Mitochondria-Targeted Antioxidants and Uncouplers of Oxidative Phosphorylation in Treatment of the Systemic Inflammatory Response Syndrome (SIRS)

Oxidation of NADH and ROS production by respiratory complex I

(2016) Andrei D. Vinogradov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

A long-linker conjugate of fluorescein and triphenylphosphonium as mitochondria-targeted uncoupler and fluorescent neuro- and nephroprotector

(2016) Yuri N. Antonenko et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Normalizing the environment recapitulates adult human immune traits in laboratory mice

(2016) Lalit K. Beura et al.   NATURE

Role of mitochondrial reactive oxygen species in age-related inflammatory activation of endothelium

(2016) Roman A. Zinovkin et al.   Aging-US

Mitochondria-targeted antioxidant SkQ1 improves impaired dermal wound healing in old mice

(2015) Ilya A. Demyanenko et al.   Aging-US

Vicious Inducible Nitric Oxide Synthase-Mitochondrial Reactive Oxygen Species Cycle Accelerates Inflammatory Response and Causes Liver Injury in Rats

(2015) Adelheid Weidinger et al.   ANTIOXIDANTS & REDOX SIGNALING

Systemic Inflammatory Response Syndrome in End-Stage Heart Failure Patients Following Continuous-Flow Left Ventricular Assist Device Implantation: Differences in Plasma Redox Status and Leukocyte Activation

(2015) Nandan K. Mondal et al.   ARTIFICIAL ORGANS

How informative is the mouse for human gut microbiota research?

(2015) T. L. A. Nguyen et al.   Disease Models & Mechanisms

Initiation and perpetuation of NLRP3 inflammasome activation and assembly

(2015) Eric I. Elliott et al.   IMMUNOLOGICAL REVIEWS

MitoQ modulates oxidative stress and decreases inflammation following hemorrhage

(2015) Rebecca D. Powell et al.   Journal of Trauma and Acute Care Surgery

Efficacy and Safety of Ropivacaine Addition to Intrathecal Morphine for Pain Management in Intractable Cancer

(2015) Ying Huang et al.   MEDIATORS OF INFLAMMATION

MitoQ modulates oxidative stress and decreases inflammation following hemorrhage

(2015) Rebecca D. Powell et al.   Journal of Trauma and Acute Care Surgery

Mitochondrial ROS Induces Cardiac Inflammation via a Pathway through mtDNA Damage in a Pneumonia-Related Sepsis Model

(2015) Xiao Yao et al.   PLoS One

A short-chain alkyl derivative of Rhodamine 19 acts as a mild uncoupler of mitochondria and a neuroprotector

(2014) Ljudmila S. Khailova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial Ca2+ influx targets cardiolipin to disintegrate respiratory chain complex II for cell death induction

(2014) M-S Hwang et al.   CELL DEATH AND DIFFERENTIATION

Mitochondria-Targeted Peptide Reverses Mitochondrial Dysfunction and Cognitive Deficits in Sepsis-Associated Encephalopathy

(2014) Jing Wu et al.   MOLECULAR NEUROBIOLOGY

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis

(2013) D.A. Lowes et al.   BRITISH JOURNAL OF ANAESTHESIA

The Effect of Selenium Therapy on Mortality in Patients With Sepsis Syndrome

(2013) Waleed Alhazzani et al.   CRITICAL CARE MEDICINE

A Randomized Trial of Glutamine and Antioxidants in Critically Ill Patients

(2013) Daren Heyland et al.   NEW ENGLAND JOURNAL OF MEDICINE

Penetrating Cations Enhance Uncoupling Activity of Anionic Protonophores in Mitochondria

(2013) Yuri N. Antonenko et al.   PLoS One

Protective effect of mitochondria-targeted antioxidants in an acute bacterial infection

(2013) E. Y. Plotnikov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systemic inflammatory response syndrome (SIRS)

(2013) Robert A Balk   Virulence

Mitochondrial Redox Signaling: Interaction of Mitochondrial Reactive Oxygen Species with Other Sources of Oxidative Stress

(2012) Eberhard Schulz et al.   ANTIOXIDANTS & REDOX SIGNALING

Role of Caspases in Cytokine-Induced Barrier Breakdown in Human Brain Endothelial Cells

(2012) M. A. Lopez-Ramirez et al.   JOURNAL OF IMMUNOLOGY

Lipidomics identifies cardiolipin oxidation as a mitochondrial target for redox therapy of brain injury

(2012) Jing Ji et al.   NATURE NEUROSCIENCE

Mice, men and the relatives: cross-species studies underpin innate immunity

(2012) C. E. Bryant et al.   Open Biology

The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities

(2011) Zhi Huang et al.   ANTIOXIDANTS & REDOX SIGNALING

Mild Mitochondrial Uncoupling as a Therapeutic Strategy

(2011) Fernanda M. Cunha et al.   CURRENT DRUG TARGETS

Mitochondria: Sovereign of inflammation?

(2011) Jürg Tschopp   EUROPEAN JOURNAL OF IMMUNOLOGY

RIP Kinase-Dependent Necrosis Drives Lethal Systemic Inflammatory Response Syndrome

(2011) Linde Duprez et al.   IMMUNITY

High-dose selenium substitution in sepsis: a prospective randomized clinical trial

(2011) Jiri Valenta et al.   INTENSIVE CARE MEDICINE

Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

(2011) Ariel C. Bulua et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Os leucócitos e a resposta inflamatória na lesão de isquemia-reperfusão

(2011) Ieda Francischetti et al.   Revista Brasileira de Cirurgia Cardiovascular

Therapeutic Targeting of Mitochondrial Superoxide in Hypertension

(2010) Anna E. Dikalova et al.   CIRCULATION RESEARCH

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Immunotherapy for Sepsis — A New Approach against an Ancient Foe

(2010) Richard S. Hotchkiss et al.   NEW ENGLAND JOURNAL OF MEDICINE

Myoglobin causes oxidative stress, increase of NO production and dysfunction of kidney's mitochondria

(2009) Egor Y. Plotnikov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Acute pancreatitis as a model of SIRS

(2009) Madhav Bhatia   Frontiers in Bioscience-Landmark

Systemic inflammatory response following acute traumatic brain injury

(2009) Jia Lu   Frontiers in Bioscience-Landmark

A Pivotal Role of Endothelial-Specific NF- B Signaling in the Pathogenesis of Septic Shock and Septic Vascular Dysfunction

(2009) J. Ding et al.   JOURNAL OF IMMUNOLOGY

Penetrating cation/fatty acid anion pair as a mitochondria-targeted protonophore

(2009) F. F. Severin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mild mitochondrial uncoupling in mice affects energy metabolism, redox balance and longevity

(2008) Camille C. Caldeira da Silva et al.   AGING CELL

The mitochondria-targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharide–peptidoglycan model of sepsis

(2008) Damon A. Lowes et al.   FREE RADICAL BIOLOGY AND MEDICINE

The role of adherens junctions and VE-cadherin in the control of vascular permeability

(2008) E. Dejana et al.   JOURNAL OF CELL SCIENCE

IL-17 produced by Paneth cells drives TNF-induced shock

(2008) Nozomi Takahashi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Contribution of free radicals to Pseudomonas aeruginosa induced acute pyelonephritis

(2008) Rahul Mittal et al.   MICROBIAL PATHOGENESIS

Mitochondria-Targeted Cytoprotective Peptides for Ischemia–Reperfusion Injury

(2007) Hazel H. Szeto   ANTIOXIDANTS & REDOX SIGNALING