Cell Morphological Profiling Enables High-Throughput Screening for PROteolysis TArgeting Chimera (PROTAC) Phenotypic Signature

In silico prediction of mitochondrial toxicity of chemicals using machine learning methods

(2021) Piaopiao Zhao et al.   JOURNAL OF APPLIED TOXICOLOGY

Comparison of Cellular Morphological Descriptors and Molecular Fingerprints for the Prediction of Cytotoxicity- and Proliferation-Related Assays

(2021) Srijit Seal et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Comparison of Chemical Structure and Cell Morphology Information for Multitask Bioactivity Predictions

(2021) Maria-Anna Trapotsi et al.   Journal of Chemical Information and Modeling

Predicting cell health phenotypes using image-based morphology profiling

(2021) Gregory P. Way et al.   MOLECULAR BIOLOGY OF THE CELL

PROTACs and Building Blocks: The 2D Chemical Space in Very Early Drug Discovery

(2021) Giuseppe Ermondi et al.   MOLECULES

Computational analyses of mechanism of action (MoA): data, methods and integration

(2021) Maria-Anna Trapotsi et al.   RSC Chemical Biology

Proteolysis‐targeting chimeras in drug development: A safety perspective

(2020) Kevin Moreau et al.   BRITISH JOURNAL OF PHARMACOLOGY

Using machine learning methods and structural alerts for prediction of mitochondrial toxicity

(2020) Jennifer Hemmerich et al.   Molecular Informatics

Tales of 1,008 small molecules: phenomic profiling through live-cell imaging in a panel of reporter cell lines

(2020) Michael J. Cox et al.   Scientific Reports

Image-based profiling for drug discovery: due for a machine-learning upgrade?

(2020) Srinivas Niranj Chandrasekaran et al.   NATURE REVIEWS DRUG DISCOVERY

Accurate Prediction of Biological Assays with High-Throughput Microscopy Images and Convolutional Networks

(2019) Markus Hofmarcher et al.   Journal of Chemical Information and Modeling

Therapeutic Approaches Targeting Nucleolus in Cancer

(2019) Pietro Carotenuto et al.   Cells

Image-based morphological profiling identifies a lysosomotropic, iron-sequestering autophagy inhibitor

(2019) Herbert Waldmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bioactivity screening of environmental chemicals using imaging-based high-throughput phenotypic profiling

(2019) Johanna Nyffeler et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Evaluation of in Vitro Mitochondrial Toxicity Assays and Physicochemical Properties for Prediction of Organ Toxicity Using 228 Pharmaceutical Drugs

(2018) Payal Rana et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation

(2017) Calla M Olson et al.   Nature Chemical Biology

A dataset of images and morphological profiles of 30 000 small-molecule treatments using the Cell Painting assay

(2017) Mark-Anthony Bray et al.   GigaScience

Lysosomal adaptation: How cells respond to lysosomotropic compounds

(2017) Shuyan Lu et al.   PLoS One

Cell Painting, a high-content image-based assay for morphological profiling using multiplexed fluorescent dyes

(2016) Mark-Anthony Bray et al.   Nature Protocols

Mitochondrial toxicity assessment in industry – a decade of technology development and insight

(2014) Yvonne Will et al.   Expert Opinion on Drug Metabolism & Toxicology

High-Content, High-Throughput Screening for the Identification of Cytotoxic Compounds Based on Cell Morphology and Cell Proliferation Markers

(2014) Heather L. Martin et al.   PLoS One

Multiplex Cytological Profiling Assay to Measure Diverse Cellular States

(2013) Sigrun M. Gustafsdottir et al.   PLoS One

A high-throughput dual parameter assay for assessing drug-induced mitochondrial dysfunction provides additional predictivity over two established mitochondrial toxicity assays

(2012) James Hynes et al.   TOXICOLOGY IN VITRO

In silico prediction of mitochondrial toxicity by using GA-CG-SVM approach

(2008) Hui Zhang et al.   TOXICOLOGY IN VITRO