Article
Biochemistry & Molecular Biology
Ly Porosk, Heleri Heike Hark, Renata Naporano Bicev, Ilja Gaidutsik, Jekaterina Nebogatova, Eger-Jasper Armolik, Piret Arukuusk, Emerson Rodrigo da Silva, Ulo Langel
Summary: Alzheimer's disease (AD) is a common neurodegenerative disease that causes dementia, and its pathophysiological dynamics are driven by genetics with high heterogeneity in biological alterations and causes. The disease is characterized by the progression of aggregated amyloid-beta (A beta) or Tau neurofibrillary tangles. Current treatments for AD are not efficient, but recent breakthroughs have led to the discovery of potential therapeutic targets such as reducing brain inflammation and limiting A beta aggregation. This study demonstrates the successful use of A beta interacting protein sequences, particularly derived from Transthyretin, to reduce or target amyloid aggregation, and also predicts anti-inflammatory properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Olga Krasnovskaya, Aina Kononova, Alexander Erofeev, Peter Gorelkin, Alexander Majouga, Elena Beloglazkina
Summary: There are over 55 million people with dementia worldwide and nearly 10 million new cases every year. Alzheimer's disease is the most common neurodegenerative disease that causes personality changes, cognitive impairment, memory loss, and physical disability. Early detection methods are important for early treatment of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Megan J. J. Lantz, Alyssa M. M. Roberts, Donovan D. D. Delgado, Robert A. A. Nichols
Summary: Alzheimer's disease is characterized by the accumulation of amyloid beta (Aβ) and neurofibrillary tangles, leading to chronic neuroinflammation. The N-terminal Aβ fragment and N-Aβ core have been shown to protect against neurodegeneration. This study provides evidence that these fragments can also alleviate persistent neuroinflammation in Alzheimer's disease.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Chemistry, Medicinal
Ivan Sanchis, Roque Spinelli, Jose Dias, Xavier Brazzolotto, Alvaro Rietmann, Florencia Aimaretti, Alvaro S. Siano
Summary: We report a series of peptide derivatives with inhibitory activity on human cholinesterases and AChE-induced β-amyloid peptide aggregation. Peptide W3 was identified as an interesting scaffold for the development of new anti-AD multitarget-directed drugs, with the lowest IC50 value against hAChE and inhibition of AChE-induced Aβ aggregation. It also showed inhibitory activity on hBChE, no in vivo toxicity, and moderate radical scavenging and Fe2+ chelating capabilities.
Article
Biochemistry & Molecular Biology
Lucia Scipioni, Daniel Tortolani, Francesca Ciaramellano, Federico Fanti, Thais Gazzi, Manuel Sergi, Marc Nazare, Sergio Oddi, Mauro Maccarrone
Summary: Chronic exposure to beta-amyloid peptides (A beta) may modify the endocannabinoid signaling in microglial cells, leading to a pro-AD phenotype. A beta-exposed microglia produced more 2-arachidonoylglycerol (2-AG) and showed altered expression of enzymes and receptors involved in 2-AG synthesis and signaling. Enhanced 2-AG signaling may contribute to the pro-AD phenotype of microglia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Max A. A. Thorwald, Justine Silva, Elizabeth Head, Caleb E. E. Finch
Summary: PET imaging studies of AD patients show progressive increases of fibrillar A beta-amyloid. This study analyzed soluble A beta levels in AD and controls, and found that soluble A beta levels overlapped significantly between AD and controls, in contrast to the PET findings on fibrillar A beta. These findings highlight the importance of further postmortem analysis to understand the relationship between diverse forms of A beta and PET.
ALZHEIMERS & DEMENTIA
(2022)
Review
Medicine, Research & Experimental
Hao Yu, Jie Wu
Summary: Amyloid-beta accumulation is a key feature of Alzheimer's disease, with both neurotoxic and potentially protective effects. Understanding the role of Aβ in depth will provide a broader perspective on Alzheimer's disease treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Nutrition & Dietetics
Aitor Blanco-Miguez, Hector Tames, Patricia Ruas-Madiedo, Borja Sanchez
Summary: This study presents evidence of A beta-like peptides released from the gut microbiome, with one peptide inducing pathways related to Alzheimer's disease in neuron cell-line model. It opens new approaches for understanding the relationship between gut microbiota and AD, suggesting potential implications for targeted microbiota modification in animal models to study the role of gut bacteria in this progressive disease.
Review
Biochemistry & Molecular Biology
Giuseppe Di Natale, Giuseppina Sabatino, Michele Francesco Maria Sciacca, Rita Tosto, Danilo Milardi, Giuseppe Pappalardo
Summary: In the last two decades, the amyloid hypothesis has been the mainstream concept in Alzheimer's Disease research. However, recent evidence suggests that tau accumulation is more closely related to cognitive decline and AD development. Failed clinical trials of amyloid-targeting drug candidates imply the need for significant amendments to the amyloid hypothesis. This article discusses the potential dangerous relationships between A beta oligomeric species and tau protein and explores the molecular determinants underlying their cross interactions.
Article
Biochemistry & Molecular Biology
Kyu-Ho Shim, Sungchan Ha, Jin Seung Choung, Jee In Choi, Daniel Youngsuk Kim, Jong Moon Kim, MinYoung Kim
Summary: This study highlighted the potential therapeutic effects of EPO administration on Alzheimer's disease, including improvements in memory function, modulation of neurotransmitters, anti-inflammatory action, and neurogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Chiara Bacchella, Simone Dell'Acqua, Stefania Nicolis, Enrico Monzani, Luigi Casella
Summary: The redox chemistry of copper(II) is significantly influenced by its coordination with amyloid-beta peptides and the stability of resulting complexes. The study investigates the oxidase activity of Cu-Aβ complexes towards dopamine and catechols, revealing that Cu-II-ATCUN site is not redox-inert and catechol coordination induces metal reduction. Additionally, vicinal histidines provide a secondary Cu-binding motif independently of the ATCUN site, affecting the oxidative reactivity towards catechol.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemical Research Methods
Israel Donizeti de Souza, Maria Eugenia Costa Queiroz
Summary: Alzheimer's disease (AD), characterized by memory loss, confusion, and cognitive impairment, is a major public health concern. Researchers have focused on finding reliable biomarkers for early diagnosis, with amyloid-beta (A beta) peptides being established as important indicators. However, quantifying A beta peptides in biological samples remains challenging due to their complex properties. Mass spectrometry techniques, such as HPLC-MS/MS, have shown promise in accurately measuring A beta peptides and have led to advancements in sample preparation and sensitivity.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Victor Marchenkov, Natalya Ryabova, Vitaly Balobanov, Anatoly Glukhov, Nelly Ilyina, Natalya Katina
Summary: The study reveals that bovine carbonic anhydrase B forms amyloid fibrils under acidic pH and elevated temperature conditions. Prior to amyloid formation, BCAB undergoes fragmentation by acid hydrolysis to give peptides, with associated peptides containing a pronounced secondary structure acting as the main precursor of amyloid fibrils.
Article
Cell Biology
Soumen Das, Narendrakumar Ramanan
Summary: Neurons in the mammalian brain exhibit diversity in nuclear morphology across different brain regions, with variations in area, perimeter, and circularity. These nuclear size parameters also change with age, showing decreases in some regions and increases in others. In an Alzheimer's disease mouse model, neuronal nuclear morphology varies with plaque size and distance from the plaque. These findings suggest that changes in nuclear size and shape may be related to transcriptional activity in different ages and Alzheimer's disease.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Yeseong Choi, Su-Mi Kim, Youhee Heo, Gyudo Lee, Ji Yoon Kang, Dae Sung Yoon
Summary: The study found that with increasing concentrations of Aβ(42) oligomers, the surface charge of exosomes increased, indicating that exosomes contain more Aβ(42) and may serve as transport vesicles for Aβ(42).
Article
Chemistry, Physical
Bogdan Tarus, Thanh T. Tran, Jessica Nasica-Labouze, Fabio Stepone, Phuong H. Nguyen, Philippe Derreumaux
JOURNAL OF PHYSICAL CHEMISTRY B
(2015)
Meeting Abstract
Biophysics
Thanh-Thuy Tran, Phuong H. Nguyen, Philippe Derreumaux
BIOPHYSICAL JOURNAL
(2016)
Review
Chemistry, Multidisciplinary
Mara Chiricotto, Thanh Thuy Tran, Phuong H. Nguyen, Simone Melchionna, Fabio Sterpone, Philippe Derreumaux
ISRAEL JOURNAL OF CHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Fabio Sterpone, Sebastien Doutreligne, Thanh Thuy Tran, Simone Melchionna, Marc Baaden, Phuong H. Nguyen, Philippe Derreumaux
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Physics, Applied
T. T. Thuy, V. T. H. Yen, T. T. Thao, Nguyen Ai Viet
MODERN PHYSICS LETTERS B
(2011)
Article
Chemistry, Multidisciplinary
Thanh Thuy Tran, Feng Pan, Linh Tran, Christopher Roland, Celeste Sagui
Summary: Alzheimer's disease is associated with the aggregation of Aβ protein of 40 or 42 amino acids, with point mutations affecting the aggregation rate and mechanism. F19 mutations have been shown to impact aggregation rate while maintaining fibril structures. Substituting Phe with Trp leads to reduced binding affinity to lipid membranes and more flexible and less stable trimer structures.