Article
Gastroenterology & Hepatology
Jade Devenney, Syed S. Hasan, Julie Morris, Peter J. Whorwell, Dipesh H. Vasant
Summary: This study conducted a secondary analysis of gut-directed hypnotherapy outcomes in patients with refractory IBS and found that patients with a higher burden of gastrointestinal and extraintestinal symptoms are most likely to benefit from this treatment. Clinical assessment of gastrointestinal, somatic, and psychological symptom profiles may play a role in selecting patients for gut-directed hypnotherapy.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Sameer K. Berry, Rani Berry, David Recker, Jeffrey Botbyl, Lucy Pun, William D. Chey
Summary: Digital gut-directed hypnotherapy (GDH) treatment program can improve symptoms of IBS, including abdominal pain and stool problems. There was no significant difference in effectiveness between digital GDH and digital muscle relaxation (MR), but the GDH treatment group had more abdominal pain responders.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Simone. L. L. Peters, Peter. R. R. Gibson, Emma. P. P. Halmos
Summary: This retrospective evaluation aimed to assess the efficacy of app-delivered gut-directed hypnotherapy (GDH) in managing irritable bowel syndrome (IBS) symptoms and investigating factors predicting response. Results showed that 64% of patients who completed the GDH program saw a >30% reduction in abdominal pain. The study highlights the effectiveness of app-delivered GDH for improving symptoms in IBS patients.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Review
Gastroenterology & Hepatology
Syed S. Hasan, Sarah Ballou, Laurie Keefer, Dipesh H. Vasant
Summary: Gut-directed hypnotherapy (GDH) is a highly effective behavioral therapy recommended for the treatment of irritable bowel syndrome (IBS). GDH has been recognized as a valuable addition to integrated care alongside medical and dietary approaches. Recent innovations, such as smartphone app-delivered GDH, have improved access to this therapy despite low adherence rates.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
Daniel R. Hoekman, Arine M. Vlieger, Pieter C. Stokkers, Nofel Mahhmod, Svend Rietdijk, Nanne K. de Boer, Tim G. de Meij, Carla Frankenhuis, Geert R. D'Haens, Marc A. Benninga
Summary: The study found that gut-directed hypnotherapy was not superior to standard medical treatment in treating IBS-type symptoms in IBD patients, suggesting that both treatment strategies are reasonable options from a clinical perspective.
JOURNAL OF CROHNS & COLITIS
(2021)
Review
Microbiology
Tarek Mazzawi
Summary: Research suggests that manipulating gut microbiota can improve symptoms of irritable bowel syndrome (IBS), with dietary management and other approaches showing promise in changing gut composition and alleviating IBS symptoms. However, more research is needed to identify the exact mixture of beneficial bacteria.
Review
Immunology
Lin Xiao, Qin Liu, Mei Luo, Lishou Xiong
Summary: Research has identified the significant roles that microbiota-derived metabolites play in the development of IBS symptoms in patients, shedding light on the complex interplay between gut microbiota and IBS.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Gastroenterology & Hepatology
Joelle BouSaba, Wassel Sannaa, Michael Camilleri
Summary: Pain relief in patients with IBS remains a significant challenge, but interventions including diet and pharmacological treatments offer hope for more effective therapeutic options. Recent advances in the field indicate a potential expansion of the therapeutic arsenal for pain in IBS.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Review
Biochemistry & Molecular Biology
Emeran A. Mayer, Hyo Jin Ryu, Ravi R. Bhatt
Summary: Irritable bowel syndrome (IBS) is a prevalent disorder of brain-gut interactions, affecting 5-10% of the global population. The current diagnosis criteria focus on recurrent abdominal pain and altered bowel habits, but patients also experience non-painful abdominal discomfort, psychiatric conditions, and other pain-related symptoms. Recent research has revealed a comprehensive disease model of brain-gut-microbiome interactions, explaining the various symptoms of IBS. This model incorporates the gut connectome, enteric nervous system, brain alterations, and correlations with genetic, gastrointestinal, immune, and gut microbiome-related factors.
MOLECULAR PSYCHIATRY
(2023)
Article
Gastroenterology & Hepatology
Qi Su, Hein M. Tun, Qin Liu, Yun Kit Yeoh, Joyce Wing Yan Mak, Francis K. L. Chan, Siew C. Ng
Summary: This study examined the association between gut microbiota and Irritable bowel syndrome (IBS) subtypes, and found that there are distinct differences in microbiota composition among different IBS subtypes. The microbial diversity is significantly reduced in IBS-D and IBS-U, but not in IBS-C. The study also identified microbial signatures associated with depression in IBS patients. Factors such as gender, age, and dietary patterns have significant effects on gut microbiota in different IBS subtypes. These findings emphasize the importance of personalized gut microbiome modulation approaches for optimal therapeutic effects in different subtypes of IBS.
Article
Multidisciplinary Sciences
Maximilian Hinse, Anja Thronicke, Anne Berghoefer, Harald Matthes
Summary: The study found that AMT can improve the quality of life for IBS patients and the effects are particularly significant for patients without psychological comorbidities. Therefore, future IBS therapies should incorporate psychological therapy, especially for patients with depression and anxiety.
Article
Gastroenterology & Hepatology
Jenny Lovdahl, Hans Tornblom, Gisela Ringstrom, Olafur S. Palsson, Magnus Simren
Summary: This study evaluated and compared the effectiveness of nurse-administered individual and group hypnotherapy for patients with IBS. The results showed that gut-directed hypnotherapy, delivered individually or in groups by nurses, can relieve IBS symptoms, improve psychological symptoms, and enhance quality of life.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Medicine, General & Internal
Jessica Gerson, Prianca Tawde, Ghoncheh Ghiasian, Jessica K. K. Salwen-Deremer
Summary: This qualitative study aimed to understand patients' experiences in virtual, group-based gut-directed hypnotherapy (GDH) in two different institutions. The results showed that most patients were supportive of the group and virtual formats of GDH and reported positive outcomes for GI symptoms and other physical and mental health conditions. Therefore, virtual, group-based GDH is a feasible treatment option for improving patients' health.
FRONTIERS IN MEDICINE
(2023)
Review
Gastroenterology & Hepatology
Brennan Spiegel
Summary: This article proposes a hypothesis, known as the gravity hypothesis, that seeks to explain the pathogenesis of irritable bowel syndrome (IBS) by relating it to the influence of gravity on human evolution. It suggests that ineffective gravity management systems may lead to the development of IBS. The article reviews the impact of gravity on human evolution, discusses the imperfect adaptation of Homo sapiens to gravity, and explores the consequences of gravity intolerance in relation to IBS. It also considers the diagnostic and therapeutic implications of this hypothesis and suggests further experiments to support or reject it.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Medicine, General & Internal
Jun Zhao, Min Chen, Xin Wang, Kun Ye, Suhua Shi, Huixia Li, Jianfang Wang, Xiaowei Chen, Jinxia Ni, Qingshuang Wei, Yunzhou Shi, Yu Hu, Jingwen Sun, Da Li, Siyuan Liu, Zhigang Li, Hui Zheng, Shu-guang Yu
Summary: This study aims to investigate the efficacy and safety of acupuncture therapy for refractory IBS. Randomly assigned patients will receive either acupuncture or sham acupuncture, and outcomes will be compared to evaluate the effectiveness of acupuncture treatment.
Review
Otorhinolaryngology
Ayodele Sasegbon, Shaheen Hamdy
Summary: This article discusses the role of the cerebellum in the control of swallowing and explores new findings from neurostimulatory and imaging studies. Through neurostimulation, a better understanding of the connections between the cerebellum and cerebral swallowing motor areas has been achieved, providing new treatment options for neurogenic dysphagia.
Editorial Material
Gastroenterology & Hepatology
Aditi Kumar, Gaurav B. Nigam, Dipesh Harshvadan Vasant, Anjan Dhar
FRONTLINE GASTROENTEROLOGY
(2023)
Review
Otorhinolaryngology
Ivy Cheng, Ayodele Sasegbon, Shaheen Hamdy
Summary: In the past two decades, management of neurogenic dysphagia has shifted from passive compensatory strategies to evidence-based rehabilitative approaches. Advances in technology have allowed for the development of neuromodulation techniques, which aim to promote neurological reorganization for the recovery of swallowing function. This review summarizes current research findings on the effects of neuromodulation techniques on the human swallowing system and evaluates their therapeutic potential for neurogenic dysphagia. Implications for future clinical research and practical considerations for clinical practice are also discussed.
Article
Gastroenterology & Hepatology
Umair Akbani, Dipesh Harshvadan Vasant
Summary: This study investigated the perceptions of foundation doctors towards gastroenterology and identified gender differences in specialty selection factors. The results showed that female doctors value patient-centred care and good mentorship, while male doctors prioritize income and length of training. Female doctors had negative perceptions of the male dominant existing workforce and the requirement to be a medical registrar in gastroenterology. Increasing flexibility in training and providing more exposure and mentorship during the foundation years may improve diversity in the specialty.
FRONTLINE GASTROENTEROLOGY
(2023)
Review
Gastroenterology & Hepatology
Alexander O'Connor, Caroline M. Byrne, Dipesh H. Vasant, Abhiram Sharma, Donghua Liao, Niels Klarskov, Edward S. Kiff, Karen Telford
Summary: This review presents the current and potential future applications of AAR and FLIP techniques, highlighting the unanswered questions associated with these novel technologies.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Editorial Material
Gastroenterology & Hepatology
Sophia Agwaonye, Dipesh H. Vasant
BMJ OPEN GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Dipesh H. Vasant, Gaurav B. Nigam, Sebastian Bate, Shaheen Hamdy, Jimmy K. Limdi
Summary: Despite advances in UC therapies, a proportion of patients experience fecal incontinence (FI) in the absence of active inflammation. In a prospective study, the prevalence and impact of FI in UC were estimated.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Hussain Jaafari, Lesley A. Houghton, Robert M. West, Anurag Agrawal, Imran Aziz, Christopher J. Black, Maura Corsetti, Farag Shuweihdi, Maria Eugenicos, Peter A. Paine, Alexander C. Ford, Peter J. Whorwell, Shrikant I. Bangdiwala, Olafur S. Palsson, Ami D. Sperber, Dipesh H. Vasant
Summary: This study compared the prevalence of disorders of gut brain interaction (DGBI) in the UK with other countries and found that the proportion of DGBI participants was lower in the UK. The prevalence of 14 out of 22 Rome IV DGBI was similar between the UK and other countries, while some specific DGBI were more prevalent in the UK. Differences in opioid prescribing, cultural, dietary, and lifestyle factors may contribute to variations in the prevalence of DGBI between the UK and other countries.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Review
Gastroenterology & Hepatology
Syed S. Hasan, Sarah Ballou, Laurie Keefer, Dipesh H. Vasant
Summary: Gut-directed hypnotherapy (GDH) is a highly effective behavioral therapy recommended for the treatment of irritable bowel syndrome (IBS). GDH has been recognized as a valuable addition to integrated care alongside medical and dietary approaches. Recent innovations, such as smartphone app-delivered GDH, have improved access to this therapy despite low adherence rates.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Multidisciplinary Sciences
Huw Purssell, Lucy Bennett, Oliver Street, Karen Piper Hanley, Neil Hanley, Dipesh H. Vasant, Varinder S. Athwal
Summary: The study evaluated the prevalence and burden of Rome IV irritable bowel syndrome (IBS) in patients with non-alcoholic fatty liver disease (NAFLD). It found that 55.6% of NAFLD patients had Rome IV bowel disorders of gut brain interaction (DGBI), with 35.2% meeting the criteria for IBS. Rome IV bowel DGBI, such as IBS, are associated with impaired quality-of-life (QoL) and psychosocial distress.
SCIENTIFIC REPORTS
(2023)
Article
Psychology, Clinical
Syed Shariq Hasan, Dipesh Vasant
Summary: Remote hypnotherapy is increasingly used internationally, especially after the COVID-19 pandemic. Video-based remote hypnotherapy is more popular and effective compared to telephone therapy, improving access to treatment. Patient satisfaction and practical considerations should be taken into account when deciding on the mode of delivery.
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL HYPNOSIS
(2023)
Article
Gastroenterology & Hepatology
Jade Devenney, Syed S. Hasan, Julie Morris, Peter J. Whorwell, Dipesh H. Vasant
Summary: This study conducted a secondary analysis of gut-directed hypnotherapy outcomes in patients with refractory IBS and found that patients with a higher burden of gastrointestinal and extraintestinal symptoms are most likely to benefit from this treatment. Clinical assessment of gastrointestinal, somatic, and psychological symptom profiles may play a role in selecting patients for gut-directed hypnotherapy.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Ayodele Sasegbon, Yuying Luo, Laurie A. Keefer, Dipesh H. Vasant
Summary: Despite the high prevalence and burden of disorders of gut-brain interaction (DGBI), there is limited teaching on this topic in medical curricula. This study evaluated the exposure and comfort levels of UK gastroenterology trainees in diagnosing and managing DGBI. Findings suggest that most trainees lack confidence in dealing with DGBI.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Review
Gastroenterology & Hepatology
Karuna Sapru, Peter Barry, Andrew Jones, John Walmsley, Javaid Iqbal, Dipesh H. Vasant
Summary: Patients with cystic fibrosis (pwCF) have a high incidence of early colorectal cancer (CRC). This study evaluated the utility and outcomes of colonoscopy and CRC at a large UK CF centre. The results showed that the uptake of colonoscopy among pwCF was low, but it was highly effective for detecting premalignant lesions in patients over 40 years old.
BMJ OPEN GASTROENTEROLOGY
(2023)