Article
Endocrinology & Metabolism
Hongli Shi, Xin Jiang, Cuidi Xu, Qun Cheng
Summary: This study investigated the differences in miRNA expression profiles in postmenopausal osteoporosis patients with fragility fractures and identified several miRNAs associated with bone mineral density. The study also explored the potential role of these miRNAs in the pathophysiology of postmenopausal osteoporosis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Simone Ciuffi, Francesca Marini, Caterina Fossi, Simone Donati, Francesca Giusti, Annalisa Botta, Laura Masi, Giancarlo Isaia, Claudio Marcocci, Silvia Migliaccio, Salvatore Minisola, Ranuccio Nuti, Umberto Tarantino, Teresa Iantomasi, Maria Luisa Brandi
Summary: This study investigated the expression of circulating microRNAs (miRNAs) in osteoporotic patients using next-generation sequencing (NGS) and droplet digital polymerase chain reaction (ddPCR). The study identified differentially expressed miRNAs, including miR-23a-3p, miR-21-5p, and miR-320a-3p, which could distinguish osteoporotic patients from individuals with normal bone mineral density (BMD). Increased expression of c-miR-320a-3p was specifically associated with fractures, suggesting it as a potential prognostic indicator of fracture risk in osteoporotic patients. These findings need to be further validated in prospective studies.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Ursula Heilmeier, Matthias Hackl, Fabian Schroeder, Soheyla Torabi, Puneet Kapoor, Klemens Vierlinger, Gudny Eiriksdottir, Elias Freyr Gudmundsson, Tamara B. Harris, Vilmundur Gudnason, Thomas M. Link, Johannes Grillari, Ann Schwartz
Summary: Specific serum microRNAs, including senescent miR-31-5p, are associated with incident fragility fractures in older diabetic women and can significantly improve fracture risk prediction when combined with femoral neck aBMD measurements.
Article
Endocrinology & Metabolism
Jacopo Antonino Vitale, Veronica Sansoni, Martina Faraldi, Carmelo Messina, Chiara Verdelli, Giovanni Lombardi, Sabrina Corbetta
Summary: The study investigated the relationship between osteocalcin (OC) and body composition, risk of fall, and bone-muscle crosstalk in osteoporotic postmenopausal women. Results showed that serum cOC levels correlated with skeletal muscle mass and function, acting as a mediator in the bone-muscle crosstalk. Circulating levels of cOC and uOC may be differentially regulated in fractured and unfractured osteoporotic women, indicating potential differences in bone metabolism.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
K. Kerschan-Schindl, M. Hackl, E. Boschitsch, U. Foeger-Samwald, O. Naegele, S. Skalicky, M. Weigl, J. Grillari, P. Pietschmann
Summary: This study aimed to investigate and evaluate the diagnostic accuracy of osteomiRs for osteoporosis, revealing their potential application in the prevention and diagnosis of osteoporosis.
CALCIFIED TISSUE INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Patrick Pflueger, Felix N. Harder, Karoline Mueller, Lukas Willinger, Peter Biberthaler, Moritz Croenlein
Summary: Trimalleolar ankle fractures predominantly affect younger men and older women, with postmenopausal women having lower bone mineral density and a higher risk of fractures. This study aimed to analyze the association between patient characteristics and cortical bone thickness of the distal tibia in trimalleolar ankle fractures. The results showed that older age and female sex were associated with reduced cortical bone thickness and an increased risk of subsequent osteoporotic fractures.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Orthopedics
Miguel Viana Pereira Filho, Kelly Cristina Stefani, Gabriel Ferraz Ferreira, Monica Paschoal Nogueira
Summary: Insufficiency fractures in the foot and ankle predominantly occur in the metatarsals, with the base of the fifth metatarsal being the most common site. Chronic corticosteroid use and low lumbar bone mineral density were identified as risk factors associated with fracture development.
FOOT & ANKLE INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Angelo Alito, Federica Bellone, Simona Portaro, Giulia Leonardi, Vittorio Cannavo, Francesca Coppini, Danilo Leonetti, Antonino Catalano, Giovanni Squadrito, Domenico Fenga
Summary: Haemophilia A (HA) and haemophilia B (HB) are X-linked bleeding disorders caused by the absence or deficiency of coagulation factors VIII (FVIII) and IX (FIX). Recent advancements in haemophilia treatment have led to increased life expectancy, resulting in a higher incidence of fragility fractures. The pathogenesis of bone loss in people with haemophilia involves multiple factors including joint bleeding, reduced physical activity, nutritional deficiencies, and FVIII/FIX deficiency. The management of fractures in people with haemophilia includes pharmacological treatment, surgery, and rehabilitation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Critical Care Medicine
R. A. Timmer, P. Krijnen, P. van der Zwaal, I. B. Schipper, S. A. G. Meylaerts
Summary: The clinical relevance of combined anterior and posterior pelvic ring fractures (PRF) in elderly patients was investigated in this study. The majority of elderly patients with anterior PRF also had posterior PRF. Patients with combined anterior and posterior fractures were found to be more dependent on walking aids at 2-4 weeks compared to patients with isolated anterior fractures, but there were no significant differences in pain scores and Activities of Daily Living scores.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2023)
Article
Immunology
Alessandra Giannella, Silvia Riccetti, Alessandro Sinigaglia, Chiara Piubelli, Elisa Razzaboni, Piero Di Battista, Matteo Agostini, Emanuela Dal Molin, Riccardo Manganelli, Federico Gobbi, Giulio Ceolotto, Luisa Barzon
Summary: This study identified circulating miRNAs associated with the severity and mortality of COVID-19. The findings suggest that the pathogenesis of COVID-19 may involve impaired interferon and antiviral responses, inflammation, organ damage, and cardiovascular failure.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Orthopedics
Christian T. Smith, David W. Barton, Amit S. Piple, Jonathan J. Carmouche
Summary: Osteoporosis screening and secondary fracture prevention after pelvic fractures were found to be inadequate in the study population. The majority of patients did not undergo dual x-ray absorptiometry (DXA) scans or receive anti-osteoporosis medications. Within 2 years, 41.0% of patients developed additional osteoporotic fractures.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2021)
Article
Endocrinology & Metabolism
Yen-Huai Lin, Michael Mu Huo Teng
Summary: Possible sarcopenic obese women have a decreased likelihood of osteoporosis but an increased likelihood of fragility fractures. Furthermore, they also have lower values of trabecular bone score.
ARCHIVES OF OSTEOPOROSIS
(2022)
Article
Endocrinology & Metabolism
M. J. Gomez de Tejada-Romero, P. Saavedra-Santana, F. de la Rosa-Fernandez, N. Suarez-Ramirez, A. Martin-Martinez, F. Martin del Rosario, M. Sosa-Henriquez
Summary: Obesity has negative effects on fracture risk, bone density, and vitamin D levels in postmenopausal women, and comorbid type 2 diabetes mellitus (T2DM) exacerbates these effects.
ACTA DIABETOLOGICA
(2022)
Article
Geriatrics & Gerontology
Qingmei Li, Jiancheng Yang, Qinghua Tang, Yan Feng, Mingming Pan, Maohong Che, Jie Shi, Yuhong Zeng
Summary: This study evaluated the gender differences in diagnosis and treatment of osteoporosis in fragility fracture patients. The results showed significant differences in bone density measurement, biochemical marker testing, medication treatment, and follow-up between male and female patients.
Article
Biochemistry & Molecular Biology
Salman M. Toor, Eman K. Aldous, Aijaz Parray, Naveed Akhtar, Yasser Al-Sarraj, Essam M. Abdelalim, Abdelilah Arredouani, Omar El-Agnaf, Paul J. Thornalley, Sajitha V. Pananchikkal, Ghulam Jeelani Pir, Raheem Ayadathil, Ashfaq Shuaib, Nehad M. Alajez, Omar M. E. Albagha
Summary: Transient ischemic attack (TIA) is a temporary neurologic deficit caused by ischemic insult to the brain, spinal cord, or retina. TIA is associated with a high risk of impending acute ischemic stroke (AIS), a condition characterized by focal infarction in the brain, spinal cord, or retina. This study investigated the differences in circulating microRNA profiles between AIS and TIA patients and identified a panel of differentially regulated microRNAs. Furthermore, a multivariate classifier was developed that could potentially be used as a biomarker to distinguish AIS and TIA patients. Understanding the molecular pathways in AIS compared to TIA may have important implications for therapeutic targeting in clinical translation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Maarten Vanhaverbeke, Ritienne Attard, Monika Bartekova, Soumaya Ben-Aicha, Timo Brandenburger, David de Gonzalo-Calvo, Costanza Emanueli, Rosienne Farrugia, Johannes Grillari, Matthias Hackl, Barbora Kalocayova, Fabio Martelli, Markus Scholz, Stephanie Bezzina Wettinger, Yvan Devaux
Summary: This study provides recommendations to standardize the RNA development process in order to facilitate research on novel RNAs for clinical use. It discusses the unmet clinical needs in cardiovascular disease and explores factors such as sample types, patient demographics, and statistical and regulatory aspects.
CARDIOVASCULAR RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Kseniya Khamina, Andreas B. Diendorfer, Susanna Skalicky, Moritz Weigl, Marianne Pultar, Teresa L. Krammer, Catharine Aquino Fournier, Amy L. Schofield, Carolin Otto, Aaron Thomas Smith, Nina Buchtele, Christian Schoergenhofer, Bernd Jilma, Bernhard J. H. Frank, Jochen G. Hofstaetter, Regina Grillari, Johannes Grillari, Klemens Ruprecht, Christopher E. Goldring, Hubert Rehrauer, Warren E. Glaab, Matthias Hackl
Summary: The plasma levels of tissue-specific microRNAs can serve as diagnostic, disease severity and prognostic biomarkers. Combining diverse microRNAs into biomarker signatures using multivariate statistics is powerful in terms of tissue and condition specific microRNA shedding into the plasma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Christian Deininger, Andrea Wagner, Patrick Heimel, Elias Salzer, Xavier Monforte Vila, Nadja Weissenbacher, Johannes Grillari, Heinz Redl, Florian Wichlas, Thomas Freude, Herbert Tempfer, Andreas Herbert Teuschl-Woller, Andreas Traweger
Summary: In this study, silk scaffolds with axially aligned pores were generated and treated with simulated body fluid to create a calcium phosphate coating. In vivo experiments demonstrated that silk scaffolds loaded with a low dose of rhBMP-2 and coated with calcium phosphate significantly improved bone regeneration, providing effective bone repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
C. Muschitz, M. Hummer, J. Grillari, A. Hlava, A. H. Birner, M. Hemetsberger, H. P. Dimai
Summary: Fragility fractures are frequent and costly in Austria, and with the aging population, the number of these fractures and their associated costs are expected to increase even further.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Nutrition & Dietetics
Andreana N. Holowatyj, Jennifer Ose, Biljana Gigic, Tengda Lin, Arve Ulvik, Anne J. M. R. Geijsen, Stefanie Brezina, Rama Kiblawi, Eline H. van Roekel, Andreas Baierl, Jurgen Bohm, Martijn J. L. Bours, Hermann Brenner, Stephanie O. Breukink, Jenny Chang-Claude, Johannes H. W. de Wilt, William M. Grady, Thomas Grunberger, Tanja Gumpenberger, Esther Herpel, Michael Hoffmeister, Eric T. P. Keulen, Dieuwertje E. Kok, Janna L. Koole, Katharina Kosma, Ewout A. Kouwenhoven, Gry Kvalheim, Christopher Li, Peter Schirmacher, Petra Schrotz-King, Marie C. Singer, Franzel J. B. van Duijnhoven, Henk K. van Halteren, Kathy Vickers, F. Jeroen Vogelaar, Christy A. Warby, Evertine Wesselink, Per M. Ueland, Alexis B. Ulrich, Martin Schneider, Nina Habermann, Ellen Kampman, Matty P. Weijenberg, Andrea Gsur, Cornelia M. Ulrich
Summary: Higher preoperative vitamin B6 status is associated with improved overall survival among stage I-III colorectal cancer patients, but not with disease recurrence.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Endocrinology & Metabolism
Zora Messner, David Carro-Vazquez, Judith Haschka, Johannes Grillari, Heinrich Resch, Christian Muschitz, Peter Pietschmann, Jochen Zwerina, Matthias Hackl, Roland Kocijan
Summary: This study investigated circulating miRNAs as potential biomarkers for monitoring treatment response in women with postmenopausal osteoporosis on denosumab therapy. The results showed significant changes in expression of seven miRNAs after two years of treatment, which correlated with changes in bone mineral density and bone turnover markers.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Gastroenterology & Hepatology
Stefanie Brezina, Martin Borkovec, Andreas Baierl, Fabienne Bastian, Andreas Futschik, Nikolaus Gasche, Thomas Gruenberger, Michael Hallas, Christian Jannsen, Gernot Leeb, Rebecca Lutz, Barbara Sladek, Andrea Gsur
Summary: The study evaluated the usability of FIT cartridges for microbiome analysis and compared it to Stool Collection and Preservation Tubes. The FIT and Preservation Tube samples had highly similar microbiome profiles, with minor differences between abundances of some bacterial taxa. The results indicate that FIT cartridges are suitable for gut microbiome analysis within CRC screening programs.
Article
Biochemistry & Molecular Biology
Oleh Lushchak, Markus Schosserer, Johannes Grillari
Summary: Cellular senescence refers to a stable cell cycle arrest state with specific characteristics. Senescent cells accumulate in the body during normal aging, limiting lifespan and promoting aging-related as well as unrelated diseases. Diseases associated with cellular senescence are referred to as senopathies, and targeting senescent cells through senolytics or senomorphics may help mitigate these diseases. Animal studies provide mechanistic evidence for the connection between senescent cell accumulation and disease progression in various senopathies, including cardiovascular, metabolic, musculoskeletal, liver, kidney, lung diseases, and neurodegeneration. The development of novel senotherapies is hindered by the heterogeneity of senescence phenotypes, resulting in a lack of universal biomarkers and difficulties in distinguishing senescent from non-senescent cells.
Article
Psychology, Applied
Barbara Beham, Ariane Ollier-Malaterre, Tammy D. Allen, Andreas Baierl, Matilda Alexandrova, Artiawati, T. Alexandra Beauregard, Vania Sofia Carvalho, Maria Jose Chambel, Eunae Cho, Bruna Coden da Silva, Sarah I. Dawkins, Pablo Escribano, Konjit Hailu Gudeta, Ting-pang Huang, Ameeta Jaga, Dominique Kost, Anna Kurowska, Emmanuelle Leon, Suzan Lewis, Chang-qin Lu, Angela Martin, Gabriele Morandin, Fabrizio Noboa, Shira Offer, Eugene Ohu, Pascale Peters, Ujvala Rajadhyaksha, Marcello Russo, Young Woo Sohn, Caroline Straub, Mia Tammelin, Leila L. Triki, Marloes van Engen, Ronit Waismel-Manor
Summary: Despite the progress made in cross-national work-family research, the impact of culture on the work-family interface has been limited due to a narrow geographical and cultural scope. This study investigates the work-family relationships in various cultures, including regions that have been understudied. It focuses on the cultural dimension of humane orientation (HO) and explores its moderating effect on the relationships between work and family social support, work-family conflict, and work-family positive spillover. The findings suggest that HO plays a compensatory role in the relationship between workplace support and work-to-family conflict, and an amplifying role in the relationship between coworker support and work-to-family positive spillover.
JOURNAL OF APPLIED PSYCHOLOGY
(2023)
Article
Gastroenterology & Hepatology
Patrick Starlinger, Laura Brunnthaler, Chantal McCabe, David Pereyra, Jonas Santol, Jessica Steadman, Matthias Hackl, Susanna Skalicky, Hubert Hackl, Raphael Gronauer, Daniel O'Brien, Renate Kain, Petra Hirsova, Gregory J. Gores, Chen Wang, Thomas Gruenberger, Rory L. Smoot, Alice Assinger
Summary: Through the analysis of blood and tissue samples from patients, this study explores the early transcriptional changes during liver regeneration and their differences in individuals with dysfunctional liver regeneration.
Article
Multidisciplinary Sciences
Diana Swolin-Eide, Gun Forsander, Auste Pundziute Lycka, Daniel Novak, Johannes Grillari, Andreas B. Diendorfer, Matthias Hackl, Per Magnusson
Summary: This case-control study aimed to investigate potential differences in circulating miRNAs between young individuals with long-duration type 1 diabetes (T1D) and healthy controls, as well as the expression of these identified miRNAs across different tissues. The results showed that 27 miRNAs were upregulated and one was downregulated in T1D. Six of these miRNAs were tissue-enriched. These findings have important implications for studying biomarkers for diabetes-related complications.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Jennifer Ose, Biljana Gigic, Stefanie Brezina, Tengda Lin, Anita R. Peoples, Pauline P. Schobert, Andreas Baierl, Eline van Roekel, Nivonirina Robinot, Audrey Gicquiau, David Achaintre, Augustin Scalbert, Fraenzel J. B. van Duijnhoven, Andreana N. Holowatyj, Tanja Gumpenberger, Petra Schrotz-King, Alexis B. Ulrich, Arve Ulvik, Per-Magne Ueland, Matty P. Weijenberg, Nina Habermann, Pekka Keski-Rahkonen, Andrea Gsur, Dieuwertje E. Kok, Cornelia M. Ulrich
Summary: Colorectal cancer is recognized as two separate diseases: colon cancer and rectal cancer, each with its own causes and outcomes. This study found that higher levels of plasma creatinine increased the risk of death in patients with rectal cancer but not colon cancer. Additionally, a biological pathway related to starch and sucrose metabolism was linked to worse clinical outcomes in colon cancer but not rectal cancer. Understanding these differences is crucial for tailored treatments.
Article
Physiology
Matthijs Luxen, Peter J. Zwiers, Femke Meester, Rianne M. Jongman, Timara Kuiper, Jill Moser, Marianne Pultar, Susanna Skalicky, Andreas B. Diendorfer, Matthias Hackl, Matijs van Meurs, Grietje Molema
Summary: This study investigated the microRNA and mRNA transcription patterns in different microvascular compartments of the mouse kidney cortex. Unique microRNA and mRNA profiles were identified, providing important molecular information for studying microvascular heterogeneity in the kidney in health and disease.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2023)
Review
Materials Science, Multidisciplinary
Elisaveta Snezhkova, Heinz Redl, Johannes Grillari, Marcin Osuchowski
Summary: This article introduces the application of activated carbon or charcoal in alleviating inflammation and explains its mechanisms of protecting the microbiome and bone marrow, as well as its anti-inflammatory and anti-oxidant effects. Early application of activated carbon and its high adsorption capacity are essential in the treatment of preventing sepsis and multi-organ failure.
C-JOURNAL OF CARBON RESEARCH
(2023)