Review
Cardiac & Cardiovascular Systems
Lina Badimon, Emma L. Robinson, Amela Jusic, Irina Carpusca, Leon J. DeWindt, Costanza Emanueli, Peter Ferdinandy, Wei Gu, Mariann Gyoengyoesi, Matthias Hackl, Kanita Karaduzovic-Hadziabdic, Mitja Lustrek, Fabio Martelli, Eric Nham, Ines Potocnjak, Venkata Satagopam, Reinhard Schneider, Thomas Thum, Yvan Devaux
Summary: The COVID-19 pandemic has unprecedented and significant impact globally. Patients with cardiovascular diseases are at higher risk of cardiac events due to the infection. RNA biomarkers show potential in aiding the fight against COVID-19 and require collaborative multi-center studies for discovery and validation.
CARDIOVASCULAR RESEARCH
(2021)
Review
Cell Biology
Mafalda Rizzuti, Luca Sali, Valentina Melzi, Simone Scarcella, Gianluca Costamagna, Linda Ottoboni, Lorenzo Quetti, Lorenzo Brambilla, Dimitra Papadimitriou, Federico Verde, Antonia Ratti, Nicola Ticozzi, Giacomo Pietro Comi, Stefania Corti, Delia Gagliardi
Summary: This article provides an overview of the research progress in investigating the molecular mechanisms of ALS using genomics, epigenomics, transcriptomics, and microRNAs. It reports the most relevant genes implicated in ALS pathogenesis and discusses the use of different high-throughput sequencing techniques and the role of epigenomic modifications. Furthermore, it presents the latest advances in transcriptomic studies and discusses the potential of microRNAs as biomarkers and molecular intervention tools.
AGEING RESEARCH REVIEWS
(2023)
Review
Genetics & Heredity
Laura Navarro, Federico Martinon-Torres, Antonio Salas
Summary: The impact of music on human beings is significant, but research on the relationship between music and human biology is still limited. Evidence of music's value in clinical science, neuroscience, and social science continues to grow. To further study the influence of sensorial input on gene expression, the development of a new discipline called sensogenomics is recommended.
Review
Biochemistry & Molecular Biology
Patricia de Carvalho Ribeiro, Lucas Felipe Oliveira, Daniel Mendes Filho, Ricardo Cambraia Parreira, Mariana Sousa Vieira, Bruno Lemes Marques, Elis Marra da Madeira Freitas, Walison N. N. Silva, Helton da Costa Santiago, Alexander Birbrair, Henning Ulrich, Valdo Jose Dias da Silva, Rodrigo R. R. Resende
Summary: Systemic arterial hypertension is a major risk factor for cardiovascular and renal diseases, and early recognition is important for prevention. The study of biomarkers is an important approach for diagnosing and predicting hypertension and related conditions. This review discusses the use of biomarkers in hypertension and associated diseases such as ischemic stroke, intracerebral hemorrhage, transient ischemic attack, acute myocardial infarction, angina pectoris, and chronic kidney disease. Establishing a pool of potential biomarkers can improve diagnosis, prognosis, risk assessment, therapy management, and pharmacological responses to enhance patients' quality of life and prevent unfavorable outcomes.
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Agriculture, Dairy & Animal Science
Tharangani R. W. Perera, David A. Skerrett-Byrne, Zamira Gibb, Brett Nixon, Aleona Swegen
Summary: This review outlines the role of new technologies in biomarker discovery, specifically in the veterinary field, with a focus on 'omics' platforms. It discusses the challenges faced in the process of biomarker development and emphasizes the importance of collaboration between clinicians, researchers, and funding bodies. The review also highlights the need for clear goals and adequate resources to ensure successful translation of biomarkers into clinical practice.
Review
Cell Biology
Jia-Chen Liu, Shan-Shan Dong, Hui Shen, Dan-Yue Yang, Bin-Bin Chen, Xue-Ying Ma, Yi-Ran Peng, Hong-Mei Xiao, Hong-Wen Deng
Summary: Sarcopenia is a systemic disease characterized by muscle dysfunction, with its genetic architecture and molecular mechanisms still largely unclear. Recent advancements in multi-omics studies offer new insights into the pathogenesis of sarcopenia and may lead to new clinical applications.
AGEING RESEARCH REVIEWS
(2022)
Article
Multidisciplinary Sciences
Julie Caroline Saether, Elisabeth Kleivhaug Vesterbekkmo, Maria Dalen Taraldsen, Bruna Gigante, Turid Follestad, Helge Rorvik Rosjo, Torbjorn Omland, Rune Wiseth, Erik Madssen, Anja Bye
Summary: This study investigated the association between circulating miRs and lipid-rich coronary plaques. The results showed that miR-133b was the miR most strongly associated with lipid-rich plaques, with an estimated 18% increase in odds of lipid-rich plaques per unit increase in miR-133b. Although the evidence is modest, miR-133b could be a potential biomarker of vulnerable coronary plaques and risk of future MI, but further evaluation is needed in larger cohorts.
SCIENTIFIC REPORTS
(2023)
Review
Medical Laboratory Technology
Qian Zeng, Jiaodi Cai, Hengquan Wan, Simin Zhao, Yao Tan, Chi Zhang, Shunlin Qu
Summary: piRNAs and PIWI proteins, traditionally considered to be expressed in germline cells, are now emerging as potential biomarkers for diagnosis and treatment of cardiac injury and various forms of CVD. They are associated with molecular and cellular pathways in cardiovascular disease.
CLINICA CHIMICA ACTA
(2021)
Review
Fisheries
Thao V. Nguyen, Andrea C. Alfaro, Craig Mundy, Jillian Petersen, Norman L. C. Ragg
Summary: The steady increase in global abalone aquaculture production has led to growing interest in applying new technologies, such as omics approaches, for abalone research. Omics techniques like genomics, transcriptomics, proteomics, and metabolomics are revealing key molecules and pathways in biological processes and identifying potential biomarkers. Integration of multiple omics approaches shows great potential in overcoming challenges and limitations to improve abalone production.
Editorial Material
Medicine, General & Internal
John C. Marshall, Aleksandra Leligdowicz
Summary: Infection leads to sepsis, and the development of clinical disease is triggered by the innate immune response of the host. However, the advancement of understanding in this biological response has not been matched by successful treatment development. The COVID-19 pandemic has brought about changes in this aspect, showing potential therapeutic approaches and the possibility of evaluating them. This article reviews the history of mediator-targeted therapy for sepsis and discusses the conceptual, biological, technological, and organizational challenges that need to be addressed to develop effective treatments for a leading cause of global morbidity and mortality.
Review
Microbiology
Ze Xiang, Jiayuan Li, Di Lu, Xuyong Wei, Xiao Xu
Summary: Viral hepatitis is a significant global public health problem that affects millions of people and has high morbidity and mortality. Multi-omics analysis has been widely used in studying the origin, diagnosis, and treatment targets of viral hepatitis.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Medical Laboratory Technology
Tianyang Wang, Ping Li, Xiangyu Meng, Jinling Zhang, Qi Liu, Cuicui Jia, Nana Meng, Kunjie Zhu, Dan Lv, Lei Sun, Tinghuizi Shang, Yan Lin, Weipan Niu, Song Lin
Summary: This study used an integrated multi-omic approach to differentiate healthy subjects from schizophrenia patients. By combining metabolomic and transcriptomic platforms, 86 differential metabolites and 189 differential expression genes were identified as potential biomarkers for schizophrenia. The functional relationships between metabolites and genes were further studied, providing more precise information on the mechanism and diagnostic evidence of schizophrenia. The establishment of characteristic diagnostic formulas enhances the predictive ability of the diagnostic spectrums.
CLINICA CHIMICA ACTA
(2022)
Review
Biochemistry & Molecular Biology
Tianyuan Xu, Zhong Zheng, Weili Zhao
Summary: Follicular lymphoma (FL) is a heterogeneous lymphoma originating from germinal center B cells. Multi-omics analysis has revealed abnormalities in FL cells and tumor microenvironment, providing insights into the mechanisms of FL progression and potential therapeutic options.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Felipe Padilla-Martinez, Gladys Wojciechowska, Lukasz Szczerbinski, Adam Kretowski
Summary: This review summarizes recent studies on biomarkers for type 2 diabetes (T2D) based on circulating nucleic acids using genomic, transcriptomic, and epigenomic technologies. Several candidate biomarkers have been identified for the risk and diagnosis of T2D, the prognosis of T2D complications, and the pharmacodynamics of T2D treatments. Further validation in larger samples and non-invasive samples is needed to support the realization of precision medicine for T2D.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Madeline Alizadeh, Natalia Sampaio Moura, Alyssa Schledwitz, Seema A. Patil, Jacques Ravel, Jean-Pierre Raufman
Summary: Studying individual data types in isolation is limited in providing comprehensive answers, but multi-omics approaches can generate and integrate multiple data types to offer a holistic understanding of biological and disease processes. Gastroenterology and hepatobiliary research benefit from these approaches due to the interconnectedness of the GI tract, brain, immune and endocrine systems, and GI microbiome. The use of big data in multi-omic, multi-site studies allows for better investigations into the connections between organ systems and more accurate evaluations of interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Soumaya Ben-Aicha, Jacqueline Buchanan, Prakash Punjabi, Costanza Emanueli, Marco Moscarelli
Summary: This study provides a systematic review and meta-analysis on the in-hospital mortality rate of COVID-19 patients with cardiovascular disease (CVD). The results indicate a high in-hospital mortality rate in COVID-19 patients with CVD. Regardless of the type of COVID-19 treatment administered, previous CVD has an impact on mortality rate. Treatments for high-risk patients should be administered carefully and closely monitored.
Review
Medical Laboratory Technology
Paivi Lakkisto, Louise Torp Dalgaard, Thalia Belmonte, Sara-Joan Pinto-Sietsma, Yvan Devaux, David De Gonzalo-Calvo
Summary: The implementation of cell-free microRNAs as biomarkers is limited due to lack of reproducibility. Technical variability and analytical caveats make the interpretation of miRNA data challenging. Standardization efforts and consideration of specific aspects in sample handling and data analysis are important for reproducibility. Providing a checklist can facilitate the control of miRNA quantification and analysis.
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2023)
Article
Medicine, General & Internal
Monika Radike, Pablo Sutelman, Soumaya Ben-Aicha, Manuel Gutierrez, Guiomar Mendieta, Sebastia Alcover, Laura Casani, Gemma Arderiu, Maria Borrell-Pages, Teresa Padro, Lina Badimon, Gemma Vilahur
Summary: Myocardial ischemia duration has a significant effect on cardiac structural and functional parameters, with 60-minute coronary occlusion already inducing alterations in cardiac structure and function.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Marilza V. C. Rudge, Fernanda C. B. Alves, Raghavendra L. S. Hallur, Rafael G. Oliveira, Sofia Vega, David R. A. Reyes, Juliana F. Floriano, Caroline B. Prudencio, Gabriela A. Garcia, Fabiana V. D. S. Reis, Costanza Emanueli, Gonzalo Fuentes, Marcelo Cornejo, Fernando Toledo, Andres Valenzuela-Hinrichsen, Catalina Guerra, Adriana Grismaldo, Paola Valero, Angelica M. P. Barbosa, Luis Sobrevia
Summary: The exposome is the cumulative measure of environmental influences and associated biological responses throughout the lifespan, including those from the environment, diet, behaviour, and endogenous processes. The concept of the exposome and the Sustainable Development Goals (SDGs) proposed by the United Nations are crucial for understanding the causes and effects of non-communicable diseases like gestational diabetes mellitus (GDM). Factors such as adverse environmental pollutants, exposure to tobacco smoke, and over-nutrition in utero play a significant role in the development of GDM. It is recommended to implement interventions based on knowledge to modify the interdependent ecto-exposome and endo-exposome, thereby preventing the occurrence and consequences of GDM.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2023)
Article
Cardiac & Cardiovascular Systems
Xi Wang, Ivan Wong, Vilhelmas Bajoras, Maarten Vanhaverbeke, Philippe Nuyens, Gintautas Bieliauskas, Troels Hojsgaard Jorgensen, Mao Chen, Ole De Backer, Lars Sondergaard
Summary: The use of a right-left cusp overlap view during transcatheter aortic valve replacement (TAVR) has been proposed to reduce permanent pacemaker implantation (PPMI). This study aimed to assess the impact of different implantation techniques on PPMI risk. The results showed that using a right-left cusp overlap view for implantation resulted in less tilt of the native aortic annulus plane and a lower 30-day PPMI rate compared to conventional implantation view.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Tullio Palmerini, Francesco Saia, Won-Keun Kim, Matthias Renker, Alessandro Iadanza, Massimo Fineschi, Antonio Giulio Bruno, Gabriele Ghetti, Maarten Vanhaverbeke, Lars Sondergaard, Ole De Backer, Enrico Romagnoli, Francesco Burzotta, Carlo Trani, Rik Adrichem, Nicolas M. Van Mieghem, Elena Nardi, Francesco Chietera, Mateusz Orzalkiewicz, Daijiro Tomii, Thomas Pilgrim, Tiziana Claudia Aranzulla, Giuseppe Musumeci, Matti Adam, Max M. Meertens, Nevio Taglieri, Cinzia Marrozzini, Hector Alfonso Alvarez Covarrubias, Michael Joner, Giulia Nardi, Francesca Maria Di Muro, Carlo Di Mario, Lucca Loretz, Stefan Toggweiler, Enrico Gallitto, Mauro Gargiulo, Luca Testa, Francesco Bedogni, Sergio Berti, Marco B. Ancona, Matteo Montorfano, Alessandro Leone, Carlo Savini, Davide Pacini, Jonas Gmeiner, Daniel Braun, Roberto Nerla, Fausto Castriota, Marco De Carlo, Anna Sonia Petronio, Marco Barbanti, Giuliano Costa, Corrado Tamburino, Pier Pasquale Leone, Bernhard Reimers, Giulio Stefanini, Mitsumasa Sudo, Georg Nickenig, Tommaso Piva, Andrea Scotti, Azeem Latib, Matteo Vercellino, Italo Porto, Pablo Codner, Ran Kornowski, Antonio L. Bartorelli, Giuseppe Tarantini, Chiara Fraccaro, Mohamed Abdel-Wahab, Eberhard Grube, Nazzareno Galie, Gregg W. Stone
Summary: This study compared clinical outcomes of transfemoral access (TFA), transthoracic access (TTA), and nonthoracic transalternative access (TAA) in TAVR patients with severe peripheral artery disease (PAD). The study found that both TFA and TAA were associated with lower 30-day and 1-year rates of major adverse events (MAE) compared with TTA. However, TAA had a higher risk of stroke/TIA compared with TFA at 1 year.
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Endocrinology & Metabolism
Zora Messner, David Carro-Vazquez, Judith Haschka, Johannes Grillari, Heinrich Resch, Christian Muschitz, Peter Pietschmann, Jochen Zwerina, Matthias Hackl, Roland Kocijan
Summary: This study investigated circulating miRNAs as potential biomarkers for monitoring treatment response in women with postmenopausal osteoporosis on denosumab therapy. The results showed significant changes in expression of seven miRNAs after two years of treatment, which correlated with changes in bone mineral density and bone turnover markers.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, Research & Experimental
Guido Rossi-Herring, Thalia Belmonte, Andrea Rivas-Urbina, Sonia Benitez, Noemi Rotllan, Javier Crespo, Vicenta Llorente-Cortes, Jose Luis Sanchez-Quesada, David de Gonzalo-Calvo
Summary: This study examined the expression profiles of miRNAs in lipoprotein fractions (VLDL, LDL, and HDL) isolated from the serum through various methods. The results showed stable detection of different miRNAs in each fraction, with VLDL-specific miRNAs detected for the first time. Functional enrichment analysis indicated the potential roles of lipoprotein-carried miRNAs in cardiovascular disease-related mechanisms.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Cardiac & Cardiovascular Systems
Gaia Spinetti, Martina Mutoli, Simona Greco, Federica Riccio, Soumaya Ben-Aicha, Franziska Kenneweg, Amela Jusic, David de Gonzalo-Calvo, Anne Yael Nossent, Susana Novella, Georgios Kararigas, Thomas Thum, Costanza Emanueli, Yvan Devaux, Fabio Martelli
Summary: Diabetes mellitus, a metabolic disorder characterized by high blood glucose levels, is a major risk factor for cardiovascular diseases. Chronic or intermittent hyperglycemia in diabetes leads to vascular damage and inflammation, resulting in micro- and macro-vascular diseases. Non-coding RNAs (ncRNAs) may play a fundamental role in the interaction between immune and cardiovascular cells in diabetic complications. This review explores the function of ncRNAs as biomarkers and treatment targets, as well as their involvement in the increased cardiovascular risk in diabetic patients with Sars-CoV-2 infection.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Rachael Heys, Gianni D. Angelini, Katherine Joyce, Helena Smartt, Lucy Culliford, Rachel Maishman, Samantha E. de Jesus, Costanza Emanueli, M-Saadeh Suleiman, Prakash Punjabi, Chris A. Rogers, Ben Gibbison
Summary: The ProMPT2 study aims to determine whether increasing the dose of propofol, a vasodilator, can enhance cardiac protection in cardiac surgery. The study will randomize patients into three groups receiving high-dose propofol, low-dose propofol, or placebo. The primary outcome is myocardial injury assessed up to 48 hours post-surgery, with secondary outcomes including biomarkers of renal function and metabolism.
Editorial Material
Cardiac & Cardiovascular Systems
Soumaya Ben-Aicha, Borja Ibanez
CARDIOVASCULAR RESEARCH
(2023)
Article
Multidisciplinary Sciences
Diana Swolin-Eide, Gun Forsander, Auste Pundziute Lycka, Daniel Novak, Johannes Grillari, Andreas B. Diendorfer, Matthias Hackl, Per Magnusson
Summary: This case-control study aimed to investigate potential differences in circulating miRNAs between young individuals with long-duration type 1 diabetes (T1D) and healthy controls, as well as the expression of these identified miRNAs across different tissues. The results showed that 27 miRNAs were upregulated and one was downregulated in T1D. Six of these miRNAs were tissue-enriched. These findings have important implications for studying biomarkers for diabetes-related complications.
SCIENTIFIC REPORTS
(2023)
Letter
Biochemistry & Molecular Biology
Elisa Avolio, Prashant K. Srivastava, Jiahui Ji, Michele Carrabba, Christopher T. W. Tsang, Yue Gu, Anita C. Thomas, Kapil Gupta, Imre Berger, Costanza Emanueli, Paolo Madeddu
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Review
Cardiac & Cardiovascular Systems
Miron Sopic, Emma L. Robinson, Costanza Emanueli, Prashant Srivastava, Claudio Angione, Carlo Gaetano, Gianluigi Condorelli, Fabio Martelli, Thierry Pedrazzini, Yvan Devaux
Summary: The field of epigenetics has gained attention in cardiovascular research due to its association with disease development. Multi-omics approaches that integrate different levels of disease regulation, such as DNA, histone, and RNA modifications, are essential for understanding complex diseases like cardiovascular diseases. This review focuses on discussing the role of epigenetic mechanisms in regulating gene expression and their interlinkage in the development of cardiac disease, particularly heart failure. The review also presents current methods and tools used for data integration and analysis, which can contribute to the discovery of novel therapeutic approaches and biomarkers for precision healthcare and improved clinical outcomes.
BASIC RESEARCH IN CARDIOLOGY
(2023)