Article
Immunology
Lei Ding, Wei Li, Jili Tu, Zhixing Cao, Jizheng Li, Haiming Cao, Junjie Liang, Qiangfeng Yu, Yiming Liang, Gencong Li
Summary: This study investigated the metabolic features and therapeutic benefit of immune checkpoint inhibitors (ICI) based on cuproptosis in hepatocellular carcinoma (HCC). The findings suggest that cuproptosis is correlated with metabolism, immune-related genes, and immunotherapy response. The identification of CRGPI as a potential biomarker for prognosis and immunotherapy in HCC patients provides novel insights into therapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Binfeng Liu, Zhongyue Liu, Chengyao Feng, Chenbei Li, Haixia Zhang, Zhihong Li, Chao Tu, Shasha He
Summary: In this study, a novel signature consisting of four lncRNAs related to cuproptosis was identified and found to effectively evaluate the prognosis, tumor immune microenvironment, and immunotherapy response in osteosarcoma (OS).
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
Qiang Song, Rui Zhou, Fangpeng Shu, Wen Fu
Summary: In this study, we investigated the characteristic patterns of cuproptosis and its relationship with clinical outcomes and the tumor microenvironment in bladder cancer. By establishing a cuproptosis score, we were able to predict prognosis and treatment response in bladder cancer patients. Our findings suggest that cuproptosis may play a role in the development and progression of bladder cancer through its interaction with the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Zhiyong Cai, You'e He, Zhengzheng Yu, Jiao Hu, Zicheng Xiao, Xiongbing Zu, Zhenghao Li, Huihuang Li
Summary: Two distinct cuproptosis-related patterns were identified, with different impacts on prognosis and immune cell infiltration in kidney renal clear cell carcinoma (KIRC). The cuproptosis signature and risk score can guide precision therapy and accurate prognosis prediction for KIRC patients, exhibiting excellent prediction accuracy for survival outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Huihuang Li, Xiongbing Zu, Jiao Hu, Zicheng Xiao, Zhiyong Cai, Ning Gao, Jinbo Chen
Summary: This study found that different cuproptosis patterns in bladder cancer patients are associated with tumor microenvironment phenotypes and immunotherapy efficacy. By constructing a cuproptosis risk score and signature, it is possible to accurately predict patient prognosis and immunotherapy efficacy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Binxiang Chu, Haihong Zheng, Xiaohe Zheng, Xingbing Feng, Zhenghua Hong
Summary: This study reveals the important role of cuproptosis-associated lncRNAs in sarcoma and their involvement in the formation of tumor immune microenvironment. By constructing the CuLncScore module and classification system, the prognosis of patients and tumor immune traits can be predicted. These findings provide insights into the molecular mechanisms of cuproptosis-associated lncRNAs in sarcoma and could contribute to the development of personalized therapeutic strategies targeting cuproptosis or cuproptosis-associated lncRNAs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Immunology
Shengnan Sha, Luyi Si, Xinrui Wu, Yuanbiao Chen, Hui Xiong, Ying Xu, Wangrui Liu, Haijun Mei, Tao Wang, Mei Li
Summary: This study investigates the potential role of cuproptosis-related genes (CRGs) in the tumor microenvironment (TME) of triple-negative breast cancer (TNBC). The results show that CRGs are closely associated with tumor immunity in TNBC and can be used to evaluate tumor immune cell infiltration, clinical features, and prognosis. This research provides new directions for the development of novel drugs in the future.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Shize Pan, Congkuan Song, Heng Meng, Ning Li, Donghang Li, Bo Hao, Zilong Lu, Qing Geng
Summary: The present study comprehensively examined the transcriptional and genetic alteration of cuproptosis-related genes (CRGs) in lung adenocarcinoma (LUAD), and identified their potential functions in the tumor microenvironment, clinicopathological characteristics, drug sensitivity, and prognosis. A cuproptosis-related gene score (CRG_score) was developed and validated, and its clinical application and predictive value in combination with TNM stage were established.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Zhonglin Zhu, Qiuyan Zhao, Wang Song, Junyong Weng, Shanbao Li, Tianan Guo, Congcong Zhu, Ye Xu
Summary: This study comprehensively analyzed the molecular patterns of cuproptosis in colorectal cancer and identified three distinct cuproptosis patterns associated with immune infiltration characteristics and clinical prognosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Xiao-Mao Tian, Bin Xiang, Yi-Hang Yu, Qi Li, Zhao-Xia Zhang, Chenghao Zhanghuang, Li-Ming Jin, Jin-Kui Wang, Tao Mi, Mei-Lin Chen, Feng Liu, Guang-Hui Wei
Summary: This study investigates the role of cuproptosis in pediatric neuroblastoma, and demonstrates the association of cuproptosis with prognosis and immunophenotype. A prognostic model based on cuproptosis-related genes is constructed and validated, which can accurately predict prognosis, immune infiltration, and immunotherapy response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Mingzhe Li, Qiang Song, Yunfeng Bai, Feng Hua, Tao Wu, Jun Liu
Summary: This study conducted a comprehensive analysis of the role of cuproptosis in osteosarcoma, a form of cell death induced by copper. The analysis revealed correlations between cuproptosis and clinicopathological features, survival outcomes, tumor microenvironment, immune-related scores, and therapeutic responses. The study also developed a cuproptosis-based risk prediction model and scoring system, which effectively differentiated high-risk and low-risk patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biology
Xiaona Xie, Qianzi Liu, Xuehua Zhou, Rongtao Liang, Shengbo Yang, Min Xu, Haiyang Zhao, Chengye Li, Yanfan Chen, Xueding Cai
Summary: This study classified the raw data of lung adenocarcinoma patients and explored the connection between copper-dependent cell death and tumor development, prognosis, and immune response. A reliable CRG score was established to predict overall survival and a credible nomogram was created to enhance the clinical application of the CRG score and estimate the survival probability of patients.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Review
Immunology
Wei-Qing Liu, Wan-Rong Lin, Li Yan, Wen-Hao Xu, Jun Yang
Summary: Copper is essential for enzyme activity and transcription factor function. Excess copper leads to the aggregation of DLAT and induces cuproptosis, a novel cell death modality that plays a crucial role in cancer progression and is considered a promising strategy for cancer therapy.
IMMUNOLOGICAL REVIEWS
(2023)
Article
Immunology
Shaoran Song, Miao Zhang, Peiling Xie, Shuhong Wang, Yaochun Wang
Summary: This study reveals the importance of cuproptosis in breast cancer progression, prognosis, immune cell infiltration, and immunotherapy response. By developing a scoring system, we successfully quantify the cuproptosis pattern and construct a gene signature. Patients with low CRG scores show higher immune cell infiltration, immune checkpoint expression, immune checkpoint inhibitor scores, and greater sensitivity to immunotherapy. Furthermore, RAD23B is identified as a favorable target associated with breast cancer progression, drug resistance, and poor prognosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Xinti Sun, Zesheng Li, Fei Meng, Xingqi Huang, Jianyao Wang, Jiaming Song, Linao Sun, Peng Zhang
Summary: This study comprehensively evaluated the relationship between cuproptosis-related genes and the molecular characteristics, prognosis, clinical treatment, and immune cell infiltration of tumor tissue in lung adenocarcinoma (LUAD). A CAG_score was established to predict overall survival (OS) and a reliable nomogram was created. The low CAG_score group showed lower immune cell infiltration and mutation burden, and had better prognosis and response to immunotherapy.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Letter
Oncology
Boda Guo, Ming Liu
ANNALS OF TRANSLATIONAL MEDICINE
(2020)
Article
Medicine, Research & Experimental
Boda Guo, Shengjing Liu, Miao Wang, Huimin Hou, Ming Liu
Summary: Renal cell carcinoma with liver metastasis is associated with poor prognosis, however, nephrectomy can significantly prolong overall survival in eligible patients. The study conducted using the SEER database showed that factors such as age, histologic type, and metastasis locations were significant predictors of survival in these patients.
BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2021)
Article
Neuroimaging
Ming Gao, Nana Feng, Xiang Liu, Jianhua Sun, Guangdong Hou, Lei Zhang, Hong Yin, Boda Guo, Jiayu Wu, Mengmeng Huang, Jianlin Yuan, Jun Guo, Peng Liu
Summary: This study investigated abnormal brain functional networks in lifelong PE patients and found altered degrees of centrality in regions involved in sensation, motivation, and inhibitory control processing, suggesting a relationship between these functional abnormalities and PE.
BRAIN IMAGING AND BEHAVIOR
(2021)
Article
Urology & Nephrology
Miao Wang, Yi-feng Yang, Bo-da Guo, Hui-min Hou, Ling-feng Meng, Xuan Wang, Millicent Amankwah, Bao-qiong Liu, Cheng-yue Jin, Ming Liu, Jian-ye Wang
Summary: This study found that patients with atrial fibrillation (AF) undergoing radical prostatectomy (RP) had higher rates of postoperative cardiac complications, longer hospital stays, and higher costs. Particularly in laparoscopic RP and open RP, the risk of cardiac complications was higher in AF patients.
WORLD JOURNAL OF UROLOGY
(2021)
Review
Medicine, Research & Experimental
Hai Wang, Boda Guo, Zhongming Huang, Xin Zhao, Zhigang Ji
Summary: This study found that vardenafil showed significant efficacy in the treatment of erectile dysfunction in men, significantly improving multiple evaluation indicators. However, further research is needed to determine the optimal dosage and course of vardenafil.
ADVANCES IN THERAPY
(2021)
Article
Andrology
Jun Guo, Fu Wang, Qing Zhou, Qiang Geng, Qinghe Gao, Rui Zhang, Chunhe Zhang, Zhihua Xuan, Jian Cai, Bin Bin, Qiang Han, Boda Guo, Bin Yan, Jiwei Zhang, Elena Colonnello, Emmanuele A. Jannini
Summary: Combined therapy with Qiaoshao formula and dapoxetine is safe and effective in treating premature ejaculation, especially for patients with severe symptoms and younger age. The treatment significantly prolongs perceived intravaginal ejaculation latency time and improves overall satisfaction of patients and their partners.
Letter
Medicine, Research & Experimental
Boda Guo, Ming Liu
JOURNAL OF TRANSLATIONAL MEDICINE
(2020)
Letter
Andrology
Boda Guo, Ming Liu
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2021)
Letter
Urology & Nephrology
Boda Guo, Ming Liu
JOURNAL OF UROLOGY
(2021)
Article
Chemistry, Multidisciplinary
Qinxin Zhao, Ganghao Liang, Boda Guo, Wenkuan Wang, Chao Yang, Dong Chen, Feiya Yang, Haihua Xiao, Nianzeng Xing
Summary: A reactive oxygen species (ROS)-responsive polyphotosensitizer-based nanoparticle (NP2) is designed to inhibit GST activity and cisplatin deactivation, as well as stimulate antitumor immune response, thus providing a new paradigm for the multimodal treatment of tumors.
Letter
Urology & Nephrology
Boda Guo, Ming Liu
JOURNAL OF UROLOGY
(2021)
Letter
Oncology
Boda Guo, Ming Liu
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2021)
Article
Oncology
Hai Wang, Zhongming Huang, Xin Zhao, Boda Guo, Zhigang Ji
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2020)
Article
Medicine, Research & Experimental
Boda Guo, Xin Chen, Miao Wang, Huimin Hou, Zhipeng Zhang, Ming Liu
MEDICAL SCIENCE MONITOR
(2020)