Article
Biochemistry & Molecular Biology
Ziqiang Zhou, Xuejuan Zhang, Lijun Xu, Huangjie Lu, Yuying Chen, Chuanbin Wu, Ping Hu
Summary: In this study, a novel hydrogel was designed as a wound dressing material for diabetic wounds. The hydrogel showed good biocompatibility and enhanced wound healing in diabetic rats.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Polymer Science
Chunxiang Mo, Li Xiang, Yuping Chen
Summary: Injectable hydrogel has great potential in disease treatment and tissue engineering, but damage often occurs during injection and use, leading to rapid degradation and material leakage. Self-healing hydrogels, especially those based on the Schiff base reaction, can automatically repair structural defects and restore function, making them ideal for biological applications such as drug delivery and cell therapy.
MACROMOLECULAR RAPID COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Lei Nie, Qianqian Wei, Meng Sun, Peng Ding, Ling Wang, Yanfang Sun, Xiaoyue Ding, Oseweuba Valentine Okoro, Guohua Jiang, Amin Shavandi
Summary: One major shortcoming of biopolymeric based wound dressing is the lack of an integrated multi-functional system. This study designed hydrogels with fast gel-forming, porous structure, stable storage modulus, suitable swelling capacity, tissue adhesion, transmission property, self-healing behavior, injectability, inherent antibacterial properties, and biocompatibility. Furthermore, Baicalein could be encapsulated into the hydrogels and its release behavior could be regulated. This study provides new insights into designing multi-functional hydrogels as a wound dressing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Haolei Shi, Dongxu Ma, Di Wu, Xiao Qiu, Shuai Yang, Yingying Wang, Lei Xiao, Xinyao Ji, Wei Zhang, Shuaiyuan Han, Pengfei Huo, Jidong Dong, Xianzhi Kong, Xue Guan, Dawei Zhang
Summary: A smart hydrogel with pH-responsive, injectable, and self-healing properties was prepared for controlled drug release. The hydrogel demonstrated tunable drug release rate and shape, and showed no cytotoxicity. Animal experiments revealed favorable biodegradability and compatibility of the hydrogel.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Lin Zhao, Zhipan Feng, Yang Lyu, Jueying Yang, Lizhi Lin, Haochen Bai, Yujing Li, Yongqiang Feng, Yu Chen
Summary: An electroactive hydrogel was constructed by rapidly forming dynamic imine bonds between oxidized sodium alginate (OSA) and carboxymethyl chitosan (CMCS), and in situ forming silver nanoparticles (AgNPs) by UV irradiation. The hydrogel exhibited injectability, self-healing ability, biocompatibility, and antibacterial activities. It promoted cell proliferation and accelerated wound healing in a skin defect model.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Pengpeng Deng, Lichao Yao, Juanjuan Chen, Zhigang Tang, Jinping Zhou
Summary: AC hydrogels can accelerate wound healing, with self-healing, low swelling rate, biocompatibility, and excellent hemostatic effect. They also show outstanding antibacterial activity and can be used for designing multifunctional dressings.
CARBOHYDRATE POLYMERS
(2022)
Article
Nanoscience & Nanotechnology
Jinfeng Cao, Ping Wu, Qianqian Cheng, Chen He, Yun Chen, Jinping Zhou
Summary: A new type of injectable CMCh hydrogel wound dressing with self-healing properties is constructed using coordination bonds and alkali/urea aqueous solutions. The hydrogel exhibits self-healing, self-adaption, and thermoresponsive ability, significantly accelerating skin tissue regeneration and wound closure. It has great potential in tissue engineering applications.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Cem Bayram
Summary: The gelation kinetics between glycerol multi-aldehyde (GMA) and carboxymethyl chitosan (CMCS) were investigated in this study, and the self-healing ability of the hydrogels was evaluated. The results showed that hydrogels with 3-4% CMCS and 0.5-1% GMA concentrations exhibited the highest self-healing capacity. Moreover, the hydrogels showed no acute cytotoxicity on mammalian cells, indicating their potential use in tissue engineering applications for soft tissues.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Huishuang Yin, Peiqin Song, Xingyu Chen, Qiuyan Huang, Huihua Huang
Summary: In this research, a composite self-healing hydrogel with pH sensitivity for drug delivery was prepared using cellulose and chitosan from hericium erinaceus residues and pineapple peel. The hydrogel showed suitable gel time, good absorbent ability, self-healing characteristic, and controlled release of rutin.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Applied
Yajie Zhong, Farzad Seidi, Yilin Wang, Ling Zheng, Yongcan Jin, Huining Xiao
Summary: An injectable self-healing hydrogel with inherent antibacterial activity was developed by forming dynamic covalent bonds between boronic acid and catechol groups in quaternized chitosan, along with encapsulating EGCG. The hydrogels showed excellent dual functions of antibacterial and antioxidant properties, and demonstrated good biocompatibility and contact-active antibacterial activity. In vivo evaluation showed the hydrogels' regenerative wound healing performance, highlighting their potential as novel wound dressings for wound management.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Applied
Chuang Li, Tao Jiang, Cong Zhou, Ankang Jiang, Cuifen Lu, Guichun Yang, Junqi Nie, Feiyi Wang, Xiaofan Yang, Zhenbing Chen
Summary: Promoting the healing of diabetic wounds is a major challenge, but Chitosan-based POSS-PEG hybrid hydrogels show excellent healing properties with strong mechanical strength, self-healing efficiency, cytocompatibility, and antibacterial properties.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Applied
Taravat Khodaei, Jhamak Nourmohammadi, Azadeh Ghaee, Zohreh Khodaii
Summary: This study developed a novel antibacterial, self-healing hydrogel made from aldehyde-carrageenan. The hydrogel was synthesized by oxidizing carrageenan and adding dopamine and zinc ions. The hydrogel showed excellent properties, including rapid recovery, reduced weight loss, antibacterial effects against E. coli, and enhanced collagen secretion and cell attachment. The hybrid hydrogel has great potential for wound healing applications.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Applied
Xiaojing Zhang, Yang Meng, Weiwei Shen, Jingcheng Dou, Ruixue Liu, Qingxian Jin, Shaoming Fang
Summary: This study successfully prepared a family of injectable nanocomposite hydrogels through the Schiff base reaction between OCAPS, CS, and HPC, demonstrating good biocompatibility and biodegradability. The addition of OCAPS enhanced the mechanical properties and drug load efficiency of the hydrogels, showing great potential for drug delivery and tissue engineering applications.
REACTIVE & FUNCTIONAL POLYMERS
(2021)
Article
Chemistry, Applied
Kepeng Hu, Erna Jia, Qimeng Zhang, Wei Zheng, Rongjiao Sun, Mengao Qian, Ying Tan, Wanle Hu
Summary: Tea tree oil (TTO) is encapsulated into the hydrogel network via a previous emulsification process, and a tough and antibacterial injectable hydrogel is synthesized by the Schiff base reaction between carboxymethyl chitosan (CMCS) and genipin (GP). The obtained hydrogels exhibit high adhesive strength (about 162.75 kPa), excellent antibacterial properties (over 90%), and great biocompatibility. The heterogeneous hydrogel shows good slow-release properties of TTO for accelerated healing of complex anal fistula wounds according to an anal fistula-like wound healing experiment.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Applied
Jianqun Wang, Wenxia Xu, Wenxuan Zhang, Junlong Da, Lixue Liu, Xiaowei Huang, Chubo Yang, Yuanbo Zhan, Han Jin, Ying Li, Bin Zhang
Summary: This study develops a chitosan injectable hydrogel based on catechol and 4-glutenoic acid to avoid swelling and promote wound healing. The hydrogel controls its swelling by forming hydrophobic alkyl chains. It exhibits good injectable and adhesive properties, and possesses antibacterial and coagulation functions. Furthermore, it accelerates wound healing and demonstrates effective hemostasis in liver and femoral artery defects in mice. Overall, this non-swelling injectable hydrogel shows promise as a treatment for defect repair.
CARBOHYDRATE POLYMERS
(2023)
Article
Biochemistry & Molecular Biology
Mehdihasan I. Shekh, Guangming Zhu, Wei Xiong, Weiling Wu, Florian J. Stadler, Dijit Patel, Chengtian Zhu
Summary: By forming multi-dynamic interactions and strong covalent interactions, stretchable, self-recoverable, conductive, and tough nanocomposite hydrogels (NCHGs) were successfully synthesized. These NCHGs exhibited high mechanical strength, toughness, stretchability, elasticity, and conductivity. The presence of Fe(III) ions and conducting fillers endowed excellent repeatability and stability in resistance change, along with ultra-broad sensitivity and minimal resistance change.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Environmental Sciences
Saud Hashmi, Rafiq Ahmed, Adeel ur Rehman, Alberto Garcia-Penas, Awan Zahoor, Firoz Khan, Mohammad Vatankhah-Varnosfaderani, Thamraa Alshahrani, Florian J. Stadler
Summary: Hybrid hydrogels based on n-isopropylacrylamide, zwitterionic comonomer, and graphene oxide were synthesized to study their physical and mechanical properties. The compositional variation greatly affected the swelling characteristics of the hybrid hydrogels, while the mechanical properties such as elongation and compression were less influenced. Rheometric swelling measurements showed a strong covalent network, which increased with increasing content of zwitterions and GO. Kinetics of swelling followed Fickian dynamics and 2-step swelling pattern was observed for zwitterion-containing gels. The study also observed differences in swelling mechanism between hydrogels with 2D GO nano-fillers and 1D CNT nano-fillers, and differences in mechanical properties between elongation and compression modes.
Review
Energy & Fuels
Amit Kumar, Atul Khosla, Sunil Kumar Sharma, Pooja Dhiman, Gaurav Sharma, Lalitha Gnanasekaran, Mu. Naushad, Florian J. Stadler
Summary: This article provides a review on the transition from Z-scheme to S-scheme photocatalytic materials, discussing different types of heterojunctions and charge transfer mechanisms. It also presents the synthetic routes to S-scheme heterojunctions and highlights their current applications in pollutant degradation, hydrogen production, and CO2 conversion. The commercialization status and existing readiness and bottlenecks of S-scheme heterojunctions are also discussed.
Article
Environmental Sciences
Pooja Dhiman, Garima Rana, Elmuez A. Dawi, Amit Kumar, Gaurav Sharma, Arun Kumar, Jayati Sharma
Summary: In this paper, a moderate band gap Nd-substituted Ni-Zn ferrite is synthesized as a nano photo catalyst. The Nd substitution significantly affects the crystallite size, shape, band gap, and magnetic characteristics of the ferrite. The Nd-doped catalyst shows enhanced degradation efficiency of methylene blue dye under solar light irradiation. The photocatalytic activity is attributed to the presence of oxygen vacancies and the mixed valence state of Ni, Fe, and Nd.
Article
Chemistry, Multidisciplinary
Jun-Feng Liu, Zhan-Yu Wu, Florian J. Stadler, Yan-Fei Huang
Summary: The incorporation of ionic liquids (ILs) in solid-state polymer electrolytes (iono-SPEs) greatly enhances Li+ transport in polymer phases. By using a poly (vinylidene fluoride-trifluoroethylene-chlorotrifluoroethylene) (PTC) as the framework of ILs, non-uniform Li+ transport among different phases is reduced. This is achieved through weaker adsorption energy of IL cations on PTC chains compared to PVDF and the higher dielectric constant of PTC facilitating the dissociation of Li-anions clusters. The LiFePO4/PTC iono-SPE/Li cells show stable cycling performance with high capacity retention after 1000 cycles at 1 C and 25 degrees C. This work provides a novel approach to induce uniform Li+ flux in iono-SPEs through polarity and dielectric design of the polymer matrix.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Biochemistry & Molecular Biology
Jhaleh Amirian, Jacek K. Wychowaniec, Ehsan Amel Zendehdel, Gaurav Sharma, Agnese Brangule, Dace Bandere
Summary: Hydrogels have become popular in tissue engineering and regenerative medicine for their biocompatibility, tunable degradation, and low immunogenicity. Silk fibroin (SF) is a commonly used biopolymer due to its known biocompatibility and range of mechanical properties. However, its simple structure limits its usability. One emerging strategy is the chemical functionalization of SF, allowing for versatile processing and making SF a useful bioink for 3D printing.
Article
Chemistry, Multidisciplinary
Stephan Handschuh-Wang, Muhammad Rauf, Tao Wang, Tiansheng Gan, Florian J. Stadler
Summary: This article introduces liquid metals as materials that can visually demonstrate extreme modulation of interfacial tension and possess a high degree of sustainability. Therefore, we recommend the use of liquid metals in chemical education in schools and universities.
CHEMIE IN UNSERER ZEIT
(2023)
Article
Biochemistry & Molecular Biology
Shi-Chang Wang, Shu-Tong Du, Saud Hashmi, Shu-Ming Cui, Ling Li, Stephan Handschuh-Wang, Xuechang Zhou, Florian J. Stadler
Summary: This study investigates the rheological properties of dual-network hydrogels based on acrylamide and sodium alginate under large deformations. The concentration of calcium ions affects the nonlinear behavior, and all gel samples exhibit strain hardening, shear thickening, and shear densification. The paper focuses on the systematic variation of the alginate concentration and the Ca2+ concentration in order to understand their impact on the hydrogel's properties.
Article
Biochemistry & Molecular Biology
Pooja Dhiman, Garima Rana, Amit Kumar, Elmuez A. Dawi, Gaurav Sharma
Summary: Antibiotic water contamination is a growing environmental problem, requiring water treatment for reduction and elimination. Photocatalysts have received significant attention for their role in resolving this issue by degrading non-biodegradable organic matter in polluted water. In this study, rare earth doped ZnO nanoparticles were successfully synthesized and characterized for their structural, optical, and magnetic properties. The dye degradation efficiency of these nanoparticles was also evaluated, with Dy doped ZnO nanoparticles showing the highest degradation efficiency for tetracycline, Malachite green, and Crystal violet dyes.
Article
Polymer Science
Gaurav Sharma, Alberto Garcia-Penas, Yaksha Verma, Amit Kumar, Pooja Dhiman, Florian J. Stadler
Summary: This study successfully designed shape-oriented hydrogel nanospheres using a facile ultrasonication-supported crosslinked copolymerization technique. The chitosan-cl-poly(MMA) hydrogel nanospheres were characterized and found to have optimal rhodamine B dye adsorption capacity at pH 5. Nanohydrogel concentration also affected the adsorption capacity and percentage.
Article
Materials Science, Composites
Ge-Ge Zheng, Xin Lin, Zhen-Xing Wen, Yu-Hao Ding, Rui-Hui Yun, Gaurav Sharma, Amit Kumar, Florian J. Stadler
Summary: Photocatalytic degradation is crucial for wastewater treatment, and efficient degradation relies on photocatalytic systems with excellent light absorption, carrier separation efficiency, and surface-active sites. S-type heterojunctions, especially the BiFeO3/ZnIn2S4 heterojunction, show remarkable potential for efficient degradation. This study focuses on enhancing the photocatalytic degradation performance by introducing sulfur vacancy defects and morphology modifications to ternary indium metal sulfide and bismuth ferrite nanofibers. The optimized 30% BiFeO3/ZnIn2S4 heterojunction exhibits superior photocatalytic performance, with high sulfur vacancy concentration and enhanced electron transport efficiency. It achieved a remarkable 99% degradation of Evans blue within 45 minutes and a significant 68% degradation of ciprofloxacin within 90 minutes. These results provide a feasible approach for developing photocatalysts to address water pollution issues under practical conditions.
JOURNAL OF COMPOSITES SCIENCE
(2023)
Article
Education, Scientific Disciplines
Stephan Handschuh-Wang, Florian J. Stadler
Summary: New experiments on redox reactions at the liquid metal (Galinstan) interface are presented in this article. These experiments link redox reactions with standard potentials and metallurgy. The experiments offer a simple setup, easy handling without hazardous chemicals, a quick visual and memorable access to redox reactions, as well as the ability to reclaim and reuse the liquid metal (Galinstan).
Article
Chemistry, Physical
Shu-Ming Cui, Saud Hashmi, Wen-Qiang Li, Stephan Handschuh-Wang, Cheng-Tian Zhu, Shi-Chang Wang, Yan-Fei Huang, Guang-Ming Zhu, Florian J. Stadler
Summary: This paper investigates Pickering emulgels stabilized by graphene oxide (GO) with didodecyldimethylammonium bromide (DDAB) as an auxiliary surfactant and liquid paraffin as the oil phase, which are proved to be excellent 3D printable ink. The structure of these emulgels is elucidated by microscopy, broadband dielectric spectroscopy and rheology analysis. It is found that the increase of DDAB surfactant and GO-contents results in an increase of modulus and viscosity, a reduction of nonlinear regime limits, and a complex variation of normal forces.
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
