Article
Nutrition & Dietetics
Jonghee Kim, Joanne F. Dorgan, Hyesook Kim, Oran Kwon, Yangha Kim, Yuri Kim, Kwang Suk Ko, Yoon Jung Park, Hyesook Park, Seungyoun Jung
Summary: The use of nutrition labels is associated with a lower risk of chronic kidney disease, especially in older adults.
Article
Endocrinology & Metabolism
P. Zhu, X. Xiong, C. Chen, J. Ran
Summary: This study found that serum aldehyde concentrations are associated with low bone mineral density and high risk of osteopenia/osteoporosis in adults. Propanaldehyde and benzaldehyde are the most critical factors.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2022)
Article
Nutrition & Dietetics
Xia Shen, Xue Gu, Yuan-Yuan Liu, Long Yang, Meng Zheng, Lei Jiang
Summary: This study investigated the relationship between dietary calcium intake and the risk of depressive symptoms in individuals over the age of 18 in the US. The findings show that higher calcium intake is associated with a lower risk of depressive symptoms.
FRONTIERS IN NUTRITION
(2023)
Article
Public, Environmental & Occupational Health
Jing Tang, Yun Xu, Zhaorui Wang, Xiaohui Ji, Qi Qiu, Zhuoyao Mai, Jia Huang, Nengyong Ouyang, Hui Chen
Summary: This study examined the association between metabolically healthy obesity (MHO) and the risk of female infertility. It found that MHO was associated with an increased risk of infertility among reproductive-aged women in the US. Obesity itself, regardless of metabolic health status, was also associated with a higher infertility risk.
Article
Cardiac & Cardiovascular Systems
Hao Zhang, Zhibin Lin, Jun Chen, Daojing Gan, Haobin Zhou, Zhuang Ma, Xianghui Zeng, Yuting Xue, Xiao Wang, Qiong Zhan, Qingchun Zeng, Dingli Xu
Summary: The study found that dietary intake of total and cereal fiber were inversely associated with heart failure in adults.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Clinical Neurology
Jiahui Yin, Yu Ding, Feikang Xu, Leiyong Zhao, Rongpeng Gong, Jiguo Yang, Yuanxiang Liu
Summary: Recent research suggests that caffeine intake is associated with a reduced risk of depression. However, the relationship between caffeine intake during different periods of the day and depression is still unclear.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Environmental Sciences
Yuchen Tang, Qiong Yi, Shenghong Wang, Yayi Xia, Bin Geng
Summary: The study found that high blood mercury levels may increase bone mineral density, especially in the femoral regions. There are differences in the relationship between blood mercury levels and bone mineral density among different populations, with a more significant association in non-Hispanic Whites and a negative correlation in non-Hispanic Blacks.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Neurosciences
Zhaohao Zeng, Yanmei Cen, Lu Wang, Xiaoguang Luo
Summary: The study aimed to explore the association between Parkinson's disease (PD) and dietary inflammatory index (DII) scores in adults over 40 years old in the US. Data from the NHANES conducted from 2003 to 2018 were analyzed, including 21,994 participants. Logistic regression analysis and propensity score matching were used to investigate the relationship between DII and PD. The results showed a positive association between higher DII scores and PD, suggesting the potential use of diet as an intervention strategy for managing PD.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Liang Su, Jianpu Chen, Hua Qu, Chenglong Luo, Jie Wu, Yongzheng Jiao
Summary: This study found that frequent snoring is inversely associated with male serum testosterone levels, especially in those aged 40-59 years and those with abdominal obesity.
Article
Food Science & Technology
Lei Zhang, Zhang Du, Zhiang Li, Fei Yu, Lijun Li
Summary: The study found that increased dietary magnesium intake is associated with a decreased prevalence of chronic constipation, with a more significant trend among men. However, there was no statistically significant association observed between magnesium intake and chronic constipation defined by stool consistency. Further longitudinal studies are needed to confirm these findings.
FOOD SCIENCE & NUTRITION
(2021)
Article
Endocrinology & Metabolism
Shiyu Peng, Gaoxiang Zhang, Decheng Wang
Summary: This study investigated the association between selenium intake and osteoporosis (OP) risk and bone mineral density (BMD) using data from NHANES. The results showed that higher dietary and total selenium intake were associated with higher BMD and a lower risk of OP among adults in the US.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Environmental Sciences
Bo Kong, Yilin Chen, Shiyao Cheng, Huan Ma, Quanjun Liu, Yu Wang, Bingqing Bai, Fengyao Liu, Qingshan Geng
Summary: This study found that low blood concentrations of Cd and Pb were positively correlated with increased prevalence of cardiovascular disease (CVD) and subtypes, with a stronger association for Cd. There were negative dose-response relationships between physical activity (PA) and the prevalence of CVD and subtypes. Regular PA could modify the adverse effect of blood Cd on CVD risk, suggesting the importance of promoting a healthy lifestyle with active PA.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Nutrition & Dietetics
Yan-Bo Zhang, Jun-Xiang Chen, Yi-Wen Jiang, Peng-Fei Xia, An Pan
Summary: The study found that higher intake of sugar-sweetened beverages (SSBs) was associated with increased risks of all-cause mortality and heart disease mortality, while high intake of artificially sweetened beverages (ASBs) was not significantly associated with mortality. Substituting SSBs with ASBs, unsweetened coffees and teas, and plain water may be optional alternatives for reducing SSB intake.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Nutrition & Dietetics
Chengcheng Wei, Liang Tian, Bo Jia, Miao Wang, Ming Xiong, Bo Hu, Changqi Deng, Yaxin Hou, Teng Hou, Xiong Yang, Zhaohui Chen
Summary: This study investigates the correlation between serum triglycerides and prostate-specific antigen (PSA) levels using the U.S. National Health and Nutrition Examination Survey (NHANES) database. The results show an independent and negative correlation between serum triglycerides and PSA levels among American males. This correlation may contribute to difficulties in detecting asymptomatic prostate cancer and diagnosing it at advanced stages due to detection bias.
Article
Nutrition & Dietetics
Yuanyuan Wang, Ruiming Yang, Ziteng Cao, Sijia Han, Tianshu Han, Wenbo Jiang, Xinyang Wang, Wei Wei
Summary: Hyperuricemia (HUA) is associated with various diseases and has a significant impact on public health. Diet, in addition to genetics, plays a crucial role in preventing and treating HUA. This study aims to explore the association between food groups, consumption time, and HUA.
Article
Endocrinology & Metabolism
Alexi Vasbinder, Elizabeth Anderson, Husam Shadid, Hanna Berlin, Michael Pan, Tariq U. Azam, Ibrahim Khaleel, Kishan Padalia, Chelsea Meloche, Patrick O'Hayer, Erinleigh Michaud, Tonimarie Catalan, Rafey Feroze, Pennelope Blakely, Christopher Launius, Yiyuan Huang, Lili Zhao, Lynn Ang, Monica Mikhael, Kara Mizokami-Stout, Subramaniam Pennathur, Matthias Kretzler, Sven H. Loosen, Athanasios Chalkias, Frank Tacke, Evangelos J. Giamarellos-Bourboulis, Jochen Reiser, Jesper Eugen-Olsen, Eva L. Feldman, Rodica Pop-Busui, Salim S. Hayek
Summary: Diabetes mellitus is a major risk factor for severe COVID-19, and the association between diabetes and COVID-19 outcomes may be largely mediated by inflammation as assessed by suPAR levels. Hyperglycemia, independent of inflammation, also plays a role in COVID-19 outcomes.
Review
Urology & Nephrology
Judy Baek, Chenchen He, Farsad Afshinnia, George Michailidis, Subramaniam Pennathur
Summary: Dyslipidaemia is a hallmark of chronic kidney disease (CKD), with insights from lipidomics studies suggesting that alterations in free fatty acid partitioning may contribute to CKD progression.
NATURE REVIEWS NEPHROLOGY
(2022)
Article
Medicine, Research & Experimental
Patrice E. Fort, Thekkelnaycke M. Rajendiran, Tanu Soni, Jaeman Byun, Yang Shan, Helen C. Looker, Robert G. Nelson, Matthias Kretzler, George Michailidis, Jerome E. Roger, Thomas W. Gardner, Steven F. Abcouwer, Subramaniam Pennathur, Farsad Afshinnia
Summary: This study found decreased synthesis of complex lipids and impaired mitochondrial beta-oxidation of fatty acids in retinal diabetic retinopathy patients, with similar changes in circulating lipids.
Article
Biochemistry & Molecular Biology
Anindita Ravindran, Danthasinghe Waduge Badrajee Piyarathna, Jie Gohlke, Vasanta Putluri, Tanu Soni, Stacy Lloyd, Patricia Castro, Subramaniam Pennathur, Jeffrey A. Jones, Michael Ittmann, Nagireddy Putluri, George Michailidis, Thekkelnaycke M. Rajendiran, Arun Sreekumar
Summary: African-American men are more likely to die of prostate cancer than European American men. This study reveals the association between lipid metabolic pathway alterations and prostate cancer disparities, as well as specific lipid changes associated with early biochemical recurrence.
Article
Endocrinology & Metabolism
Christine P. Limonte, Erkka Valo, Viktor Drel, Loki Natarajan, Manjula Darshi, Carol Forsblom, Clark M. Henderson, Andrew N. Hoofnagle, Wenjun Ju, Matthias Kretzler, Daniel Montemayor, Viji Nair, Robert G. Nelson, John F. O'Toole, Robert D. Toto, Sylvia E. Rosas, John Ruzinski, Niina Sandholm, Insa M. Schmidt, Tomas Vaisar, Sushrut S. Waikar, Jing Zhang, Peter Rossing, Tarunveer S. Ahluwalia, Per-Henrik Groop, Subramaniam Pennathur, Janet K. Snell-Bergeon, Tina Costacou, Trevor J. Orchard, Kumar Sharma, Ian H. de Boer
Summary: The objective of this study was to understand the mechanisms underlying rapid eGFR decline in T1D patients. The researchers discovered that the urinary protein cathepsin D was associated with eGFR decline and could reflect tubulointerstitial injury in the kidneys.
Article
Multidisciplinary Sciences
Joonsang Lee, Elisa Warner, Salma Shaikhouni, Markus Bitzer, Matthias Kretzler, Debbie Gipson, Subramaniam Pennathur, Keith Bellovich, Zeenat Bhat, Crystal Gadegbeku, Susan Massengill, Kalyani Perumal, Jharna Saha, Yingbao Yang, Jinghui Luo, Xin Zhang, Laura Mariani, Jeffrey B. Hodgin, Arvind Rao
Summary: Pathologists use visual classification to assess kidney biopsy samples, but current methods lack reproducibility. To overcome this, we developed an unsupervised bag-of-words model and successfully predicted kidney function levels in chronic kidney disease patients. Our study ranked important morphological features as diagnostic markers for kidney disease.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Hetal S. Shah, Lorena Ortega Moreno, Mario Luca Morieri, Yaling Tang, Christine Mendonca, Jenny Marie Jobe, Jonathan B. Thacker, Joanna Mitri, Stefano Monti, Monika A. Niewczas, Subramaniam Pennathur, Alessandro Doria
Summary: This study aims to identify novel biomarkers of cardiovascular disease (CVD) risk in type 2 diabetes (T2D) patients through a hypothesis-free global metabolomics study, considering renal function as an important confounder. The results show that serum orotidine is a potential biomarker for increased CVD risk in T2D patients, independent of renal function. Additionally, orotidine may mediate the association between declining kidney function and CVD risk in T2D patients and could help improve CVD risk prediction.
Article
Clinical Neurology
Farsad Afshinnia, Evan L. Reynolds, Thekkelnaycke M. Rajendiran, Tanu Soni, Jaeman Byun, Masha G. Savelieff, Helen C. Looker, Robert G. Nelson, George Michailidis, Brian C. Callaghan, Subramaniam Pennathur, Eva L. Feldman
Summary: This study found that differences in serum lipidomic profiles were associated with neuropathy in type 2 diabetes. Changes in abundance of medium-chain acylcarnitines and total free fatty acids, as well as phosphatidylcholines and lysophosphatidylcholines, were observed 10 years prior to the development of neuropathy. These findings suggest that lipid profiles early in the disease course may be useful in identifying individuals at risk for neuropathy in type 2 diabetes.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Pradeep Kayampilly, Nancy Roeser, Thekkelnaycke M. Rajendiran, Subramaniam Pennathur, Farsad Afshinnia
Summary: The study showed that high glucose concentration increases de novo lipogenesis (DNL) in podocytes and tubular epithelial cells, while ACC inhibition can effectively halt or mitigate this upregulation, and reduce the expression of fibrosis and apoptosis markers. ACC inhibition is identified as a potential therapeutic target to alleviate or halt hyperglycemia-induced upregulation of DNL in podocytes and tubular cells.
Article
Endocrinology & Metabolism
Jiahao Liu, Viji Nair, Yi-Yang Zhao, Dong-Yuan Chang, Christine Limonte, Nisha Bansal, Damian Fermin, Felix Eichinger, Emily C. Tanner, Keith A. Bellovich, Susan Steigerwalt, Zeenat Bhat, Jennifer J. Hawkins, Lalita Subramanian, Sylvia E. Rosas, John R. Sedor, Miguel A. Vasquez, Sushrut S. Waikar, Markus Bitzer, Subramaniam Pennathur, Frank C. Brosius, Ian De Boer, Min Chen, Matthias Kretzler, Wenjun Ju
Summary: The study identified plasma angiopoietin 2 (ANGPT2) as a promising prognostic endothelial biomarker with potential functional impact on glomerular pathogenesis in diabetic kidney disease (DKD).
Article
Environmental Sciences
Seonyoung Park, Amber L. Cathey, Wei Hao, Lixia Zeng, Subramaniam Pennathur, Max T. Aung, Zaira Rosario-Pabon, Carmen M. Velez-Vega, Jose F. Cordero, Akram Alshawabkeh, Deborah J. Watkins, John D. Meeker
Summary: The study found that gestational exposure to phthalates, a type of plasticizer, may lead to preeclampsia and preterm birth through pathways such as endocrine disruption, oxidative stress, and inflammation. The researchers investigated the associations between urinary phthalates and their mixtures with plasma eicosanoid levels during pregnancy. In both single-pollutant analysis and mixture analysis, associations with certain phthalate metabolites were found, indicating the complexity of the physiological impacts of phthalate exposure.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
S. V. Thangaraj, L. Zeng, S. Pennathur, R. Lea, K. D. Sinclair, M. Bellingham, N. P. Evans, R. Auchus, V. Padmanabhan
Summary: This study investigates the impact of exposure to environmental chemicals (ECs) derived from human waste on the maternal steroid, cytokine, and oxidative stress environments. The results show that exposure to biosolids disrupts these environments and may contribute to reproductive and metabolic disruptions in offspring. This research is important for understanding the effects of ECs on pregnant individuals and their babies.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Medicine, Research & Experimental
Madathilparambil Suresh, Sinan Aktay, George Yalamanchili, Sumeet Solanki, Dily Thazhath Sathyarajan, Manikanta Swamy Arnipalli, Subramaniam Pennathur, Krishnan Raghavendran
Summary: Research findings indicate that hypoxia from lung injury following trauma is regulated by hypoxia-inducible factor 1 alpha (HIF-1 alpha), driving the acute inflammatory response in airway epithelial cells (AEC). Metabolomics profiling reveals increased glycolytic and TCA intermediates in Type II AEC after lung contusion, while succinate directly promotes inflammation in human small AEC.
Article
Biochemistry & Molecular Biology
Stephanie A. Eid, Phillipe D. O'Brien, Katharina H. Kretzler, Dae-Gyu Jang, Faye E. Mendelson, John M. Hayes, Andrew Carter, Hongyu Zhang, Subramaniam Pennathur, Frank C. C. Brosius III, Emily J. Koubek, Eva L. Feldman
Summary: Patients with type 2 diabetes often develop microvascular complications, including diabetic kidney disease and diabetic peripheral neuropathy. This study compared the effects of three dietary interventions on a type 2 diabetes mouse model and found that they improved weight and glycemic status and alleviated diabetic kidney disease, but did not impact diabetic peripheral neuropathy. Additionally, diets that decrease fat mass may be a promising non-pharmacological approach to improve diabetic peripheral neuropathy in type 2 diabetes.
Review
Physiology
Markus Bitzer, Wenjun Ju, Lalita Subramanian, Jonathan P. Troost, Joseph Tychewicz, Becky Steck, Roger C. Wiggins, Debbie S. Gipson, Crystal A. Gadegbeku, Frank C. Brosius III, Matthias Kretzler, Subramaniam Pennathur
Summary: The research on kidney diseases is changing due to the rapid growth and advancements in omics technologies. However, the analysis, integration, and interpretation of big data have been a challenge in using these technologies. To address this issue, the University of Michigan's MKTC has established the Applied Systems Biology Core to provide support and services for the global kidney research community.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)