Article
Biochemistry & Molecular Biology
Ziqiang Zhou, Xuejuan Zhang, Lijun Xu, Huangjie Lu, Yuying Chen, Chuanbin Wu, Ping Hu
Summary: In this study, a novel hydrogel was designed as a wound dressing material for diabetic wounds. The hydrogel showed good biocompatibility and enhanced wound healing in diabetic rats.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Huishuang Yin, Peiqin Song, Xingyu Chen, Qiuyan Huang, Huihua Huang
Summary: In this research, a composite self-healing hydrogel with pH sensitivity for drug delivery was prepared using cellulose and chitosan from hericium erinaceus residues and pineapple peel. The hydrogel showed suitable gel time, good absorbent ability, self-healing characteristic, and controlled release of rutin.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Nanoscience & Nanotechnology
Jinfeng Cao, Ping Wu, Qianqian Cheng, Chen He, Yun Chen, Jinping Zhou
Summary: A new type of injectable CMCh hydrogel wound dressing with self-healing properties is constructed using coordination bonds and alkali/urea aqueous solutions. The hydrogel exhibits self-healing, self-adaption, and thermoresponsive ability, significantly accelerating skin tissue regeneration and wound closure. It has great potential in tissue engineering applications.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Nanoscience & Nanotechnology
Xia Qiu, Jiamin Zhang, Lilong Cao, Qin Jiao, Junhao Zhou, Lijun Yang, Hong Zhang, Yuping Wei
Summary: Dextran-based hydrogels with zwitterionic structures showed faster wound healing rates compared to natural dextran hydrogel and commercial dressings, attributed to their protein resistance and ability to scavenge free radicals. These hydrogels also demonstrated excellent cytocompatibility and antibacterial properties, along with self-healing capabilities for irregular wounds, providing a new pathway for multifunctional polysaccharide hydrogels in wound treatment and pain relief during dressing changes.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Nanoscience & Nanotechnology
Ye Wang, Changyuan He, Chong Chen, Wentao Dong, Xuekun Yang, Ye Wu, Qingquan Kong, Bin Yan
Summary: In this study, an injectable zwitterionic hydrogel with excellent self-healing property, good cytocompatibility, and antibacterial adhesion was developed. The hydrogel showed a distinct thermal-induced sol-gel transition and could be easily applied to complex wounds. It possessed rapid self-healing ability and low cytotoxicity, and effectively prevented bacterial adhesion, promoting wound healing.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Polymer Science
Pavel Yudaev, Yaroslav Mezhuev, Evgeniy Chistyakov
Summary: This review examines the use of dressings containing nanoparticles for wound repair and evaluates their antimicrobial effects and healing actions. The analysis of 31 sources published between 2021 and 2022 demonstrates a trend towards the development of modern antibacterial wound-healing nanomaterials.
Article
Chemistry, Applied
Jhaleh Amirian, Yue Zeng, Mehdihasan Shekh, Gaurav Sharma, Florian J. Stadler, Jun Song, Bing Du, Yanxia Zhu
Summary: By adjusting the content of amine and aldehyde groups from AP and OC, the properties of the hydrogel can be controlled to have desirable gelation time, swelling capability, high hemocompatibility and biocompatibility. The AP-OC-65 hydrogel, in particular, stands out with superior swelling capability and better hemo- and bio-compatibility, showing great potential for applications in wound dressing or skin substitute.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Applied
Chuang Li, Tao Jiang, Cong Zhou, Ankang Jiang, Cuifen Lu, Guichun Yang, Junqi Nie, Feiyi Wang, Xiaofan Yang, Zhenbing Chen
Summary: Promoting the healing of diabetic wounds is a major challenge, but Chitosan-based POSS-PEG hybrid hydrogels show excellent healing properties with strong mechanical strength, self-healing efficiency, cytocompatibility, and antibacterial properties.
CARBOHYDRATE POLYMERS
(2023)
Article
Biochemistry & Molecular Biology
Cem Bayram
Summary: The gelation kinetics between glycerol multi-aldehyde (GMA) and carboxymethyl chitosan (CMCS) were investigated in this study, and the self-healing ability of the hydrogels was evaluated. The results showed that hydrogels with 3-4% CMCS and 0.5-1% GMA concentrations exhibited the highest self-healing capacity. Moreover, the hydrogels showed no acute cytotoxicity on mammalian cells, indicating their potential use in tissue engineering applications for soft tissues.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Environmental
Yao Wu, Zhaoyu Yang, Xuexuan Li, Teng Li, Jun Zheng, Mingrui Hu, Zhe Yu, Weikang Luo, Wei Zhang, Fei Zheng, Tao Tang, Yang Wang
Summary: This study successfully develops a self-assembled hydrogel that integrates easy absorption, satisfactory injectability, rapid self-healing property, and multiple therapeutic effects. The hydrogel exhibits good adhesion and easy peeling off from tissues, allowing for percutaneous absorption within a short time. It shows broad-spectrum antibacterial activities without cytotoxicity and promotes wound healing through various effects. Additionally, it can induce anti-inflammatory macrophages. This research provides an environmentally friendly and efficient design for complicated wound treatment.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Materials Science, Multidisciplinary
Shuyuan Wu, Zhuojun Zhang, Ran Xu, Shuo Wei, Feng Xiong, Wenzhuo Cui, Biyun Li, Ye Xue, Hongyun Xuan, Huihua Yuan
Summary: This study developed a multifunctional self-healing hydrogel as a wound dressing, which demonstrated strong tissue adhesion, spray film-forming ability, and excellent bioactivity. The hydrogel exhibited rapid self-healing performance, robust mechanical strength, and strong adhesion, as well as spray film-forming ability, hemostatic property, antibacterial property, and good biocompatibility. It is a promising candidate for full-thickness skin wound healing.
MATERIALS & DESIGN
(2022)
Article
Chemistry, Multidisciplinary
Rui Yu, Zhenlong Li, Guoying Pan, Baolin Guo
Summary: Wounds on stretchable parts of the human body cause prolonged suffering and involve more severe healing processes than wounds on stationary parts. However, they have received insufficient attention compared with other types of chronic wounds. In this study, a novel supramolecular gelatin (GT) hydrogel composed of GT-graft-aniline tetramer and quaternized chitosan was presented. The hydrogel exhibited flexibility, self-healing, and tissue adhesiveness and well adapted to motion wounds. Moreover, it showed bioactive properties such as conductivity, antioxidant, hemostatic, antibacterial, and photothermal effects. In MRSA-infected motional wound healing experiment, this hydrogel demonstrated significantly enhanced wound healing efficacy with fast wound closure, mild inflammatory response, high collagen deposition, and enhanced re-epithelialization. The hydrogel has great potential in wound healing and skin tissue engineering, serving as an inspiration for the design of supramolecular biomaterials.
SCIENCE CHINA-CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Qida Zong, Shiya Zhou, Jing Ye, Xinxuan Peng, Huiying Wu, Mohan Li, Xuanjiayi Ye, Naixin Tian, Wei Sun, Yinglei Zhai
Summary: A hydrogel matrix (MTC-Ban-b-PEG6k-b-MTC-Ban, MBP) was prepared by ring opening polymerization using aldehyde modified aliphatic cyclic carbonate monomer (MTC-Ba) and polyethylene glycol (PEG) as the initiator. The resulting self-healing hydrogel (SH-Gel) was covalently linked with adipic acid dihydrazide (ADH) through dynamic hydrazide bond. Curcumin was also loaded into the hydrogel as a functional model drug. The hydrogel exhibited porosity, injectability, appropriate swelling rate, friendly cell compatibility, and safe degradability. In vivo wound healing evaluation, histological evaluation, and immunofluorescence staining confirmed the effectiveness of the hydrogel in promoting wound closure, re-epithelium, and collagen regeneration.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Engineering, Biomedical
Zhengzhe Han, Lanlan Dong, Ang Li, Zongyue Li, Landie Fu, Zhichang Zhang, Xiang Li, Xiaolin Li
Summary: This study designed a P-sEVs@hydrogel wound dressing that accelerates angiogenesis and wound healing, achieving fast healing in a full-thickness defect wound model.
MATERIALS TODAY BIO
(2022)
Review
Chemistry, Multidisciplinary
Yongping Liang, Jiahui He, Baolin Guo
Summary: Hydrogels have shown promising advantages as wound dressings due to their excellent biochemical and mechanical properties. This review summarizes the advanced functions of hydrogel dressings, such as antimicrobial, adhesion, hemostasis, anti-inflammatory, substance delivery, self-healing, stimulus response, and conductivity, as well as the emerging wound monitoring feature. The potential applications for different types of wounds, including chronic wounds and focus on infected, burn, and diabetic wounds, are discussed, along with proposed future directions for hydrogel wound dressings in wound healing.
Article
Nanoscience & Nanotechnology
Ding Zhou, Shangzhi Li, Minjie Pei, Hongjun Yang, Shaojin Gu, Yongzhen Tao, Dezhan Ye, Yingshan Zhou, Weilin Xu, Pu Xiao
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Polymer Science
Xing Liu, Adrien Baldit, Emilie de Brosses, Frederic Velard, Ghislaine Cauchois, Yun Chen, Xiong Wang, Natalia de Isla, Cedric Laurent
Article
Nanoscience & Nanotechnology
Jinfeng Cao, Ping Wu, Qianqian Cheng, Chen He, Yun Chen, Jinping Zhou
Summary: A new type of injectable CMCh hydrogel wound dressing with self-healing properties is constructed using coordination bonds and alkali/urea aqueous solutions. The hydrogel exhibits self-healing, self-adaption, and thermoresponsive ability, significantly accelerating skin tissue regeneration and wound closure. It has great potential in tissue engineering applications.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Materials Science, Paper & Wood
Yanteng Zhao, Qiankun Yang, Qianqian Cheng, Junjie Ai, Mengna Feng, Chengshuang Wang, Xianping Lv, Meng He, Yun Chen
Summary: By in situ synthesizing PPy, the electrical conductivity and mechanical properties of HEC/SPI sponges were improved without affecting their cytocompatibility and hemocompatibility, showing potential application in tissue engineering that requires electrical conductivity for stimulation or sensing.
Article
Engineering, Biomedical
Xianzhen Dong, Ping Wu, Lesan Yan, Kun Liu, Wenying Wei, Qiang Cheng, Xinyue Liang, Yun Chen, Honglian Dai
Summary: This study explores the effect of an oriented nanofiber/Deferoxamine (DFO) scaffold in the construction of a favorable regenerative microenvironment for nerve regeneration. In vitro experiments showed that the scaffold sustained release of DFO, promoting the migration and tube formation of endothelial cells and the expression of angiogenesis-related genes. The physical cues provided by the nanofibers regulated macrophage polarization and reduced the expression of inflammatory factors. In vivo results demonstrated reduced inflammation and enhanced nerve regeneration with the use of the oriented nanofibrous scaffold and in-situ release of DFO.
Article
Cell & Tissue Engineering
Minhao Wu, Yufeng Zhang, Ping Wu, Feixiang Chen, Zhiqiang Yang, Sheng Zhang, Lingfei Xiao, Lin Cai, Chong Zhang, Yun Chen, Zhouming Deng
Summary: The study successfully developed LYN/HA-coated hybrid scaffolds with dual therapeutic actions, promoting osteogenesis and inhibiting osteoclastogenesis, and confirmed their excellent performance and effects through experimental validations.
NPJ REGENERATIVE MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Ping Chen, Chao Xu, Ping Wu, Kun Liu, Feixiang Chen, Yun Chen, Honglian Dai, Zhiqiang Luo
Summary: The study developed a high-performance 3D piezoelectric scaffold with ultrasound-driven wireless electrical stimulation for repairing spinal cord injuries in rats. This scaffold can accelerate motor function recovery and enhance spinal cord injury repair.
Article
Nanoscience & Nanotechnology
Lili Deng, Liu Wang, Li Li, Zuguang Gong, Ruilan Wang, Wendi Fei, Yingshan Zhou, Fang Wang
Summary: This study presents a hemostatic gauze dressing based on N-carboxyethyl chitosan (CECS) gelling fibers. The CECS fibrillar gauze combines the ultra-hydrophilic, cationic chemical property of the fiber components with the fluffy nonwoven material form, exhibiting good conformability for wound filling, high fluid uptaking capacity, and enhanced bloodconcentrating effect. In a swine femoral artery injury model, the CECS fibrillar gauze achieves shorter time to hemostasis and less blood loss compared with commercially available hemostatic dressings. This chitosan gelling fiber gauze demonstrates comparable bioabsorbability to clinically used absorbable hemostat and thus may be applied to treat fatal hemorrhage both in emergency medical services and in internal surgical procedures.
ACS APPLIED BIO MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Zonglei Wang, Yuli Wang, Han Wang, Hanlin Gang, Naidan Zhang, Yingshan Zhou, Shaojin Gu, Yan Zhuang, Weilin Xu, Guizhen Ke, Zhongyu Li, Hongjun Yang
Summary: In this study, a biobased adhesive, MAG-PETMP (MP), was prepared from magnolol (MAG) and pentaerythritol tetra (3-mercaptopropionate) (PETMP) by thiol-ene click chemistry reaction, inspired by the adhesion mechanisms of barnacles and mussels. The MP adhesive exhibited high bond strength with other substrates due to hydrogen bonds at the interface and showed excellent thermal stability, solvent resistance, and mechanical strength. The cross-linking degree of MP could be easily controlled by adjusting the molar ratio of MAG and PETMP. This work provides a biomimetic strategy for the application of MAG in adhesives.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Tingting Wan, Penghui Fan, Mengfan Zhang, Kai Shi, Xiao Chen, Hongjun Yang, Xin Liu, Weilin Xu, Yingshan Zhou
Summary: The study synthesized modified hyaluronic acid to prepare a hydrogel with rapid gelling capacity and improved compressive strength, which was then used to create high-resolution hydrogel scaffolds via 3D printing. The hydrogel exhibited good structural stability, cytocompatibility, and the ability to support cell adherence, showing great potential for tissue engineering scaffolds.
ACS APPLIED BIO MATERIALS
(2022)
Article
Materials Science, Biomaterials
Hongyu Liu, Yanan Zhao, Jun Tong, Xiaowen Shi, Yun Chen, Yumin Du
Summary: The study demonstrates that a new type of chitosan-based nerve-guide hydrogel conduit fabricated using one-step electrofabrication technology has enhanced mechanical flexibility. The CNHC shows cytocompatibility by promoting cell proliferation and adhesion, and is able to guide axon growth to reach a distal stump, indicating great potential in peripheral nerve regeneration.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Materials Science, Biomaterials
Yanteng Zhao, Yinping Li, Qiaoyue Du, Qiang Zhang, Xianping Lv, Qiankun Yang, Peter R. Chang, Debbie P. Anderson, Meng He, Yun Chen
JOURNAL OF MATERIALS CHEMISTRY B
(2019)
Article
Materials Science, Biomaterials
Jianwei Zhang, Shuai Xue, Xinyi Zhu, Yanan Zhao, Yun Chen, Jun Tong, Xiaowen Shi, Yumin Du, Zibiao Zhong, Qifa Ye
JOURNAL OF MATERIALS CHEMISTRY B
(2019)
