 and RIPK1 identified as potential therapeutic targets to improve the efficacy of immunotherapy. Targeting PRMT1 and RIPK1 sensitized tumors to T-cell killing and anti-PD-1/OX40 treatment, providing novel targets for rational immuno-oncology combinations.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Engineering, Biomedical
Guoxin Jing, Linnan Yang, Hong Wang, Jintong Niu, Huichao Wang, Yi Gao, Youyuan Li, Bangguo Wei, Yechang Qian, Shilong Wang
Summary: This study reveals that LDHs composed of different cations have distinct abilities to regulate the polarity of TAMs. Mg-Al LDH has a stronger ability to promote the repolarization of TAMs from M2 to M1 and inhibit the formation of MDSCs compared to Mg-Fe LDH. Additionally, Mg-Al LDH inhibits tumor growth and promotes the infiltration of activated immune cells into the TME more effectively. LDHs exert their polarization ability by inhibiting the autophagy of TAMs, and this mechanism might be related to the ionic composition of LDHs.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Li Wang, Zhuo Mao, Jie Wu, Xiaoliang Cui, Yuanjie Wang, Nailin Yang, Jun Ge, Huali Lei, Zhihui Han, Wei Tang, Shanyue Guan, Liang Cheng
Summary: Sonodynamic therapy (SDT) relies on O2 activation to generate reactive oxygen species (ROS), but limitations in sonocatalysts and the hypoxic tumor microenvironment (TME) reduce treatment efficacy. In this study, Fe-based layered double hydroxide (LDH) nanosheets were reconstructed using a local element rearrangement strategy by substituting Mg with Mn element (MMF NSs), which serve as novel sonocatalysts for high-performance SDT of cancer. The Mn substitution improves O2 generation yield and promotes electron-hole separation and lifetime under ultrasound irradiation. Additionally, the MMF NSs modulate TME and enhance breast cancer therapy by regulating the macrophage subtype ratio and promoting dendritic cell maturation. This study highlights the use of LDH-based sonocatalysts for improved SDT-enhanced immunotherapy.
Article
Chemistry, Physical
Ru Xu, Dongdong Zhang, Shuhan Chen, Jiajun Qiu, Xuanyong Liu
Summary: CoFe-layered double hydroxides (CoFe-LDH) were synthesized by a coprecipitation method and calcination treatment at different temperatures. The LDH-250 sample exhibited peroxidase-like catalytic activity and good photothermal effects. Furthermore, LDH-250 and LDH-500 showed excellent antibacterial and antitumor properties under near-infrared irradiation. In conclusion, thermally treated CoFe-LDHs with enhanced Fenton catalytic ability and photothermal property have great potential for biomedical applications.
APPLIED CLAY SCIENCE
(2023)
Article
Oncology
Dipti Thakkar, Shalini Paliwal, Bhushan Dharmadhikari, Siyu Guan, Lillian Liu, Shreya Kar, Nikhil K. Tulsian, Joshua J. Gruber, Leah DiMascio, Konrad H. Paszkiewicz, Piers J. Ingram, Jerome D. Boyd-Kirkup
Summary: This study developed the first Fc-independent anti-VISTA antibody HMBD-002, which reverses VISTA-induced immune suppression by blocking the functional domain of VISTA. The antibody has a neutralizing, non-depleting effect, effectively inhibiting tumor growth and enhancing T cell activity.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Fabiana Pani, Yoshinori Yasuda, Sylvie T. Rousseau, Kevin C. Bermea, Solmaz Roshanmehr, Rulin Wang, Srinivasan Yegnasubramanian, Patrizio Caturegli, Luigi Adamo
Summary: The pre-conditioning of the immune system can modulate the therapeutic effect of immune checkpoint inhibitors (ICI); however, the mechanisms behind this phenomenon are still unclear. This study showed that the simultaneous induction of immune-mediated thyroiditis (IET) and papillary thyroid cancer (PTC) in mice resulted in a decreased incidence of PTC in response to ICI treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Shakoora A. Sabree, Andrew P. Voigt, Sue E. Blackwell, Ajaykumar Vishwakarma, Michael S. Chimenti, Aliasger K. Salem, George J. Weiner
Summary: The study found that anti-Q beta-coated CMP-001 induces IFN-alpha production by pDCs, which has secondary effects on monocytes and enhances their response to IFN-alpha, promoting autologous CD4 T-cell proliferation. Despite exhibiting aspects of an immunosuppressive phenotype, these monocytes show increased ability to augment T-cell proliferation, shedding light on the complex mechanism of action of anti-Q beta-coated CMP-001 and providing insights into pathways to enhance the efficacy of this novel immunotherapy approach.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Chemistry, Multidisciplinary
Boda Guo, Feiya Yang, Lingpu Zhang, Qinxin Zhao, Wenkuan Wang, Lu Yin, Dong Chen, Mingshuai Wang, Sujun Han, Haihua Xiao, Nianzeng Xing
Summary: A new reactive oxygen species-sensitive polymer is designed to encapsulate elesclomol and copper, forming nanoparticles. These nanoparticles can efficiently transport copper into cancer cells and induce cell death through cuproptosis. This study combines nanomedicine-induced cuproptosis with alpha PD-L1 antibody for enhanced cancer therapy, providing a novel strategy for future cancer treatment.
ADVANCED MATERIALS
(2023)
Article
Oncology
Alex Frias, Luca Di Leo, Asier Antoranz, Loulieta Nazerai, Marco Carretta, Valerie Bodemeyer, Chiara Pagliuca, Christina Dahl, Giuseppina Claps, Giulio Eugenio Mandelli, Madhavi Dipak Andhari, Maria Pires Pacheco, Thomas Sauter, Caroline Robert, Per Guldberg, Daniel Hargbol Madsen, Francesco Cecconi, Francesca Maria Bosisio, Daniela De Zio
Summary: Loss of Ambra1 in melanoma affects the tumor immune microenvironment (TIME) and the antitumor immune response. It leads to changes in TIME composition and reduces the infiltration of regulatory T cells, resulting in accelerated tumor growth and decreased overall survival. However, loss of Ambra1 also sensitizes melanoma to anti-PD-1 treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Pharmacology & Pharmacy
Kaili Deng, Dongxue Yang, Yuping Zhou
Summary: Immune evasion is a common cause of failure in anticancer immune therapy. Nanotechnology-based siRNA delivery strategies have shown great potential for overcoming immune evasion by activating immune responses and delivering immunomodulatory agents to the tumor microenvironment. This review discusses the current advances and challenges in using nanotechnology for siRNA delivery and offers insights into therapeutic options for clinical cancer treatment.
Review
Oncology
Lei Dou, Xiangdan Meng, Huiyuan Yang, Haifeng Dong
Summary: Host-tumor immune interactions are crucial in the progression and treatment of tumors, requiring a deeper understanding and effective manipulation. Despite some breakthroughs in tumor immunotherapy, no single strategy has been able to elicit sufficient and sustained antitumor immune responses in most specific malignancy patients and adequately reshape the tolerogenic tumor immune microenvironment.
BIOMARKER RESEARCH
(2021)
Article
Oncology
Daryl Kai Ann Chia, Yong Xiang Gwee, Raghav Sundar
Summary: Immune checkpoint inhibition (ICI) is an established therapeutic option for certain tumor patients, but a significant proportion of patients exhibit resistance to this treatment. Current studies have mainly focused on intrinsic tumor factors and paid less attention to host factors. Recent research has found that the peritoneal microenvironment may affect the efficacy of ICI, as shown in a study on metastatic gastrointestinal cancer patients by investigating the presence of ascites and its impact on ICI.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Pharmacology & Pharmacy
Jiayi Ye, Bo Hou, Fangmin Chen, Shunan Zhang, Muya Xiong, Tianliang Li, Yechun Xu, Zhiai Xu, Haijun Yu
Summary: A bispecific prodrug nanoparticle was engineered to target multiple immune resistance mechanisms in tumor cells and improve cancer immunotherapy. The nanoparticle combines photodynamic therapy (PDT) to induce immunogenic cell death, providing a novel strategy for blocking immune evasion pathways.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Oncology
Robin Reschke, Jovian Yu, Blake Flood, Emily F. Higgs, Ken Hatogai, Thomas F. Gajewski
Summary: In human melanoma metastases, CD45(+) cells and Sox10(+) cells are identified as the major cellular sources for CXCL10. CXCL10 within the tumor site serves as a positive prognostic factor for response to immunotherapy, and the use of RNAscope technique is feasible in paraffin tissue. Strategies supporting effector T cell recruitment through the induction of CXCL10 may enhance the efficacy of immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Kelly Boelaars, Laura Goossens-Kruijssen, Di Wang, Charlotte M. de Winde, Ernesto Rodriguez, Dimitri Lindijer, Babet Springer, Irene van der Haar avila, Aram de Haas, Laetitia Wehry, Louis Boon, Reina E. Mebius, Nadine van Montfoort, Manfred Wuhrer, Joke M. M. den Haan, Sandra J. van Vliet, Yvette van Kooyk
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer, and immunotherapy has been unsuccessful in its treatment. This study shows that tumor-derived sialic acids play a critical role in shaping the immune landscape of PDAC. The absence of sialic acids allows for better infiltration of T cells into the tumor, resulting in improved response to immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Tao Liu, Zhibin Feng, Zhan Li, Zefeng Lin, Lingling Chen, Binglin Li, Zehua Chen, Zugui Wu, Juan Zeng, Jingwei Zhang, Jiaying Hong, Hong Xia, Lihua Li, Xiangling Ye, Ying Zhang
Summary: A mussel-inspired multifunctional hydrogel (CAC/PDA/Cu(H2O2)) was prepared, which exhibited antibacterial, anti-inflammatory, and angiogenesis-promoting properties, accelerating wound healing. The hydrogel showed excellent therapeutic effects in Methicillin-resistant Staphylococcus aureus (MRSA) induced-rat infection models, efficiently eliminating MRSA, significantly reducing inflammatory expression, promoting angiogenesis, and ultimately shortening the wound healing time.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Food Science & Technology
Li Tao, Jingyi Wang, Qiyuan Zhu, Jingwei Zhang, Yufei Li, Shixin Song, Lei Yu
Summary: This study investigated the effects of fermentation on probiotic-rich mung bean, chickpea, and tiger skin kidney bean powders. The results showed that fermentation reduced the particle size and increased the specific surface area of the bean powders, improving their dissolution rate and flowability. This study provides a technical foundation for the deep processing of bean resources.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2023)
Article
Meteorology & Atmospheric Sciences
Ping Li, Siyao Yue, Xiaoyang Yang, Di Liu, Qiang Zhang, Wei Hu, Shengjie Hou, Wanyu Zhao, Hong Ren, Gang Li, Yuanguan Gao, Junjun Deng, Qiaorong Xie, Yele Sun, Zifa Wang, Pingqing Fu
Summary: This study collected PM2.5 samples over a one-year period at the Shangdianzi station in North China to analyze its chemical and optical characteristics. The major chemical components of PM2.5 were identified, and the sources of water-soluble organic matter and water-insoluble organic matter were determined. Additionally, different types of fluorescent components were identified and their intensity varied with seasons, indicating the main impact of burning sources. This study provides insights into the chemical and optical characteristics of ambient aerosols in the background atmosphere.
ADVANCES IN ATMOSPHERIC SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Fuxin Zhang, Ruixi Zhou, Tao Yang, Kailing Yang, Saisai Xin, Jingwei Zhang, Yuqiu Li, Guanqun Zhan, Zengjun Guo
Summary: Four undescribed biflavonoid alkaloids, sinenbiflavones A-D, were isolated from Cephalotaxus sinensis using a MS/MS-based molecular networking guided strategy. Their structures were elucidated by series of spectroscopic methods (HR-ESI-MS, UV, IR, 1D, and 2D NMR). Sinenbiflavones A-D are the first examples of amentoflavone-type (C-3'-C-8'') biflavonoid alkaloids. Meanwhile, sinenbiflavones B and D are the unique C-6-methylated amentoflavone-type biflavonoid alkaloids. Sinenbiflavone D showed weak SARS-CoV-2 3CL(pro) inhibitory activity with 43% inhibition rate at 40 mu M.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Environmental Sciences
Jian Li, Tim J. Daniell, Ming-Kang Jin, Rui-Ying Chang, Tao Wang, Jing Zhang, Xiao-Ru Yang, Yong-Guan Zhu
Summary: The spread of antibiotic-resistance genes (ARGs) has become a significant threat to human health. However, little is known about the profile and drivers of ARGs in the phyllosphere, which is an important habitat for microorganisms. In this study, leaf samples were collected from different stages of plant community succession to investigate the development of phyllosphere ARGs in natural habitats. The results showed that the presence of ARGs in the phyllosphere is influenced by environmental factors such as plant community composition, host leaf properties, and the phyllosphere microbiome.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Jian Li, Ming-Kang Jin, Roy Neilson, Shi-Lin Hu, Yi-Jia Tang, Zhao Zhang, Fu-Yi Huang, Jing Zhang, Xiao-Ru Yang
Summary: This study investigates the microbial communities and abundance of genes related to nutrient cycling on the leaves of different plant species in urban and natural environments. The results show significant differences in leaf microbial communities between urban and natural habitats, with plant species being a major influencing factor. Leaf functional traits are identified as potential drivers of both phyllosphere microbial community structure and nutrient cycling gene abundance.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Di Feng, Xueyan Li, Xiaojie Fan, Yifan Guo, Jingwei Zhang, Hang Yuan, Wenjuan Wang, Tingting Zhao, Tian Han
Summary: The cytotoxicity and endocrine-disruption activity of 42 food contact silicone products (FCSPs) obtained from the Chinese market were studied. The results showed that 96% of the kitchenwares and 84% of the products showed cytotoxicity and estrogenic/anti-estrogenic/androgenic/anti-androgenic activities respectively. However, 11 bottle nipples showed no cytotoxicity or hormonal activity. Overall, it is important to detect the toxicity of final products since FCSPs can contain complex chemical substances that result in biological toxicity.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Cell Biology
Ya-ru Huang, Xi-xiu Xie, Jing Yang, Xiao-ying Sun, Xiao-yun Niu, Cheng-gang Yang, Ling-jie Li, Lun Zhang, Dan Wang, Chun-yu Liu, Sheng-jie Hou, Chen-yang Jiang, Yu-ming Xu, Rui-tian Liu
Summary: In this study, it was found that the levels of ArhGAP11A significantly increase in patients with AD and APP/PS1 mice. By reducing ArhGAP11A level in neurons, both AD generation and ADo neurotoxicity can be inhibited through the RhoA/ROCK/Erk signaling pathway. Furthermore, specific reduction of ArhGAP11A level significantly reduces AD production, plaque deposition, and improves neuronal damage, neuroinflammation, and cognitive deficits in APP/PS1 mice.
Article
Green & Sustainable Science & Technology
Tiansheng Xia, Xiujuan Fan, Jingwei Zhang, Tingting Liu
Summary: Packaging design plays a crucial role in influencing consumers' perception of the health of low-fat foods. This study developed a sequential mediation model to examine the impact of packaging complexity on consumers' purchase intentions. The results showed that increasing consumers' conceptual fluency and brand attitude could lead to higher purchase intentions. The study also highlighted the mediating role of brand attitude between packaging complexity and purchase intention.
Article
Engineering, Mechanical
Jingwei Zhang, Yuan Zhang, Yanling Zhao, Wenguang Han
Summary: The factors affecting the lubrication effect of a ball bearing without cage and containing a functional slot are analyzed, and an initial oil volume equation is established. Using the multiple mesh method and Matlab programming, the distribution rules of oil film pressure, thickness, and flow rate are obtained under different speed conditions. The experiment verifies that lubricating oil in the functional slot can have a lubricating effect, and the required initial amount of lubricating oil increases with speed.
Article
Chemistry, Applied
Li Tao, Jingyi Wang, Yihua Wei, Boyu Xiong, Jingwei Zhang, Wenfei Lan, Lei Yu
Summary: An efficient decolorization method for ginseng residue oligosaccharides (GROs) was developed using ultrasound-assisted D392 macroporous resin. The decolorization effects and color differences of activated carbon adsorption, hydrogen peroxide oxidation, and resin adsorption were compared. The ultrasound-assisted decolorization showed the best effect, reducing the decolorization time to 80 minutes and achieving the removal of most pigments.
Article
Food Science & Technology
Li Tao, Jingwei Zhang, Wenfei Lan, Lei Yu, Yunfeng Bi, Shixin Song, Boyu Xiong, Heyu Wang
Summary: This review summarizes the principles and influencing factors of polysaccharide decolorization and compares different decolorization methods. Research findings show that polysaccharide decolorization mainly focuses on plant polysaccharides, and the measurement indices for decolorization effect include decolorization ratio, polysaccharide recovery ratio, and comprehensive evaluation index. Resin adsorption is the most widely used method for polysaccharide decolorization. Structural characterization was performed to determine the impact of decolorization on polysaccharide structure and functions. The limitations of current research on polysaccharide decolorization have also been discussed.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Manufacturing
Jingwei Zhang, Yin-Da Wang, Yunqiu Wu, Kai Kang, Wen-Yan Yin
Summary: To improve the performance of on-chip interconnects, a transfer learning-based deep neural network (TL-DNN) is proposed for the inverse and fully-automatic design. The TL-DNN surrogate model consists of two DNNs, where the first DNN maps performance parameters to geometric parameters, and the second DNN is trained using electromagnetic solver space datasets. The proposed method achieves a high testing accuracy of 93.67% and requires only 6.15 hours of modeling time compared to other design methods.
IEEE TRANSACTIONS ON COMPONENTS PACKAGING AND MANUFACTURING TECHNOLOGY
(2023)
Article
Geochemistry & Geophysics
Dong Liang, Jing-Wei Zhang, Ying-Peng Tang, Sheng-Jun Huang
Summary: In this article, a novel active learning (AL) method is proposed for cost-effective aerial object detection. It considers both object-level and image-level informativeness, and incorporates an easy-to-use class-balancing criterion to address the long-tailed class distribution problem. Extensive experiments on the DOTA-v1.0 and DOTA-v2.0 benchmarks validate the effectiveness of the proposed method.
IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING
(2023)
Article
Computer Science, Theory & Methods
Gulsim Rysbayeva, Jingwei Zhang
Summary: Sequence recommendation systems are increasingly popular in various fields, aiming to predict user preferences and provide personalized recommendations. This research explores the effectiveness of Recurrent Neural Networks (RNNs), specifically Long Short-Term Memory (LSTM) and Gated Recurrent Unit (GRU), in movie and Instagram recommendation systems. The study also investigates the impact of additional user information and evaluates the performance of RNN-based systems compared to traditional approaches.
INTERNATIONAL JOURNAL OF ADVANCED COMPUTER SCIENCE AND APPLICATIONS
(2023)